Niels E Skakkebaek

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    N E Skakkebaek
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:198-204; discussion 204-5. 2007
  2. pmc Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'
    A M Andersson
    Int J Androl 31:74-80. 2008
  3. pmc Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study
    Christine Wohlfahrt-Veje
    University Dept, of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Environ Health 10:79. 2011
  4. ncbi Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
  5. ncbi Endocrine disrupters and testicular dysgenesis syndrome
    Niels E Skakkebaek
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Denmark
    Horm Res 57:43. 2002
  6. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
  7. ncbi Should we watch what we eat and drink? Report on the International Workshop on Hormones and Endocrine Disrupters in Food and Water: possible impact on human health, Copenhagen, Denmark, 27-30 May 2000
    N E Skakkebaek
    Copenhagen University Dept of Growth and Reproduction, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Trends Endocrinol Metab 11:291-3. 2000
  8. pmc Normal reference ranges for semen quality and their relations to fecundity
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen DK, Denmark
    Asian J Androl 12:95-8. 2010
  9. ncbi Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    APMIS 111:1-9; discussion 9-11. 2003
  10. ncbi Testicular dysgenesis syndrome
    Niels E Skakkebaek
    University Department of Growth and Reproduction, University Hospital, Copenhagen, Denmark
    Horm Res 60:49. 2003

Collaborators

Detail Information

Publications156 found, 100 shown here

  1. ncbi Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    N E Skakkebaek
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:198-204; discussion 204-5. 2007
    ....
  2. pmc Adverse trends in male reproductive health: we may have reached a crucial 'tipping point'
    A M Andersson
    Int J Androl 31:74-80. 2008
    ..Consequently, we must face the possibility of more infertile couples and lower fertility rates in the future...
  3. pmc Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study
    Christine Wohlfahrt-Veje
    University Dept, of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Environ Health 10:79. 2011
    ..The purpose of this study was to assess possible effects of prenatal exposure to currently used pesticides on children's growth, endocrine and reproductive function...
  4. ncbi Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  5. ncbi Endocrine disrupters and testicular dysgenesis syndrome
    Niels E Skakkebaek
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Denmark
    Horm Res 57:43. 2002
    ..Experimental and epidemiological evidence suggests that testicular dysgenesis syndrome is a result of disruption of foetal programming and gonadal development during foetal life...
  6. ncbi Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    N E Skakkebaek
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 16:972-8. 2001
    ..Otherwise, important biological information may be lost...
  7. ncbi Should we watch what we eat and drink? Report on the International Workshop on Hormones and Endocrine Disrupters in Food and Water: possible impact on human health, Copenhagen, Denmark, 27-30 May 2000
    N E Skakkebaek
    Copenhagen University Dept of Growth and Reproduction, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Trends Endocrinol Metab 11:291-3. 2000
    ..The most important scientific findings and reviews are to be published in Human Reproduction and Human Reproduction Update. Some of the highlights are presented here...
  8. pmc Normal reference ranges for semen quality and their relations to fecundity
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen DK, Denmark
    Asian J Androl 12:95-8. 2010
    ..As a result large groups of subfertile men across the world may not receive appropriate andrological help in the future...
  9. ncbi Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    APMIS 111:1-9; discussion 9-11. 2003
    ..We speculate that most of these abnormalities are caused by adverse environmental effects rather than specific gene mutations...
  10. ncbi Testicular dysgenesis syndrome
    Niels E Skakkebaek
    University Department of Growth and Reproduction, University Hospital, Copenhagen, Denmark
    Horm Res 60:49. 2003
    ..It is recommended that future epidemiological studies on trends in male reproductive health should not focus on one symptom alone, but be more comprehensive and take all aspects of TDS into account...
  11. doi The exposure of fetuses and children to endocrine disrupting chemicals: a European Society for Paediatric Endocrinology (ESPE) and Pediatric Endocrine Society (PES) call to action statement
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:3056-8. 2011
    ..Relatively few clinical scientists have been engaged in research on this topic to date. The aim of this statement is to have pediatric endocrinologists consider the issue of endocrine disrupters in their clinical work and research...
  12. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  13. ncbi Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys
    Katharina M Main
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:2732-7. 2006
    ..Recent studies showed that male reproductive health problems, such as cryptorchidism, hypospadias, testicular cancer, and low sperm quality, are more prevalent in Denmark than in Finland...
  14. ncbi Early pituitary-gonadal activation before clinical signs of puberty in 5- to 8-year-old adopted girls: a study of 99 foreign adopted girls and 93 controls
    Grete Teilmann
    Department of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2538-44. 2007
    ..Recent studies have indicated that internationally adopted girls are at high risk of developing precocious puberty. Clinical studies including a contemporary control group are lacking...
  15. doi Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years
    Grete Teilmann
    Department of Growth and Reproduction GR 5064, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Horm Res 72:236-46. 2009
    ..Hypothetically, this could be due to selection bias. The aim of this study was to determine age at reaching pubertal milestones in healthy internationally adopted girls in a prospective, clinical study...
  16. pmc Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age
    Katharina M Main
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 114:270-6. 2006
    ..We investigated whether phthalate monoester contamination of human breast milk had any influence on the postnatal surge of reproductive hormones in newborn boys as a sign of testicular dysgenesis...
  17. pmc Risk factors for congenital cryptorchidism in a prospective birth cohort study
    Ida N Damgaard
    University Department of Growth and Reproduction, GR 5064 Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e3051. 2008
    ..Risk factors for congenital cryptorchidism were investigated in a prospective birth cohort study in Denmark and Finland from 1997 to 2001...
  18. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  19. ncbi Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection
    Claudia Mau Kai
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2598-603. 2007
    ..Concern has been raised for the health of the offspring conceived by assisted reproduction technologies. Basal reproductive hormones around 3 months of age reflect the pituitary-testicular axis, which is transiently active at this age...
  20. ncbi Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cell Tissue Res 322:159-65. 2005
    ..The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular germ cell cancer...
  21. ncbi Deregulation of the G1/S-phase control in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    APMIS 111:252-65; discussion 265-6. 2003
    ....
  22. ncbi Testicular dysgenesis syndrome: possible role of endocrine disrupters
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 20:77-90. 2006
    ..Clinicians should be aware of the interconnection between the different features of TDS, and inclusion of a programme for early detection of testis cancer in the management of infertile men with poor semen quality is recommended...
  23. ncbi High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
    ..The aim of this study was to evaluate the HPG axis in KS infants...
  24. doi Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms
    David M Kristensen
    University Department of Growth and Reproduction, Section GR5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 23:775-82. 2008
    ....
  25. ncbi Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4020-7. 2007
    ..The Leydig cell hormone insulin-like factor 3 (INSL3) is important for testicular descent. Currently INSL3 levels in cord blood, in serum throughout childhood, and in relation to congenital cryptorchidism are unknown...
  26. ncbi CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
    ..In conclusion, despite high mRNA levels, the CDH1 protein is not expressed in CIS, suggesting translational suppression of CDH1 protein expression. CDH1 serum levels may be a serological marker for staging of TGCT patients...
  27. ncbi Testicular carcinoma in situ in subfertile Danish men
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen
    Int J Androl 30:406-11; discussion 412. 2007
    ....
  28. ncbi Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility
    Martin Jensen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Hum Reprod 19:65-70. 2004
    ..In this study, we explored a possible role of the polymerase gamma (POLG) gene polymorphism, recently reported to be associated with male infertility in some populations...
  29. doi Acquired cryptorchidism is frequent in infancy and childhood
    Christine Wohlfahrt-Veje
    University Department of Growth and Reproduction, GR 5064 Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:423-8. 2009
    ..We therefore recommend that all boys should have testis position checked regularly during childhood, at least up to 3 years of age...
  30. ncbi Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
    ..In this study we aimed to investigate the expression pattern of AP-2gamma and to shed light on this factor in germ cell differentiation and the pathogenesis of germ cell neoplasia...
  31. doi Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:839-45. 2011
    ..We therefore aimed at determining circulating AMH concentrations in patients with 47,XXY Klinefelter syndrome (KS) with or without cryptorchidism...
  32. ncbi From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
    Kristian Almstrup
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Androl 29:211-8. 2006
    ....
  33. ncbi ATM activation in normal human tissues and testicular cancer
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell Cycle 4:838-45. 2005
    ..The new tools characterized here should facilitate monitoring of ATM activation in clinical specimens, and help develop future treatment strategies...
  34. doi Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Androl 35:227-35. 2012
    ..However, longitudinal studies are needed to evaluate possible perinatal or long-term postnatal effects of phthalates on healthy boys...
  35. ncbi Genital anomalies in boys and the environment
    Katharina M Main
    University Department of Growth and Reproduction GR, Section 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 24:279-89. 2010
    ..It may be the cocktail effect of many simultaneous exposures that result in adverse effects, especially during foetal life and infancy...
  36. ncbi Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Pathol 200:370-4. 2003
    ..The findings therefore support the hypothesis that this cancer is part of a testicular dysgenesis syndrome. The presence of contralateral carcinoma in situ was higher in the present study than previously reported...
  37. doi Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
    Martin Blomberg Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:1303-11. 2010
    ..Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa...
  38. ncbi Improved gene expression signature of testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Int J Androl 30:292-302; discussion 303. 2007
    ..The merged CIS data from two different microarray platforms, to our knowledge, provide the most precise CIS gene expression signature to date...
  39. pmc Gene expression profiles of mouse spermatogenesis during recovery from irradiation
    Fozia J Shah
    University Department of Growth and Reproduction GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen O, Denmark
    Reprod Biol Endocrinol 7:130. 2009
    ....
  40. ncbi Fertility treatment and reproductive health of male offspring: a study of 1,925 young men from the general population
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 165:583-90. 2007
    ..Although the cause of these findings is unknown, they raise concern about possible late effects of fertility treatment. Larger-scale studies of children born after fertility treatment should be performed...
  41. doi Caffeine intake and semen quality in a population of 2,554 young Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Epidemiol 171:883-91. 2010
    ..Therefore, the authors cannot exclude the possibility of a threshold above which cola, and possibly caffeine, negatively affects semen quality. Alternatively, the less healthy lifestyle of these men may explain these findings...
  42. ncbi Longitudinal changes in semen parameters in young Danish men from the Copenhagen area
    Elisabeth Carlsen
    University Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen
    Hum Reprod 20:942-9. 2005
    ..We conducted a longitudinal follow-up study to address this question...
  43. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  44. ncbi Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development
    David Møbjerg Kristensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cell Endocrinol 288:111-8. 2008
    ....
  45. ncbi Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men
    Anna Maria Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 89:2873-9. 2004
    ....
  46. ncbi Environment, testicular dysgenesis and carcinoma in situ testis
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 21:462-78. 2007
    ..It is of great importance that clinicians in different specialties treating patients with TDS are aware of the association between the different symptoms...
  47. ncbi Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    ..Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells...
  48. ncbi Increased risk of precocious puberty in internationally adopted children in Denmark
    Grete Teilmann
    Department of Growth and Reproduction GR, University Hospital of Copenhagen, Rigshospitalet, DK 2100 Copenhagen 0, Denmark
    Pediatrics 118:e391-9. 2006
    ..We aimed to assess the risk of developing precocious puberty in intercountry adoptees, children immigrating with their family, and descendants of immigrants living in Denmark...
  49. ncbi Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 159:49-58. 2004
    ..Maternal smoking may have long-term implications for the reproductive health of the offspring. This is another good reason to advise pregnant women to avoid smoking...
  50. ncbi Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark Electronic address
    Int J Hyg Environ Health 216:710-20. 2013
    ..Small children were relatively more exposed to BPA than older children, while higher exposures to TCS, BP-3 and ∑DCP were seen among adolescents. ..
  51. ncbi Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
    ..Finally, some of the highly expressed genes identified in this study are promising candidates for new diagnostic markers for CIS and/or TGCTs...
  52. pmc Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
    ..The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes...
  53. doi Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index
    Trine L Ravnborg
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 26:1000-11. 2011
    ..The aim of this study was to investigate the associations between these factors while controlling for the effects of current smoking in young adulthood...
  54. doi Insulin-like factor 3 levels in second-trimester amniotic fluid
    Katrine Bay
    University Department of Growth and Reproduction, Rigshospitalet, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:4048-51. 2008
    ..Despite this, human prenatal INSL3 production has been poorly investigated...
  55. ncbi Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction
    Ida Norgil Damgaard
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 16:289-309. 2002
    ..This topic is not only relevant to basic scientists but also to clinical endocrinologists, who should also be encouraged to participate in research concerning this problem...
  56. doi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
    ..Here we present new European data systematically collected from the same region and by 1 research group at the beginning and end of the recent 15-year period...
  57. ncbi Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern
    Niels Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:54-61; discussion 105-8. 2006
    ..In Denmark, the situation is of concern and a continued surveillance of semen quality in young men was established in 2001 by a government-supported programme...
  58. doi OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres
    David M Kristensen
    University Department of Growth and Reproduction, Section GR5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Mol Hum Reprod 16:835-45. 2010
    ..Our results show that OCT4 and associated genes are expressed in somatic epithelial cells from the urogenital tract and that these cells can form spheres, a general marker of stem cell behaviour...
  59. ncbi Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study of 1962 normal boys
    Malene Boas
    University Department of Growth and Reproduction Section 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Endocrinol 154:125-9. 2006
    ..The objective of the study was to investigate the correlation between endogenous testosterone levels and penile size and growth...
  60. ncbi Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:537-42. 2007
    ..Our findings indicate that puberty, as assessed by age at voice break in boys, may be starting earlier in Denmark as it has been observed in the USA, and suggest a relationship between pre-pubertal BMI and the timing of puberty...
  61. pmc Cryptorchidism and maternal alcohol consumption during pregnancy
    Ida N Damgaard
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:272-7. 2007
    ..Prenatal exposure to alcohol can adversely affect the fetus. We investigated the association between maternal alcohol consumption during pregnancy and cryptorchidism (undescended testis) among newborn boys...
  62. ncbi Deregulation of the RB pathway in human testicular germ cell tumours
    Jirina Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    J Pathol 200:149-56. 2003
    ..We hope that this study will inspire further immunohistochemical applications of phosphospecific antibodies in pathology, and examination of the RB pathway defects in relation to curability of TGCTs...
  63. ncbi Effects of ejaculatory frequency and season on variations in semen quality
    Elisabeth Carlsen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Fertil Steril 82:358-66. 2004
    ..To describe the intraindividual variation in semen parameters...
  64. ncbi Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio
    Mette Holm
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 199:378-86. 2003
    ..The presence of micronodules thus seems to be a histological marker of testicular failure in man...
  65. ncbi Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies
    Ulla Lønberg
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Obstet Gynecol 188:247-51. 2003
    ....
  66. ncbi The sensitivity of the child to sex steroids: possible impact of exogenous estrogens
    Lise Aksglaede
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod Update 12:341-9. 2006
    ..Because no lower threshold for estrogenic action has been established, caution should be taken to avoid unnecessary exposure of fetuses and children to exogenous sex steroids and endocrine disruptors, even at very low levels...
  67. ncbi Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction
    Claudia Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:4352-60. 2006
    ..Concern has been raised about the safety of assisted reproduction techniques for the offspring...
  68. pmc Persistent pesticides in human breast milk and cryptorchidism
    Ida N Damgaard
    University Department of Growth and Reproduction, Copenhagen, Denmark
    Environ Health Perspect 114:1133-8. 2006
    ..We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children...
  69. ncbi Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys
    Anna Maria Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Sect GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4696-705. 2007
    ..These secular trends may also be reflected by changes in Leydig cell function...
  70. ncbi Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?
    Rikke Bodin Beck Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Horm Res 60:136-48. 2003
    ..Thus IGF-I may serve as a link between fetal growth and adult-onset disease...
  71. doi Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans
    Nadeem Rezaq Janjua
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 31:118-30. 2008
    ..The three chemicals are systemically absorbed, metabolized and excreted in urine following application on the skin in a cream preparation. More DEP than DBP was absorbed, presumably because of a faster absorption rate for DEP...
  72. ncbi High-resolution comparative genomic hybridization detects extra chromosome arm 12p material in most cases of carcinoma in situ adjacent to overt germ cell tumors, but not before the invasive tumor development
    Anne Marie Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, University Hospital of Copenhagen, Copenhagen, Denmark
    Genes Chromosomes Cancer 38:117-25. 2003
    ..The gain of extra chromosome 12 material may not be an early event in the neoplastic transformation, but is most likely associated with a more malignant progression of the CIS cell...
  73. ncbi A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population
    A K Bang
    University Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod 20:3109-13. 2005
    ..The objective of this study was to explore the association between the ratio of 2nd to 4th finger length (2D:4D ratio) and testis function in a sample of young Danish men from the general population...
  74. ncbi Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment
    K Sørensen
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:3189-96. 2007
    ..The regulation of SHBG is complex and influenced by sex steroids and insulin...
  75. ncbi Preserved male fertility despite decreased androgen sensitivity caused by a mutation in the ligand-binding domain of the androgen receptor gene
    A Giwercman
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 85:2253-9. 2000
    ..The patients inherited the mutation from their grandfathers through their mothers, and one of the young men possessing the mutation has fathered a daughter...
  76. ncbi Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arch Dis Child 93:30-4. 2008
    ..To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome (KS)...
  77. ncbi A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
    M Chellakooty
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:820-6. 2006
    ..Many aspects of hormonal regulation and mechanisms of normal infancy growth are poorly understood...
  78. doi Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:298-303. 2010
    ....
  79. ncbi Testicular dysgenesis and fertility
    N E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Andrologia 37:217-8. 2005
  80. ncbi Increased frequency of reproductive health problems among fathers of boys with hypospadias
    C Asklund
    University Department of Growth and Reproduction, University Hospital of Copenhagen, GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 22:2639-46. 2007
    ..We therefore compared male reproductive health among a group of fathers of boys with hypospadias and a group of fathers to normal children...
  81. ncbi Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries
    K A Boisen
    University Department of Growth and Reproduction, Rigshospitalet DK 2100 Copenhagen, Denmark
    Lancet 363:1264-9. 2004
    ..Since maldescent of the testis is a shared risk factor for these conditions we undertook a joint prospective study for the prevalence of congenital cryptorchidism...
  82. ncbi Cytogenetic and molecular analysis of a family with three brothers afflicted with germ-cell cancer
    A M Ottesen
    Department of Growth and Reproduction, Julianne Marie Center, University Hospital of Copenhagen, Blegdamsveg, Denmark
    Clin Genet 65:32-9. 2004
    ....
  83. ncbi Regional differences in waiting time to pregnancy among fertile couples from four European cities
    T K Jensen
    Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, The Juliane Marie Centre, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 16:2697-704. 2001
    ..A co-ordinated, cross-sectional study of pregnant couples from Denmark (Copenhagen), France (Paris), Scotland (Edinburgh) and Finland (Turku) was therefore undertaken to assess differences in waiting TTP among couples from these cities...
  84. ncbi Pulsatile gonadotropin-releasing hormone treatment of men with idiopathic hypogonadotropic hypogonadism
    Peter Christiansen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 57:32-6. 2002
    ....
  85. ncbi Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. N. E. Skakkebaek. Histopathology 1978; 2; 157-170
    N E Skakkebaek
    University Department of Growth and Reproduction, Copenhagen, Denmark, Rigshospitalet
    Histopathology 41:2-3; discussion 3-4. 2002
  86. doi Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome
    L Aksglaede
    University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:376-84. 2009
    ..The small semen volume supports the notion of 47,XXY patients being androgen insufficient despite serum testosterone levels within the normal range...
  87. ncbi Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age
    K A Boisen
    University Department of Growth and Reproduction, GR 5064 Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 90:4041-6. 2005
    ..Hypospadias is one of the most frequent male congenital malformations and may be part of the testicular dysgenesis syndrome...
  88. doi Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty
    A Mouritsen
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:346-59. 2010
    ..The effects may differ between boys and girls, as there are sex differences in age at onset of puberty, hormonal profiles and prevalence of precocius puberty...
  89. ncbi Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans
    Nadeem Rezaq Janjua
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    J Invest Dermatol 123:57-61. 2004
    ..A minor difference in serum estradiol and inhibin B levels were observed in men only. These differences in hormone levels were not related to sunscreen exposure...
  90. ncbi A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2gamma in semen samples: case report
    C E Hoei-Hansen
    University Department of Growth and Reproduction GR 5064, Rigshospitalet Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 20:579-82. 2005
    ..The value of this method for diagnostic use in the clinic requires further careful validation in a large series of patients and controls, but the preliminary results are promising...
  91. doi Semen quality, reproductive hormones and fertility of men operated for hypospadias
    C Asklund
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:80-7. 2010
    ..They can be informed that hypospadias in such cases is not generally associated with poor semen quality. Particularly among patients with HAGD, several may, however, need fertility treatment to reproduce...
  92. ncbi Serum inhibin B, FSH, LH and testosterone levels before and after human chorionic gonadotropin stimulation in prepubertal boys with cryptorchidism
    P Christiansen
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Denmark
    Eur J Endocrinol 147:95-101. 2002
    ..It is not known if inhibin B can be used to demonstrate early damage of seminiferous tubules in prepubertal boys with cryptorchidism...
  93. ncbi New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 209:25-33. 2006
    ....
  94. ncbi Low birth weight and male reproductive function
    K M Main
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 65:116-22. 2006
    ....
  95. ncbi D-type cyclins in adult human testis and testicular cancer: relation to cell type, proliferation, differentiation, and malignancy
    J Bartkova
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Pathol 187:573-81. 1999
    ....
  96. ncbi Longitudinal studies of inhibin B levels in boys and young adults with Klinefelter syndrome
    P Christiansen
    Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:888-91. 2003
    ..However, during late puberty inhibin B levels decreased gradually to the low/unmeasurable levels observed later in adult KS, while remaining unchanged in the controls...
  97. ncbi Endocrine function in patients treated for carcinoma in situ in the testis with irradiation
    Peter Meidahl Petersen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:93-8; discussion 98-9. 2003
    ..However, the optimal dose level has to be defined...
  98. ncbi Testicular neoplasia in childhood and adolescence
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Endocr Dev 5:110-23. 2003
  99. ncbi Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle
    Mette Holm
    University Department of Growth and Reproduction, Copenhagen University Hospital, Denmark
    J Urol 170:1163-7. 2003
    ..We compared clinical and histological data regarding the contralateral testicle in a population of men diagnosed with testicular germ cell cancer to find features associated with an increased risk of bilateral neoplasia...
  100. ncbi Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries
    Grete Teilmann
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Pediatrics 116:1323-8. 2005
    ..The aim of this study was to estimate the prevalence and incidence of precocious pubertal development in Denmark in a 9-year period...
  101. ncbi History of febrile illness and variation in semen quality
    Elisabeth Carlsen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 and Department of Biostatistics, University of Copenhagen, Denmark
    Hum Reprod 18:2089-92. 2003
    ..The purpose of this study was to analyse the effect of a history of febrile illness on semen quality...