Affiliation: H. Lundbeck A/S
Forsingdal A, Jørgensen T, Olsen L, Werge T, Didriksen M, Nielsen J. Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?. Biol Psychiatry. 2019;85:13-24 pubmed publisher
..We also discuss strengths and limitations of the CNV models, and how they can advance our biological understanding of mechanisms that can lead to schizophrenia and can be used to develop new and better treatments for schizophrenia. ..
Nielsen J, Fejgin K, Sotty F, Nielsen V, Mørk A, Christoffersen C, et al
. A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission. Transl Psychiatry. 2017;7:1261 pubmed publisher
..1 deletion. With aspects of both construct and face validity, the Df(h1q21)/+ model may be used to gain insight into schizophrenia-relevant alterations in dopaminergic transmission. ..