Christoph G Dietrich

Summary

Country: Denmark

Publications

  1. ncbi Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2
    Christoph G Dietrich
    Department of Internal Medicine III, Aachen University, Germany
    Gastroenterology 126:1044-53. 2004
  2. ncbi Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    Hepatology 38:345-54. 2003
  3. ncbi Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
  4. ncbi Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha
    Christoph G Dietrich
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, University Hospital Aachen, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G585-90. 2007
  5. ncbi Cytokine-independent repression of rodent Ntcp in obstructive cholestasis
    Andreas Geier
    Department of Internal Medicine III, Aachen University (RWTH, Aachen, Germany
    Hepatology 41:470-7. 2005
  6. ncbi Enlarged cervical lymph nodes and elevated liver chemistry tests: a therapeutic dilemma
    Christoph G Dietrich
    Department of Medicine III, Aachen University, 52074 Aachen, Germany
    Ann Hepatol 3:118-20. 2004
  7. ncbi Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Hepatology 40:327-34. 2004
  8. ncbi Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Biochim Biophys Acta 1609:87-94. 2003
  9. ncbi Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen
    Christoph G Dietrich
    Department of Gastroenterology and Hepatology, Aachen University, Aachen, Germany
    Int J Cancer 129:546-52. 2011
  10. ncbi Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    Andreas Geier
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochim Biophys Acta 1773:283-308. 2007

Collaborators

Detail Information

Publications21

  1. ncbi Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2
    Christoph G Dietrich
    Department of Internal Medicine III, Aachen University, Germany
    Gastroenterology 126:1044-53. 2004
    ....
  2. ncbi Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    Hepatology 38:345-54. 2003
    ..In contrast to in vitro studies, HNF1 and RXR/RAR-independent mechanisms appear to be more important in regulation of Mrp2 and Ntcp gene expression in endotoxemia...
  3. ncbi Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride
    Andreas Geier
    Department of Internal Medicine III, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 37:198-205. 2002
    ..Maintained binding activity of RXRalpha:RARalpha may explain differences in Mrp2 expression...
  4. ncbi Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha
    Christoph G Dietrich
    Department of Internal Medicine III, Division of Gastroenterology and Hepatology, University Hospital Aachen, Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 293:G585-90. 2007
    ..We conclude that upregulation of the basolateral bile acid transporters Ntcp, Oatp1, and Oatp2 in fasted rats is mediated via the HNF4alpha/PGC-1alpha pathway...
  5. ncbi Cytokine-independent repression of rodent Ntcp in obstructive cholestasis
    Andreas Geier
    Department of Internal Medicine III, Aachen University (RWTH, Aachen, Germany
    Hepatology 41:470-7. 2005
    ..In conclusion, during obstructive cholestasis accumulating bile acids per se, without major contribution of cytokines, leads to downregulation of Ntcp via repression of HNF-1alpha and HNF-4alpha...
  6. ncbi Enlarged cervical lymph nodes and elevated liver chemistry tests: a therapeutic dilemma
    Christoph G Dietrich
    Department of Medicine III, Aachen University, 52074 Aachen, Germany
    Ann Hepatol 3:118-20. 2004
    ..Liver involvement of tuberculosis can have many facets and may be treated by gradual dosing of standard drugs...
  7. ncbi Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Hepatology 40:327-34. 2004
    ..In conclusion, RANTES haplotypes might contribute to the polygenic interaction between HCV and the host immune system and could help to risk stratify patients prior to antiviral therapy...
  8. ncbi Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Biochim Biophys Acta 1609:87-94. 2003
    ..Reduction in transporter gene expression seems to be mediated by a diminished nuclear binding activity of transactivators such as HNF1, C/EBP and PXR by estrogens...
  9. ncbi Downregulation of breast cancer resistance protein in colon adenomas reduces cellular xenobiotic resistance and leads to accumulation of a food-derived carcinogen
    Christoph G Dietrich
    Department of Gastroenterology and Hepatology, Aachen University, Aachen, Germany
    Int J Cancer 129:546-52. 2011
    ..This might promote the adenoma-carcinoma sequence by higher genotoxic effects. The results indicate a possible role of transporter deficiencies in susceptibility for colon carcinoma...
  10. ncbi Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
    Andreas Geier
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochim Biophys Acta 1773:283-308. 2007
    ..Moreover, the potential therapeutic role of nuclear receptor agonists for the management of liver diseases is highlighted...
  11. ncbi Interleukin-6 regulates hepatic transporters during acute-phase response
    Elmar Siewert
    Department of Internal Medicine III, Aachen University RWTH, Aachen, Germany
    Biochem Biophys Res Commun 322:232-8. 2004
    ..IL-6 is required for transporter down-regulation during aseptic inflammation. Furthermore, IL-6 also contributes to transporter regulation during LPS-induced cholestasis at more delayed time points...
  12. ncbi Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Pauwelsstrasse 30, D-52074, Aachen, Germany
    J Hepatol 36:718-24. 2002
    ..This might represent the first injury to hepatocytes in chronic cholangitis as an extension of liver injury from the level of cholangiocytes to hepatocytes in PSC...
  13. ncbi The presence of non-organ-specific autoantibodies is associated with a negative response to combination therapy with interferon and ribavirin for chronic hepatitis C
    Hermann E Wasmuth
    Department of Internal Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Aachen, Germany
    BMC Infect Dis 4:4. 2004
    ..Previous studies investigated the clinical relevance of these antibodies in patients treated with interferon monotherapy, but not combination therapies...
  14. ncbi Occult celiac disease prevents penetrance of hemochromatosis
    Andreas Geier
    Department of Internal Medicine III, Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    World J Gastroenterol 11:3323-6. 2005
    ..To report a patient with C282Y homozygocity, depleted body iron and intestinal atrophy caused by celiac disease (CD) who experienced resolution of the enteropathy with subsequent normalization of iron metabolism upon gluten-free diet...
  15. ncbi Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC
    Andreas Geier
    Department of Internal Medicine III, University of Technology Aachen, Aachen, Germany
    World J Gastroenterol 9:2681-5. 2003
    ..To investigate the systemic availability of budesonide in a patient with Child A cirrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma, who developed serious side effects...
  16. ncbi Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver
    Andreas Geier
    Dept of Internal Medicine III, Division of Gastroenterology and Hepatology, Aachen Univ, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G831-41. 2005
    ..Activity of HNF-1alpha as regulator of mNtcp is suppressed by both cytokines. Decreased binding activities of nuclear receptor heterodimers may be explained by a reduction of the ubiquitous heterodimerization partner RXR-alpha...
  17. ncbi Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat
    Andreas Geier
    Department of Gastroenterology, Aachen University RWTH, Aachen, Germany
    J Hepatol 43:1021-30. 2005
    ..Alterations in hepatobiliary transporters may render fatty livers more vulnerable against various toxic insults...
  18. ncbi Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury
    Martin Roderfeld
    Department of Gastroenterology Medical Clinic 11, University Hospital, Justus Liebig University, Giessen, Germany
    Liver Int 26:579-86. 2006
    ....
  19. ncbi [Diagnosis of cholestatic disorders]
    Andreas Geier

    Med Klin (Munich) 98:499-509. 2003
    ..In summary, application of these diagnostic tools will finally lead to an unequivocal diagnosis in the majority of cholestatic patients with consecutive rational therapy...
  20. ncbi Extrahepatic cholestasis downregulates Oatp1 by TNF-alpha signalling without affecting Oatp2 and Oatp4 expression and sodium-independent bile salt uptake in rat liver
    Andreas Geier
    Department of Medicine III, University Hospital Aachen UKA, Aachen University RWTH, Aachen, Germany
    Liver Int 27:1056-65. 2007
    ....
  21. ncbi It takes more than one--is a single UGT polymorphism enough to bother detoxification?
    Christoph G Dietrich
    Hepatology 42:1462; author reply 1463. 2005