Donna Bozyczko-Coyne

Summary

Affiliation: H. Lundbeck A/S
Country: Denmark

Publications

  1. ncbi request reprint Inhibition of microglial inflammation by the MLK inhibitor CEP-1347
    Søren Lund
    Disease Biology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    J Neurochem 92:1439-51. 2005
  2. ncbi request reprint Mixed lineage kinase activity of indolocarbazole analogues
    Chikara Murakata
    Kyowa Hakko Kogyo Co, Ltd, Tokyo, Japan
    Bioorg Med Chem Lett 12:147-50. 2002
  3. ncbi request reprint Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
    Joanne R Mathiasen
    Neurobiology, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Brain Res 1003:86-97. 2004
  4. ncbi request reprint CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice
    John R Ciallella
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Eur J Pharmacol 515:179-87. 2005
  5. ncbi request reprint Targeting the JNK pathway for therapeutic benefit in CNS disease
    Donna Bozyczko-Coyne
    Cephalon Inc, West Chester, PA 19380, USA
    Curr Drug Targets CNS Neurol Disord 1:31-49. 2002
  6. doi request reprint Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models
    Robert L Hudkins
    Discovery Research, Cephalon, Incorporated, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA
    J Med Chem 51:5680-9. 2008

Collaborators

  • P Ghezzi
  • Robert L Hudkins
  • J T Durkin
  • John R Ciallella
  • Ming Tao
  • Joanne R Mathiasen
  • Søren Lund
  • Beth Ann W McKenna
  • Michael S Saporito
  • Beth Ann Thomas
  • Chikara Murakata
  • Marina Bianchi
  • Malika Bsibsi
  • Thomas Hartung
  • Peter Porzgen
  • Anne Louise Mortensen
  • Sipke Dijkstra
  • Henrik Hasseldam
  • Marcel Leist
  • Siegfried Morath
  • Beverly P Holskin
  • Ghanashyam D Ghadge
  • Jeffrey C Thomas
  • Thomas C Connors
  • Stephen P Trusko
  • Raymond P Roos
  • Zhi liang Wu
  • Anna C Maroney
  • Mark A Ator
  • Thelma S Angeles
  • George Gessner
  • Teresa M O'Kane
  • Masami Kaneko

Detail Information

Publications6

  1. ncbi request reprint Inhibition of microglial inflammation by the MLK inhibitor CEP-1347
    Søren Lund
    Disease Biology, H Lundbeck A S, Ottiliavej 9, 2500 Valby, Denmark
    J Neurochem 92:1439-51. 2005
    ..These data imply MLKs as important, yet unrecognized, modulators of microglial inflammation, and demonstrate a novel anti-inflammatory potential of CEP-1347...
  2. ncbi request reprint Mixed lineage kinase activity of indolocarbazole analogues
    Chikara Murakata
    Kyowa Hakko Kogyo Co, Ltd, Tokyo, Japan
    Bioorg Med Chem Lett 12:147-50. 2002
    ..Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported...
  3. ncbi request reprint Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
    Joanne R Mathiasen
    Neurobiology, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Brain Res 1003:86-97. 2004
    ..These studies show that inhibition of the MLK 3/JNK pathway attenuates MPP(+)-mediated SH-SY5Y cell death in culture and supports the mechanism of action of CEP-1347 as an MLK family inhibitor...
  4. ncbi request reprint CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice
    John R Ciallella
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Eur J Pharmacol 515:179-87. 2005
    ..These results suggest that MLK blockade may be useful in inhibiting pro-inflammatory cytokine production in a wide range of diseases...
  5. ncbi request reprint Targeting the JNK pathway for therapeutic benefit in CNS disease
    Donna Bozyczko-Coyne
    Cephalon Inc, West Chester, PA 19380, USA
    Curr Drug Targets CNS Neurol Disord 1:31-49. 2002
    ..Also included is the progress on development of inhibitors targeting the JNK pathway for therapeutic benefit...
  6. doi request reprint Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models
    Robert L Hudkins
    Discovery Research, Cephalon, Incorporated, 145 Brandywine Parkway, West Chester, Pennsylvania 19380, USA
    J Med Chem 51:5680-9. 2008
    ..The MLK1 structure-activity relationships were supported by the first-reported X-ray crystal structure of MLK1 bound with 16...