Anne Tjonneland


Affiliation: Danish Cancer Society
Country: Denmark


  1. Andersen V, Kopp T, Tjønneland A, Vogel U. No association between HMOX1 and risk of colorectal cancer and no interaction with diet and lifestyle factors in a prospective Danish case-cohort study. Int J Mol Sci. 2015;16:1375-84 pubmed publisher
    ..These results should be sought and replicated in other well-characterized cohorts with high meat intake. ..
  2. Outzen M, Tjønneland A, Larsen E, Andersen K, Christensen J, Overvad K, et al. The effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake. Nutrients. 2015;7:608-24 pubmed publisher
    ..2, 19.7) for whole blood selenium, and 7.0 ng/mL (95% CI: 3.1, 10.9) for plasma SelP (Weeks 0-26). Selenium concentrations were significantly increased after 26 weeks of intervention, albeit to a lower degree than expected. ..
  3. Andersen V, Halekoh U, Tjønneland A, Vogel U, Kopp T. Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish "Diet, Cancer and Health" Cohort. Int J Mol Sci. 2019;20: pubmed publisher
    ..All new findings should be sought replicated in independent prospective studies. Future studies on the cancer-protective effects of aspirin/NSAID should include gene and meat assessments. ..
  4. Wu H, Kyrø C, Tjønneland A, Boll K, Olsen A, Overvad K, et al. Long-Term Whole Grain Wheat and Rye Intake Reflected by Adipose Tissue Alkylresorcinols and Breast Cancer: A Case-Cohort Study. Nutrients. 2019;11: pubmed publisher
    ..Similar results were obtained with the FFQ data. Based on these data, further investigation of the role of specific grain types in reducing or increasing breast cancer risk, and their overall impact on health, is warranted. ..
  5. Hvidtfeldt U, Sørensen M, Geels C, Ketzel M, Khan J, Tjønneland A, et al. Long-term residential exposure to PM2.5, PM10, black carbon, NO2, and ozone and mortality in a Danish cohort. Environ Int. 2019;123:265-272 pubmed publisher
    ..This study supports a role of PM, BC, and NO2 in all-cause and CVD mortality independent of road traffic noise exposure. ..
  6. Hansen L, Tjønneland A, Køster B, Brot C, Andersen R, Cohen A, et al. Vitamin D Status and Seasonal Variation among Danish Children and Adults: A Descriptive Study. Nutrients. 2018;10: pubmed publisher
    ..Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population. ..
  7. Venø S, Bork C, Jakobsen M, Lundbye Christensen S, Bach F, McLennan P, et al. Substitution of Fish for Red Meat or Poultry and Risk of Ischemic Stroke. Nutrients. 2018;10: pubmed publisher
    ..88; 95% CI: 0.77; 0.99). In conclusion, replacing red meat with fish was not associated with risk of total ischemic stroke but was associated with a lower risk of subtypes of ischemic stroke. ..
  8. Roswall N, Hvidtfeldt U, Harrington J, Levine K, Sørensen M, Tjønneland A, et al. Predictors of Urinary Arsenic Levels among Postmenopausal Danish Women. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..However, the majority of variation in UAs concentration in this study population is still unexplained. ..
  9. van Roekel E, Trijsburg L, Assi N, Carayol M, Achaintre D, Murphy N, et al. Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort. Nutrients. 2018;10: pubmed publisher
    ..This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions. ..

More Information


  1. Romaguera D, Ward H, Wark P, Vergnaud A, Peeters P, van Gils C, et al. Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study. BMC Med. 2015;13:107 pubmed publisher
    ..Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients. ..
  2. Lacoppidan S, Kyrø C, Loft S, Helnæs A, Christensen J, Hansen C, et al. Adherence to a Healthy Nordic Food Index Is Associated with a Lower Risk of Type-2 Diabetes--The Danish Diet, Cancer and Health Cohort Study. Nutrients. 2015;7:8633-44 pubmed publisher
    ..Adherence to a healthy Nordic food index was found to be inversely associated with risk of T2D, suggesting that regional diets other than the Mediterranean may also be recommended for prevention of T2D. ..
  3. Kayser L, Hansen Nord N, Osborne R, Tjønneland A, Hansen R. Responses and relationship dynamics of men and their spouses during active surveillance for prostate cancer: health literacy as an inquiry framework. BMC Public Health. 2015;15:741 pubmed publisher
    ..The HLQ used as a dialogue tool may be an adjunct to assist healthcare providers to understand the need for support and information of men with prostate cancer on active surveillance and the dynamics within couples. ..
  4. request reprint
    Tjønneland A, Christensen J, Thomsen B, Olsen A, Overvad K, Ewertz M, et al. Hormone replacement therapy in relation to breast carcinoma incidence rate ratios: a prospective Danish cohort study. Cancer. 2004;100:2328-37 pubmed
    ..In addition, relative to other types of HRT regimens, continuous estrogen + progestin regimens were found to be associated with an increased risk of breast carcinoma, and particularly estrogen receptor-positive breast carcinoma. ..
  5. Huynh S, von Euler Chelpin M, Raaschou Nielsen O, Hertel O, Tjønneland A, Lynge E, et al. Long-term exposure to air pollution and mammographic density in the Danish Diet, Cancer and Health cohort. Environ Health. 2015;14:31 pubmed publisher
    ..80- 0.98 per 10 μg/m(3) of NO2). There was no interaction with menopause, smoking, or obesity. Traffic-related air pollution exposure does not increase MD, indicating that if air pollution increases breast cancer risk, it is not via MD. ..
  6. Bhoo Pathy N, Peeters P, Uiterwaal C, Bueno de Mesquita H, Bulgiba A, Bech B, et al. Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study. Breast Cancer Res. 2015;17:15 pubmed publisher
    ..Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer. ..
  7. Campmans Kuijpers M, Sluijs I, Nöthlings U, Freisling H, Overvad K, Weiderpass E, et al. Isocaloric substitution of carbohydrates with protein: the association with weight change and mortality among patients with type 2 diabetes. Cardiovasc Diabetol. 2015;14:39 pubmed publisher
    ..Therefore, future research is needed whether dietary guidelines should not actively promote substitution of carbohydrates by total protein, but rather focus on substitution of carbohydrates with plant protein. ..
  8. Campa D, Barrdahl M, Gaudet M, Black A, Chanock S, Diver W, et al. Genetic risk variants associated with in situ breast cancer. Breast Cancer Res. 2015;17:82 pubmed publisher
  9. Eriksen K, Halkjær J, Meliker J, McElroy J, Sørensen M, Tjønneland A, et al. Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study. BMC Cancer. 2015;15:177 pubmed publisher
    ..Educational level, smoking status, BMI, zinc or iron intake did not modify the association. In our study, we did not find an association between dietary cadmium intake and prostate cancer risk in a cohort of Danish men. ..
  10. Hellmann S, Njor S, Lynge E, von Euler Chelpin M, Olsen A, Tjønneland A, et al. Body mass index and participation in organized mammographic screening: a prospective cohort study. BMC Cancer. 2015;15:294 pubmed publisher
    ..Effect of BMI on mammographic screening participation was not significantly modified by HT, previous screening participation, or morbidities. ..
  11. Merritt M, Riboli E, Murphy N, Kadi M, Tjønneland A, Olsen A, et al. Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study. BMC Med. 2015;13:252 pubmed publisher
    ..These findings may contribute to the development of improved strategies to promote better long-term health in women. ..
  12. Hansen L, Tjønneland A, Køster B, Brot C, Andersen R, Lundqvist M, et al. Sun Exposure Guidelines and Serum Vitamin D Status in Denmark: The StatusD Study. Nutrients. 2016;8: pubmed publisher
    ..In conclusion, adherence to the sun exposure guidelines on shade and protective clothing was associated with lower vitamin D status among Danish adults, but not children. ..
  13. Aleksandrova K, Pischon T, Jenab M, Bueno de Mesquita H, Fedirko V, Norat T, et al. Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study. BMC Med. 2014;12:168 pubmed publisher
    ..Prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention. ..
  14. Jørgensen J, Andersen J, Tjønneland A, Andersen Z. Determinants of frequent attendance in Danish general practice: a cohort-based cross-sectional study. BMC Fam Pract. 2016;17:9 pubmed publisher
  15. Andersen V, Christensen J, Overvad K, Tjønneland A, Vogel U. Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes. BMC Cancer. 2010;10:484 pubmed publisher
    ..A polymorphism in NFkB was associated with CRC risk and there was interaction between this polymorphism and meat intake in relation to CRC risk. This study suggests a role for NFkB in CRC aetiology. ..
  16. Andersen V, Ostergaard M, Christensen J, Overvad K, Tjønneland A, Vogel U. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. BMC Cancer. 2009;9:407 pubmed publisher
    ..Our results suggest that MDR1 polymorphisms affect the relationship between meat and CRC risk. ..
  17. Campa D, Husing A, McKay J, Sinilnikova O, Vogel U, Tjønneland A, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer. 2010;10:563 pubmed publisher
  18. Hansen R, Sørensen M, Tjønneland A, Overvad K, Wallin H, Raaschou Nielsen O, et al. A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study. BMC Cancer. 2008;8:54 pubmed publisher
    ..We found no evidence of gene-environment interaction between the three polymorphisms and the haplotype and smoking intensity and alcohol consumption, respectively, in relation to the risk of colorectal cancer. ..
  19. Tikk K, Sookthai D, Fortner R, Johnson T, Rinaldi S, Romieu I, et al. Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study. Breast Cancer Res. 2015;17:49 pubmed publisher
    ..15; Phet=0.07). Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer. ..