Research Topics
Species | K SchmiegelowSummaryAffiliation: Copenhagen University Hospital Country: Denmark Publications
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Detail Information
Publications
Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexatePeter Buur van Kooten Niekerk
Department of Paediatrics, University Hospital, Aarhus, Denmark
Eur J Haematol 81:391-8. 2008..We investigated the influence of polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene and coadministration of antimetabolites on post-HDMTX toxicity...- High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemiaK Schmiegelow
Pediatric Clinics, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark
Leukemia 26:675-81. 2012..These data indicate strong genetic and/or environmental risk factors for childhood ALL that are restricted to specific ALL subtypes, which must be taken into account, when performing epidemiological studies to reveal etiological factors... 
[Cancer in childhood and inheritance]Kjeld Schmiegelow
H S Rigshospitalet, Juliane Marie Centret, Paediatrisk klinik, Blegdamsvej 9, DK 2100 København Ø
Ugeskr Laeger 168:2373-6. 2006....- The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapseK Schmiegelow
Department of Pediatric Oncology, The University Hospital Rigshospitalet, Copenhagen, Denmark
Leukemia 24:715-20. 2010..38, P=0.02), which was not the case for those who developed a relapse (r(S)=0.15, P=0.60). Thus, compliance to maintenance therapy may influence the risk of relapse for adolescents with ALL... - Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemiaK Schmiegelow
Faculty of Medicine, The Institute of Gynaecology, Obstetrics, and Paediatrics, University of Copenhagen, Copenhagen, Denmark
Leukemia 24:345-54. 2010.... - Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 studyKjeld Schmiegelow
Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, University Hospitals, Rigshospitalet Copenhagen, Denmark
J Pediatr Hematol Oncol 31:385-92. 2009..These results indicate that oral MTX/6MP maintenance therapy administered after the first year of remission can improve the cure rates of children with T-lineage or with higher risk B-lineage ALL... 
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 studyKjeld Schmiegelow
Faculty of Medicine, Institute of Gynecology, Obstetrics, and Pediatrics, University of Copenhagen, Copenhagen, Denmark
Blood 113:6077-84. 2009..7 vs 60.4 mg/m2; P = .03). This study indicates that the duration and intensity of 6MP/MTX maintenance therapy of childhood ALL may influence the risk of SMNs in childhood ALL...- Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemiaKjeld Schmiegelow
Department of Pediatrics, The University Hospital and The University of Copenhagen, Denmark
J Clin Oncol 21:1332-9. 2003..We explored whether dose adjustment of MP and MTX by erythrocyte (E) levels of TGN and MTX (including polyglutamates) could improve outcome in childhood acute lymphoblastic leukemia (ALL)... - Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 studyK Schmiegelow
The Institute of Gynecology, Obstetrics, and Pediatrics, The Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark
Leukemia 23:557-64. 2009..These data suggest that children with ALL and TPMT wild type might have their cure rate improved, if the pharmacokinetics/-dynamics of TPMT low-activity patients could be mimicked without a concurrent excessive risk of second cancers... - Etiology of common childhood acute lymphoblastic leukemia: the adrenal hypothesisK Schmiegelow
The Pediatric Clinic, The University Hospital Rigshospitalet, Copenhagen, Denmark
Leukemia 22:2137-41. 2008.... - Advances in individual prediction of methotrexate toxicity: a reviewKjeld Schmiegelow
The Faculty of Medicine, Institute of Gynaecology, Obstetrics and Paediatrics, University of Copenhagen, Copenhagen, Denmark
Br J Haematol 146:489-503. 2009..This paper discusses the pharmacology of methotrexate and reviews studies on haematological malignancies that have attempted to predict the risk of toxicity by specific clinical or genetic features... - Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemiaKjeld Schmiegelow
Pediatric Clinic II, Juliane Marie Centre, Department of Clinical Immunology, The University Hospital, Rigshospitalet, Copenhagen, Denmark
Blood 100:3757-60. 2002..9 vs 5.2 years; P =.04). The study shows that the presence of low-level MBL genotypes is associated with an increased risk of childhood ALL, particularly with early age at onset... - Competitive PCR for quantification of minimal residual disease in acute lymphoblastic leukaemiaC Nyvold
Department of Clinical Immunology, The National University Hospital, Rigshospitalet, Tagensvej 20, DK 2200, Copenhagen, Denmark
J Immunol Methods 233:107-18. 2000..The method is very sensitive with a detection limit of at least one malignant cell in 10(5) normal cells. This method may be used for treatment stratification based on the early response to antileukaemic therapy... - Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumorsM Schmiegelow
Department of Growth and Reproduction, Juliane Marie Centre, National University Hospital, Rigshospitalet, Copenhagen, Denmark
Horm Res 54:53-9. 2000.... - 6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemiaK Schmiegelow
The Laboratory for Pediatric Oncology, The Pediatric Clinic II, The Juliane Marie Centre, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
Leukemia 15:74-9. 2001..0057, P = 0.046). In conclusion, the study indicates that reductions of the dose of concurrently given oral 6MP could be one way of reducing the risk of significant myelotoxicity following HDM during maintenance therapy of childhood ALL... - Cryopreservation of semen from pubertal boys with cancerJ Muller
Clinic of Growth and Reproduction, Juliane Marie Centre, University Hospital, Rigshospitalet, Copenhagen, Denmark
Med Pediatr Oncol 34:191-4. 2000..The possibility of cryopreservation of semen from adolescents has until now received only little attention. Therefore, we have investigated the possibility of cryopreservation of semen in adolescent boys with cancer... - Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemiaU Nygaard
The Pediatric Clinic II, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
Leukemia 17:1344-8. 2003..001).The reduction of 6MP dosage during HDM can significantly reduce the risk of severe myelotoxicity and prevent treatment interruptions... - Glucagon-like peptide-2 (GLP-2) response to enteral intake in children during anti-cancer treatmentB U Andreassen
Paediatric Nutrition Unit, Rigshospitalet, Coppenhagen, Denmark
J Pediatr Gastroenterol Nutr 40:48-53. 2005..Lack of GLP-2 may increase the risk of malabsorption and intestinal bacterial translocation. The aim of this study is to evaluate meal stimulated secretion of GLP-2 in children with cancer undergoing anti-cancer treatment... - The role of parvovirus B19 infection in childhood acute lymphoblastic leukemiaE D Heegaard
Department of Clinical Microbiology, University State Hospital, Copenhagen, Denmark
Pediatr Hematol Oncol 16:329-34. 1999..The results suggest that there is an insignificant chance of finding a parvovirus B19 infection in pediatric patients with ALL at the time of diagnosis. However, parvovirus B19 infection may infrequently serve as a prodrome to ALL... - [Individualized cancer treatment. Illustrated by acute lymphoblastic leukemia in children]K Schmiegelow
H S Righospitalet, Juliane Marie Centret, paediatrisk klinik II
Ugeskr Laeger 163:1062-6. 2001.... - Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemiaC Bohnstedt
Pediatrics and Adolescent Medicine, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark
Leukemia 27:866-70. 2013..31 and 0.72 (P=0.02), and the mWBC hazard ratio for DS-ALL patients was 2.0 (P<0.0005). We conclude that insufficient treatment intensity during maintenance therapy of DS-ALL patients may contribute to their poor prognosis... - Pneumocystis carinii pneumonia during maintenance treatment of childhood acute lymphoblastic leukemiaA Poulsen
Section of Pediatric Hematology and Oncology, Pediatric Clinic II, The Juliane Marie Center, The Copenhagen University Hospital, Rigshospitalet, Denmark
Med Pediatr Oncol 37:20-3. 2001..The very low incidence of PCP during the later part of MT emphasizes that methotrexate/6-mercaptopurine MT have more impact on B-cell than on T-cell function. TMP/SMX prophylaxis should be recommended for all children treated for ALL... - Transient pancytopenia preceding acute lymphoblastic leukaemia (pre-ALL) precipitated by parvovirus B19E D Heegaard
Department of Clinical Microbiology, University State Hospital, Rigshospitalet, Denmark
Br J Haematol 114:810-3. 2001..In this patient the observed cytopenias were probably the result of B19 acting in concert with the failing BM and B19 is possibly one of several factors capable of triggering the onset of pre-ALL... - Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemiaK Schmiegelow
Department of Paediatrics, University Hospital, Copenhagen, Denmark
Br J Cancer 61:767-72. 1990..5 year CCR: 0.70 and 0.50, P = 0.06; and 4.5 year haematological remission: 0.83 and 0.63, P = 0.03). The favourable outcome for patients with hepatoxicity could be demonstrated for all risk groups... - Gonadal status in male survivors following childhood brain tumorsM Schmiegelow
Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
J Clin Endocrinol Metab 86:2446-52. 2001..However, because the number of patients with RT + CT and RT only are small, these data must be confirmed in further studies... - Hepatoblastoma in the Nordic countriesS de Fine Licht
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Int J Cancer 131:E555-61. 2012..These may include low birth weight and asphyxia leading to neonatal intensive care. Alternatively, the factors may be a consequence of hepatoblastoma developing in utero... - Estimation of dynamic treatment strategies for maintenance therapy of children with acute lymphoblastic leukaemia: an application of history-adjusted marginal structural modelsS Rosthøj
Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
Stat Med 31:470-88. 2012..The implementation is complicated, and we touch upon the limitations of the methods in relation to the formulation of alternative dosing strategies for the maintenance therapy... - Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in DenmarkH Hansson
The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
Eur J Cancer Care (Engl) 21:59-66. 2012..In future studies, interviews with children and siblings could be an important source of information for planning and delivering care suited to the families' perceived needs... - Post-induction residual leukemia in childhood acute lymphoblastic leukemia quantified by PCR correlates with in vitro prednisolone resistanceK Schmiegelow
Department of Pediatrics, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
Leukemia 15:1066-71. 2001.... - Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/lE C Larsen
Fertility Clinic, Department of Growth and Reproduction, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
Hum Reprod 18:417-22. 2003..05). CONCLUSIONS: Childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/l seem to have a diminished ovarian reserve. Consequently, they may have a shortened reproductive span and an early menopause... - Evaluation of plasma 3,4-dihydroxyphenylacetic acid (DOPAC) and plasma 3,4-dihydroxyphenylalanine (DOPA) as tumor markers in children with neuroblastomaE Eldrup
Department of Internal Medicine E Herlev Hospital, University of Copenhagen, Denmark
Scand J Clin Lab Invest 61:479-90. 2001..Plasma analyses of DOPA and DOPAC seem to be useful alternatives in the diagnosis and follow-up of NB if urine sampling is to be avoided. Plasma DOPAC may be an index of nutritional status in various diseases... - [Chromosome changes associated with childhood leukaemia occur prenatally]Marianne Olsen
H S Rigshospitalet, Juliane Marie Centret, paediatrisk klinik II
Ugeskr Laeger 168:2152-7. 2006..The findings provide a basic understanding of the natural history of childhood leukaemia and may make the development of preventive measures feasible... - Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemiaBritt Marie Frost
Department of Women s and Children s Health, University Children s Hospital, Uppsala, Sweden
Br J Haematol 122:376-85. 2003..In conclusion, our data indicate that in vitro testing of cellular drug resistance can be used to predict the clinical outcome in HR ALL, while the final evaluation of the results in IR and SR patients must await longer follow-up... - Leaving home after cancer in childhood: a measure of social independence in early adulthoodSusanne Vinkel Koch
Section of Pediatric Hematology and Oncology, Pediatric Clinic II, Juliane Marie Center, University Hospital, H:S Rigshospitalet, Copenhagen, Denmark
Pediatr Blood Cancer 47:61-70. 2006..97). CONCLUSION: Overall, the psychosocial effects of cancer in childhood or adolescence and its treatment on the survivor and family did not appear to impede social independence in early adulthood, except for survivors of CNS tumors... - The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrationsErik Forestier
Department of Clinical Sciences, Pediatrics, University of Ume, Sweden, and Pediatric Clinic II, The University Hospital Rigshospitalet, Copenhagen, Denmark
J Pediatr Hematol Oncol 28:486-95. 2006..Further research is needed to explore whether the 2 to 7 years age incidence peak in childhood ALL harbor yet unidentified cytogenetic subsets with the same natural history as the high-hyperdiploid and t(12;21)-positive leukemias... - Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemiaPäivi Halonen
Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
Pediatr Blood Cancer 46:762-6. 2006..Whether they are associated with hepatotoxicity manifested as histological liver changes is not known. We studied the association of the metabolites and cumulative doses of 6MP and MTX with histological liver disease... - Post-induction residual disease in translocation t(12;21)-positive childhood ALLJeanette Seyfarth
Department of Clinical Immunology, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
Med Pediatr Oncol 40:82-7. 2003.... - Cognitive deficits in long-term survivors of childhood brain tumors: Identification of predictive factorsTonny Solveig Reimers
Department of Psychology, Play Therapy, and Social Work, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Denmark
Med Pediatr Oncol 40:26-34. 2003..To describe cognitive function and to evaluate the association between potentially predictive factors and cognitive outcome in an unselected population of survivors of childhood brain tumors... - [Individual monitoring of thiopurine and methotrexate treatment]Bo Baslund
H:S Rigshospitalet, reumatologisk klinik, Klinisk Farmakologisk Afdeling
Ugeskr Laeger 167:2177-9. 2005 - Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusionLise Borgwardt
Positron Emission Tomography and Cyclotron Unit, Department of Clinical Physiology, Nuclear Medicine and Positron Emission Tomography, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Clin Oncol 23:3030-7. 2005..CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading. Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use... - Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and IcelandLisa Lyngsie Hjalgrim
Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
J Natl Cancer Inst 96:1549-56. 2004..We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia... - High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemiaArend von Stackelberg
Department of Pediatric Oncology Hematology, University of Berlin Charité Universitätsmedizin Berlin, Augustenburgerplatz 1, Berlin, Germany
Blood 111:2573-80. 2008..In conclusion, methotrexate infusions at 5 g/m(2) per 24 hours, compared with 1 g/m(2) per 36 hours, are not associated with increased disease control in relapsed childhood PBC acute lymphoblastic leukemia... - Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicityUlrikka Nygaard
The Pediatric Clinic II, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
Clin Pharmacol Ther 75:274-81. 2004.... - Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiencyBirgitte Lausen
Pediatric Clinic II, Juliane Marie Centre, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Eur J Haematol 76:481-7. 2006..Thus, these patients have been proposed to be candidates for MBL replacement therapy... - Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemiaKamilla B Petersen
Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
Cancer Chemother Pharmacol 51:465-73. 2003..Due to the small inter- and intraindividual variations in the pharmacokinetic parameters, body surface area-based dosing is sufficient to obtain similar systemic exposure among patients... - Long-term neurological outcome of childhood brain tumors treated by surgery onlySigne Sønderkaer
Pediatric Clinic II and the Department of Growth and Reproduction, Juliane Marie Center, H S Rigshospitalet, Copenhagen, Denmark
J Clin Oncol 21:1347-51. 2003..To evaluate the pattern of neurological late effects in patients who have received surgery only for a brain tumor in childhood and to identify possible risk factors for neurological sequelae... - [Beta-thalassemia major in children and adolescents in Denmark]Anne Jung
H:S Rigshospitalet, Juliane Marie Centret, paediatrisk klinik II, afsnit for vaekst og reproduktion
Ugeskr Laeger 164:5803-6. 2002..An earlier and more effective iron chelation therapy together with improved patient support may reduce growth disturbances and endocrine and cardiac late effects... - Radiotherapy at a young age reduces uterine volume of childhood cancer survivorsElisabeth C Larsen
The Fertility Clinic, Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Acta Obstet Gynecol Scand 83:96-102. 2004..We measured uterine volume in a cohort of childhood cancer survivors, and assessed uterine response to a high-dose estrogen replacement regimen... - Anti-Erwinia asparaginase antibodies during treatment of childhood acute lymphoblastic leukemia and their relationship to outcome: a case-control studyBirgitte Klug Albertsen
Department of Pharmacology, The Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
Cancer Chemother Pharmacol 50:117-20. 2002.... - [Trimethoprim-sulfamethoxazole as antibacterial prophylaxis during induction therapy of children with acute lymphatic leukemia]Kirstine E Agger
Arhus Universitetshospital, Skejby Sygehus, , DK-8200 Arhus N
Ugeskr Laeger 164:488-92. 2002..44). There were no cases of P. carinii pneumonia in the period of induction therapy. DISCUSSION: TMP/SMX prophylaxis during induction therapy for childhood ALL seems to reduce the risk of bacteraemias and febrile illness... - Precise quantification of minimal residual disease at day 29 allows identification of children with acute lymphoblastic leukemia and an excellent outcomeCharlotte Nyvold
Department of Clinical Immunology and Department of Pediatrics, National University Hospital, Rigshospitalet, Copenhagen, Denmark
Blood 99:1253-8. 2002..Further trials are needed to reveal whether such patients with D29 MRD less than 0.01% can be cured with less intensive chemotherapy, which would reduce the risk of serious late effects as well as the costs of therapy... - ETV6-RUNX1 transcript is not frequent in early human haematopoiesisUlrik Lausten-Thomsen
Eur J Haematol 81:161-2. 2008 - Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detectionKaren Marie Olesen
Department of Pharmaceuticals and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
J Chromatogr B Analyt Technol Biomed Life Sci 864:149-55. 2008..8 to 15.5%. In a small cohort of eight children with acute lymphoblastic leukaemia (ALL), a median of one 6-thioguanine base was found for each 3000 normal bases (range 1:2000-1:11000)... - Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemiaBritt Marie Frost
Department of Women s and Children s Health, University Children s Hospital, SE 751 85 Uppsala, Sweden
Blood 104:2452-7. 2004..High throughput techniques should now be used to elucidate the cellular mechanisms by which ETV6/RUNX1 gene fusion is linked to increased sensitivity to these drugs... - Intensive chemotherapy without radiotherapy gives more than 85% event-free survival for non-Hodgkin lymphoma without central nervous involvement: a 6-year population-based study from the nordic society of pediatric hematology and oncologyIldiko Marky
Department of Pediatrics, The Queen Silivia Children s Hospital, Goteborg, Sweden
J Pediatr Hematol Oncol 26:555-60. 2004..The authors report the results from a 6-year population-based study of clinical characteristics and treatment results of NHL from the five Nordic countries... - Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancerElisabeth C Larsen
The Fertility Clinic, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
J Clin Endocrinol Metab 88:5307-14. 2003..Consequently, cessation of fertility may occur much earlier than anticipated. Adult survivors with spontaneous cycles should be informed hereof to plan childbearing... - Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemiaAnders Castor
Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, 221 84 Lund, Sweden
Nat Med 11:630-7. 2005.... - Multiplex reverse transcription polymerase chain reaction screening in acute myeloid leukemia detects cytogenetically unrevealed abnormalities of prognostic significanceMarianne Hutchings Hoffmann
Haematologica 90:984-6. 2005..In five patients, a cytogenetically unrevealed fusion gene of prognostic importance was detected, while the assay failed to detect one case of t(15;17)... - [Central nervous system tumours in children. An evaluation of the completeness and validity of the Cancer Registry]Rikke Thorsteinsson
Kraeftens Bekaempelse,
Ugeskr Laeger 167:3782-5. 2005..The relatively low validity might be explained by the anatomic location of CNS tumours, which makes tissue sampling for histological verification and therefore diagnosis difficult... - Memory deficits in long-term survivors of childhood brain tumors may primarily reflect general cognitive dysfunctionsTonny Solveig Reimers
Clinic of Psychology, Play Therapy and Social Work, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Pediatr Blood Cancer 48:205-12. 2007..To analyze the impact of potential predictors on memory performance in survivors of childhood brain tumors and to examine whether deficits in memory after radiotherapy (RT) should be considered part of a more global mental dysfunction... - Flow cytometric DNA index, G-band karyotyping, and comparative genomic hybridization in detection of high hyperdiploidy in childhood acute lymphoblastic leukemiaUlrikka Nygaard
Department of Pediatrics, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
J Pediatr Hematol Oncol 28:134-40. 2006..In addition, FCM detects patients with high hyperdiploid subclones, not detected by either GBK or HR-CGH, and the challenge remains to determine the prognosis of patients with such high hyperdiploid subclones... - Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countriesLisa Lyngsie Hjalgrim
Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
J Natl Cancer Inst 95:1539-44. 2003.... - Preleukemic TEL-AML1-positive clones at cell level of 10(-3) to 10(-4) do not persist into adulthoodMarianne Olsen
Copenhagen University Hospital Rigshospitalet, Juliane Marie Center, Bonkolab 5704, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Pediatr Hematol Oncol 28:734-40. 2006..The findings are compatible with the risk of t(12;21)(p13;q22) ALL correlating with the total number of TEL-AML1-positive cells in peripheral blood in both childhood and adulthood... - Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populationsNina Toft
Bonkolab 5704, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Acta Paediatr 95:1665-7. 2006..To determine the frequency of thiopurine methyltransferase (TPMT) low-activity alleles in the Greenlandic and Danish populations... - High-resolution comparative genomic hybridisation yields a high detection rate of chromosomal aberrations in childhood acute lymphoblastic leukaemiaTim D Kristensen
Department of Pediatrics, The University Hospital, Rigshospitalet, Copenhagen, Denmark
Eur J Haematol 70:363-72. 2003..CONCLUSION: HRCGH is superior to conventional CGH as an adjunct to G-band karyotyping as it detects recurrent aberrations at a significantly higher rate than both these techniques... - [Procalcitonin for early diagnosis of bacteraemia in children with cancer]Bo Lund Chawes
Paediatrisk Klinik II og Klinisk Mikrobiologisk Afdeling, Diagnostisk Center
Ugeskr Laeger 169:138-42. 2007..Furthermore, we compared the usefulness of procalcitonin with that of C-reactive protein (CRP)...