Anne Tjonneland

..Epidemiological studies suggest that long-term exposure to transport noise increases the risk for cardiovascular disorders. The effect of transport noise on blood pressure and hypertension is uncertain...

..Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer...

..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...

..To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC)...

..The whole region seems related to the cellular response to external damaging agents and markers in it are associated with risk of several cancers...

..The purpose was to reveal if any of the common variants lead to increased susceptibility to colorectal cancer...

..We investigated whether single nucleotide polymorphisms (SNPs) in the IL-1 beta, IL-10, and HO-1 genes, together with smoking, were associated with risk of CD and UC...

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..The study groups included 434 postmenopausal breast cancer cases and an identical number of individually matched controls...

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..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...

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..Particular attention was paid to the type of HRT used and to the association of HRT type with estrogen receptor status and tumor histology...

..Since many women consume alcohol, detection of a risk-reducing mechanism would have major public health implications...

..Our results suggest that baseline intake of alcohol is a more important determinant of postmenopausal breast cancer risk than earlier lifetime exposure...

..Variation in diet associated with drinking patterns may explain why wine seems to reduce ischemic heart disease mortality...

..However, it has not been investigated how the breast cancer risk for a given total alcohol consumption depends on the drinking frequency...

..Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer...

..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population...

..Stratification for smoking seems to be advantageous in case-cohort studies of genetic polymorphisms and lung cancer...

..To assess the importance of body fat mass (BFM) and fat free mass (FFM) for the established positive association between BMI and breast cancer among post-menopausal women...

..Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence...

..There were no significant interactions between the GST polymorphisms and smoking...

..To evaluate the association between wholegrain products intake and other dietary, lifestyle, anthropometric and socio-economic factors...

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..In accordance with earlier research, we found a tendency toward a lower risk for breast cancer with higher concentrations of enterolactone, which was restricted almost entirely to ERalpha-negative breast cancer...

..So far, however, results from the few epidemiological studies on the relation have been inconsistent, with no clear associations found...

..The results suggest that OGG1 mRNA levels should be regarded as a biomarker of exposure to oxidative stress with induction of DNA rather than a marker of inborn DNA repair capacity...

..The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.43-0.84; p=0.003) per 50% increase in fruit intake. No convincing interactions were detected between the polymorphisms and smoking...

..In conclusion, intake of whole grain products was not associated with risk of breast cancer in a cohort of Danish postmenopausal women...

..74 (1.25-2.44)]. Exclusion of antibiotics users strengthened the results slightly. In conclusion, with higher enterolactone levels, we found lower risk of colon cancer among women and higher risk of rectal cancer among men...

..Previous studies have shown associations between air pollution and risk for lung cancer...

..The finding of a higher risk with this genotype is in accordance with the only previous study. Further research is needed to confirm the finding...

..The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking...

..We investigated whether differences in exposure to certain risk factors contribute to this gradient, as measured from education, income and occupation...

..However, smoking intensity increased CRC risk among carriers of both NAT1 and NAT2 fast. This indicates that N-acetylator status affects the relationship between smoking and CRC risk...

..To identify the dietary, lifestyle and socio-economic factors associated with the intake of whole grains (WG) in Norway, Sweden and Denmark...

..Future studies on micronutrients and lung cancer should take source into account...

..Our results indicate that bulky DNA adducts may have a weak association with lung cancer risk...

..02). Moreover, an interaction between DLG5 R30Q and NSAID use was found (P for interaction=0.02). Our results do not suggest that inborn variations in the inflammatory response play any major role in risk of colorectal cancer...

..To investigate the effects of occupational activity and leisure time activity on incident colon cancer risk in a Danish middle-aged population...

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..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...

..99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer...

..The aims of this paper are to give a description of the study design, measurement procedures, and differences between participants and non-participants with special reference to socioeconomic characteristics...

..We examined this issue in the Danish Diet, Cancer, and Health Study...

..Waist circumference, BMI and hip circumference are differentially associated with mortality. We investigated the potential influence of selected lifestyle aspects such as smoking, alcohol intake, sports activity and education...

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..We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking...

..The NAT2 fast acetylator genotype seemed to be protective against lung cancer in light smokers (< or =20 cigarettes/day) and not among heavy smokers (>20 cigarettes/day)...

..We also observe interaction between NSAID, alcohol consumption and PPARgamma2 Pro12Ala genotype in relation to breast cancer risk...

..Higher levels of occupational physical activity had no protective effect; the lowest IRR was found for sitting work. Our study shows no convincing protective effect of physical activity on lung cancer risk...

..03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers...

..Our purpose was to examine associations between organochlorines and the development of breast cancer in a large prospective study using stored adipose tissue...

..The aim of the present study was to investigate the relationship between the intake of whole-grain products and risk of prostate cancer in a large prospective cohort...

..Our results indicate that predictors of PCBs varied according to substitution group, suggesting that ortho-substituted groups should be analyzed separately...

..The increased breast cancer incidence among NSAID users may reflect a noncausal association, but our study provides no evidence of a chemopreventive effect of NSAIDs against breast cancer over the durations studied...

..04-1.24) per 10g alcohol/day, but not among homozygous wild type carriers (p for interaction=0.06). Thus, slow oxidation of ethanol seemed to be associated with breast cancer risk...

..The aim of this study was to investigate the relation between exposure to road traffic noise and risk for stroke, which has not been studied before...

..To investigate whether the association between BMI and all-cause mortality could be disentangled into opposite effects of body fat and fat-free mass (FFM)...

..48 (0.19-1.22) in carriers of one variant allele and 0.21 (0.04-1.07) in carriers of two variant alleles, and a significant trend (P=0.04). These results indicate that PTGS2 could be implicated in the development of lung cancer...

..13) for supplemental intake. CONCLUSIONS: We found no evidence of an association between breast cancer and intake of vitamin A or E for postmenopausal women. For vitamin C we found an increase in breast cancer rate with increasing intake...

..The purpose was to investigate whether the concentration of nitrogen oxides (NOx) at the residence, used as an indicator of air pollution from traffic, is associated with risk for lung cancer...

..However, studies on folate and colorectal cancer have found contradicting results; dietary folate seems preventive, whereas folic acid in supplements and fortification may increase the risk...

..04; 95 % CI 1.00, 1.08). The present results provide some support for previously observed inverse associations between fresh fruit intake, particularly apples, and ACS risk...

..Exposure to air pollution in early life contributes to the burden of childhood asthma, but it is not clear whether long-term exposure to air pollution can lead to asthma onset or progression in adulthood...

..Epidemiologic studies have shown increased cancer risks among individuals exposed to high concentrations of arsenic in drinking-water, whereas studies of the carcinogenic effect of low doses have had inconsistent results...

..In conclusion, only a few dietary determinants of Hb-AA and Hb-GA were identified. Thus, the present study implies that dietary intake measured by an FFQ explains only to a limited extent the variation in Hb-AA and Hb-GA concentrations...

..No association was found, but more studies are warranted to further explore AR as a marker of whole-grain exposure in relation to cancer and other disease endpoints...

..We investigated the association between DWC and the subsequent risk of diabetes in middle-aged men and women, and evaluated the influence from concurrent changes in body mass index (DBMI)...

..90 (95% CI, 0.81-0.99). In conclusion, we did not find the overall breast cancer rate to be associated with the intake of fruits and vegetables, but there seemed to be different effects for ER(+) and ER(-) breast cancer...

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..In conclusion, this study showed that higher intakes of fish were significantly associated with higher incidence rates of breast cancer. The association was present only for development of ER+ breast cancer...

..The aim of this study was to analyse the impact of alcohol intake and drinking pattern on the risk of breast cancer...

..The diet may influence the development of abdominal obesity, but the few studies that have prospectively examined the relations between diet and changes in waist circumference (WC) have given inconsistent results...

..To address the prospective association between alcohol drinking pattern and all-cause mortality...

..This is the first study of polymorphisms in base excision repair genes in relation to lung cancer among Danes...

..Whilst the relative 5-year survival after breast cancer was high (79%), there was significantly poorer relative survival amongst less advantaged and single women...

..Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group...

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..Furthermore, when ER+ and ER- breast cancer cases were analyzed separately, no clear associations were observed...

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..Measurement of waist circumference alone as a proxy of abdominal fat mass has been suggested as a simple clinical alternative to BMI for detecting adults with possible health risks due to obesity...

..This study indicates that traditional, healthy food items should be considered before public recommendations for major dietary changes are made...

..47; 95% confidence interval: 0.32-0.68) and breast cancer mortality (HR: 0.56; 95% confidence interval: 0.36-0.87). Higher prediagnostic plasma levels of enterolactone were found related to lower mortality among breast cancer patients...

..These results suggest that the GSTT1 null-genotype is associated with an increased risk of lung cancer, especially in younger individuals...

..The aim of this study was to assess the influence of socioeconomic status on the risk of childhood leukaemia...

..The circumference at the natural waist was overestimated for women, depending on baseline waist circumference, and slightly underestimated for men, depending on baseline BMI...

..Little is known about the health behaviour changes women with breast cancer initiate compared to those made by other women...