Julio E Celis

Summary

Affiliation: Danish Cancer Society
Country: Denmark

Publications

  1. ncbi Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, and Department of Proteomics in Cancer, Institute of Cancer Biology, The Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 3:327-44. 2004
  2. ncbi Towards discovery-driven translational research in breast cancer
    Julio E Celis
    The Danish Centre for Translational Breast Cancer Research, Copenhagen, Denmark
    FEBS J 272:2-15. 2005
  3. ncbi Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interaction
    Julio E Celis
    Department of Proteomics in Cancer, Institute of Cancer Biology, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 4:492-522. 2005
  4. ncbi Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research DCTB, Copenhagen, Denmark
    Mol Cell Proteomics 5:462-83. 2006
  5. ncbi Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research DCTB, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    FEBS Lett 580:2935-44. 2006
  6. ncbi Impact of proteomics on bladder cancer research
    Julio E Celis
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Pharmacogenomics 5:381-94. 2004
  7. ncbi 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
    Julio E Celis
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 7:1795-809. 2008
  8. ncbi Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research
    Julio E Celis
    The Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 2:369-77. 2003
  9. ncbi Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Oncol 1:97-119. 2007
  10. ncbi Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, Copenhagen, Denmark
    Mol Oncol 1:321-49. 2007

Detail Information

Publications39

  1. ncbi Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, and Department of Proteomics in Cancer, Institute of Cancer Biology, The Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 3:327-44. 2004
    ....
  2. ncbi Towards discovery-driven translational research in breast cancer
    Julio E Celis
    The Danish Centre for Translational Breast Cancer Research, Copenhagen, Denmark
    FEBS J 272:2-15. 2005
    ..The ultimate goal of this initiative is to coalesce knowledge-based complementary procedures into a systems biology approach to fight breast cancer...
  3. ncbi Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interaction
    Julio E Celis
    Department of Proteomics in Cancer, Institute of Cancer Biology, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 4:492-522. 2005
    ..In addition, the results open new possibilities to the study of obesity, which has a strong association with type 2 diabetes, hypertension, and coronary heart disease...
  4. ncbi Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research DCTB, Copenhagen, Denmark
    Mol Cell Proteomics 5:462-83. 2006
    ....
  5. ncbi Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research DCTB, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    FEBS Lett 580:2935-44. 2006
    ..Here we review published and recent results in the context of the current state of research on breast apocrine cancer...
  6. ncbi Impact of proteomics on bladder cancer research
    Julio E Celis
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Pharmacogenomics 5:381-94. 2004
    ....
  7. ncbi 15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma
    Julio E Celis
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 7:1795-809. 2008
    ....
  8. ncbi Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research
    Julio E Celis
    The Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 2:369-77. 2003
    ....
  9. ncbi Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Oncol 1:97-119. 2007
    ..These studies also revealed p53 positive, non-apocrine putative precancerous lesions as well as novel phenotypes for ME and some luminal cells characterized by the expression of cytokeratin 15...
  10. ncbi Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research, Copenhagen, Denmark
    Mol Oncol 1:321-49. 2007
    ....
  11. ncbi Proteomics in translational cancer research: toward an integrated approach
    Julio E Celis
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Cancer Cell 3:9-15. 2003
    ..In general, these studies have emphasized the potential of the technology for biomarker discovery, as well as for addressing the issue of cancer heterogeneity...
  12. ncbi Molecular characterization of apocrine carcinoma of the breast: validation of an apocrine protein signature in a well-defined cohort
    Julio E Celis
    Danish Centre for Translational Breast Cancer Research DCTB, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Oncol 3:220-37. 2009
    ..These results pave the way for addressing issues such as prognosis of IACs, patient stratification for targeted therapeutics, as well as research strategies for identifying novel therapeutic targets for developing new cancer therapies...
  13. ncbi Proteomic strategies to reveal tumor heterogeneity among urothelial papillomas
    Julio E Celis
    Institute of Cancer Biology and Danish Centre for Human Genome Research, The Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 1:269-79. 2002
    ....
  14. ncbi A new start in Madrid. Symposium on basic and translational cancer research
    Julio E Celis
    Institute of Cancer Biology, The Danish Cancer Society, Copenhagen, Denmark
    EMBO Rep 3:718-23. 2002
  15. ncbi Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Oncol 4:539-61. 2010
    ....
  16. ncbi Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas
    Gita Ohlsson
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark DK 2100, USA
    Mol Cell Proteomics 4:570-81. 2005
    ..Taken together, these results provide evidence that deregulation of A-FABP may play a role in bladder cancer progression and suggest that A-FABP could have a significant prognostic value in combination with other biomarkers...
  17. ncbi Bladder cancer-associated protein, a potential prognostic biomarker in human bladder cancer
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen Ø, Denmark
    Mol Cell Proteomics 9:161-77. 2010
    ..The implications of these results in biomarker discovery are discussed...
  18. ncbi Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast
    Pavel Gromov
    Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Oncol 4:65-89. 2010
    ....
  19. ncbi A combined proteome and ultrastructural localization analysis of 14-3-3 proteins in transformed human amnion (AMA) cells: definition of a framework to study isoform-specific differences
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology and Danish Centre for Translational Breast Cancer Research DCTB, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 7:1225-40. 2008
    ....
  20. ncbi Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast
    Jose M A Moreira
    Department of Proteomics in Cancer, Institute of Cancer Biology and Danish Centre for Translational Breast Cancer Research, Danish Cancer Society, DK 2100 Copenhagen
    Mol Cell Proteomics 4:555-69. 2005
    ..Our data suggest that, contrary to what was previously thought, loss of expression of 14-3-3sigma protein is not a frequent event in breast tumorigenesis...
  21. ncbi A single lysis solution for the analysis of tissue samples by different proteomic technologies
    Pavel Gromov
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Oncol 2:368-79. 2008
    ....
  22. ncbi Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition
    Jose M A Moreira
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Cell Proteomics 3:410-9. 2004
    ....
  23. ncbi Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer
    Teresa Cabezon
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 121:1433-44. 2007
    ..Using a specific ELISA test, we detected a significant higher concentration of S100A4 in the tumor interstitial fluid (TIF) as compared to their corresponding normal counterparts (NIF)...
  24. ncbi Proteomic Profiling of Triple-negative Breast Carcinomas in Combination With a Three-tier Orthogonal Technology Approach Identifies Mage-A4 as Potential Therapeutic Target in Estrogen Receptor Negative Breast Cancer
    Teresa Cabezon
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100, Copenhagen, Denmark
    Mol Cell Proteomics 12:381-94. 2013
    ....
  25. ncbi Human proteomic databases: a powerful resource for functional genomics in health and disease
    Pavel S Gromov
    Institute of Cancer Biology and Danish Centre for Human Genome Research, The Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Prog Biophys Mol Biol 80:3-22. 2002
    ..Here, we review the current status of human 2D PAGE databases that we are systematically constructing for the study of bladder cancer and skin ageing...
  26. ncbi Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-gamma-induced polypeptides that includes manganese-superoxide dismutase and the p85beta subunit of phosphatidylinositol 3-kinase
    Pavel Gromov
    Department of Medical Biochemistry and Danish Centre for Molecular Gerontology, The University of Aarhus, Ole Worms Alle, build 170, DK 8000 Aarhus C, Denmark
    Mol Cell Proteomics 2:70-84. 2003
    ....
  27. ncbi bc10: A novel human bladder cancer-associated protein with a conserved genomic structure downregulated in invasive cancer
    Irina Gromova
    Institute of Cancer Biology and Danish Center for Human Genome Research, The Danish Cancer Society, København, Danmark
    Int J Cancer 98:539-46. 2002
    ..The downregulation of this novel marker in invasive tumors suggests a putative role in bladder cancer progression...
  28. ncbi Proteomic strategies in bladder cancer: From tissue to fluid and back
    Pavel Gromov
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Proteomics Clin Appl 2:974-88. 2008
    ..In addition, we provide a brief description of a novel and highly promising source of biomarkers, the tumor interstitial fluid (TIF) that perfuses the tumor microenvironment...
  29. ncbi Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  30. ncbi Genome-wide study of gene copy numbers, transcripts, and protein levels in pairs of non-invasive and invasive human transitional cell carcinomas
    Torben F Ørntoft
    Department of Clinical Biochemistry, Molecular Diagnostic Laboratory, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Mol Cell Proteomics 1:37-45. 2002
    ..With few exceptions we found a good correlation (p < 0.005) between transcript alterations and protein levels. The implications, as well as limitations, of the approach are discussed...
  31. ncbi Study of therapy resistance in cancer cells with functional proteome analysis
    Julia Poland
    , , Berlin, Germany
    Clin Chem Lab Med 40:221-34. 2002
    ..Possible implications of differential protein expression will be discussed...
  32. ncbi Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide
    Dennis van der Vlies
    Centre for Biomembranes and Lipid Enzymology, Department of Biochemistry of Lipids, Institute of Biomembranes, Utrecht University, The Netherlands
    Biochem J 366:825-30. 2002
    ..In agreement, confocal laser scanning microscopy showed co-localization of TyrFluo-labelled proteins and the KDEL receptor ERD-2, a marker for the endoplasmic reticulum...
  33. ncbi The Human Proteome Organization: a mission to advance proteome knowledge
    Sam Hanash
    University of Michigan Medical Center, Ann Arbor, Michigan 48109-0510, USA
    Mol Cell Proteomics 1:413-4. 2002
  34. ncbi Gel-based proteomics: what does MCP expect?
    Julio E Celis
    Mol Cell Proteomics 3:949. 2004
  35. ncbi Promoting basic research in Europe
    Julio E Celis
    FEBS Lett 563:1-2. 2004
  36. ncbi Strong support from the scientific community to the idea of establishing a European Research Council within the Life Sciences
    Julio E Celis
    FEBS Lett 539:1. 2003
  37. ncbi A European Research Council for all sciences: a dream that may come true
    Julio E Celis
    FEBS Lett 555:179. 2003
  38. ncbi The European Research Council: the 'Mayor Group' report and the Commission's views on basic research and its impact
    Julio E Celis
    FEBS Lett 561:1-2. 2004
  39. ncbi [Pathogenesis of breast cancer]
    Ole William Petersen
    Københavns Universitet, Institut for Cellulaer og Molekylaer Medicin, Panumbygningen, Det Sundhedsvidenskabelige Fakultet, København N
    Ugeskr Laeger 169:2968-72. 2007
    ..Here we discuss the possible existence of normal and cancer stem cells in the human breast and in breast cancer and their potential role in the evolution of this disease...