Jørn Wetterslev

Summary

Affiliation: Copenhagen Trial Unit
Country: Denmark

Publications

  1. pmc Effect of intermediate care on mortality following emergency abdominal surgery. The InCare trial: study protocol, rationale and feasibility of a randomised multicentre trial
    Morten Vester-Andersen
    Department of Anaesthesiology and Intensive Care Medicine, Herlev Hospital, Copenhagen University, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Trials 14:37. 2013
  2. pmc Estimating required information size by quantifying diversity in random-effects model meta-analyses
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    BMC Med Res Methodol 9:86. 2009
  3. ncbi [Preoperative fasting in adults and perioperative complications]
    Jørn Wetterslev
    H S Rigshospitalet, Center for Klinisk Interventionsforskning, Copenhagen Trial Unit
    Ugeskr Laeger 167:40-3. 2005
  4. ncbi Benefits and harms of perioperative beta-blockade
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Best Pract Res Clin Anaesthesiol 20:285-302. 2006
  5. ncbi [The patient with cardiac disease]
    Jørn Wetterslev
    H S Rigshospitalet, Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, København Ø
    Ugeskr Laeger 168:4305-9. 2006
  6. ncbi Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Epidemiol 61:64-75. 2008
  7. doi The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Psychiatry Res 200:354-60. 2012
  8. doi Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
    Bianca Hemmingsen
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark ctu rh dk
    BMJ 344:e1771. 2012
  9. pmc Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial
    Anne Benedicte Juul
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Denmark
    BMJ 332:1482. 2006
  10. pmc The effects of centralised and specialised intervention in the early course of severe unipolar depressive disorder: a randomised clinical trial
    Hanne Vibe Hansen
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 7:e32950. 2012

Detail Information

Publications52

  1. pmc Effect of intermediate care on mortality following emergency abdominal surgery. The InCare trial: study protocol, rationale and feasibility of a randomised multicentre trial
    Morten Vester-Andersen
    Department of Anaesthesiology and Intensive Care Medicine, Herlev Hospital, Copenhagen University, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Trials 14:37. 2013
    ..The aim of the present trial is to evaluate the effect of postoperative intermediate care following emergency major abdominal surgery in high-risk patients...
  2. pmc Estimating required information size by quantifying diversity in random-effects model meta-analyses
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    BMC Med Res Methodol 9:86. 2009
    ..The required information size in a meta-analysis may be calculated from an anticipated a priori intervention effect or from an intervention effect suggested by trials with low-risk of bias...
  3. ncbi [Preoperative fasting in adults and perioperative complications]
    Jørn Wetterslev
    H S Rigshospitalet, Center for Klinisk Interventionsforskning, Copenhagen Trial Unit
    Ugeskr Laeger 167:40-3. 2005
  4. ncbi Benefits and harms of perioperative beta-blockade
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Best Pract Res Clin Anaesthesiol 20:285-302. 2006
    ..Larger randomized trials are needed to determine dosage, optimal duration, and safety of therapy, and to identify populations in whom-and how-perioperative beta-blockade may be beneficial...
  5. ncbi [The patient with cardiac disease]
    Jørn Wetterslev
    H S Rigshospitalet, Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, København Ø
    Ugeskr Laeger 168:4305-9. 2006
    ..Evidence-based preoperative risk assessment and perioperative patient care for patients with heart disease and hypertension are summarised...
  6. ncbi Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    Jørn Wetterslev
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Epidemiol 61:64-75. 2008
    ..Trial sequential analysis (TSA) corresponds to group sequential analysis of a single trial and may be applied to meta-analysis to evaluate the evidence...
  7. doi The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Psychiatry Res 200:354-60. 2012
    ..However, change in salivary cortisol was one out of multiple outcome measures. The results of the present trial do not refute salivary cortisol as a potential endophenotype for depression...
  8. doi Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses
    Bianca Hemmingsen
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark ctu rh dk
    BMJ 344:e1771. 2012
    ..To compare the benefits and harms of metformin and insulin versus insulin alone as reported in randomised clinical trials of patients with type 2 diabetes...
  9. pmc Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial
    Anne Benedicte Juul
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Denmark
    BMJ 332:1482. 2006
    ..To evaluate the long term effects of perioperative beta blockade on mortality and cardiac morbidity in patients with diabetes undergoing major non-cardiac surgery...
  10. pmc The effects of centralised and specialised intervention in the early course of severe unipolar depressive disorder: a randomised clinical trial
    Hanne Vibe Hansen
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 7:e32950. 2012
    ..The aim of the present study was to assess the benefits and harms of centralised and specialised secondary care intervention in the early course of severe unipolar depression...
  11. pmc Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e31980. 2012
    ..The present trial is the first to test the hypothesis that escitalopram may reduce neuroticism in healthy first-degree relatives of patients with major depressive disorder (MD)...
  12. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
    ..However, benefit and harm of RBCs have not been established in this group of high-risk patients...
  13. ncbi The effects of a randomised multi-centre trial and international accreditation on availability and quality of clinical guidelines
    Anne Benedicte Juul
    The Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Health Care Qual Assur Inc Leadersh Health Serv 18:321-8. 2005
    ..To examine the availability and quality of clinical guidelines on perioperative diabetes care in hospital units before and after a randomised clinical trial (RCT) and international accreditation...
  14. ncbi The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery
    Anne Benedicte Juul
    Copenhagen Trial Unit, Center for Clinical Intervention Research, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Am Heart J 147:677-83. 2004
    ..Patients with diabetes mellitus are at a high-risk for postoperative cardiac morbidity and mortality. They may, therefore, benefit from perioperative beta-blockade...
  15. doi Sulphonylurea monotherapy for patients with type 2 diabetes mellitus
    Bianca Hemmingsen
    CopenhagenTrialUnit, Centre forClinical InterventionResearch, Department 7812, Rigshospitalet, CopenhagenUniversityHospital, Copenhagen, Denmark
    Cochrane Database Syst Rev 4:CD009008. 2013
    ..Type 2 diabetes mellitus (T2DM) is a growing health problem worldwide. Whether sulphonylureas show better, equal or worse therapeutic effects in comparison with other antidiabetic interventions for patients with T2DM remains controversial...
  16. doi Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial
    Lars Vedel Kessing
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 202:212-9. 2013
    ..Little is known about whether treatment in a specialised out-patient mood disorder clinic improves long-term prognosis for patients discharged from initial psychiatric hospital admissions for bipolar disorder...
  17. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    ..Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis...
  18. pmc Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
    Bianca Hemmingsen
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Denmark
    BMJ 343:d6898. 2011
    ....
  19. pmc Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial
    Ulla Knorr
    Department of Psychiatry Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e21224. 2011
    ....
  20. pmc Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 346:f839. 2013
    ..To assess the effects of fluid therapy with hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin on mortality, kidney injury, bleeding, and serious adverse events in patients with sepsis...
  21. pmc Evidence at a glance: error matrix approach for overviewing available evidence
    Frederik Keus
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    BMC Med Res Methodol 10:90. 2010
    ..We aimed at conceptualizing a visual assessment tool, i.e., a matrix for overviewing studies and their data in order to assess the clinical evidence at a glance...
  22. doi Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease
    Christian H Møller
    Department of Cardiothoracic Surgery, RT 2152, Copenhagen University Hospital, Rigshospitalet, Copenhagen
    Cochrane Database Syst Rev 3:CD007224. 2012
    ..Coronary artery bypass grafting (CABG) is performed both without and with cardiopulmonary bypass, referred to as off-pump and on-pump CABG respectively. However, the preferable technique is unclear...
  23. pmc The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders--design of two randomised c
    Lars Vedel Kessing
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 12:32. 2011
    ..It is not known whether centralised and specialised secondary care intervention initiated early after the onset of the diseases can prevent the progression and thereby improve the prognosis...
  24. doi Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    Jesper Brok
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Cochrane Hepato Biliary Group, Dept 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 61:763-9. 2008
    ..Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial...
  25. doi Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
    Bianca Hemmingsen
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev 11:CD008143. 2013
    ..Our previous systematic review of intensive glycaemic control versus conventional glycaemic control was based on 20 randomised clinical trials that randomised 29 ,986 participants with T2D. We now report our updated review...
  26. doi Do young adults with bipolar disorder benefit from early intervention?
    Lars Vedel Kessing
    Copenhagen Affective Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Electronic address
    J Affect Disord 152:403-8. 2014
    ..The aim of the present report was to compare the effects of early intervention among patients with bipolar disorder aged 18-25 years to that of patients aged 26 years or older...
  27. ncbi Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial
    Christian S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesth Analg 115:849-54. 2012
    ..In this follow-up study of the PROXI trial we assessed the association between long-term mortality and perioperative oxygen fraction in patients undergoing abdominal surgery...
  28. doi Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis
    Arash Afshari
    Department of Anesthesiology, Rigshospitalet, University of Copenhagen, Anestheisa, Juliane Marie Centre, Copenhagen, 2100, Denmark
    Anesth Analg 112:1411-21. 2011
    ..We assessed the risk of bias through assessment of trial methodological components. We assessed the risk of random error by applying trial sequential analysis...
  29. doi Trial sequential analyses of meta-analyses of complications in laparoscopic vs. small-incision cholecystectomy: more randomized patients are needed
    Frederik Keus
    The Cochrane Hepato Biliary Group, Copenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Epidemiol 63:246-56. 2010
    ..Trial sequential analysis (TSA) evaluates random errors in meta-analysis. We analyzed meta-analyses on laparoscopic vs. small-incision cholecystectomy regarding different outcome measures for the occurrence of type I errors...
  30. doi Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    Jesper Brok
    The Copenhagen Trial Unit, Center for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Epidemiol 38:287-98. 2009
    ..This is analogous to sequential monitoring boundaries in a single trial...
  31. doi Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?
    Kristian Thorlund
    Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen University Hospital, Department 3344, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Epidemiol 38:276-86. 2009
    ..e. applying trial sequential monitoring boundaries)...
  32. doi Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark
    Intensive Care Med 39:2126-34. 2013
    ..We aimed to characterize the degree and clinical importance of bleeding in patients treated with hydroxyethyl starch (HES)...
  33. doi Effects of hydroxyethyl starch in subgroups of patients with severe sepsis: exploratory post-hoc analyses of a randomised trial
    Rasmus G Müller
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen, Denmark
    Intensive Care Med 39:1963-71. 2013
    ..It has been speculated that certain subgroups of sepsis patients may benefit from treatment with hydroxyethyl starch (HES) 130/0.42, specifically in the earlier resuscitation of patients with more severely impaired circulation...
  34. pmc Pulmonary perfusion with oxygenated blood or custodiol HTK solution during cardiac surgery for postoperative pulmonary function in COPD patients: a trial protocol for the randomized, clinical, parallel group, assessor and data analyst blinded Pulmonary Pr
    Katrine B Buggeskov
    Department of Thoracic Anaesthesiology, Copenhagen University Hospital, Rigshospitalet, The Heart Centre dept, 4142, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Trials 14:30. 2013
    ..Impaired pulmonary function can, however, be attenuated by pulmonary perfusion with oxygenated blood or custodiol HTK (histidine-tryptophan-ketoglutarate) solution...
  35. pmc Statistical multiplicity in systematic reviews of anaesthesia interventions: a quantification and comparison between Cochrane and non-Cochrane reviews
    Georgina Imberger
    Cochrane Anaesthesia Review Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e28422. 2011
    ..This study measured the quantity of statistical multiplicity present in a population of systematic reviews and aimed to assess whether this quantity is different in Cochrane and non-Cochrane reviews...
  36. pmc Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus
    Ulla Knorr
    Department of Psychiatry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 10:66. 2009
    ..The primary outcome measure is the change in plasma cortisol in the dexamethasone-corticotrophin releasing hormone test from baseline to the end of intervention...
  37. doi High body mass index is a weak predictor for difficult and failed tracheal intubation: a cohort study of 91,332 consecutive patients scheduled for direct laryngoscopy registered in the Danish Anesthesia Database
    Lars H Lundstrøm
    Department of Anesthesia and Intensive Care Herlev, and Copenhagen Trial Unit, Centre of Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Anesthesiology 110:266-74. 2009
    ..Previous studies have failed to detect high body mass index (BMI) as a risk factor for difficult tracheal intubation (DTI). BMI was investigated as a risk factor for DTI in patients planned for direct laryngoscopy...
  38. doi Clinical outcomes in randomized trials of off- vs. on-pump coronary artery bypass surgery: systematic review with meta-analyses and trial sequential analyses
    Christian H Møller
    Department of Cardio Thoracic Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur Heart J 29:2601-16. 2008
    ..To assess the clinical outcomes of off- vs. on-pump coronary artery bypass surgery in randomized trials...
  39. doi Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial
    Christian S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 302:1543-50. 2009
    ..Use of 80% oxygen during surgery has been suggested to reduce the risk of surgical wound infections, but this effect has not been consistently identified. The effect of 80% oxygen on pulmonary complications has not been well defined...
  40. doi Salivary cortisol in depressed patients versus control persons: a systematic review and meta-analysis
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychoneuroendocrinology 35:1275-86. 2010
    ..Based on the available studies there is not firm evidence for a difference of salivary cortisol in depressed patients and control persons and salivary cortisol is unable to discriminate between persons with and without depression...
  41. ncbi Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
    Arash Afshari
    The Cochrane Anaesthesia Review Group and Copenhagen Trial Unit and Department of Paediatric and Obstetric Anaesthesia, Rigshospitalet, Blegdamsvej 9, Afsnit 3342, rum 52, Copenhagen, Denmark, 2100
    Cochrane Database Syst Rev 3:CD007871. 2011
    ..Thromboelastography (TEG) and thromboelastometry (ROTEM) are increasingly used to guide transfusion strategy but their roles remain disputed...
  42. ncbi Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
    Bianca Hemmingsen
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev 6:CD008143. 2011
    ..Observational studies report a relationship between reduced blood glucose and reduced risk of both micro- and macrovascular complications in patients with T2D...
  43. doi Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
    Mette Krag
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Intensive Care Med 40:11-22. 2014
    ....
  44. pmc The effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
    Rune Rasmussen
    Department of Neurosurgery, Copenhagen University Hospital, 9 Blegdamsvej, Copenhagen, Denmark
    Trials 13:102. 2012
    ..No randomised, clinical trials have been conducted, investigating the possible pharmacodynamic effects of prostacyclin on the human brain following SAH...
  45. doi Flow-regulated versus differential pressure-regulated shunt valves for adult patients with normal pressure hydrocephalus
    Morten Ziebell
    Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Cochrane Database Syst Rev 5:CD009706. 2013
    ..Surgical intervention with flow-regulated and differential pressure-regulated ventriculo-peritoneal shunts remains controversial. Knowledge about the benefits and harms of these interventions is limited...
  46. doi Design and rationale for the PREVAIL study: effect of e-Health individually tailored encouragements to physical exercise on aerobic fitness among adolescents with congenital heart disease--a randomized clinical trial
    Susanne Hwiid Klausen
    Research Unit Women s and Children s Health, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Am Heart J 163:549-56. 2012
    ..The trial is expected to contribute with new knowledge regarding how physical activity in adolescents with CHD can be increased and, possibly, comorbidity be reduced...
  47. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
    ..Now lower molecular weight HES 130/0.4 is the preferred colloid in Scandinavian intensive care units (ICUs) and 1st choice fluid for patients with severe sepsis. However, HES 130/0.4 is largely unstudied in patients with severe sepsis...
  48. ncbi [Reporting adverse reactions and events in randomised clinical trials]
    Bianca Hemmingsen
    Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 172:2381-4. 2010
    ....
  49. ncbi Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma
    Roberto S Oliveri
    Department of Oncology, The Finsen Centre, Section 5073, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark, DK 2100
    Cochrane Database Syst Rev 3:CD004787. 2011
    ..Hepatocellular carcinoma (HCC) results in more than 600,000 deaths per year. Transarterial embolisation (TAE) and transarterial chemoembolisation (TACE) have become standard loco-regional treatments for unresectable HCC...
  50. pmc Antithrombin III in critically ill patients: systematic review with meta-analysis and trial sequential analysis
    Arash Afshari
    Department of Anaesthesiology, Rigshospitalet, Juliane Marie Centre, University of Copenhagen, Copenhagen, Denmark
    BMJ 335:1248-51. 2007
    ..To evaluate the benefits and harms of antithrombin III in critically ill patients...
  51. doi One-year results of total arterial revascularization vs. conventional coronary surgery: CARRPO trial
    Sune Damgaard
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur Heart J 30:1005-11. 2009
    ..To investigate clinical and angiographic outcomes after coronary surgery using total arterial revascularization (TAR)...
  52. doi Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes
    Bianca Hemmingsen
    Copenhagen Trial Unit, Rigshospitalet, 2100 Copenhagen Ø, Denmark Steno Diabetes Center, Niels Steensensvej 2 4, 2820 Gentofte, Denmark
    Eur J Endocrinol 161:1-9. 2009
    ..It may be reasonable to aim for an intervention targeting multiple CVD risk factors such as dyslipidaemia, hypertension and albuminuria in T2D patients...