Affiliation: Danish Cancer Society
- Fos family members: regulation, structure and role in oncogenic transformationE Tulchinsky
Department of Molecular Cancer Biology, The Danish Cancer Society, Institute of Cancer Biology, Copenhagen
Histol Histopathol 15:921-8. 2000..Interestingly, this function is independent of the documented invalidity of the Fra-1 and Fra-2 proteins as transcriptional activators in rodent fibroblasts...
- Metastasis-associated protein S100A4: spotlight on its role in cell migrationS Tarabykina
Novo Nordisk A S, Maaloev, Denmark
Curr Cancer Drug Targets 7:217-28. 2007..We discuss the approaches for down-regulation of S100A4 expression and their potential for application in the clinics...
- The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factorN Ambartsumian
Department of Molecular Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
Oncogene 20:4685-95. 2001..An oligomeric fraction of the protein was detected in the conditioned media as well as in human serum. The data obtained allowed us to conclude that mts1(S100A4) might induce tumor progression via stimulation of angiogenesis...
- Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interactionM Grigorian
Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
J Biol Chem 276:22699-708. 2001..In this way, Mts1 can contribute to the development of a more aggressive phenotype during tumor progression...
- Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequencesE Tulchinsky
Cancer Center, University of Rochester, NY 14642
Proc Natl Acad Sci U S A 89:9146-50. 1992..The possible role of methylation in progression of the nonmetastatic CSML-0 adenosarcoma cell line toward the metastatic CSML-100 adenosarcoma cell line is discussed...
- A kappaB-related binding site is an integral part of the mts1 gene composite enhancer element located in the first intron of the geneE Tulchinsky
Danish Cancer Society, Department of Molecular Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
J Biol Chem 272:4828-35. 1997..However, in vivo occupancy of this site was observed only in Mts1-expressing CSML100 cells, suggesting the involvement of the described element in positive control of mts1 transcription...
- Characterization of two splice variants of metastasis-associated human mts1 geneN Ambartsumian
Danish Cancer Society, Dept of Molecular Cancer Biology, Copenhagen
Gene 159:125-30. 1995....
- Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein familyA Ebralidze
Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow
Genes Dev 3:1086-93. 1989..1987; Goto et al. 1988). Thus, the mts1 protein is a member of the calcium-modulated protein family, and our data indicate that mts1 is involved in regulating the metastatic behavior of tumor cells...
- Characterization of a positive regulatory element in the mts1 geneE Tulchinsky
University of Rochester, New York 14642
Oncogene 8:79-86. 1993..Differences in the methylation pattern of the mts1 gene in CSML-100 cells and CSML-0 cells are known to exist, and may in part be responsible for the mts1 footprinting differences observed in vivo from the different cell lines...
- Combination treatment with ionising radiation and gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor (EGFR) inhibitor, significantly inhibits bladder cancer cell growth in vitro and in vivoA J Colquhoun
Department of Cancer Studies and Molecular Medicine, Clinical Sciences Unit, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW
J Radiat Res 48:351-60. 2007..Ionising radiation (IR) stimulates EGFR causing activation of cytoprotective signalling cascades and thus may be an underlying cause of radioresistance in bladder tumours...