P B Jeppesen

Summary

Country: Denmark

Publications

  1. ncbi request reprint Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats
    P B Jeppesen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
    Phytomedicine 9:9-14. 2002
  2. doi request reprint Isosteviol increases insulin sensitivity and changes gene expression of key insulin regulatory genes and transcription factors in islets of the diabetic KKAy mouse
    I Nordentoft
    Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 10:939-49. 2008
  3. ncbi request reprint Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat
    P B Jeppesen
    Department of Endocrinology and Metabolism, Molecular Diagnostic Laboratory, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Metabolism 52:372-8. 2003
  4. doi request reprint Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content
    I Nordentoft
    Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Agric Food Chem 56:4377-85. 2008
  5. doi request reprint Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels
    R Abudula
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 10:1074-85. 2008
  6. ncbi request reprint Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure
    J Hong
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Odense, Denmark
    Am J Physiol Endocrinol Metab 290:E416-22. 2006
  7. doi request reprint Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction
    X Chen
    Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 14:1020-31. 2012
  8. ncbi request reprint Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal--jejunal transposition or small bowel resection
    J Thulesen
    Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Dig Dis Sci 46:379-88. 2001
  9. ncbi request reprint Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon
    K V Haderslev
    Dept of Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Scand J Gastroenterol 37:392-8. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats
    P B Jeppesen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
    Phytomedicine 9:9-14. 2002
    ..In conclusion, stevioside exerts antihyperglycaemic, insulinotropic, and glucagonostatic actions in the type 2 diabetic GK rat, and may have the potential of becoming a new antidiabetic drug for use in type 2 diabetes...
  2. doi request reprint Isosteviol increases insulin sensitivity and changes gene expression of key insulin regulatory genes and transcription factors in islets of the diabetic KKAy mouse
    I Nordentoft
    Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 10:939-49. 2008
    ....
  3. ncbi request reprint Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat
    P B Jeppesen
    Department of Endocrinology and Metabolism, Molecular Diagnostic Laboratory, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Metabolism 52:372-8. 2003
    ....
  4. doi request reprint Increased insulin sensitivity and changes in the expression profile of key insulin regulatory genes and beta cell transcription factors in diabetic KKAy-mice after feeding with a soy bean protein rich diet high in isoflavone content
    I Nordentoft
    Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Agric Food Chem 56:4377-85. 2008
    ..The results indicate that SBP improves glucose and insulin sensitivity and up-regulates the expression of key insulin regulatory genes...
  5. doi request reprint Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels
    R Abudula
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 10:1074-85. 2008
    ..The results indicate that rebaudioside A may offer a distinct therapeutic advantage over sulphonylureas because of less risk of causing hypoglycaemia...
  6. ncbi request reprint Stevioside counteracts the alpha-cell hypersecretion caused by long-term palmitate exposure
    J Hong
    Department of Endocrinology and Metabolism, Aarhus University Hospital, Odense, Denmark
    Am J Physiol Endocrinol Metab 290:E416-22. 2006
    ..This indicates that stevioside may be a promising antidiabetic agent in treatment of type 2 diabetes...
  7. doi request reprint Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction
    X Chen
    Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 14:1020-31. 2012
    ..Furthermore, we wanted to explore if glucagon-like peptide-1 (GLP-1), isosteviol (ISV) and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR) counteract changes in α-cell function induced by chronic exposure to leucine...
  8. ncbi request reprint Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal--jejunal transposition or small bowel resection
    J Thulesen
    Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Dig Dis Sci 46:379-88. 2001
    ..The adaptive intestinal growth is associated with increased plasma levels of GLP-2, and GLP-2 seems to act in an endocrine as well as a paracrine manner...
  9. ncbi request reprint Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon
    K V Haderslev
    Dept of Gastroenterology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Scand J Gastroenterol 37:392-8. 2002
    ..This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients...