Zorana J Andersen

..Exposure to air pollution in early life contributes to the burden of childhood asthma, but it is not clear whether long-term exposure to air pollution can lead to asthma onset or progression in adulthood...

..To study the association between short-term exposure to ultrafine particles and morbidity in Copenhagen, Denmark...

..We examined the association between long-term exposure to traffic-related air pollution and incident and fatal stroke in a prospective cohort study...

..A study was undertaken to examine the effect of exposure to air pollution on wheezing symptoms in children under the age of 3 years with genetic susceptibility to asthma...

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..We studied the association between long-term exposure to traffic-related air pollution and incidence of diabetes...

..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...

..Overall, our study showed only few associations between dietary, environmental, and genetic factors and levels of bulky DNA adducts measured in peripheral leukocytes in a general Danish population...

..Overall, the results of the present study indicate that the four polymorphisms are not of major importance in colorectal cancer carcinogenesis...

..There were no significant interactions between the GST polymorphisms and smoking...

..The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.43-0.84; p=0.003) per 50% increase in fruit intake. No convincing interactions were detected between the polymorphisms and smoking...

..The same tendency was seen in relation to intake of fruit. There were no statistically significant interactions between the OGG1 polymorphism and smoking...

..The results suggest that OGG1 mRNA levels should be regarded as a biomarker of exposure to oxidative stress with induction of DNA rather than a marker of inborn DNA repair capacity...

..In a recent population-based case-control study using 2,400 cases of childhood cancer, we found a statistically significant association between residential radon and acute lymphoblastic leukemia risk...

..Previous studies have shown associations between air pollution and risk for lung cancer...

..Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer...

..Epidemiological studies suggest that long-term exposure to transport noise increases the risk for cardiovascular disorders. The effect of transport noise on blood pressure and hypertension is uncertain...

..This is the first study of polymorphisms in base excision repair genes in relation to lung cancer among Danes...

..Higher levels of occupational physical activity had no protective effect; the lowest IRR was found for sitting work. Our study shows no convincing protective effect of physical activity on lung cancer risk...

..03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers...

..99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer...

..The purpose was to investigate whether the concentration of nitrogen oxides (NOx) at the residence, used as an indicator of air pollution from traffic, is associated with risk for lung cancer...

..The NAT2 fast acetylator genotype seemed to be protective against lung cancer in light smokers (< or =20 cigarettes/day) and not among heavy smokers (>20 cigarettes/day)...

..The observed inverse association between high intakes of plant food seems chiefly to be a real protective effect, and not solely due to residual confounding...

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..These results suggest that the GSTT1 null-genotype is associated with an increased risk of lung cancer, especially in younger individuals...

..Associations between trichloroethylene exposure and other cancers are less consistent...

..Our results indicate that bulky DNA adducts may have a weak association with lung cancer risk...

..Stratification for smoking seems to be advantageous in case-cohort studies of genetic polymorphisms and lung cancer...

..Our results indicate that predictors of PCBs varied according to substitution group, suggesting that ortho-substituted groups should be analyzed separately...

..02). Moreover, an interaction between DLG5 R30Q and NSAID use was found (P for interaction=0.02). Our results do not suggest that inborn variations in the inflammatory response play any major role in risk of colorectal cancer...

..Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation...

..48 (0.19-1.22) in carriers of one variant allele and 0.21 (0.04-1.07) in carriers of two variant alleles, and a significant trend (P=0.04). These results indicate that PTGS2 could be implicated in the development of lung cancer...

..Both road traffic noise and ambient air pollution have been associated with risk for ischemic heart disease, but only few inconsistent studies include both exposures...

..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...

..Our purpose was to examine associations between organochlorines and the development of breast cancer in a large prospective study using stored adipose tissue...

..The aim of this study was to investigate the relation between exposure to road traffic noise and risk for stroke, which has not been studied before...

..Epidemiologic studies have shown increased cancer risks among individuals exposed to high concentrations of arsenic in drinking-water, whereas studies of the carcinogenic effect of low doses have had inconsistent results...

..However, smoking intensity increased CRC risk among carriers of both NAT1 and NAT2 fast. This indicates that N-acetylator status affects the relationship between smoking and CRC risk...

..5), BS and NO(2) depends on many factors besides the outdoor levels, and that information on, for example, time of season or outdoor temperature and residence exposure, could improve the accuracy of the personal exposure estimation...

..We have investigated the association between occasional smoking and cancer of the bladder, kidney, pancreas, upper aero-digestive tract and lung...

..Particulate matter, especially ultrafine particles (UFPs), may cause health effects through generation of oxidative stress, with resulting damage to DNA and other macromolecules...

..Our results indicate that lifestyle-related oxidative stress may be a risk factor for colorectal cancer among subjects with a lowered defence...

..Particulate matter (PM) in ambient air is responsible for adverse health effects in adults and children. Relatively little is known about the concentrations, sources and health effects of PM in indoor air...

..The present study aims to assess the biological uptake in children of polycyclic aromatic hydrocarbons measured as 1-hydroxypyrene in urine from children living in city and rural residences...

..Single determinants varied among the individual compounds, even within related chlordane residues, suggesting that organochlorine pesticides should not be treated as a homogenous group...

..Objective: We investigated whether long-term exposure to residential road traffic noise is associated with an increased risk of diabetes...

..These novel results may merit future research of potential mechanism, whereas at present, no single PM(10) source can be attributed to all morbidity...

..Our results suggest that there are no causal relationship between non-occupational exposure to paint fumes in the residence during pregnancy and fetal growth...

..Epidemiological studies of health effects of TCE may benefit from evaluating potential risk within different strata of calendar time, number of company employees, sex, and type of industry...

..The aim of this study was to assess the influence of socioeconomic status on the risk of childhood leukaemia...

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..This raises concern and further large scale investigations are warranted to confirm this...

..We tested the hypothesis that domestic radon exposure increases the risk for childhood cancer...

..abstract:..

..Ambient air pollution is a risk factor for mortality and morbidity. The aim of this study was to quantify the health effects related to particulate matter (PM10) in Denmark...

..To update a study of risks for leukaemia, brain cancer and breast cancer in a Danish nationwide, population-based cohort of utility employees...

..In particular, nondifferential misclassification of exposure might have masked true, weak associations...

..We also found a moderate pattern of better survival from cancers at both sites in the most advantaged groups, most clearly reflected by the level of education, disposable income and affiliation to the work market...

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..The familial aggregation of testicular and possibly other cancers may be explained by shared genes and/or shared environmental factors, but the mutual importance of each of these is difficult to determine...

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..If the sample size in extreme categories provides enough power, a study in which this job-exposure matrix is used should allow detection of a true association between exposure to 50-Hz magnetic field and disease...

..These data suggest that the incidence rate of CNS tumours among Danish children has truly increased, although alternative explanations cannot be excluded...

..We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia)...