Mikkel Harndahl

Summary

Country: Denmark

Publications

  1. doi request reprint Peptide-MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity
    Mikkel Harndahl
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur J Immunol 42:1405-16. 2012
  2. doi request reprint Real-time, high-throughput measurements of peptide-MHC-I dissociation using a scintillation proximity assay
    Mikkel Harndahl
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Immunol Methods 374:5-12. 2011
  3. pmc Functional recombinant MHC class II molecules and high-throughput peptide-binding assays
    Sune Justesen
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Immunome Res 5:2. 2009
  4. pmc Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes formed with natural ligands
    Gustav Roder
    Laboratory of Experimental Immunology, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Panum DK 2200 Copenhagen, Denmark
    J Biol Chem 286:20547-57. 2011
  5. pmc Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities
    Lasse Eggers Pedersen
    Laboratory of Experimental Immunology, University of Copenhagen, Denmark
    Immunogenetics 63:821-34. 2011
  6. pmc HLA class I binding 9mer peptides from influenza A virus induce CD4 T cell responses
    Mingjun Wang
    Department of International Health, Immunology and Microbiology, Faculty of Heath Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e10533. 2010
  7. doi request reprint Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy
    Susanne Rasmussen
    Department of International Health, Immunology and Microbiology, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Immunopharmacol Immunotoxicol 35:487-96. 2013
  8. pmc Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response
    Caroline B Madsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50139. 2012
  9. doi request reprint The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I
    Gustav Roder
    Department of Experimental Immunology, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Panum Institute, DK 2200 Copenhagen, Denmark
    Eur J Immunol 39:2682-94. 2009
  10. doi request reprint The peptide-binding specificity of HLA-A*3001 demonstrates membership of the HLA-A3 supertype
    Kasper Lamberth
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Panum 18 3 12, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Immunogenetics 60:633-43. 2008

Collaborators

Detail Information

Publications12

  1. doi request reprint Peptide-MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity
    Mikkel Harndahl
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur J Immunol 42:1405-16. 2012
    ..We conclude that the availability of accurate predictors of pMHC-I stability might be helpful in the elucidation of MHC-I restricted antigen presentation, and might be instrumental in future search strategies for MHC-I epitopes...
  2. doi request reprint Real-time, high-throughput measurements of peptide-MHC-I dissociation using a scintillation proximity assay
    Mikkel Harndahl
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Immunol Methods 374:5-12. 2011
    ..To exemplify this, we screened a panel of 384 high-affinity peptides binding to the MHC class I molecule, HLA-A*02:01, and observed the rates of dissociation that ranged from 0.1h to 46h depending on the peptide used...
  3. pmc Functional recombinant MHC class II molecules and high-throughput peptide-binding assays
    Sune Justesen
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Immunome Res 5:2. 2009
    ..CONCLUSION: We have successfully developed versatile MHC-II resources, which may assist in the generation of MHC class II -wide reagents, data, and tools...
  4. pmc Tapasin discriminates peptide-human leukocyte antigen-A*02:01 complexes formed with natural ligands
    Gustav Roder
    Laboratory of Experimental Immunology, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Panum DK 2200 Copenhagen, Denmark
    J Biol Chem 286:20547-57. 2011
    ..These findings are important for understanding the biogenesis of HLA-I molecules, the selection of presented T-cell epitopes, and the identification of immunogenic targets in both basic research and vaccine design...
  5. pmc Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities
    Lasse Eggers Pedersen
    Laboratory of Experimental Immunology, University of Copenhagen, Denmark
    Immunogenetics 63:821-34. 2011
    ..These data indicate that it is possible to extend the biochemical and bioinformatics tools of the Human MHC Project to other vertebrate species...
  6. pmc HLA class I binding 9mer peptides from influenza A virus induce CD4 T cell responses
    Mingjun Wang
    Department of International Health, Immunology and Microbiology, Faculty of Heath Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e10533. 2010
    ..Identification of human leukocyte antigen class I (HLA-I) restricted cytotoxic T cell (CTL) epitopes from influenza virus is of importance for the development of new effective peptide-based vaccines...
  7. doi request reprint Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy
    Susanne Rasmussen
    Department of International Health, Immunology and Microbiology, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Immunopharmacol Immunotoxicol 35:487-96. 2013
    ..This may have interest in future cancer vaccines, but more studies are needed to elucidate the immunological mechanisms of action in potentially cured patients treated with an immunotherapeutic agent...
  8. pmc Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response
    Caroline B Madsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50139. 2012
    ..GalNAc glycosylation of MUC1 antigen therefore facilitates uptake, MHC class II presentation, and antibody response but might block the antigen presentation to CD8+ T cells...
  9. doi request reprint The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I
    Gustav Roder
    Department of Experimental Immunology, Institute of International Health, Immunology and Microbiology, University of Copenhagen, Panum Institute, DK 2200 Copenhagen, Denmark
    Eur J Immunol 39:2682-94. 2009
    ....
  10. doi request reprint The peptide-binding specificity of HLA-A*3001 demonstrates membership of the HLA-A3 supertype
    Kasper Lamberth
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Panum 18 3 12, Blegdamsvej 3b, 2200, Copenhagen, Denmark
    Immunogenetics 60:633-43. 2008
    ..We discuss approaches to supertype assignment and underscore the importance of experimental verification...
  11. doi request reprint Wildtype p53-specific antibody and T-cell responses in cancer patients
    Anders Elm Pedersen
    Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Denmark
    J Immunother 34:629-40. 2011
    ..However, none of the wt p53 reactivity observed justified use of 15-mer or was related to survival in this rare patient population...
  12. doi request reprint Peptide binding to HLA class I molecules: homogenous, high-throughput screening, and affinity assays
    Mikkel Harndahl
    Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Biomol Screen 14:173-80. 2009
    ..We have successfully applied this assay to more than 60 different HLA molecules, leading to more than 2 million measurements...