R Scott Heller

Summary

Affiliation: Hagedorn Research Institute
Country: Denmark

Publications

  1. ncbi request reprint Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas
    R S Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820, Gentofte, Denmark
    Diabetes 50:1553-61. 2001
  2. doi request reprint The comparative anatomy of islets
    R Scott Heller
    Hagedorn Research Institute, Department of Beta Cell Regeneration, Gentofte DK2820, Denmark
    Adv Exp Med Biol 654:21-37. 2010
  3. doi request reprint Intracranial ectopic pancreatic tissue
    R Scott Heller
    Department of Beta Cell Regeneration, Hagedorn Research Institute, Gentofte, Denmark
    Islets 2:65-71. 2010
  4. ncbi request reprint The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
    R Scott Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Dev Biol 268:123-34. 2004
  5. ncbi request reprint Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas
    R Scott Heller
    JDRF Center for Beta Cell Therapy, Europe
    Gene Expr 11:141-7. 2003
  6. ncbi request reprint Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, Gentofte, Denmark
    Dev Dyn 225:260-70. 2002
  7. ncbi request reprint Genetic determinants of pancreatic epsilon-cell development
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, DK 2820 Gentofte, Denmark
    Dev Biol 286:217-24. 2005
  8. doi request reprint The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds
    Carsten R Gustavsen
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, Gentofte DK2820, Denmark
    Gen Comp Endocrinol 159:241-9. 2008
  9. doi request reprint Acomys, the closest relatives to Gerbils, do express Pdx-1 protein and have similar islet morphology to Gerbils
    Carsten R Gustavsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Islets 1:191-7. 2009
  10. ncbi request reprint Nestin is expressed in vascular endothelial cells in the adult human pancreas
    Tino Klein
    JDRF Center for Beta Cell Therapy in Europe, Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Histochem Cytochem 51:697-706. 2003

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas
    R S Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820, Gentofte, Denmark
    Diabetes 50:1553-61. 2001
    ..The mechanisms underlying these observations remain to be elucidated...
  2. doi request reprint The comparative anatomy of islets
    R Scott Heller
    Hagedorn Research Institute, Department of Beta Cell Regeneration, Gentofte DK2820, Denmark
    Adv Exp Med Biol 654:21-37. 2010
    ....
  3. doi request reprint Intracranial ectopic pancreatic tissue
    R Scott Heller
    Department of Beta Cell Regeneration, Hagedorn Research Institute, Gentofte, Denmark
    Islets 2:65-71. 2010
    ..It is speculated that the ectopic pancreas domain may arise from misexpression of homeodomain transcription factors related to Pdx1 within a domain of Ptf1a expression...
  4. ncbi request reprint The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
    R Scott Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Dev Biol 268:123-34. 2004
    ..2 cells. The pancreatic phenotype of the pax6 mutants can be rescued with a YAC clone containing the human Pax6 gene...
  5. ncbi request reprint Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas
    R Scott Heller
    JDRF Center for Beta Cell Therapy, Europe
    Gene Expr 11:141-7. 2003
    ..In situ hybridization for Frz 1-7 showed that expression colocalized with the islets of Langerhans. Together the data suggest that active Wnt signaling occurs in adult pancreas and is probably important for physiological functions...
  6. ncbi request reprint Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, Gentofte, Denmark
    Dev Dyn 225:260-70. 2002
    ..Taken together, these results suggest that Wnt genes participate in epithelial-mesenchymal signaling and may specify region identity in the anterior foregut...
  7. ncbi request reprint Genetic determinants of pancreatic epsilon-cell development
    R Scott Heller
    Hagedorn Research Institute, Department of Developmental Biology, DK 2820 Gentofte, Denmark
    Dev Biol 286:217-24. 2005
    ....
  8. doi request reprint The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds
    Carsten R Gustavsen
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, Gentofte DK2820, Denmark
    Gen Comp Endocrinol 159:241-9. 2008
    ....
  9. doi request reprint Acomys, the closest relatives to Gerbils, do express Pdx-1 protein and have similar islet morphology to Gerbils
    Carsten R Gustavsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Islets 1:191-7. 2009
    ..During the evolution of the spiny mice and the gerbils, it appears that the Pdx-1 gene was lost...
  10. ncbi request reprint Nestin is expressed in vascular endothelial cells in the adult human pancreas
    Tino Klein
    JDRF Center for Beta Cell Therapy in Europe, Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    J Histochem Cytochem 51:697-706. 2003
    ..We have shown that nestin is expressed by vascular endothelial cells in human pancreas, and therefore it is unlikely that nestin specifically marks a subpopulation of cells representing endocrine progenitors in the adult pancreas...
  11. doi request reprint Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus
    Louise Vedtofte
    Department of Beta Cell Regeneration, Hagedorn Research Institute, Gentofte, Denmark
    Regul Pept 160:106-14. 2010
    ..obesus by increasing their insulin content and improving the function of the beta-cells. In contrast, vildagliptin does not improve glycaemic control in P. obesus nor affect beta-cell insulin content...
  12. doi request reprint Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction
    Tino Klein
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Pancreas 38:36-48. 2009
    ..In addition, we tested the effect of vascular endothelial growth factor (VEGF) on endothelial cell proliferation and endocrine differentiation of the duct cells...
  13. ncbi request reprint An immunohistochemical study of the endocrine pancreas of the African ice rat, Otomys sloggetti robertsi
    Carsten R Gustavsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte DK2820, Denmark
    Acta Histochem 110:294-301. 2008
    ..In conclusion, the endocrine pancreas of the African ice rat is quite similar to that of other studied rodents, but these animals have more glucagon and SS cells than rat (Rattus) or mouse (Mus) species...
  14. pmc Expression of the GLP-1 receptor in mouse, rat, and human pancreas
    Ditte Tornehave
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, DK2820 Gentofte, Denmark
    J Histochem Cytochem 56:841-51. 2008
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  15. ncbi request reprint Developmental biology of the Psammomys obesus pancreas: cloning and expression of the Neurogenin-3 gene
    Louise Vedtofte
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    J Histochem Cytochem 55:97-104. 2007
    ..5 and E22.5. In conclusion, despite the lack of detection of Pdx-1, the P. obesus pancreas develops similarly to Muridae species, and the Ngn-3 sequence and expression pattern is highly conserved in P. obesus...
  16. ncbi request reprint A possible role for the canonical Wnt pathway in endocrine cell development in chicks
    Anna Hauntoft Pedersen
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensensvej 6, DK2820 Gentofte, Denmark
    Biochem Biophys Res Commun 333:961-8. 2005
    ....
  17. ncbi request reprint Artifactual insulin release from differentiated embryonic stem cells
    Mattias Hansson
    Department of Developmental Biology, Hagedorn Research Institute, Niels Steensens Vej 6, DK 2820 Gentofte, Denmark
    Diabetes 53:2603-9. 2004
    ..We conclude that C-peptide biosynthesis and secretion should be demonstrated to claim insulin production from embryonic stem cell progeny...