H R Siebner

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Brain-derived neurotrophic factor--a major player in stimulation-induced homeostatic metaplasticity of human motor cortex?
    Claudia Mastroeni
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    PLoS ONE 8:e57957. 2013
  2. pmc Transcranial magnetic stimulation with a half-sine wave pulse elicits direction-specific effects in human motor cortex
    Nikolai H Jung
    Department of Pediatrics, Technical University Munich, Kinderzentrum München gemeinnützige GmbH, Heiglhofstrasse 63, Munich 81377, Germany
    BMC Neurosci 13:139. 2012
  3. doi request reprint Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson's disease
    Joyce P M van der Vegt
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Brain 136:1192-203. 2013
  4. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
  5. pmc From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging
    H R Siebner
    Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen University, Denmark
    Neuroscience 164:1-6. 2009
  6. doi request reprint Consensus paper: combining transcranial stimulation with neuroimaging
    Hartwig R Siebner
    Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark Department of Neurology, Christian Albrechts University, Kiel, Germany
    Brain Stimul 2:58-80. 2009
  7. pmc How does transcranial magnetic stimulation modify neuronal activity in the brain? Implications for studies of cognition
    Hartwig R Siebner
    Danish Research Centre for Magnetic Resonance, Hvidovre University Hospital, Copenhagen, Denmark
    Cortex 45:1035-42. 2009
  8. ncbi request reprint Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 270:37-40. 1999
  9. ncbi request reprint Repetitive transcranial magnetic stimulation causes a short-term increase in the duration of the cortical silent period in patients with Parkinson's disease
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, 81675, Munich, Germany
    Neurosci Lett 284:147-50. 2000
  10. doi request reprint Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans
    S Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neuroscience 166:1219-25. 2010

Collaborators

Detail Information

Publications30

  1. pmc Brain-derived neurotrophic factor--a major player in stimulation-induced homeostatic metaplasticity of human motor cortex?
    Claudia Mastroeni
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    PLoS ONE 8:e57957. 2013
    ....
  2. pmc Transcranial magnetic stimulation with a half-sine wave pulse elicits direction-specific effects in human motor cortex
    Nikolai H Jung
    Department of Pediatrics, Technical University Munich, Kinderzentrum München gemeinnützige GmbH, Heiglhofstrasse 63, Munich 81377, Germany
    BMC Neurosci 13:139. 2012
    ..Here we tested whether similar direction-specific effects could be elicited in M1-HAND using TMS pulses with a half-sine wave configuration...
  3. doi request reprint Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson's disease
    Joyce P M van der Vegt
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Brain 136:1192-203. 2013
    ....
  4. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
    ....
  5. pmc From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging
    H R Siebner
    Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Copenhagen University, Denmark
    Neuroscience 164:1-6. 2009
    ..Therefore, this special issue also focuses on how these challenges can be met to fully exploit the synergism of genetically informed brain imaging...
  6. doi request reprint Consensus paper: combining transcranial stimulation with neuroimaging
    Hartwig R Siebner
    Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark Department of Neurology, Christian Albrechts University, Kiel, Germany
    Brain Stimul 2:58-80. 2009
    ..We then discuss the use of specific brain mapping techniques in conjunction with TMS. We emphasize that the various neuroimaging techniques offer complementary information and have different methodologic strengths and weaknesses...
  7. pmc How does transcranial magnetic stimulation modify neuronal activity in the brain? Implications for studies of cognition
    Hartwig R Siebner
    Danish Research Centre for Magnetic Resonance, Hvidovre University Hospital, Copenhagen, Denmark
    Cortex 45:1035-42. 2009
    ..We argue that this is not necessarily the case. Awareness of the problem may help resolve some apparent anomalies in the literature...
  8. ncbi request reprint Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurosci Lett 270:37-40. 1999
    ..05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies...
  9. ncbi request reprint Repetitive transcranial magnetic stimulation causes a short-term increase in the duration of the cortical silent period in patients with Parkinson's disease
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, 81675, Munich, Germany
    Neurosci Lett 284:147-50. 2000
    ..The lack of a prolongation of the SP in healthy controls suggests that PD patients may be particularly susceptible to modulatory effects of rTMS on motocortical inhibition...
  10. doi request reprint Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans
    S Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neuroscience 166:1219-25. 2010
    ..75 mA in Experiment 1. The results show that so-tDCS can induce bidirectional shifts in corticospinal excitability in a similar fashion as c-tDCS if the total amount of applied current during the tDCS session is matched...
  11. doi request reprint Motor pathway excitability in ATP13A2 mutation carriers: a transcranial magnetic stimulation study
    S Zittel
    Department of Neurology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Parkinsonism Relat Disord 18:590-4. 2012
    ..To describe excitability of motor pathways in Kufor-Rakeb syndrome (PARK9), an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration caused by a mutation in the ATP13A2 gene, using transcranial magnetic stimulation (TMS)...
  12. pmc Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
    B F L van Nuenen
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Neurology 72:1041-7. 2009
    ..Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease alters the cortical control of sequential finger movements...
  13. ncbi request reprint Brain correlates of fast and slow handwriting in humans: a PET-performance correlation analysis
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Moehlstrasse 28, D 81675 Munich, Germany
    Eur J Neurosci 14:726-36. 2001
    ....
  14. ncbi request reprint Subthreshold 5-Hz repetitive transcranial magnetic stimulation of the human primary motor cortex reduces intracortical paired-pulse inhibition
    A Peinemann
    Department of Neurology, Technische Universitat Munchen, D 81675, Munich, Germany
    Neurosci Lett 296:21-4. 2000
    ..The lasting effect of subthreshold 5-Hz rTMS on intracortical inhibition provides a useful probe for studying short-term plasticity of the human M1(HAND)...
  15. ncbi request reprint Lasting cortical activation after repetitive TMS of the motor cortex: a glucose metabolic study
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Neurology 54:956-63. 2000
    ..Cerebral [18F]fluorodeoxy-D-glucose PET ([18F]FDG-PET) was used to visualize the lasting neuronal activation after repetitive transcranial magnetic stimulation (rTMS) over the left hand area of the primary motor cortex (M1HAND)...
  16. ncbi request reprint Abnormal increase in the corticomotor output to the affected hand during repetitive transcranial magnetic stimulation of the primary motor cortex in patients with writer's cramp
    H R Siebner
    Department of Neurology, Technical University of Munich, Germany
    Neurosci Lett 262:133-6. 1999
    ..The abnormal rTMS-associated facilitation of the corticomotor output to the affected hand demonstrates an increased excitability of the corticospinal motor system in writer's cramp...
  17. doi request reprint Slow pre-movement cortical potentials do not reflect individual response to therapy in writer's cramp
    K E Zeuner
    Department of Neurology, Christian Albrechts University Kiel, Arnold Heller Strasse 3, Haus 41, 24105 Kiel, Germany
    Clin Neurophysiol 120:1213-9. 2009
    ..To investigate whether movement-related cortical potentials (MRCP) provide a physiological correlate that indicates the response to treatment in patients with writer's cramp...
  18. ncbi request reprint Trigeminal sensory input elicited by electric or magnetic stimulation interferes with the central motor drive to the intrinsic hand muscles
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Clin Neurophysiol 110:1090-9. 1999
    ..Therefore, trigeminomotor inhibition has to be considered in all TMS studies that use a conditioning-test design...
  19. ncbi request reprint Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease
    H R Siebner
    Department of Neurology, Technische Universitat Munchen, Moehlstrasse 28, D 81675, Munich, Germany
    J Neurol Sci 178:91-4. 2000
    ..This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD...
  20. doi request reprint Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study
    T Baumer
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Neurophysiol 120:1724-31. 2009
    ..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)...
  21. ncbi request reprint Continuous transcranial magnetic stimulation during positron emission tomography: a suitable tool for imaging regional excitability of the human cortex
    H R Siebner
    Department of Neurology, , Moehlstrasse 28, 81675 Munich, Germany
    Neuroimage 14:883-90. 2001
    ..These data demonstrate that, by varying the variables of rTMS across scans, continuous rTMS during H(2)(15)O PET provides a noninvasive tool to study the regional excitability profile of a distinct cortical area...
  22. ncbi request reprint Age-related decrease in paired-pulse intracortical inhibition in the human primary motor cortex
    A Peinemann
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munich, Germany
    Neurosci Lett 313:33-6. 2001
    ..In conclusion, paired-pulse TMS provides a non-invasive means of studying age-related functional changes in the motor cortex...
  23. pmc Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease
    K Reetz
    Department of Neurology, University of Luebeck, 23538 Luebeck, Germany
    Open Neuroimag J 2:102-5. 2008
    ..The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies...
  24. doi request reprint A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee
    S Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Clin Neurophysiol 123:858-82. 2012
    ..Additional sections cover safety issues, the triple stimulation technique, and neuropediatric aspects of TMS...
  25. ncbi request reprint Sensorimotor integration is abnormal in asymptomatic Parkin mutation carriers: a TMS study
    T Baumer
    Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Neurology 69:1976-81. 2007
    ....
  26. doi request reprint Resting-state connectivity of pre-motor cortex reflects disability in multiple sclerosis
    A M Dogonowski
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
    Acta Neurol Scand 128:328-35. 2013
    ..To characterize the relationship between motor resting-state connectivity of the dorsal pre-motor cortex (PMd) and clinical disability in patients with multiple sclerosis (MS)...
  27. doi request reprint Subthalamic nucleus stimulation modulates audiospinal reactions in Parkinson disease
    M Potter
    Department of Neurology, Christian Albrechts University, Schittenhelmstr 10 m D 24105 Kiel, Germany
    Neurology 70:1445-51. 2008
    ..In this study, we assessed whether modulation of basal ganglia activity by high-frequency stimulation of the subthalamic nucleus (STN-HFS) in PD had an impact on the brainstem-controlled startle system...
  28. doi request reprint Chronic cerebrospinal venous insufficiency and venous stenoses in multiple sclerosis
    M Blinkenberg
    Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Neurol Scand 126:421-7. 2012
    ..Our aim was to assess the prevalence of CCSVI in Danish MS patients using sonography and compare these findings with MRI measures of venous flow and morphology...
  29. ncbi request reprint Laterality of interhemispheric inhibition depends on handedness
    T Baumer
    Department of Neurology, University of Hamburg, Martinstrasse 52, 20246 Hamburg, Germany
    Exp Brain Res 180:195-203. 2007
    ..We hypothesize that IHI is a function of handedness perhaps reflecting predominant usage of the dominant hand, while lateralisation of thresholds and intracortical excitability are determined by other factors...
  30. ncbi request reprint Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression
    J Macoveanu
    Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Copenhagen University Hospital, Denmark
    Psychol Med 44:1183-95. 2014
    ....