Connie Sanchez

Summary

Affiliation: H. Lundbeck A/S
Country: Denmark

Publications

  1. ncbi request reprint In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro
    C Sanchez
    Pharmacological Research, H Lundbeck A S, Copenhagen, Denmark
    Psychopharmacology (Berl) 137:233-40. 1998
  2. ncbi request reprint Depression and poor sleep: the effect of monoaminergic antidepressants in a pre-clinical model in rats
    Connie Sanchez
    Neuroscience, Lundbeck Research USA Inc, Paramus, NJ 07652 1431, USA
    Pharmacol Biochem Behav 86:468-76. 2007
  3. ncbi request reprint The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram
    Connie Sanchez
    H Lundbeck A S, Neuropharmacological Research, Ottiliavej 9, DK 2500 Valby, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 99:91-5. 2006
  4. ncbi request reprint Escitalopram versus citalopram: the surprising role of the R-enantiomer
    Connie Sanchez
    Research and Development, H Lundbeck A S, Ottiliavej 9, 2500 Valby Copenhagen, Denmark
    Psychopharmacology (Berl) 174:163-76. 2004
  5. ncbi request reprint R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck, Ottiliavej 9, DK 2500 Valby, Copenhagen, Denmark
    Pharmacol Biochem Behav 77:391-8. 2004
  6. ncbi request reprint R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model
    C Sanchez
    Neuropharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Behav Pharmacol 14:465-70. 2003
  7. ncbi request reprint R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Pharmacol Biochem Behav 75:903-7. 2003
  8. ncbi request reprint Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities
    C Sanchez
    Research Laboratories, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen, Denmark
    Psychopharmacology (Berl) 167:353-62. 2003
  9. ncbi request reprint R-citalopram attenuates anxiolytic effects of escitalopram in a rat ultrasonic vocalisation model
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Eur J Pharmacol 464:155-8. 2003
  10. ncbi request reprint Stress-induced vocalisation in adult animals. A valid model of anxiety?
    Connie Sanchez
    Neuropharmacology Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Eur J Pharmacol 463:133-43. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro
    C Sanchez
    Pharmacological Research, H Lundbeck A S, Copenhagen, Denmark
    Psychopharmacology (Berl) 137:233-40. 1998
    ..In conclusion, the drug discrimination studies suggest a unique activity profile of Lu 25-109, and the in vivo profile suggests none or a very low frequency of unwanted cholinergic mediated effects...
  2. ncbi request reprint Depression and poor sleep: the effect of monoaminergic antidepressants in a pre-clinical model in rats
    Connie Sanchez
    Neuroscience, Lundbeck Research USA Inc, Paramus, NJ 07652 1431, USA
    Pharmacol Biochem Behav 86:468-76. 2007
    ..7 mg/kg also modulated the noradrenaline system. Thus, in this animal model, the enhancement of noradrenergic activity is more disruptive on the sleep architecture than enhancement of serotonergic activity...
  3. ncbi request reprint The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram
    Connie Sanchez
    H Lundbeck A S, Neuropharmacological Research, Ottiliavej 9, DK 2500 Valby, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 99:91-5. 2006
    ....
  4. ncbi request reprint Escitalopram versus citalopram: the surprising role of the R-enantiomer
    Connie Sanchez
    Research and Development, H Lundbeck A S, Ottiliavej 9, 2500 Valby Copenhagen, Denmark
    Psychopharmacology (Berl) 174:163-76. 2004
    ..e. containing the same amount of the S-enantiomer, showed better effect for escitalopram. These results suggested that the R-citalopram in citalopram inhibits the effect of the S-enantiomer...
  5. ncbi request reprint R-citalopram inhibits functional and 5-HTP-evoked behavioural responses to the SSRI, escitalopram
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck, Ottiliavej 9, DK 2500 Valby, Copenhagen, Denmark
    Pharmacol Biochem Behav 77:391-8. 2004
    ..The mechanism involved in this interaction is currently unknown, but may be related to an improved clinical effect seen with escitalopram in comparison with citalopram...
  6. ncbi request reprint R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model
    C Sanchez
    Neuropharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Behav Pharmacol 14:465-70. 2003
    ....
  7. ncbi request reprint R-citalopram counteracts the effect of escitalopram in a rat conditioned fear stress model of anxiety
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Pharmacol Biochem Behav 75:903-7. 2003
    ..The finding that R-citalopram inhibits the effect of escitalopram may be relevant to the improved clinical efficacy seen with escitalopram compared to R,S-citalopram in the treatment of anxiety and depression...
  8. ncbi request reprint Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities
    C Sanchez
    Research Laboratories, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen, Denmark
    Psychopharmacology (Berl) 167:353-62. 2003
    ..The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram...
  9. ncbi request reprint R-citalopram attenuates anxiolytic effects of escitalopram in a rat ultrasonic vocalisation model
    Connie Sanchez
    Neuropharmacological Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Eur J Pharmacol 464:155-8. 2003
    ..Furthermore, R-citalopram attenuated the effect of escitalopram. These findings may be relevant to the enhanced clinical efficacy seen with escitalopram compared to citalopram...
  10. ncbi request reprint Stress-induced vocalisation in adult animals. A valid model of anxiety?
    Connie Sanchez
    Neuropharmacology Research, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Eur J Pharmacol 463:133-43. 2003
    ..There is also a need for further studies of how changes in stress-axis function may modulate ultrasonic vocalisation and for studies of the effects of chronic drug treatment on ultrasonic vocalisation...
  11. ncbi request reprint N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline studies on the role of 5-HT1A and 5-HT2 receptors in mediating foot-shock-induced ultrasonic vocalisation in adult rats
    C Sanchez
    Pharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Eur Neuropsychopharmacol 9:287-94. 1999
    ..However, the function of 5-HT1A and 5-HT2 receptors in this model seems to differ as vocalisation was preserved after protection of 5-HT2 but not 5-HT1A receptors...
  12. ncbi request reprint The selective sigma2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression
    C Sanchez
    Pharmacological Research, Copenhagen, Denmark
    Behav Pharmacol 11:117-24. 2000
    ..However, this effect was confounded by decreased intake in the vehicle controls. Lu 28-179 did not affect sucrose intake in non-stressed rats at any of the doses tested...
  13. ncbi request reprint In-vivo assessment of 5-HT2A and 5-HT2C antagonistic properties of newer antipsychotics
    C Sanchez
    Neuropharmacology Department, H Lundbeck A S, Valby, Denmark
    Behav Pharmacol 11:291-8. 2000
    ..The ratio between in vivo inhibitory potencies at 5-HT2A and 5-HT2C receptors did not correlate with corresponding ratios from in-vitro affinity and ex-vivo occupancy studies in the literature...
  14. ncbi request reprint Lack of generalisation between the GABAA receptor agonist, gaboxadol, and allosteric modulators of the benzodiazepine binding site in the rat drug discrimination procedure
    Signe Michelsen
    Department of Neuropharmacology, H Lundbeck A S, Ottiliavej 9, 2500, Copenhagen, Valby, Denmark
    Psychopharmacology (Berl) 193:151-7. 2007
    ....
  15. pmc R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter
    Signe I Storustovu
    Department of Electrophysiology, H Lundbeck A S, 9 Ottiliavej, Valby DK 2500, Denmark
    Br J Pharmacol 142:172-80. 2004
    ..6. We propose that the kinetic interaction of R- and S-citalopram with SERT is a critical factor contributing to the antagonistic effects of R-citalopram on S-citalopram in vitro and in vivo...
  16. doi request reprint Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study
    Alan L Pehrson
    Lundbeck Research USA, 215 College Rd, Paramus, NJ 07652, USA
    Eur Neuropsychopharmacol 23:133-45. 2013
    ..In conclusion, Lu AA21004, acting via two pharmacological modalities, 5-HT receptor modulation and SERT inhibition, results in a brain region-dependent increase of multiple neurotransmitter concentrations...
  17. ncbi request reprint Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice
    Suzanne L Hansen
    Department of Neuropharmacology, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    Prog Neuropsychopharmacol Biol Psychiatry 28:105-13. 2004
    ....
  18. doi request reprint Gaboxadol -- a different hypnotic profile with no tolerance to sleep EEG and sedative effects after repeated daily dosing
    Bjarke Ebert
    H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
    Pharmacol Biochem Behav 90:113-22. 2008
    ..Withdrawal from gaboxadol, zolpidem and indiplon did not affect the seizure threshold to bicuculline. Gaboxadol's apparent rapid development of tolerance in the rotarod assay appears to be kinetically determined...
  19. doi request reprint Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
    Arne Mørk
    Department of Synaptic Transmission 1, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Pharmacol Biochem Behav 105:41-50. 2013
    ..In conclusion, vortioxetine enhanced contextual and episodic memory in rat behavioral models. Further demonstration of its potential effect on memory functions in clinical settings is warranted...
  20. doi request reprint The effects of combining serotonin reuptake inhibition and 5-HT7 receptor blockade on circadian rhythm regulation in rodents
    Ligia Westrich
    Lundbeck Research USA, 215 College Avenue, Paramus, NJ 07652, USA
    Physiol Behav 110:42-50. 2013
    ....
  21. ncbi request reprint An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant
    Huailing Zhong
    Department of Biological Research, Lundbeck Research USA, Paramus, NJ 07652, USA
    Neurosci Lett 462:207-12. 2009
    ....
  22. pmc Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction
    Alan L Pehrson
    External Sourcing and Scientific Excellence, Lundbeck Research USA, Inc, Paramus, New Jersey, USA
    CNS Spectr 19:121-33. 2014
    ....
  23. pmc Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats
    Kenneth V Christensen
    Dept of Molecular Biology, Discovery Biology Research, H, Lundbeck A S, DK 2500 Valby, Denmark
    BMC Neurosci 11:9. 2010
    ..Furthermore, effects of the anti-epileptic drug levetiracetam on kindling-induced gene expression were examined...
  24. ncbi request reprint Rotarod studies in the rat of the GABAA receptor agonist gaboxadol: lack of ethanol potentiation and benzodiazepine cross-tolerance
    Jeppe Voss
    Department of Neuropharmacology, H Lundbeck A S, Ottiliavej 9, DK 2500 Valby, Denmark
    Eur J Pharmacol 482:215-22. 2003
    ..No cross-tolerance was observed, indicating that the motor coordination effects observed with gaboxadol and zolpidem may arise from interaction with different receptor populations...
  25. ncbi request reprint EEG measurements by means of radiotelemetry after intracerebroventricular (ICV) cannulation in rodents
    Vanessa Vogel
    Department of Neuropharmacology, H Lundbeck A S, 9 Ottiliavej, 2500 Valby, Copenhagen, Denmark
    J Neurosci Methods 118:89-96. 2002
    ..The present study has demonstrated that ICV cannulation can be used effectively in studying the effects of pharmacological agents on the sleep-wake cycle of rodents by measuring EEG and EMG by radiotelemetry...
  26. ncbi request reprint Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors
    Mette B Hermit
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, 2 Universitetsparken, Copenhagen, DK 2100, Denmark
    Eur J Pharmacol 486:241-50. 2004
    ..These studies demonstrate how subtle differences in chemical structures can result in profound differences in pharmacological activity...