A Mørk

Summary

Affiliation: H. Lundbeck A/S
Country: Denmark

Publications

  1. ncbi Abnormal involuntary movement (AIM) expression following D2 dopamine agonist challenge is determined by the nature of prior dopamine receptor stimulation (priming) in 6-hydroxydopamine lesioned rats
    Jonathan D Drake
    Department of Biology, University of Massachusetts Boston, United States
    Pharmacol Biochem Behav 105:26-33. 2013
  2. ncbi Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
    Arne Mørk
    Department of Synaptic Transmission 1, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Pharmacol Biochem Behav 105:41-50. 2013
  3. ncbi Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder
    A Mørk
    Synaptic Transmission 1, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    J Pharmacol Exp Ther 340:666-75. 2012
  4. ncbi Effects of lithium treatment on extracellular serotonin levels in the dorsal hippocampus and wet-dog shakes in the rat
    A Mørk
    Department of Pharmacology, The Panum Institute, University of Copenhagen, Denmark
    Eur Neuropsychopharmacol 8:267-72. 1998
  5. ncbi The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats
    A Mørk
    Department of Neurochemistry and Discovery ADME, H Lundbeck A S, Copenhagen, Denmark
    Neuropharmacology 45:167-73. 2003
  6. ncbi Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved
    Arne Mørk
    Department of Neurophysiology, Discovery Pharmacology Research, H Lundbeck A S, Ottiliavej 9, 2500, Valby, Copenhagen, Denmark
    Psychopharmacology (Berl) 206:39-49. 2009
  7. ncbi Acute and long-term treatments with the selective serotonin reuptake inhibitor citalopram modulate the HPA axis activity at different levels in male rats
    J B Jensen
    Department of Clinical Biochemistry, Bispebjerg Hospital, Copenhagen, Denmark
    J Neuroendocrinol 11:465-71. 1999
  8. ncbi N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline studies on the role of 5-HT1A and 5-HT2 receptors in mediating foot-shock-induced ultrasonic vocalisation in adult rats
    C Sanchez
    Pharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Eur Neuropsychopharmacol 9:287-94. 1999
  9. ncbi Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: effects of acute stress and 5-HT(1A) receptor activation
    J B Jensen
    Department of Neurobiology, H Lundbeck A S, Copenhagen, Denmark
    J Neuroendocrinol 13:887-93. 2001
  10. ncbi D-fenfluramine activates rat oxytocinergic and vasopressinergic neurons through different mechanisms
    J D Mikkelsen
    Department of Neurobiology, H Lundbeck A S, Copenhagen Valby, Denmark
    Brain Res 851:247-51. 1999

Collaborators

Detail Information

Publications13

  1. ncbi Abnormal involuntary movement (AIM) expression following D2 dopamine agonist challenge is determined by the nature of prior dopamine receptor stimulation (priming) in 6-hydroxydopamine lesioned rats
    Jonathan D Drake
    Department of Biology, University of Massachusetts Boston, United States
    Pharmacol Biochem Behav 105:26-33. 2013
    ..These data suggest that the types of AIMs expressed following challenge with Quin depend on the dopamine receptor subtype and dose of dopamine agonist used during priming...
  2. ncbi Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
    Arne Mørk
    Department of Synaptic Transmission 1, H Lundbeck A S, Ottiliavej 9, 2500 Copenhagen Valby, Denmark
    Pharmacol Biochem Behav 105:41-50. 2013
    ..In conclusion, vortioxetine enhanced contextual and episodic memory in rat behavioral models. Further demonstration of its potential effect on memory functions in clinical settings is warranted...
  3. ncbi Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder
    A Mørk
    Synaptic Transmission 1, H Lundbeck A S, Ottiliavej 9, DK 2500 Copenhagen Valby, Denmark
    J Pharmacol Exp Ther 340:666-75. 2012
    ..The multimodal activity profile of Lu AA21004 is distinct from that of current antidepressants...
  4. ncbi Effects of lithium treatment on extracellular serotonin levels in the dorsal hippocampus and wet-dog shakes in the rat
    A Mørk
    Department of Pharmacology, The Panum Institute, University of Copenhagen, Denmark
    Eur Neuropsychopharmacol 8:267-72. 1998
    ....
  5. ncbi The R-enantiomer of citalopram counteracts escitalopram-induced increase in extracellular 5-HT in the frontal cortex of freely moving rats
    A Mørk
    Department of Neurochemistry and Discovery ADME, H Lundbeck A S, Copenhagen, Denmark
    Neuropharmacology 45:167-73. 2003
    ..In conclusion, the 5-HT-reuptake inhibitory activity of citalopram resides in escitalopram, and the R-enantiomer counteracts this effect. This observation would predict an improved clinical profile of escitalopram compared to citalopram...
  6. ncbi Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved
    Arne Mørk
    Department of Neurophysiology, Discovery Pharmacology Research, H Lundbeck A S, Ottiliavej 9, 2500, Valby, Copenhagen, Denmark
    Psychopharmacology (Berl) 206:39-49. 2009
    ..Second-generation antipsychotics have some beneficial effect on cognition. Recent studies, furthermore, indicate differential effects of second-generation antipsychotics on impairment in executive cognitive function...
  7. ncbi Acute and long-term treatments with the selective serotonin reuptake inhibitor citalopram modulate the HPA axis activity at different levels in male rats
    J B Jensen
    Department of Clinical Biochemistry, Bispebjerg Hospital, Copenhagen, Denmark
    J Neuroendocrinol 11:465-71. 1999
    ..These results support the hypothesis that the therapeutic effects of long-term antidepressant treatments reduce HPA axis responsiveness...
  8. ncbi N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline studies on the role of 5-HT1A and 5-HT2 receptors in mediating foot-shock-induced ultrasonic vocalisation in adult rats
    C Sanchez
    Pharmacological Research, H Lundbeck A S, Copenhagen Valby, Denmark
    Eur Neuropsychopharmacol 9:287-94. 1999
    ..However, the function of 5-HT1A and 5-HT2 receptors in this model seems to differ as vocalisation was preserved after protection of 5-HT2 but not 5-HT1A receptors...
  9. ncbi Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: effects of acute stress and 5-HT(1A) receptor activation
    J B Jensen
    Department of Neurobiology, H Lundbeck A S, Copenhagen, Denmark
    J Neuroendocrinol 13:887-93. 2001
    ..In conclusion, antidepressant treatments decrease basal POMC mRNA expression without affecting the acute stress response, and the reduced POMC mRNA may be related to reduced 5-HT(1A)-stimulated hypothalamic output...
  10. ncbi D-fenfluramine activates rat oxytocinergic and vasopressinergic neurons through different mechanisms
    J D Mikkelsen
    Department of Neurobiology, H Lundbeck A S, Copenhagen Valby, Denmark
    Brain Res 851:247-51. 1999
    ....
  11. ncbi A comparative study on the effects of tetracyclines and lithium on the cyclic AMP second messenger system in rat brain
    A Mørk
    Department of Pharmacology, Panum Institute, University of Copenhagen, Denmark
    Prog Neuropsychopharmacol Biol Psychiatry 19:157-69. 1995
    ..The decreased receptor agonist-stimulated cAMP production in cortical slices in the presence of DMC and MC may be due to the Ca(2+)-chelating ability of these tetracyclines...
  12. ncbi Abnormal protein phosphorylation in post-mortem brain tissue from bipolar patients
    J B Jensen
    Department of Clinical Biochemistry, Bispebjerg Hospital, Copenhagen, Denmark
    J Neural Transm 107:501-9. 2000
    ..The present study demonstrates abnormal phosphorylation of specific proteins in brain tissue obtained from bipolar patients in comparison to schizophrenics and controls...
  13. ncbi Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment
    J B Jensen
    Department of Clinical Biochemistry, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400, Copenhagen, Denmark
    Eur Neuropsychopharmacol 10:105-11. 2000
    ..This may indicate enhanced AC/G protein coupling. Thus, citalopram may increase cAMP signalling by acting on components of the AC system without affecting the protein level of the AC type 1...