Jiri Bartek

Summary

Affiliation: Danish Cancer Society
Country: Denmark

Publications

  1. ncbi request reprint Cell biology. The stress of finding NEMO
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 311:1110-1. 2006
  2. ncbi request reprint TOPping up ATR activity
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 124:888-90. 2006
  3. doi request reprint Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Int J Androl 34:e103-13. 2011
  4. ncbi request reprint DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 6:2344-7. 2007
  5. ncbi request reprint Cell biology. Balancing life-or-death decisions
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 314:261-2. 2006
  6. ncbi request reprint DNA damage signalling guards against activated oncogenes and tumour progression
    J Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 26:7773-9. 2007
  7. ncbi request reprint Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006
  8. ncbi request reprint Microcephalin guards against small brains, genetic instability, and cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 10:91-3. 2006
  9. ncbi request reprint DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
  10. doi request reprint SUMO boosts the DNA damage response barrier against cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 17:9-11. 2010

Detail Information

Publications90

  1. ncbi request reprint Cell biology. The stress of finding NEMO
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 311:1110-1. 2006
  2. ncbi request reprint TOPping up ATR activity
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 124:888-90. 2006
    ..In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity...
  3. doi request reprint Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours
    J Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Int J Androl 34:e103-13. 2011
    ....
  4. ncbi request reprint DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 6:2344-7. 2007
    ....
  5. ncbi request reprint Cell biology. Balancing life-or-death decisions
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Science 314:261-2. 2006
  6. ncbi request reprint DNA damage signalling guards against activated oncogenes and tumour progression
    J Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Oncogene 26:7773-9. 2007
    ....
  7. ncbi request reprint Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006
    ..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
  8. ncbi request reprint Microcephalin guards against small brains, genetic instability, and cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 10:91-3. 2006
    ..These findings and aberrantly reduced expression in human carcinomas identify microcephalin as a candidate novel tumor suppressor...
  9. ncbi request reprint DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
    ..Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression...
  10. doi request reprint SUMO boosts the DNA damage response barrier against cancer
    Jiri Bartek
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cancer Cell 17:9-11. 2010
    ..Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO...
  11. ncbi request reprint DNA damage checkpoints: from initiation to recovery or adaptation
    Jiri Bartek
    Department of Cell Cycle and Cancer, and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Curr Opin Cell Biol 19:238-45. 2007
    ..Such studies highlight the dynamic nature of these processes and help us to better understand the molecular basis, spatiotemporal orchestration and biological significance of the DNA damage response in normal and cancerous cells...
  12. pmc Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
    Shizhou Liu
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Biol 26:6056-64. 2006
    ..Together, these results suggest that while TopBP1 is a general regulator of ATR, Claspin operates downstream of TopBP1 to selectively regulate the Chk1-controlled branch of the genotoxic stress response...
  13. doi request reprint HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
    Simon Bekker-Jensen
    Centre for Genotoxic Stress Research, Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Nat Cell Biol 12:80-6; sup pp 1-12. 2010
    ....
  14. ncbi request reprint Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Cancer Cell 3:247-58. 2003
    ..Our results provide evidence that the mammalian S phase checkpoint functions via amplification of physiologically operating, Chk1-dependent mechanisms...
  15. ncbi request reprint RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Cell 131:887-900. 2007
    ..These data suggest that MDC1-mediated and RNF8-executed histone ubiquitylation protects genome integrity by licensing the DSB-flanking chromatin to concentrate repair factors near the DNA lesions...
  16. ncbi request reprint Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
    Alwin Krämer
    Danish Cancer Society, Institute of Cancer Biology, Department of Cell Cycle and Cancer, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    Nat Cell Biol 6:884-91. 2004
    ....
  17. ncbi request reprint Deregulation of the G1/S-phase control in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    APMIS 111:252-65; discussion 265-6. 2003
    ....
  18. ncbi request reprint Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    Niels Mailand
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100, Copenhagen, Denmark
    Mol Cell 23:307-18. 2006
    ..Our data suggest that degradation of Claspin facilitates timely reversal of the checkpoint response and delineates the period permissive for Chk1 activation during cell cycle progression...
  19. pmc Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    Randi G Syljuåsen
    Institute of Cancer Biology, Department of Cell Cycle and Cancer, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Mol Cell Biol 25:3553-62. 2005
    ..These results may help explain why Chk1 is an essential kinase and should be taken into account when drugs to inhibit this kinase are considered for use in cancer treatment...
  20. ncbi request reprint Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway
    Jeppe Agner
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen, Denmark
    Exp Cell Res 302:162-9. 2005
    ....
  21. pmc Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
    Fredrik Melander
    Institute of Cancer Biology and 2Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 181:213-26. 2008
    ..Together, these data suggest that phosphorylation of the SDT repeats in the MDC1 N terminus functions to recruit NBS1 and, thereby, increases the local concentration of MRN at the sites of chromosomal breakage...
  22. ncbi request reprint ATM activation in normal human tissues and testicular cancer
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 4:838-45. 2005
    ..The new tools characterized here should facilitate monitoring of ATM activation in clinical specimens, and help develop future treatment strategies...
  23. pmc Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100, Copenhagen, Denmark
    J Cell Biol 170:201-11. 2005
    ....
  24. pmc The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
    Dorthe Helena Larsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 190:731-40. 2010
    ..Thus, CHD4 emerges as a novel genome caretaker and a factor that facilitates both checkpoint signaling and repair events after DNA damage...
  25. pmc Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    Simon Bekker-Jensen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 173:195-206. 2006
    ..We propose that subclassification of DSB regulators according to their residence sites provides a useful framework for understanding their involvement in diverse processes of genome surveillance...
  26. pmc Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
    Claudia Lukas
    Danish Cancer Society, Institute of Cancer Biology, Copenhagen, Denmark
    EMBO J 23:2674-83. 2004
    ....
  27. ncbi request reprint Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
    Zuzana Horejsi
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100 Denmark
    Oncogene 23:3122-7. 2004
    ..Although not absolutely required for ATM activation, the MRN nuclease complex may help reach the threshold activity of ATM necessary for optimal genome maintenance and prevention of cancer...
  28. ncbi request reprint Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks
    Simon Bekker-Jensen
    Centre for Genotoxic Stress Research and Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen DK 2100, Denmark
    J Biol Chem 282:19638-43. 2007
    ..Collectively, these findings implicate Xip1 as a new regulator of genome maintenance pathways, which may function to organize DNA strand break repair complexes at sites of DNA damage...
  29. ncbi request reprint ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, Copenhagen, Denmark
    Cell Cycle 3:941-5. 2004
    ..DNA damage further activates and switches this pathway from its constitutively operating "surveillance mode" compatible with DNA replication into an "emergency" checkpoint response...
  30. pmc Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment
    Lenka Oplustilova
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Cell Cycle 11:3837-50. 2012
    ..Overall, this study helps characterize genetic and functional determinants of cellular responses to PARP-1i and contributes to the search for biomarkers to exploit PARP inhibitors in cancer therapy...
  31. pmc Differentiation-induced radioresistance in muscle cells
    Lucia Latella
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mol Cell Biol 24:6350-61. 2004
    ....
  32. doi request reprint HCLK2 is required for activity of the DNA damage response kinase ATR
    Jannie M Rendtlew Danielsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Biol Chem 284:4140-7. 2009
    ..Importantly, our results suggest that HCLK2 functions in the same pathway as TopBP1 but that the two proteins regulate different steps in ATR activation...
  33. pmc Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
    Kasper Fugger
    Institute of Cancer Biology and Center for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 186:655-63. 2009
    ..Thus, by possessing both pro- and anti-recombinogenic potential, hFbh1 may cooperate with other DNA helicases in tightly controlling cellular HR activity...
  34. ncbi request reprint Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time
    Jiri Lukas
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    DNA Repair (Amst) 3:997-1007. 2004
    ....
  35. ncbi request reprint Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation
    Randi G Syljuåsen
    Department of Cell Cycle and Cancer and Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 64:9035-40. 2004
    ..These results demonstrate that transient Chk1 inhibition by CEP-3891 allows premature mitotic entry of irradiated cells, thereby leading to accelerated onset of mitotic nuclear fragmentation and increased cell death...
  36. doi request reprint Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene
    Jirina Bartkova
    Institute Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Mol Oncol 2:296-316. 2008
    ....
  37. doi request reprint 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    Claudia Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:243-53. 2011
    ..Together, these data indicate that restoration of DNA or chromatin integrity at loci prone to replication problems requires mitotic transmission to the next cell generations...
  38. ncbi request reprint Checking on DNA damage in S phase
    Jiri Bartek
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Rev Mol Cell Biol 5:792-804. 2004
    ....
  39. ncbi request reprint Deregulation of the RB pathway in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    J Pathol 200:149-56. 2003
    ..We hope that this study will inspire further immunohistochemical applications of phosphospecific antibodies in pathology, and examination of the RB pathway defects in relation to curability of TGCTs...
  40. doi request reprint TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
    Thorkell Gudjonsson
    Chromosome Biology Unit, Danish Cancer Society Research Center and Center for Genotoxic Stress Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 150:697-709. 2012
    ..We provide evidence that this mechanism is vital for the homeostasis of ubiquitin-controlled events after DNA breakage and can be subverted during tumorigenesis...
  41. pmc Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
    Anja Groth
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    EMBO J 22:1676-87. 2003
    ....
  42. pmc USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin
    Helene Faustrup
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 184:13-9. 2009
    ..Thus, Claspin turnover is controlled by multiple ubiquitylation and deubiquitylation activities, which together provide a flexible means to regulate the ATR-Chk1 pathway...
  43. ncbi request reprint Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    Frederic Tort
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 66:10258-63. 2006
    ....
  44. doi request reprint LEDGF (p75) promotes DNA-end resection and homologous recombination
    Mads Daugaard
    Cell Death and Metabolism, Danish Cancer Society Research Center, Copenhagen, Denmark
    Nat Struct Mol Biol 19:803-10. 2012
    ..These data highlight the role of PWWP-domain proteins in DNA repair and provide a molecular explanation for the antiapoptotic and cancer cell survival-activities of LEDGF...
  45. ncbi request reprint E2F activity is essential for survival of Myc-overexpressing human cancer cells
    Eric Santoni-Rugiu
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, 2100 Copenhagen E, Denmark
    Oncogene 21:6498-509. 2002
    ....
  46. doi request reprint RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
    Carsten Doil
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell 136:435-46. 2009
    ..Thus, RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance...
  47. ncbi request reprint The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 7:195-201. 2005
    ..These results highlight a crucial role for the Chk1 signalling pathway in protecting cells against lethal DNA lesions through regulation of HRR...
  48. ncbi request reprint Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges
    Claudia Lukas
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, Copenhagen, Denmark
    Chromosoma 114:146-54. 2005
    ..We delineate benefits and limitations of these assays and highlight the key recent discoveries where live microscopy provided unprecedented insights into how cells defend themselves against genome-destabilizing effects of DNA damage...
  49. ncbi request reprint Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  50. ncbi request reprint Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis
    Martin Mistrik
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 8:2592-9. 2009
    ....
  51. ncbi request reprint Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
    Randi G Syljuåsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cancer Res 66:10253-7. 2006
    ..Such cell division in the presence of damaged DNA may be detrimental for genetic stability and could potentially contribute to cancer development...
  52. ncbi request reprint Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4
    Thomas Farkas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    J Biol Chem 277:26741-52. 2002
    ..These results further elucidate the complex regulation of p130 and provide a molecular mechanism to explain the differential control of p107 and p130 by cyclin-dependent kinases...
  53. ncbi request reprint Checking out the centrosome
    Alwin Krämer
    Danish Cancer Society, Institute of Cancer Biology, Department of Cell Cycle and Cancer, Copenhagen, Denmark
    Cell Cycle 3:1390-3. 2004
    ..This review will focus on recent advances in the understanding of the role of centrosomes as integrators of positive and negative pathways for mitotic entry...
  54. ncbi request reprint Chk1 and Chk2 kinases in checkpoint control and cancer
    Jiri Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Cell 3:421-9. 2003
    ....
  55. ncbi request reprint Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    Claudia Lukas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 5:255-60. 2003
    ..These results unravel a dynamic nature of Nbs1 interaction with DSB lesions and identify Chk2 as a candidate transmitter of the checkpoint signal, allowing for a coordinated pan-nuclear response to focal DNA damage...
  56. ncbi request reprint Watching the DNA repair ensemble dance
    Jiri Lukas
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100, Copenhagen
    Cell 118:666-8. 2004
    ..In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks...
  57. ncbi request reprint The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
    Jacob Falck
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Genet 30:290-4. 2002
    ..We conclude that in response to ionizing radiation, phosphorylations of Nbs1 and Chk2 by ATM trigger two parallel branches of the DNA damage-dependent S-phase checkpoint that cooperate by inhibiting distinct steps of DNA replication...
  58. pmc Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
    Niels Mailand
    Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    EMBO J 21:5911-20. 2002
    ..Thus, phosphorylation-mediated switches among three differentially stable forms ensure distinct thresholds, and thereby distinct roles for Cdc25A in multiple cell cycle transitions and checkpoints...
  59. ncbi request reprint Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer
    Jirina Bartkova
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK 2100, Denmark
    Oncogene 23:8545-51. 2004
    ....
  60. doi request reprint More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    Jiri Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:1161-9. 2011
    ..Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity...
  61. ncbi request reprint Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
    Niels Mailand
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 4:317-22. 2002
    ..These results indicate that Cdc14A is a physiological regulator of the centrosome duplication cycle, which, when disrupted, can lead to genomic instability in mammalian cells...
  62. ncbi request reprint Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines
    Harald Loffler
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Oncogene 22:8063-71. 2003
    ..Given the frequency of this mechanism, we propose that the DNA integrity checkpoint controlling Cdc25A protein stability might be a common target for deregulation in breast cancer...
  63. ncbi request reprint A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3
    Christina Aaen Hansen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 7:325-34. 2008
    ..Collectively, our findings suggest an intimate functional relationship between the Cdc14A phosphatase and the Erk3 kinase in signaling pathways that regulate key cell-fate decisions in human cells...
  64. ncbi request reprint The emerging phenotype of the testicular carcinoma in situ germ cell
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:267-78; discussion 278-9. 2003
    ....
  65. ncbi request reprint Cell-cycle regulatory proteins in human wound healing
    Jirina Bartkova
    Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Arch Oral Biol 48:125-32. 2003
    ..These data indicate that downmodulation of several G(1)/S-phase cyclins and a relative excess of CKIs may cooperate to ensure the quiescent state of migrating keratinocytes during wound healing...
  66. ncbi request reprint Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay
    Petra Knizetova
    Faculty of Medicine, Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    Cell Cycle 7:2553-61. 2008
    ....
  67. ncbi request reprint Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research
    Julio E Celis
    The Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell Proteomics 2:369-77. 2003
    ....
  68. ncbi request reprint Tethered genes get checked during replication
    Jiri Lukas
    Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Cell 146:189-91. 2011
    ..Now, Bermejo et al. (2011) identify a mechanism directly linking checkpoint function to the relief of topological tension at nuclear pore tethered genes...
  69. ncbi request reprint Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
    Magtouf Gatei
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Biol Chem 278:14806-11. 2003
    ..In addition, this study also demonstrates that Chk1 is essential for IR-induced inhibition of DNA synthesis and the G(2)/M checkpoint...
  70. ncbi request reprint Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
    Michalis Liontos
    Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece
    Cancer Res 67:10899-909. 2007
    ..In addition, stable expression of hCdc6 and hCdt1 in premalignant papilloma cells led to transformation of the cells that produced tumors upon injection into nude mice depicting the oncogenic potential of their deregulation...
  71. pmc A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer
    Pia Vahteristo
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 8, FIN 00029 HUS, Helsinki, Finland
    Am J Hum Genet 71:432-8. 2002
    ....
  72. ncbi request reprint MDC1 is required for the intra-S-phase DNA damage checkpoint
    Michal Goldberg
    The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK
    Nature 421:952-6. 2003
    ..These findings reveal that MDC1-mediated focus formation by the MRE11 complex at sites of DNA damage is crucial for the efficient activation of the intra-S-phase checkpoint...
  73. ncbi request reprint 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    Richard A DiTullio
    Wistar Institute, Philadelphia, PA 19104 4268, USA
    Nat Cell Biol 4:998-1002. 2002
    ..We conclude that the constitutive activation of the DNA damage checkpoint pathway may be linked to the high frequency of p53 mutations in human cancer, as p53 is a downstream target of Chk2 and ATM...
  74. ncbi request reprint DNA repair: Damage alert
    Jiri Bartek
    Nature 421:486-8. 2003
  75. ncbi request reprint Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression
    Fiona Wyllie
    Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom
    Exp Cell Res 285:236-42. 2003
    ..Our data suggest that p53-mediated senescence depends on factor(s) other than p21 which modulate formation of cyclin E-cdk2 complexes...
  76. ncbi request reprint RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
    Kate M Sleeth
    The Institute for Cancer Studies, University of Sheffield, Sheffield, UK
    J Mol Biol 373:38-47. 2007
    ..Furthermore, our data suggest that replacement of RPA with the RAD51 and RAD52 proteins is affected by checkpoint signalling...
  77. ncbi request reprint ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    Ali Jazayeri
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QN, UK
    Nat Cell Biol 8:37-45. 2006
    ..Thus, in response to DSBs, ATR activation is regulated by ATM in a cell-cycle dependent manner...
  78. ncbi request reprint Cell division: the heart of the cycle
    Jiri Lukas
    Nature 432:564-7. 2004
  79. ncbi request reprint p16INK4A is a robust in vivo biomarker of cellular aging in human skin
    Sigrun Ressler
    Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, Austria
    Aging Cell 5:379-89. 2006
    ..p16INK4A therefore is a biomarker for human aging in vivo. The data reported here suggest a model for changes in regulatory gene expression that drive aging in human skin...
  80. ncbi request reprint Evaluation of RAD50 in familial breast cancer predisposition
    Johanna Tommiska
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    Int J Cancer 118:2911-6. 2006
    ..Altogether, these results suggest RAD50 can only be making a very minor contribution to familial breast cancer predisposition in UK and Finland...
  81. ncbi request reprint Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events
    Harald Loffler
    Clinical Cooperation Unit for Molecular Hematology Oncology, German Cancer Research Center DKFZ
    Cell Cycle 5:2543-7. 2006
    ..Analogous to Chk1 inhibition, the 'paraspindle' phenotype was induced by overexpression of Cdc25B but not Cdc25A. Our results suggest that Chk1 functions to coordinate mitotic events through regulation of Cdc25B...
  82. ncbi request reprint Structure meets function--centrosomes, genome maintenance and the DNA damage response
    Harald Loffler
    Clinical Cooperation Unit for Molecular Hematology Oncology, German Cancer Research Center DKFZ and Department of Internal Medicine V, University of Heidelberg, Germany
    Exp Cell Res 312:2633-40. 2006
    ..However, many missing links and discrepancies between different model systems remain...
  83. ncbi request reprint CHEK2 variant I157T may be associated with increased breast cancer risk
    Outi Kilpivaara
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital HUCH, Helsinki, Finland
    Int J Cancer 111:543-7. 2004
    ..The I157T variant may be associated with breast cancer risk, but the risk is lower than for 1100delC...
  84. pmc Loss of Geminin induces rereplication in the presence of functional p53
    Marina Melixetian
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Cell Biol 165:473-82. 2004
    ..These data show that Geminin is required for maintaining genomic stability in human cells...
  85. ncbi request reprint DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function
    Harald Loffler
    Clinical Cooperation Unit for Molecular Hematology Oncology, German Cancer Research Center DKFZ and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cell Cycle 6:2541-8. 2007
    ....
  86. pmc Human CtIP promotes DNA end resection
    Alessandro A Sartori
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 450:509-14. 2007
    ..These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination...
  87. ncbi request reprint Targeting the checkpoint kinases: chemosensitization versus chemoprotection
    Bin Bing S Zhou
    Drug Discovery Biology, Incyte Corporation, Experimental Station, Rt 141 and Henry Clay Road, Bldg 400, Wilmington, DE 19880, USA
    Nat Rev Cancer 4:216-25. 2004
  88. ncbi request reprint Regulation of replication fork progression through histone supply and demand
    Anja Groth
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR218 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 318:1928-31. 2007
    ....
  89. doi request reprint An oncogene-induced DNA damage model for cancer development
    Thanos D Halazonetis
    Department of Molecular Biology and Department of Biochemistry, University of Geneva, CH 1205 Geneva, Switzerland
    Science 319:1352-5. 2008
    ..Thus, oncogene-induced DNA damage may explain two key features of cancer: genomic instability and the high frequency of p53 mutations...
  90. ncbi request reprint Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    Yael Ziv
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 8:870-6. 2006
    ..These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators...