G van Hall

Summary

Affiliation: Copenhagen Muscle Research Centre
Country: Denmark

Publications

  1. pmc Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle
    Mark A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 538:911-7. 2002
  2. pmc High triacylglycerol turnover rate in human skeletal muscle
    Massimo Sacchetti
    The Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    J Physiol 561:883-91. 2004
  3. doi request reprint Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals
    Gerrit van Hall
    Copenhagen Muscle Research Centre, Rigshospitalet, 9 Blegdamsvej, Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:2851-8. 2008
  4. ncbi request reprint Interleukin-6 stimulates lipolysis and fat oxidation in humans
    Gerrit van Hall
    Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3005-10. 2003
  5. ncbi request reprint Leg and arm lactate and substrate kinetics during exercise
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Denmark
    Am J Physiol Endocrinol Metab 284:E193-205. 2003
  6. ncbi request reprint Similar carbohydrate but enhanced lactate utilization during exercise after 9 wk of acclimatization to 5,620 m
    G van Hall
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 283:E1203-13. 2002
  7. pmc Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Copenhagen, Denmark
    J Physiol 543:1047-58. 2002
  8. pmc The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives
    G van Hall
    The Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    J Physiol 587:1117-29. 2009
  9. pmc Whole body and leg acetate kinetics at rest, during exercise and recovery in humans
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, DK 2100, Copenhagen, Denmark
    J Physiol 542:263-72. 2002
  10. ncbi request reprint Exercise economy does not change after acclimatization to moderate to very high altitude
    C Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
    Scand J Med Sci Sports 17:281-91. 2007

Detail Information

Publications37

  1. pmc Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle
    Mark A Febbraio
    Exercise Physiology and Metabolism Laboratory, Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 538:911-7. 2002
    ..In addition, because CK did not increase and we found no evidence of HSP72 in the venous effluent, our data suggest that skeletal muscle is impermeable to HSP72...
  2. pmc High triacylglycerol turnover rate in human skeletal muscle
    Massimo Sacchetti
    The Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    J Physiol 561:883-91. 2004
    ..An increase in FA level, as a consequence of short-term fasting, does not seem to increase IMTAG synthesis rate and pool size...
  3. doi request reprint Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals
    Gerrit van Hall
    Copenhagen Muscle Research Centre, Rigshospitalet, 9 Blegdamsvej, Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:2851-8. 2008
    ..IL-6 is a key modulator of immune function and suggested to be involved in skeletal muscle wasting as seen in sepsis...
  4. ncbi request reprint Interleukin-6 stimulates lipolysis and fat oxidation in humans
    Gerrit van Hall
    Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3005-10. 2003
    ..In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia...
  5. ncbi request reprint Leg and arm lactate and substrate kinetics during exercise
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Denmark
    Am J Physiol Endocrinol Metab 284:E193-205. 2003
    ..Skeletal muscle can change its limb net glucose uptake severalfold within minutes, causing a redistribution of the available glucose because whole body glucose turnover was unchanged...
  6. ncbi request reprint Similar carbohydrate but enhanced lactate utilization during exercise after 9 wk of acclimatization to 5,620 m
    G van Hall
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 283:E1203-13. 2002
    ....
  7. pmc Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Copenhagen, Denmark
    J Physiol 543:1047-58. 2002
    ....
  8. pmc The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives
    G van Hall
    The Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    J Physiol 587:1117-29. 2009
    ..High-altitude natives from the Andes actually exhibit a higher anaerobic energy production than lowlanders after 8 weeks of acclimatization reflected by an increased muscle lactate accumulation and enhanced adenine nucleotide breakdown...
  9. pmc Whole body and leg acetate kinetics at rest, during exercise and recovery in humans
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, DK 2100, Copenhagen, Denmark
    J Physiol 542:263-72. 2002
    ..Furthermore, under resting conditions the whole-body acetate correction factor can be used to correct for leg, skeletal muscle, substrate oxidation, but not during exercise...
  10. ncbi request reprint Exercise economy does not change after acclimatization to moderate to very high altitude
    C Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen Ø, Denmark
    Scand J Med Sci Sports 17:281-91. 2007
    ..In conclusion, results from several, independent investigations indicate that exercise economy remains unchanged after acclimatization to high altitude...
  11. pmc The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude
    G van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Copenhagen Ø, Denmark
    J Physiol 536:963-75. 2001
    ..The present study clearly shows the absence of a lactate paradox in lowlanders sufficiently acclimatized to altitude...
  12. ncbi request reprint Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m
    C Lundby
    The Copenhagen Muscle Research Centre, Copenhagen Ø, Denmark
    Acta Physiol Scand 176:195-201. 2002
    ..2 +/- 0.02 g min(-1) in ACrel and 0.3 +/- 0.02 g min(-1) in CHrel. In conclusion, substrate utilization is unaffected by AH and CH, when the work rate is matched to the same relative intensity as at SL...
  13. pmc Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content
    A Steensberg
    The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 537:633-9. 2001
    ..A significant net IL-6 release was not observed until 2 h in the control leg. 4. This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle...
  14. ncbi request reprint Peak heart rate decreases with increasing severity of acute hypoxia
    C Lundby
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    High Alt Med Biol 2:369-76. 2001
    ..This study clearly demonstrates a progressive decrease in peak HR with increasing altitude, despite evidence of similar exercise effort and unchanged sympathetic excitation...
  15. ncbi request reprint Muscle glycogen resynthesis during recovery from cycle exercise: no effect of additional protein ingestion
    G van Hall
    Copenhagen Muscle Research Center, Rigshospitalet, DK 2200 Copenhagen, Denmark
    J Appl Physiol 88:1631-6. 2000
    ....
  16. ncbi request reprint Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans
    N Hiscock
    The Copenhagen Muscle Research Center, Rigshospitalet, Denmark
    Am J Physiol Endocrinol Metab 289:E2-7. 2005
    ..These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6...
  17. ncbi request reprint Heterogeneity in limb fatty acid kinetics in type 2 diabetes
    M Sacchetti
    Copenhagen Muscle Research Centre, Rigshospitalet section 7652, 9 Blegdamsvej, 2100 Copenhagen, Denmark
    Diabetologia 48:938-45. 2005
    ....
  18. pmc Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle
    M Sacchetti
    The Copenhagen Muscle Research Centre, University Hospital, Copenhagen, Denmark
    J Physiol 540:387-95. 2002
    ....
  19. doi request reprint Fat metabolism during exercise in patients with McArdle disease
    M C Ørngreen
    Neuromuscular Research Unit, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Neurology 72:718-24. 2009
    ..We questioned whether patients with McArdle disease can compensate for the blocked muscle glycogen breakdown by enhancing fat oxidation during exercise...
  20. ncbi request reprint Correction factors for 13C-labelled substrate oxidation at whole-body and muscle level
    G van Hall
    The Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    Proc Nutr Soc 58:979-86. 1999
    ..The present paper explains the theoretical and physiological basis of these correction factors and makes recommendations as to how these correction factors should be used in various physiological conditions...
  21. ncbi request reprint Peak heart rates at extreme altitudes
    C Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    High Alt Med Biol 2:41-5. 2001
    ..The peak heart rates at 8,750 m are in agreement with other field studies, but considerably higher than values reported from hypobaric chamber studies...
  22. doi request reprint The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy
    B Lindegaard
    Department of Infectious Diseases, Copenhagen Muscle Research Centre, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:3860-9. 2008
    ..Fat redistribution, insulin resistance, and low-grade inflammation characterize HIV-infected patients with lipodystrophy. Currently, no effective therapies exist for the combined treatment of fat redistribution and insulin resistance...
  23. pmc Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
    Adam Steensberg
    The Copenhagen Muscle Research Centre, Denmark
    J Physiol 548:631-8. 2003
    ..These data demonstrate that acute IL-6 administration does not impair whole-body glucose disposal, net leg-glucose uptake, or increase endogenous glucose production at rest in healthy young humans...
  24. ncbi request reprint PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion
    Henriette Pilegaard
    August Krogh Building, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Diabetes 55:3020-7. 2006
    ....
  25. ncbi request reprint Counterpoint: the lactate paradox does not occur during exercise at high altitude
    Gerrit van Hall
    J Appl Physiol 102:2399-401; discussion 2401-2. 2007
  26. ncbi request reprint Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen Ø, Denmark
    Diabetes 56:2070-7. 2007
    ..The increased glucose uptake may in part be explained by increased dephosphorylation of GS (site 3a + b), resulting in increased GS activity...
  27. ncbi request reprint Tumor necrosis factor-alpha modulates human in vivo lipolysis
    Peter Plomgaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:543-9. 2008
    ..Low-grade systemic inflammation is a feature of most lifestyle-related chronic diseases. Enhanced TNF-alpha concentrations have been implicated in the development of hyperlipidemia...
  28. pmc Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives
    Carsten Lundby
    Copenhagen Muscle Center, Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen O, Denmark
    J Physiol 573:535-47. 2006
    ..This would suggest that the major determinant V(o2max)for not to increase with acclimatization is the observed reduction in maximal leg blood flow and O(2) conductance...
  29. pmc Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation
    Adam Steensberg
    The Copenhagen Muscle Research Centre and The Department of Infectious Diseases, Rigshospitalet, The University of Copenhagen, Copenhagen, Denmark
    J Physiol 541:273-81. 2002
    ..However, this is only the case when delivery of substrates and hormones remains constant. When delivery of substrates and hormones is altered, the potential effect of glycogen on glucose uptake is negated...
  30. ncbi request reprint Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans
    Henning Bundgaard
    Department of Medicine, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Heart Circ Physiol 284:H1028-34. 2003
    ..Thus increased lactate levels in acutely and severely ill patients should not be managed only from the point of view that it reflects hypoxia...
  31. pmc Regional fat metabolism in human splanchnic and adipose tissues; the effect of exercise
    Gerrit van Hall
    The Copenhagen Muscle Research Centre, University Hospital, Copenhagen, Denmark
    J Physiol 543:1033-46. 2002
    ..The extracellular FA reesterification rate does not change with exercise but is higher during recovery. Furthermore, the uptake of glycerol by adipose tissue indicates that adipose tissue can metabolize glycerol...
  32. ncbi request reprint Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, Sect 7652, 9 Blegdamsvej, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R1202-8. 2004
    ..4 mmHg). In conclusion, lowlanders substantially improve pulmonary gas exchange with acclimatization, but even acclimatization for 8 wk is insufficient to achieve levels reached by high-altitude natives...
  33. ncbi request reprint Lactate metabolism at high altitude
    Carsten Lundby
    High Alt Med Biol 5:195-6; author reply 197-8. 2004
  34. ncbi request reprint Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle
    Carsten Lundby
    The Copenhagen Muscle Research Centre at Rigshospitalet section 7652, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Exp Biol 207:3865-71. 2004
    ..05). In conclusion, human muscle VEGF mRNA expression and capillary density are not significantly increased by 8 weeks of exposure to high altitude and are not increased in Aymara high-altitude natives compared with sea level residents...
  35. pmc Lactate dehydrogenase is not a mitochondrial enzyme in human and mouse vastus lateralis muscle
    Hans N Rasmussen
    Department of Biochemistry, August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK 2100, Copenhagen Ø, Denmark
    J Physiol 541:575-80. 2002
    ..This excluded artificial loss from the mitochondria of all activity of a possible LDH. It was concluded that skeletal muscle mitochondria are devoid of LDH and unable to metabolize lactate...
  36. ncbi request reprint Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
    Bente Klarlund Pedersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Pflugers Arch 446:9-16. 2003
    ..Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise..
  37. ncbi request reprint Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxia
    Carsten Lundby
    The Copenhagen Muscle Research Centre, Rigshospitalet, DK 2200 Copenhagen N, Denmark
    Toxicology 192:229-36. 2003
    ....