Susanne K Kjaer

..To estimate the occurrence of and risk factors associated with genital warts in Danish men..

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..Smoking has been associated with cervical cancer. We examined whether smoking increases the risk for high-grade cervical lesions in women with high-risk human papillomavirus (HPV) infection...

..g., years of sex life without barrier contraceptive use, early age at first genital warts and smoking. Whether the risk factors that are applicable only to HSIL represent factors related to progression remains unknown...

..This is the first study to assess risk factors for acquisition and persistence of HPV. The sexually transmitted nature of the infection is confirmed, and the data point to an important role of having multiple HPV types for persistence...

..To assess the burden and correlates of genital warts in women...

..Persistent HPV infection could also be a useful screening marker. We estimated the long-term risk of high-grade CIN after one-time detection of high-risk HPV DNA and after persistent infection with individual high-risk HPV types...

..The efficacy of quadrivalent HPV vaccine against high-grade cervical and external anogenital neoplasia remains high through 42 months post vaccination...

..These results indicate that even a single positive HPV test in cytologically negative women is substantially predictive of high-grade CIN and suggest that HC2 testing can help stratify women into different risk categories...

..On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization...

..Remarkably, no cervical lesions were found in HPV 16 DNA positive women who had seroconverted. Although based on small numbers, this may suggest that the development of antibodies had a protective effect...

..Knowledge about the generalizability of this age dependency is important to understand the natural history of the infection, but may also have implications in relation to the use of HPV testing in cervical cancer screening...

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..A small number of studies investigated the survival of patients with p53 mutations in OC, but their conclusions are not in agreement...

..In the present study, using a large population-based sample of 64 659 women aged 18-45 years in four Nordic countries, we investigate whether young age at first sexual intercourse is associated with subsequent risk-taking behaviours...

..To assess the fraction of women who have heard of human papillomavirus (HPV) in four Nordic countries (Denmark, Iceland, Norway, and Sweden) and to study the correlates of this awareness, just before the vaccines were released...

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..31-0.74) compared to patients with <10% expression for both receptors. In conclusion, our results predict that an elevated expression of ER and PR, alone and in combination, point to a favorable outcome for patients with OC...

..00001). Multivariate Cox regression analysis found that less than 20% tissue expression of p53 was associated with longer OC disease-specific survival. Tissue p53 expression may be of prognostic value in women with OC...

..Loss of heterozygosity (LOH) may be detected in individuals heterozygous for an allele and is associated with loss of function of tumor suppressor genes...

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..The aim of the study was to describe patterns in women's sexual behavior in four Nordic countries...

..We examined the association between analgesic use and risk of ovarian cancer. In addition, we examined whether the association differed according to histological types...

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..The p53 gene is frequently mutated in various human tumours. In addition, single nucleotide polymorphisms are often observed in exons and introns of the p53 gene in normal tissues and tumours...

..Activation of ras oncogenes has been demonstrated in ovarian tumours. All the reported studies are based on a relatively small number of patients and the results therefore remain a subject of debate...

..To evaluate the reliability of self-reported family history of cancer in first-degree female relatives and to examine possible determinants of accurate reporting...

..Further we assessed the risk factor profile for prevalent high risk (HR) HPV infection and infection with multiple HR HPV types...

..The aim of the study was to examine the overall risk factors for epithelial ovarian cancer and according to histologic subtypes...

..CONCLUSION: Smoking at the time of diagnosis and premorbid overweight were negative prognostic factors for ovarian cancer-specific survival. The negative effect of smoking decreased with increasing time since stop of smoking...

..In conclusion, plasma levels of YKL-40 proved of prognostic value in stage III OC patients...

..The aim of the study was to determine the expression of YKL-40 in tumor tissue and plasma in patients with borderline ovarian tumor or epithelial ovarian cancer (OC), and investigate prognostic value of this marker...

..The presence of increased serum p53 AAb in patients with diagnosed OC could not be correlated with any clinical data and preoperative serum p53 AAb status had no evident value...

..To determine the variation in expression of carcinoembryonic antigen (CEA) in 760 epithelial ovarian tumours from Denmark, and to correlate expression with clinicopathological parameters and prognosis for the disease...

..To investigate the association between cone depth of the loop electrosurgical excision procedure (LEEP) of the cervix and subsequent risk of spontaneous preterm delivery...

..The objective of this study was to describe continuous regular analgesics use and examine factors associated with a continuous regular analgesic use...

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..Anti-smoking programs should focus on the social network of the women. Furthermore, there is a need to target mothers who smoke, especially less educated mothers...

..We performed a systematic review and meta-analysis of the association between NSAID use and ovarian cancer risk...

..The purpose of our study is to assess the occurrence of risky behaviour in men aged 18-45 years from the general population. Furthermore, we aim to examine factors associated with risky sexual behaviour...

..To assess the trends in incidence of penile cancer during 1978-2008 and high-grade penile intraepithelial neoplasia (PIN2/3) during 1998-2008 in Denmark...

..No association was found with viral load or smoking. In conclusion, persistent high-risk HPV infection, especially HPV 16 persistence, was common among women positive for high-risk HPV...

..Our aim was to assess the association between loop electrosurgical excision procedure (LEEP) and the subsequent risk for spontaneous preterm delivery, with the use of population-based data from various nationwide registries...

..Secondly, to evaluate whether WT1 tissue expression levels correlate with clinico-pathological parameters and finally to investigate the prognostic value of WT1 expression levels in ovarian cancer (OC) patients...

..To better understand the natural history of HPV, we assessed the incidence of type-specific HPV infection and examined risk factors for acquisition of high-risk (HR) HPV infection in Danish women...

..Socioeconomic position seemed to affect both the incidence of and the survival from cancers of the female genital organs...

..This suggests that an efficacious HPV 16/18 vaccine will have a substantial preventive potential in the general female population...

..We conducted a large national cohort study to examine the risk of cancer among men and women with genital warts (GW)...

..18 ng/ml), age, histological type of tumour and serum CA 125 had no independent prognostic value. In conclusion, preoperative plasma suPAR level was of no prognostic value in this cohort of Danish stage III OC patients...

..An explanation behind the excess of CNS tumours could not be identified, but the effect of diagnostic X-rays in newborns may deserve further attention...

..The increased risk associated with endometriosis among postmenopausal women may be due to common risk factors between postmenopausal endometriosis and breast cancer or an altered endogenous estrogen...

..No difference in time to progression was observed between patients with BCl-2-positive and negative tumors. These data suggest that BCl-2 expression may not be of important clinical value in the treatment of Danish OC patients...

..Using data from a large Danish population-based case-control study we here further examined the association between dairy consumption, lactose, and calcium and risk of overall ovarian cancer and histological types of ovarian cancer...

..CONCLUSIONS: The amount of daily smoking prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas the duration of smoking does not seem to be related to an increased risk of spontaneous abortion...

..The aim of the study was to describe smoking and examine the association between socio-demographic factors (age, educational level and degree of urbanization) and smoking status, age at smoking initiation and heavy smoking...

..The low level of awareness of HPV, particularly in men, can be a barrier in preventing HPV-related diseases. Education is warranted to increase such awareness to ensure success of HPV vaccination...

..To evaluate the prognostic significance of histologic grade on survival of ovarian serous cancer in Denmark during nearly 30 years...

..To examine period-, age- and histology-specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978-2006...

..Our findings indicate that vaccines against HPV might play an important role in the prevention of anal cancer and its precursor lesions...

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..Gonadotropins, and possibly clomiphene and human chorionic gonadotropin, may increase the risk of uterine cancer, with higher doses and longer follow-up leading to greater risk...

..The objective of this article is to describe continuous regular use of acetaminophen, ibuprofen and aspirin in Denmark and to examine factors associated with their use...

..To explore the variation in ovarian cancer survival in Denmark in the period 1978-2002 in relation to time since diagnosis, age at diagnosis, period of diagnosis, stage and histology...

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..HPV16 is the type most often found in HNCs; thus, the recent introduction of vaccination against HPV may in the future prevent HPV-associated cancers of the head and neck...

..or=17 years) at the expense of both oral contraception and condom use. Finally, NU was found to predict high-risk sexual behavior in terms of subsequent multiple sex partners, non-use of condoms, and induced abortion...

..To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women...

..This descriptive study confirms the hypothesis that birth cohort has a major influence on the incidence pattern of testicular tumours and suggests that seminoma and non-seminoma have common aetiological factors...

..Using data from the largest cohort of infertile women to date, the aim of this study was to examine the effects of fertility drugs on breast cancer risk overall and according to histologic subtypes...

..However, since these results could not distinguish the effects of underlying infertility from the effects of fertility treatment, additional studies are needed to disentangle the effects of these two factors...

..Social inequality in the prognosis of most cancers was observed, with poorer relative survival related to fewer advantages, often most pronounced in the first year after diagnosis...

..Our study shows that inequalities in cancer incidence and survival must be addressed in all aspects of public health, with interventions both to reduce incidence and to prolong survival...

..The p53 gene is frequently mutated in various human tumours. In addition, single nucleotide polymorphisms are often observed in exons and introns of the p53 gene in normal tissues and tumours...

..The aim was to examine the effects of fertility drugs on malignant melanoma risk using data from the largest cohort of infertile women to date...

..To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. Design. Population-based, multidisciplinary Danish case-control study of OvCa...

..Even though the mortality rate of ovarian cancer also declined, Denmark had the highest mortality rate of ovarian cancer in the world. Part of it may be explained by a less-favorable distribution of stage at diagnosis...

..The DGCD is a multidisciplinary database that contains data for research and quality improvement...

..Serum CA125 levels might therefore be included as a prognostic factor in future clinical trials of stage I EOC...

..To investigate the association between loop electrosurgical excision procedure (LEEP) and other potential risk factors, and subsequent preterm delivery (<37 weeks), using data from a large cohort study of Danish women...

..We determined the incidence of GWs in Denmark since 1996, focusing on the period after licensing of HPV vaccination (October 2006)...

..The aim of the study was to examine the value of TN, smoking and alcohol as indicators of postoperative complications in OC patients...

..The aim was to examine if and how educational level and degree of urbanization are related to age at first intercourse, lifetime number of sexual partners and condom use...

..06-1.26). CONCLUSION: The risk profile of ovarian borderline tumors is similar to that of ovarian carcinomas, and we observed significant etiological differences between serous and mucinous borderline tumors...

..If a woman does not want prophylactic oophorectomy, then tubal ligation or oral contraceptive use can be considered as these have been shown to reduce ovarian cancer risk also in mutation carriers...