M Frodin

Summary

Affiliation: Glostrup Hospital
Country: Denmark

Publications

  1. ncbi A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1
    M Frodin
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    EMBO J 19:2924-34. 2000
  2. ncbi A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
    Morten Frodin
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    EMBO J 21:5396-407. 2002
  3. ncbi 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1
    C J Jensen
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    J Biol Chem 274:27168-76. 1999
  4. ncbi Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells
    M Frodin
    Department of Clinical Chemistry, Glostrup Hospital, Denmark
    Neuroscience 65:599-608. 1995

Collaborators

Detail Information

Publications4

  1. ncbi A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1
    M Frodin
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    EMBO J 19:2924-34. 2000
    ..Our results suggest a novel regulatory mechanism based on phosphoserine-mediated recruitment of PDK1 to RSK2, leading to coordinated phosphorylation and activation of PDK1 and RSK2...
  2. ncbi A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
    Morten Frodin
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    EMBO J 21:5396-407. 2002
    ..Sequence conservation suggests that this mechanism is a key feature in activation of >40 human AGC kinases...
  3. ncbi 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1
    C J Jensen
    Department of Clinical Biochemistry, Glostrup Hospital, DK 2600 Glostrup, Denmark
    J Biol Chem 274:27168-76. 1999
    ..Our study extend recent findings which implicate PDK1 in the activation of protein kinases B and C and p70(S6K), suggesting that PDK1 controls several major growth factor-activated signal transduction pathways...
  4. ncbi Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells
    M Frodin
    Department of Clinical Chemistry, Glostrup Hospital, Denmark
    Neuroscience 65:599-608. 1995
    ..Our data suggest that neurally derived PACAP38, in conjunction with glucocorticoids, may override growth factor mitogenic signals, leading to the postmitotic state of chromaffin cells in the adult adrenal medulla...