Per Bech

Summary

Affiliation: Frederiksborg General Hospital
Country: Denmark

Publications

  1. ncbi request reprint The Bech-Rafaelsen Mania Scale in clinical trials of therapies for bipolar disorder: a 20-year review of its use as an outcome measure
    Per Bech
    Psychiatric Research Unit, WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Hillerød, Denmark
    CNS Drugs 16:47-63. 2002
  2. doi request reprint Escitalopram, problem-solving therapy, and poststroke depression
    Alice Rasmussen
    JAMA 300:1758; author reply 1758-9. 2008
  3. pmc Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales
    Niels Henrik Hjollund
    Department of Clinical Social Medicine, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Health Qual Life Outcomes 5:12. 2007
  4. ncbi request reprint The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, DK 3400 Hilleroed, Denmark
    J Affect Disord 66:159-64. 2001
  5. ncbi request reprint Escitalopram dose-response revisited: an alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depression
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Denmark
    Int J Neuropsychopharmacol 7:283-90. 2004
  6. ncbi request reprint Dose-response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400, Hilleroed, Denmark
    Psychopharmacology (Berl) 188:273-80. 2006
  7. ncbi request reprint Social functioning: should it become an endpoint in trials of antidepressants?
    Per Bech
    Psychiatric Research Unit, WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Hillerød, Denmark
    CNS Drugs 19:313-24. 2005
  8. ncbi request reprint Work-related stressors, depression and quality of life in Danish managers
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hilleroed, Denmark
    Eur Psychiatry 20:S318-25. 2005
  9. ncbi request reprint The internalising and externalising dimensions of affective symptoms in depressed (unipolar) and bipolar patients
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerod, Denmark
    Psychother Psychosom 75:362-9. 2006
  10. ncbi request reprint Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Nord J Psychiatry 60:181-2. 2006

Detail Information

Publications55

  1. ncbi request reprint The Bech-Rafaelsen Mania Scale in clinical trials of therapies for bipolar disorder: a 20-year review of its use as an outcome measure
    Per Bech
    Psychiatric Research Unit, WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Hillerød, Denmark
    CNS Drugs 16:47-63. 2002
    ..MAS has also been used to add to the literature on the evidence-based effect of lithium as a short-term therapy for hypomania or mixed bipolar states and as a long-term therapy of bipolar states...
  2. doi request reprint Escitalopram, problem-solving therapy, and poststroke depression
    Alice Rasmussen
    JAMA 300:1758; author reply 1758-9. 2008
  3. pmc Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales
    Niels Henrik Hjollund
    Department of Clinical Social Medicine, Institute of Public Health, Aarhus University, Aarhus, Denmark
    Health Qual Life Outcomes 5:12. 2007
    ..There may be differences in characteristics of fatigue between diseases and generic measurement instruments may facilitate documentation of such differences, which may be of clinical importance...
  4. ncbi request reprint The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, DK 3400 Hilleroed, Denmark
    J Affect Disord 66:159-64. 2001
    ..This Major Depression Inventory (MDI) can be scored both according to the DSM-IV and the ICD-10 algorithms for depressive symptomatology and according to severity scales by the simple total sum of the items...
  5. ncbi request reprint Escitalopram dose-response revisited: an alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depression
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Denmark
    Int J Neuropsychopharmacol 7:283-90. 2004
    ..After 8 wk of treatment 20 mg escitalopram was superior to 40 mg citalopram, but not after 2 wk of treatment...
  6. ncbi request reprint Dose-response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400, Hilleroed, Denmark
    Psychopharmacology (Berl) 188:273-80. 2006
    ..The varying sensitivity of scales that measure the severity of depression is one of the many factors affecting the evaluation of the dose-response relationship with antidepressants...
  7. ncbi request reprint Social functioning: should it become an endpoint in trials of antidepressants?
    Per Bech
    Psychiatric Research Unit, WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Hillerød, Denmark
    CNS Drugs 19:313-24. 2005
    ..These scales should be considered as supplementary to each other rather than alternatives; it may be necessary to use more than one of these scales in a trial...
  8. ncbi request reprint Work-related stressors, depression and quality of life in Danish managers
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hilleroed, Denmark
    Eur Psychiatry 20:S318-25. 2005
    ..By use of valid questionnaires to investigate work-related stress and distress in Danish managers...
  9. ncbi request reprint The internalising and externalising dimensions of affective symptoms in depressed (unipolar) and bipolar patients
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerod, Denmark
    Psychother Psychosom 75:362-9. 2006
    ..To analyse the internalising and externalising dimensions of affective states in depressed (unipolar) and bipolar patients approximately 2 years after discharge from psychiatric hospitals in Denmark...
  10. ncbi request reprint Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Nord J Psychiatry 60:181-2. 2006
    ..In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity...
  11. ncbi request reprint Validity of HoNOS in identifying frequently hospitalized patients with ICD-10 mental disorders
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej, Hillerød, Denmark
    Acta Psychiatr Scand 113:485-91. 2006
    ....
  12. ncbi request reprint Effective dose of escitalopram in moderate versus severe DSM-IV major depression
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, 3400 Hillerød, Denmark
    Pharmacopsychiatry 39:128-34. 2006
    ..The hypothesis tested was that escitalopram 10 mg/d might be an effective dose in moderate MDD, whereas escitalopram 20 mg/d might be needed in severe depression...
  13. pmc Rating scales in depression: limitations and pitfalls
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Dialogues Clin Neurosci 8:207-15. 2006
    ..The problem of statistical versus clinical significance when analyzing placebo-controlled trials, including dose-response relationship, is outlined, with the recommendation to use effect size statistics...
  14. ncbi request reprint [The SBU report on the treatment of depression can increase the quality of care. Hopefully it will be read!]
    Per Bech
    Frederiksborgs sygehus, Hillerød, Danmark
    Lakartidningen 101:534-5. 2004
  15. ncbi request reprint Health of the Nation Outcome Scales (HoNOS): Implementability, subscale structure and responsiveness in the daily psychiatric hospital routine over the first 18 months
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Nord J Psychiatry 57:285-90. 2003
    ....
  16. ncbi request reprint Meta-analysis of placebo-controlled trials with mirtazapine using the core items of the Hamilton Depression Scale as evidence of a pure antidepressive effect in the short-term treatment of major depression
    P Bech
    Psychiatric Research Unit, WHO Collaborating Center for Mental Health, Frederiksberg General Hospital, Hillerød, Denmark
    Int J Neuropsychopharmacol 4:337-45. 2001
    ..In conclusion, a purely antidepressive effect of mirtazapine has been demonstrated concerning both improvement after the acute therapy of major depression and early onset of action...
  17. ncbi request reprint The effect of prandial glucose regulation with repaglinide on treatment satisfaction, wellbeing and health status in patients with pharmacotherapy naïve Type 2 diabetes: a placebo-controlled, multicentre study
    Per Bech
    Psychiatric Research Unit, WHO Collaborating Centre in Mental Health, Frederiksborg General Hospital, Hillerød, Denmark
    Qual Life Res 12:413-25. 2003
    ..The results suggest that repaglinide provides a higher level of treatment satisfaction than placebo, and this may in part relate to improved glycaemic control...
  18. ncbi request reprint Citalopram dose-response revisited using an alternative psychometric approach to evaluate clinical effects of four fixed citalopram doses compared to placebo in patients with major depression
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, 3400 Hillerød, Denmark
    Psychopharmacology (Berl) 163:20-5. 2002
    ..Among the many problems in interpreting dose-response studies with antidepressants are the psychometric problems in the identification of true antidepressive effect versus true adverse drug effect...
  19. ncbi request reprint Quality of life in schizophrenic patients: association with depressive symptoms
    Vibeke Nørholm
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400, Hillerød, Denmark
    Nord J Psychiatry 60:32-7. 2006
    ..In these patients, depressive symptoms, as in the general population, was found to have association with reduced quality of life...
  20. ncbi request reprint Measuring well-being rather than the absence of distress symptoms: a comparison of the SF-36 Mental Health subscale and the WHO-Five Well-Being Scale
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerod, Denmark
    Int J Methods Psychiatr Res 12:85-91. 2003
    ..In conclusion, the WHO-Five, which measures psychological well-being, reflects aspects other than just the absence of depressive symptoms...
  21. ncbi request reprint The Bech-Rafaelsen Melancholia Scale (MES) in clinical trials of therapies in depressive disorders: a 20-year review of its use as outcome measure
    P Bech
    Psychiatric Research, Unit WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Denmark
    Acta Psychiatr Scand 106:252-64. 2002
    ..To evaluate the psychometric properties of the Bech-Rafaelsen Melancholia Scale (MES) by reviewing clinical trials in which it has been used as outcome measure...
  22. doi request reprint Transcranial low voltage pulsed electromagnetic fields in patients with treatment-resistant depression
    Klaus Martiny
    Psychiatric Research Unit, Mental Health Center North Zealand, Hillerød, Denmark
    Biol Psychiatry 68:163-9. 2010
    ....
  23. doi request reprint Relapse prevention and residual symptoms: a closer analysis of placebo-controlled continuation studies with escitalopram in major depressive disorder, generalized anxiety disorder, social anxiety disorder, and obsessive-compulsive disorder
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hillerød, Denmark
    J Clin Psychiatry 71:121-9. 2010
    ....
  24. ncbi request reprint [Stress and psychometrics]
    Per Bech
    Psykiatrisk Forskningsenhed, Psykiatrisk Center Nordsjælland, Dyrehavevej 48, 3400 Hillerød, Denmark
    Ugeskr Laeger 174:195-7. 2012
    ..In PTSD patients the unspecific arousal syndrome (HAM-D9) is the first syndrome to emerge, typically after the two first weeks...
  25. doi request reprint The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale
    Per Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    J Affect Disord 119:43-51. 2009
    ..We have re-analysed our previous double-blind, placebo-controlled clomipramine study, changing the focus from depression to anxiety both in the response analysis and in the classification of minor affective states...
  26. doi request reprint Mood and anxiety in the medically ill
    Per Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, University of Copenhagen, Hillerød, Denmark
    Adv Psychosom Med 32:118-32. 2012
    ..The Clinical Interview for Depression and Related Syndromes (CIDRS) is included in the appendix as this CIDRS covers many of the rating scales measuring mood and anxiety...
  27. doi request reprint Quality of life assessment in schizophrenia: applicability of the Lehman Quality of Life Questionnaire (TL-30)
    Vibeke Nørholm
    Frederiksborg General Hospital, Psychiatric Research Institute, Hilleroed, Denmark
    Nord J Psychiatry 61:438-42. 2007
    ..01). The results of the present study confirm that the Lehman Quality of Life questionnaire can be validly used in stable schizophrenics...
  28. ncbi request reprint The lack of sustained effect of bright light, after discontinuation, in non-seasonal major depression
    Klaus Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Psychol Med 36:1247-52. 2006
    ..Whether bright light has a sustained effect after discontinuation is, however, poorly investigated...
  29. ncbi request reprint Decreasing TSH levels in patients with Seasonal Affective Disorder (SAD) responding to 1 week of bright light therapy
    Klaus Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hillerød, Denmark
    J Affect Disord 79:253-7. 2004
    ..These symptoms seem associated with hypothyroidism, but the results of evaluations of the thyroid function in SAD patients have been conflicting, most likely due to the very small number of observations...
  30. ncbi request reprint [Experiences from a stress clinic. A pilot study]
    Bo Netterstrøm
    Hillerød Sygehus, arbejdsmedicinsk klinik, Hillerød
    Ugeskr Laeger 169:132-7. 2007
    ..The aim of the study was to develop a multi-disciplinary stress management program for employees with long-term stress...
  31. pmc Eysenck's Two Big Personality Factors and Their Relationship to Depression in Patients with Chronic Idiopathic Pain Disorder: A Clinimetric Validation Analysis
    Per Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, University of Copenhagen, 3400 Hillerød, Denmark
    ISRN Psychiatry 2012:140458. 2012
    ..Conclusion. Within the Eysenck factor of neuroticism it is important to differentiate between the anxiety and depression subscales. The clinimetric analysis of the Eysenck factor of extraversion identified valid subscales...
  32. ncbi request reprint [Screening and case finding instruments for depression--results from a Cochrane review]
    Lars Vedel Kessing
    H S Rigshospitalet, Psykiatrisk Klinik, Neurocentret, København Ø
    Ugeskr Laeger 168:3412-5. 2006
  33. ncbi request reprint [The prevalence of depression in Denmark]
    Lis Raabaek Olsen
    Psykiatrisk Forskningsenhed, Region Hovestaden
    Ugeskr Laeger 169:1425-6. 2007
    ..Risk factors for depression include traumatic life events in social life or other stressors, social status as well as over-consumption of alcohol. Information, detection and treatment of depression are of great importance...
  34. doi request reprint The GRID-HAMD: standardization of the Hamilton Depression Rating Scale
    Janet B W Williams
    Columbia University, New York, NY, USA
    Int Clin Psychopharmacol 23:120-9. 2008
    ..Overall, these data suggest that the GRID-HAMD is an improvement over the original Guy version as well as the SIGH-D in its incorporation of innovative features and preservation of high reliability and validity...
  35. ncbi request reprint Reliability and validity of the Japanese version of the World Health Organization-Five Well-Being Index in the context of detecting depression in diabetic patients
    Shuichi Awata
    Division of Neuropsychiatry and Center for Dementia, Sendai City Hospital, Sendai, Japan
    Psychiatry Clin Neurosci 61:112-9. 2007
    ..The WHO-5-J was thus found to have a sufficient reliability and validity, indicating that it is a useful instrument for detecting current depressive episodes in diabetic patients...
  36. ncbi request reprint [Affective disorders--depression diagnosis and prognosis]
    Jens Knud Larsen
    Psykiatrisk Center Gentofte, Hellerup
    Ugeskr Laeger 169:1427-31. 2007
    ..The course of affective disorders underlines the severity of the disorders with many recurrent episodes and long duration, especially in the depressive state...
  37. ncbi request reprint Quality of life in unaffected twins discordant for affective disorder
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Affect Disord 99:133-8. 2007
    ..The disability and hardship associated with affective disorder is shared by the family members of affective patients and might affect the family member's quality of life...
  38. ncbi request reprint Comparison of depressive indices: reliability, validity, relationship to anxiety and personality and the role of age and life events
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    J Affect Disord 97:187-95. 2007
    ..The current study aimed to compare the properties of some of the most popular of these scales...
  39. ncbi request reprint A double-blind, placebo-controlled study of sertraline in the prevention of depression in stroke patients
    Alice Rasmussen
    Department of Psychiatry, Copenhagen University Hospital, Frederiksberg, Denmark
    Psychosomatics 44:216-21. 2003
    ..On the HAM-D(6) the superiority of sertraline to placebo was demonstrated already after 6 weeks of therapy. Treatment was well tolerated; patients treated with sertraline experienced significantly fewer adverse events...
  40. pmc The Greek translation of the symptoms rating scale for depression and anxiety: preliminary results of the validation study
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece
    BMC Psychiatry 3:21. 2003
    ..The scale consists of 42 items and permits the calculation of the scores of the Beck Depression Inventory (BDI)-21, the BDI 13, the Melancholia Subscale, the Asthenia Subscale, the Anxiety Subscale and the Mania Subscale..
  41. ncbi request reprint Neurobiological and psychological correlates of suicidal attempts and thoughts of death in patients with major depression
    Konstantinos N Fountoulakis
    3rd Department of Psychiatry, Aristotle University, Thessaloniki, Greece
    Neuropsychobiology 49:42-52. 2004
    ..Further study is needed to test whether psychophysiological methods, which are noninvasive and easy to perform, are of value in the therapeutic planning and monitoring of responses...
  42. pmc Thyroid function in clinical subtypes of major depression: an exploratory study
    Konstantinos N Fountoulakis
    Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thessaloniki, University Hospital AHEPA, Thessaloniki, Greece
    BMC Psychiatry 4:6. 2004
    ....
  43. ncbi request reprint The impact of the SCL-90 on the validity of the DSM-IV neurotic or stress-related disorders
    Per Bech
    Acta Psychiatr Scand 110:161-2. 2004
  44. ncbi request reprint Selecting methodologies for the evaluation of differences in time to response between antidepressants
    Stuart A Montgomery
    Imperial College School of Medicine, London, United Kingdom
    J Clin Psychiatry 63:694-9. 2002
    ..The delay in the therapeutic effect of antidepressants is a considerable impediment to their successful clinical use, and attention has recently been focused on antidepressant drugs that may have a faster onset of action...
  45. ncbi request reprint Why the Hamilton Depression Rating Scale endures
    Rasmus W Licht
    Am J Psychiatry 162:2394-5; author reply 2397-8. 2005
  46. ncbi request reprint General health and well-being in outpatients with depressive and bipolar disorders
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Nord J Psychiatry 60:150-6. 2006
    ..Thus, depressive symptoms seem to be the strongest predictor of general health and well-being in both disorders. As the response rate to the questionnaire was relatively low, the findings should be interpreted with caution...
  47. ncbi request reprint Depressive and bipolar disorders: patients' attitudes and beliefs towards depression and antidepressants
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark
    Psychol Med 35:1205-13. 2005
    ..However, these attitudes have received little study in patients whose disorders were sufficiently severe to require hospitalization...
  48. ncbi request reprint The Gotland Male Depression Scale: a validity study in patients with alcohol use disorder
    Finn Zierau
    Alcohol Unit, Copenhagen University Hospital, Hvidovre, Kettegård 30, DK 2650 Hvidovre, Denmark
    Nord J Psychiatry 56:265-71. 2002
    ..The Gotland Depression Subscale was found to be better than the Gotland Distress Subscale at discriminating between patients treated and not treated with antidepressants...
  49. ncbi request reprint Satisfaction with treatment among patients with depressive and bipolar disorders
    Lars Vedel Kessing
    Dept of Psychiatry, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Soc Psychiatry Psychiatr Epidemiol 41:148-55. 2006
    ..Patients' satisfaction with care may be an important factor in relation to adherence to treatment and continued psychiatric care. Few studies have focused on satisfaction in patients with depressive and bipolar disorders...
  50. ncbi request reprint Why the Hamilton Depression Rating Scale endures
    Per Bech
    Am J Psychiatry 162:2396; author reply 2397-8. 2005
  51. ncbi request reprint [A 50-year register follow-up of 112 patients with a classic diagnosis of neurosis]
    Peter Winning Jepsen
    Rigshospitalet, Psykiatrisk Klinik, Distriktspsykiatrisk Center Sankt Joseph, afsnit 8101
    Ugeskr Laeger 169:1678-82. 2007
    ..The study group consists of the 'hospital material' used by the late Erling Jacobsen, M.D., in his doctoral thesis of 1965...
  52. ncbi request reprint Vitamin B6 level is associated with symptoms of depression
    Anne Mette Hvas
    Department of Clinical Biochemistry, Aarhus University Hospital, AKH, Aarhus, Denmark
    Psychother Psychosom 73:340-3. 2004
    ..In the present study, we examined the association between depression and the phosphate derivative of vitamin B6 in plasma, pyridoxal phosphate (PLP)...
  53. ncbi request reprint Postmyocardial infarction mortality in relation to depression: a systematic critical review
    Claus Sørensenf
    The Medical Research Unit, Ringkøbing, Denmark
    Psychother Psychosom 74:69-80. 2005
    ..Future studies should include a minimum of 1,000 patients, use a validated instrument, re-examine the patients, and describe participants and non-participants in detail...
  54. ncbi request reprint [Abuse of psychiatry]
    Raben Rosenberg
    Ugeskr Laeger 167:531-2; author reply 532. 2005
  55. ncbi request reprint [Quality of life concept]
    Bobby Zachariae
    Arhus Universitetshospital, Arhus
    Ugeskr Laeger 170:821-5. 2008
    ..HRQOL measures can guide treatment decisions and increase the possibility of involving patients in decisions concerning treatment, care and rehabilitation...