Research Topics
Species | Jens Benn SørensenSummaryAffiliation: Copenhagen University Hospital Country: Denmark Publications
| Collaborators
|
Detail Information
Publications
Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancerSøren Astrup Jensen
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Acta Oncol 47:1054-61. 2008....
Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expressionSøren A Jensen
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
BMC Cancer 9:25. 2009..The association of MSI and MMR status with outcome and with thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression in colorectal cancer were evaluated...- Current concepts in chemotherapy for malignant pleural mesotheliomaJens Benn Sørensen
Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark
Clin Respir J 2:74-9. 2008..The aim of this study was to provide an overview of the most active single agents and combination regimens in malignant pleural mesothelioma (MPM)... - Pharmacokinetic evaluation of pemetrexedJens Benn Sørensen
FinsenCentre National University Hospital, Deptartment Oncology, 9 Blegdamsvej, DK Copenhagen, Denmark
Expert Opin Drug Metab Toxicol 7:919-28. 2011..However, future trials might expand on the combined use of pemetrexed with other targeted agents that could be beneficial to other selected patients harboring relevant mutations or other biological features... - Preoperative staging of mesothelioma by 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography fused imaging and mediastinoscopy compared to pathological findings after extrapleural pneumonectomyJens Benn Sørensen
Department of Oncology, Finsen Centre National University Hospital, Copenhagen, Denmark
Eur J Cardiothorac Surg 34:1090-6. 2008..Staging is difficult and the accuracy of preoperative CT scan, 18F-FDG PET/CT scan (PET/CT), and mediastinoscopy is unclear. The objectives were to compare these staging techniques to each other and to surgical-pathological findings... - Double-blind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignanciesJens Benn Sorensen
Department Oncology, Finsen Centre National University Hospital, Copenhagen, Denmark
Cancer 112:1600-6. 2008..The purpose was to evaluate prevention of oral mucositis (OM) using chlorhexidine compared with placebo and with oral cooling (cryotherapy) during fluorouracil (5-FU)-based chemotherapy in gastrointestinal (GI) cancer... - Cisplatin and vinorelbine first-line chemotherapy in non-resectable malignant pleural mesotheliomaJ B Sørensen
Department Oncology, Finsen Centre National University Hospital, 9 Blegdamsvej, Copenhagen DK 2100, Denmark
Br J Cancer 99:44-50. 2008..6 to 40.6 + months). There were two CRs and 14 PRs (response rate 29.6%). Cisplatin and intravenous vinorelbine is a highly active regimen in MPM with a response rate and survival comparable to the most active regimens so far reported... - A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesotheliomaZarah Glad Zimling
Department of Oncology, National University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
Cancer Chemother Pharmacol 70:743-54. 2012..We further explored the possibility of combining markers into a treatment-response profile to increase the predictive power... - 5-fluorouracil-based therapy induces endovascular injury having potential significance to development of clinically overt cardiotoxicitySøren Astrup Jensen
Department of Oncology 5073, Rigshospitalet, Copenhagen University Hospital, 9 Blegdamsvej, 2100 Copenhagen, Denmark
Cancer Chemother Pharmacol 69:57-64. 2012..This study aimed to elucidate the influence of 5-fluorouracil (5-FU)-based therapy on the vascular endothelium and its association with 5-FU-induced heart ischemia... 
Adjuvant chemotherapy in elderly patients (>or=75 yr) completely resected for colon cancer stage III compared to younger patients: toxicity and prognosisSøren Astrup Jensen
Department of Oncology, Rigshospitalet, University of Copenhagen, Denmark
Med Oncol 23:521-31. 2006..To compare benefits and risks to adjuvant chemotherapy following complete resection of node-positive colon cancer stage III for patients aged >or=75 yr and younger...- ERCC1, toxicity and quality of life in advanced NSCLC patients randomized in a large multicentre phase III trialAdam Vilmar
Department of Oncology 5073, Finsen Centre, National University Hospital, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Eur J Cancer 46:1554-62. 2010..Excision repair cross complementation group 1 (ERCC1) is a promising biomarker in advanced non-small cell lung cancer (NSCLC). However, current evidence regarding the impact of ERCC1 on toxicity and quality of life (QOL) is limited... - Prognosis of small bowel adenocarcinoma treated with Mayo or Xelox regimen: a matched case-control study from a database of 581 patients with colorectal cancerJacob Thomsen Lønborg
Department of Oncology 5073, Finsen Centre, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
Oncol Rep 18:1023-9. 2007..Standard chemotherapy regimes seemed less effective on SBC than on CRC patients, and had a less favorable prognosis. However, reliable conclusions cannot be drawn from a small patient population, and multicentre studies are needed... - Pemetrexed as second-line treatment in malignant pleural mesothelioma after platinum-based first-line treatmentJens Benn Sørensen
Department of Oncology, Finsen Centre National University Hospital, Copenhagen, Denmark
J Thorac Oncol 2:147-52. 2007..Pemetrexed is active as first-line treatment of malignant pleural mesothelioma. The objective was to evaluate its activity as second-line treatment... - The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracilSøren Astrup Jensen
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Denmark
Int J Cancer 120:694-701. 2007..This may be utilized in the selection of patients for treatment approaches and for decision on follow-up programs... - Class III β-tubulin in advanced NSCLC of adenocarcinoma subtype predicts superior outcome in a randomized trialAdam Christian Vilmar
Department of Oncology 5073, Finsen Centre, and Department of Pathology 5442, Diagnostic Center, National University Hospital, Copenhagen, Denmark
Clin Cancer Res 17:5205-14. 2011..Class III β-tubulin (TUBB3) has been shown of value in NSCLC, but evidence is not uniform. Accordingly, we explored the predictive role of TUBB3 in advanced NSCLC... - Excision repair cross-complementation group 1 (ERCC1) in platinum-based treatment of non-small cell lung cancer with special emphasis on carboplatin: a review of current literatureAdam Vilmar
Department of Oncology 5073, Finsen Centre, National University Hospital, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Lung Cancer 64:131-9. 2009..Carboplatin has gained widespread use in the treatment of advanced NSCLC and its mechanisms of action are likely similar to that of cisplatin... - Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricleSøren Astrup Jensen
Rigshospitalet, Copenhagen University Hospital, and Department of Oncology 5073, University of Copenhagen, 9 Blegdamsvej, Copenhagen, DK 2100, Denmark
J Clin Oncol 28:5280-6. 2010..Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart. This study aimed to clarify the pathophysiology, risk factors, and long-term effects of FU cardiotoxicity... - Pulmonary toxicity following IMRT after extrapleural pneumonectomy for malignant pleural mesotheliomaClaus Andrup Kristensen
Department of Oncology, Copenhagen University Hospital Rigshospitalet, Denmark
Radiother Oncol 92:96-9. 2009..The present study reports and analyses the incidence of fatal pulmonary toxicity in patients treated at Rigshospitalet, Copenhagen... - Benefits and risks of palliative capecitabine based therapy to elderly patients with advanced colorectal cancer: Danish single centre experiencesSøren Astrup Jensen
Department of Oncology, National University Hospital, 9 Blegdamsvej, Copenhagen, DK 2100, Denmark
Acta Oncol 45:67-76. 2006..68). Palliative capecitabine based therapy for advanced colorectal cancer should be considered also for elderly who are in good performance without major comorbidities... - Intratumor heterogeneity and chemotherapy-induced changes in EGFR status in non-small cell lung cancerJan Nyrop Jakobsen
Department of Oncology, Finsencentre, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Cancer Chemother Pharmacol 69:289-99. 2012..NSCLC is highly heterogeneous and biomarker expression may vary in different areas within the same tumor. This review explores the tumor heterogeneity and chemotherapy-induced changes in EGFR biomarker status in NSCLC... - Chemotherapy induced pathologic complete response in malignant pleural mesothelioma: a review and case reportCecilia Bech
Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark
J Thorac Oncol 5:735-40. 2010..pCR after chemotherapy is thus possible but rare, and we here present the cases from our institution together with a review on the literature available on the subject... - Review on clinical trials of targeted treatments in malignant mesotheliomaJan Nyrop Jakobsen
Department of Oncology, Finsencentre, Copenhagen, Denmark
Cancer Chemother Pharmacol 68:1-15. 2011..This article is a comprehensive review of all clinical trials evaluating the effect of targeted treatments in MM... - Polyneuropathy in a patient with malignant pleural mesothelioma: a paraneoplastic syndromeCecilia Bech
Department of Oncology, Finsen Centre, National University Hospital, Copenhagen, Denmark
J Thorac Oncol 3:1359-60. 2008..We therefore suggest that polyneuropathy is a possible paraneoplastic syndrome in MPM... - [Screening for asbestos-related conditions]Charlotte Brauer
arbejdsmedicinsk klinik, Glostrup Hospital, DK 2600 Glostrup
Ugeskr Laeger 171:433-6. 2009..Since mesothelioma is most often an occupational disease, these patients should be admitted to an occupational clinic for aetiological evaluation... - Expression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent stroma cells--associations with histopathology and patients outcomeSøren Astrup Jensen
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Eur J Cancer 46:3233-42. 2010.... - Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabineSøren Astrup Jensen
Department of Oncology 5073, National University Hospital, 9 Blegdamsvej, 2100, Copenhagen, Denmark
Cancer Chemother Pharmacol 58:487-93. 2006..5-fluorouracil (5-FU) and its prodrug capecitabine are cardiotoxic. This retrospective study aimed to identify risk factors and to give practical measures to make such chemotherapy feasible if cardiotoxicity occur... - Clinical impact of ki-67 labeling index in non-small cell lung cancerJan Nyrop Jakobsen
Department of Oncology, Finsencentre, Rigshospitalet, 9 Blegdamsvej, 2100 Copenhagen, Denmark
Lung Cancer 79:1-7. 2013..A predictive impact of ki-67 to treatment in NSCLC remains unclear... - Oxidative damage to guanine nucleosides following combination chemotherapy with 5-fluorouracil and oxaliplatinShoaib Afzal
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet, 20 Tagensvej, 2200 Copenhagen, Denmark
Cancer Chemother Pharmacol 69:301-7. 2012....