Kenneth Alan Howard

Summary

Affiliation: Interdisciplinary Nanoscience Center
Country: Denmark

Publications

  1. ncbi request reprint Nanocarrier stimuli-activated gene delivery
    Kenneth A Howard
    Interdisciplinary Nanoscience Center and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Small 3:54-7. 2007
  2. ncbi request reprint Polycation-based nanoparticle delivery for improved RNA interference therapeutics
    Kenneth A Howard
    University of Aarhus, Interdisciplinary Nanoscience Center iNANO and Department of Molecular Biology, 8000 Aarhus, Denmark
    Expert Opin Biol Ther 7:1811-22. 2007
  3. pmc Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    Kenneth A Howard
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
    Mol Ther 17:162-8. 2009
  4. doi request reprint Delivery of RNA interference therapeutics using polycation-based nanoparticles
    Kenneth Alan Howard
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Adv Drug Deliv Rev 61:710-20. 2009
  5. doi request reprint Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery
    Menglin Chen
    Interdisciplinary Nanoscience Center iNANO, Aarhus University, DK 8000 Aarhus C, Denmark
    ACS Nano 6:4835-44. 2012
  6. doi request reprint RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications
    Morten Østergaard Andersen
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Methods Mol Biol 555:77-86. 2009
  7. pmc The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    Shan Gao
    Department of Molecular Biology, University of Aarhus, Denmark
    Mol Ther 17:1225-33. 2009
  8. doi request reprint Polycation-based nanoparticle delivery of RNAi therapeutics: adverse effects and solutions
    Borja Ballarín-González
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark
    Adv Drug Deliv Rev 64:1717-29. 2012

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Nanocarrier stimuli-activated gene delivery
    Kenneth A Howard
    Interdisciplinary Nanoscience Center and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Small 3:54-7. 2007
  2. ncbi request reprint Polycation-based nanoparticle delivery for improved RNA interference therapeutics
    Kenneth A Howard
    University of Aarhus, Interdisciplinary Nanoscience Center iNANO and Department of Molecular Biology, 8000 Aarhus, Denmark
    Expert Opin Biol Ther 7:1811-22. 2007
    ..Issues including use of stimuli-responsive systems for intracellular trafficking of siRNA are discussed as part of necessary future directives towards the development of RNA-based clinical therapeutics...
  3. pmc Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    Kenneth A Howard
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
    Mol Ther 17:162-8. 2009
    ..This work demonstrates nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages as a method to reduce both local and systemic inflammation, thereby presenting a novel strategy for arthritis treatment...
  4. doi request reprint Delivery of RNA interference therapeutics using polycation-based nanoparticles
    Kenneth Alan Howard
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark
    Adv Drug Deliv Rev 61:710-20. 2009
    ..This work highlights the versatile nature of polycation-based nanoparticles to fulfil the delivery requirements for RNA molecules with flexibility in design to evolve alongside an expanding repertoire of RNAi-based drugs...
  5. doi request reprint Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery
    Menglin Chen
    Interdisciplinary Nanoscience Center iNANO, Aarhus University, DK 8000 Aarhus C, Denmark
    ACS Nano 6:4835-44. 2012
    ..The interesting release profile was further investigated for siRNA transfection, where the encapsulated chitosan/siRNA NPs exhibited up to 50% EGFP gene silencing activity after 48 h post-transfection on H1299 cells...
  6. doi request reprint RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications
    Morten Østergaard Andersen
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Methods Mol Biol 555:77-86. 2009
    ..The method exploits the mucoadhesive and mucopermeable properties of this cationic polysaccharide to deliver siRNA across mucosal epithelium and provides a platform for targeting human diseases with RNAi therapeutics...
  7. pmc The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    Shan Gao
    Department of Molecular Biology, University of Aarhus, Denmark
    Mol Ther 17:1225-33. 2009
    ..This comparative study highlights improvements to siRNA stability and pharmacokinetics, key determinants for development of clinically relevant RNAi therapeutics...
  8. doi request reprint Polycation-based nanoparticle delivery of RNAi therapeutics: adverse effects and solutions
    Borja Ballarín-González
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark
    Adv Drug Deliv Rev 64:1717-29. 2012
    ..A greater understanding of the cellular mechanisms involved allows design-based solutions for rationale development of safe, effective and clinically relevant polyplex-based RNAi drugs...