Affiliation: Danish Institute for Food and Veterinary Research
- Sucrose and IQ induced mutations in rat colon by independent mechanismMax Hansen
Danish Institute for Food and Veterinary Research, 19 Mørkhøj Bygade, DK 2860 Søborg
Mutat Res 554:279-86. 2004..In conclusion, sucrose and IQ in the diet induced mutations in the colon by independent mechanisms, whereas an interaction was observed in liver leading to a decrease in mutations by the combined treatment...
- Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolomeM Hansen
The National Food Institute, Technical University of Denmark, 19 Mørkhøj Bygade, DK 2860 Søborg, Denmark
Food Chem Toxicol 46:752-60. 2008..In conclusion, the genotoxicity may be related to the altered chemical environment in the caecum and thereby also in the colon but we found no related changes in insulin resistance or oxidative stress...
- Effects of an onion by-product on bioactivity and safety markers in healthy ratsEduvigis Roldán-Marín
Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, Søborg, Denmark
Br J Nutr 102:1574-82. 2009..In conclusion, the onion by-products have no in vivo genotoxicity, may support in vivo antioxidative defence and alter the functionality of the rat gut microbiota...
- A sucrose-rich diet induces mutations in the rat colonLars O Dragsted
Institute of Food Safety and Nutrition, Division of Biochemical and Molecular Toxicology, The Danish Veterinary and Food Administration, DK 2860 Søborg, Denmark
Cancer Res 62:4339-45. 2002..Both sucrose intake and colon cancer rates are high in the Western world, and our present results call for an examination of a possible direct relationship between the two...
- Effects of apples and specific apple components on the cecal environment of conventional rats: role of apple pectinTine R Licht
Department of Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
BMC Microbiol 10:13. 2010..The objective was to identify effects of apple and apple product consumption on the composition of the cecal microbial community in rats, as well as on a number of cecal parameters, which may be influenced by a changed microbiota...
- The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokersLars O Dragsted
Danish Institute for Food and Veterinary Research, Søborg, Denmark
Am J Clin Nutr 79:1060-72. 2004..Fruit and vegetables contain both nutritive and nonnutritive factors that might contribute to redox (antioxidant and prooxidant) actions...
- Dietary carbohydrate source influences molecular fingerprints of the rat faecal microbiotaTine R Licht
Department of Microbiological Food Safety, Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
BMC Microbiol 6:98. 2006..Fructans are, opposite sucrose and starches, not digestible by mammalian gut enzymes, but are known to be fermentable by specific bacteria in the large intestine...