Lene Mellemkjær

..We investigated incidence of cancer among Crohn's disease patients in comparison with the incidence in the general population of Denmark...

..To assess the importance of body fat mass (BFM) and fat free mass (FFM) for the established positive association between BMI and breast cancer among post-menopausal women...

..We investigated the risks for skin and other cancers among patients with a prior burn...

..An explanation behind the excess of CNS tumours could not be identified, but the effect of diagnostic X-rays in newborns may deserve further attention...

..However, the sampling variability was such that modest increases in risk could not be excluded. Nonetheless, because this is a rare mutation, it is unlikely to explain a major fraction of CBC in the population...

..This study was initiated to evaluate the risks of NHL associated with a personal or family history of a wide range of autoimmune diseases...

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..The absence of an increased risk among relatives suggests that the increased cancer morbidity in patients with CVID is related to the immunodeficiency per se rather than to specific genetic traits shared with their relatives...

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..To increase the knowledge of the long-term effects of artificial hip and knee joint implants...

..To investigate if birth weight is associated with early-onset breast cancer. The mechanism behind an association with high birth weight could be the link between fetal growth and estrogens in utero...

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..Further research into the determinants of these inconsistencies is warranted...

..To test the hypothesis in humans, we investigated cancer incidence among patients with anorexia nervosa, who have had an extremely low intake of calories for prolonged periods of their lives...

..We investigated the risk for a second primary cancer in pre- and postmenopausal women with breast cancer treated by surgery alone, to assess the importance of non-treatment factors and menopausal status...

..99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders...

..02, 95% CI = 1.05-8.69). Obesity was unrelated to risk. These results confirm that prior bile duct diseases increase risk of ICC and suggest that alcoholic liver disease and diabetes may also increase risk...

..In contrast, there are limited data on risk of Hodgkin lymphoma following autoimmune diseases and almost no data addressing whether there is a familial association between the conditions...

..We aimed to assess the risk of cancer and survival after hospital admission for fever of unknown origin in a nationwide Danish follow-up study...

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..We estimate that the absolute lifetime risk for a first-degree relative of an NHL case to develop NHL is 3.6% (compared with a population risk of 2.1%) and higher if the index case had an aggressive subtype of NHL...

..Although endometriosis and uterine leiomyomas are common conditions, the extent to which either is associated with certain types of malignancies remains uncertain...

..To analyze whether fibromyalgia (FM) and FM-like symptoms are related to an increased incidence of cancer...

..The increased risk associated with endometriosis among postmenopausal women may be due to common risk factors between postmenopausal endometriosis and breast cancer or an altered endogenous estrogen...

..Thus, there were no strong associations between socioeconomic position and the incidence of these cancers; survival after NHL might be affected...

..Only a few small studies have assessed clinical characteristics and prognosis for familial patients, with inconsistent findings...

..A genetic link between benign breast disease and breast cancer was indicated by our data but needs to be confirmed in future studies...

..To investigate whether oral contraceptive (OC) use and postmenopausal hormones (PMH) are associated with an increased risk of developing asynchronous bilateral breast cancer among women diagnosed with breast cancer younger than 55 years...

..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...

..Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer...

..To describe the incidence of malignancies in a cohort of Danish patients with Wegener's granulomatosis (WG) and to investigate the cancer risk associated with cyclophosphamide (CYC) -therapy in WG...

..Several chronic diseases have been hypothesized to affect the risk of subsequent gynecologic malignancies, possibly through shared hormonal mechanisms...

..The clustering of cancers of the lung and bladder in PFTC patients may suggest shared smoking aetiology. The excess of colorectal and breast cancers after PFTC may indicate a genetic aetiology...

..This is the first study to consider the changes of incidence over time as a source of bias when evaluating anticipation in lymphoproliferative cancers...

..The data might support reduced risks for prostate and rectal cancer among male patients with schizophrenia, whereas a changing smoking pattern might explain the reduced risk for tobacco-related cancers...

..However, the spectrum of malignancies associated with common genetic etiology and the effects of gender and age on familial risk have not been established...

..There are very limited data available regarding the prognosis of patients with fatty liver. We examined the overall and cause-specific mortality of fatty liver patients in a large Danish cohort...

..We examined overall and cause-specific mortality in a population-based cohort of individuals prescribed paracetamol. We evaluated rates of death due to liver and renal disease, cancer, and other major causes of death...

..CONCLUSIONS: The risk of hospitalization for a psychiatric disorder is not increased among survivors of cancer in childhood or adolescence, except among survivors of brain tumor...

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..91; 95% confidence interval, 0.71-1.12). Studies not taking parity into account may overestimate the risk for breast cancer in schizophrenic women...

..To examine the risk of cancer in patients with fatty liver...

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..Selective serotonin reuptake inhibitors (SSRIs) have been suspected of increasing the risk of bleeding. We examined the risk of upper gastrointestinal tract (GI) bleeding with use of antidepressant medication...

..02) after 10 or more years of follow-up. These data provide no support for the hypothesis that depression independently increases risk of cancer, but they emphasize the deleterious effect that depression can have on lifestyle factors...

..This study attempted to determine whether a genetic protection against cancer might be manifest in parents of offspring with schizophrenia...

..The elevated risks for cancers of the esophagus, lung and liver are most likely a result of confounding variables, but may warrant further investigation...

..We examined the association between IGF-I, IGF-II, IGF binding protein (IGFBP)-2, IGFBP-3, and IGFBP-3 protease activity and breast cancer risk in postmenopausal women, taking ER status of the breast cancer into consideration...

..It was found that the risk of Wilms tumor increased with fetal growth in girls, but decreased with fetal growth in boys, although the findings did not reach statistical significance...

..On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization...

..Particular attention was paid to the type of HRT used and to the association of HRT type with estrogen receptor status and tumor histology...

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..68, 95% CI = 1.16 to 5.29). Our data suggest that use of glucocorticoids may be a shared risk factor for certain skin cancers and lymphomas...

..2-fold (95% CI, 22.1-100.9) compared with the general population. CONCLUSIONS: Patients with "lupoid hepatitis" have a reduced life expectancy, mainly caused by excess deaths from liver cirrhosis, malignancy and heart disease...

..7-fold (95%CI 1.0-3.0; p=0.05) and a 1.5-fold (95%CI 0.6-3.9) elevated MM risk, respectively. Pneumonia could be a trigger to the development of MM or a manifestation of immune disturbances in late-stage MGUS...