K Schmiegelow

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi request reprint Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate
    Peter Buur van Kooten Niekerk
    Department of Paediatrics, University Hospital, Aarhus, Denmark
    Eur J Haematol 81:391-8. 2008
  2. pmc Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries
    Kjeld Schmiegelow
    Faculty of Medicine, Institute of Gynecology, Obstetrics and Pediatrics, and the Department of Pediatrics, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Mediterr J Hematol Infect Dis 3:e2011020. 2011
  3. pmc Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Paediatric and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 31:2469-76. 2013
  4. doi request reprint High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia
    K Schmiegelow
    Pediatric Clinics, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 26:675-81. 2012
  5. ncbi request reprint Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Pediatric Clinic II, Juliane Marie Centre, Department of Clinical Immunology, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    Blood 100:3757-60. 2002
  6. ncbi request reprint Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Pediatrics, The University Hospital and The University of Copenhagen, Denmark
    J Clin Oncol 21:1332-9. 2003
  7. doi request reprint Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    Kjeld Schmiegelow
    Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, University Hospitals, Rigshospitalet Copenhagen, Denmark
    J Pediatr Hematol Oncol 31:385-92. 2009
  8. doi request reprint Advances in individual prediction of methotrexate toxicity: a review
    Kjeld Schmiegelow
    The Faculty of Medicine, Institute of Gynaecology, Obstetrics and Paediatrics, University of Copenhagen, Copenhagen, Denmark
    Br J Haematol 146:489-503. 2009
  9. pmc Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    Kjeld Schmiegelow
    Faculty of Medicine, Institute of Gynecology, Obstetrics, and Pediatrics, University of Copenhagen, Copenhagen, Denmark
    Blood 113:6077-84. 2009
  10. doi request reprint Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    K Schmiegelow
    The Institute of Gynecology, Obstetrics, and Pediatrics, The Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark
    Leukemia 23:557-64. 2009

Detail Information

Publications69

  1. doi request reprint Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate
    Peter Buur van Kooten Niekerk
    Department of Paediatrics, University Hospital, Aarhus, Denmark
    Eur J Haematol 81:391-8. 2008
    ..We investigated the influence of polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene and coadministration of antimetabolites on post-HDMTX toxicity...
  2. pmc Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries
    Kjeld Schmiegelow
    Faculty of Medicine, Institute of Gynecology, Obstetrics and Pediatrics, and the Department of Pediatrics, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Mediterr J Hematol Infect Dis 3:e2011020. 2011
    ..In conclusion, the duration and intensity of 6MP/MTX maintenance therapy of childhood ALL may influence the risk of SMN...
  3. pmc Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Paediatric and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 31:2469-76. 2013
    ..Second malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events...
  4. doi request reprint High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia
    K Schmiegelow
    Pediatric Clinics, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 26:675-81. 2012
    ..These data indicate strong genetic and/or environmental risk factors for childhood ALL that are restricted to specific ALL subtypes, which must be taken into account, when performing epidemiological studies to reveal etiological factors...
  5. ncbi request reprint Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Pediatric Clinic II, Juliane Marie Centre, Department of Clinical Immunology, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    Blood 100:3757-60. 2002
    ..9 vs 5.2 years; P =.04). The study shows that the presence of low-level MBL genotypes is associated with an increased risk of childhood ALL, particularly with early age at onset...
  6. ncbi request reprint Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia
    Kjeld Schmiegelow
    Department of Pediatrics, The University Hospital and The University of Copenhagen, Denmark
    J Clin Oncol 21:1332-9. 2003
    ..We explored whether dose adjustment of MP and MTX by erythrocyte (E) levels of TGN and MTX (including polyglutamates) could improve outcome in childhood acute lymphoblastic leukemia (ALL)...
  7. doi request reprint Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    Kjeld Schmiegelow
    Institute of Gynecology, Obstetrics, and Pediatrics, Department of Pediatrics, University Hospitals, Rigshospitalet Copenhagen, Denmark
    J Pediatr Hematol Oncol 31:385-92. 2009
    ..These results indicate that oral MTX/6MP maintenance therapy administered after the first year of remission can improve the cure rates of children with T-lineage or with higher risk B-lineage ALL...
  8. doi request reprint Advances in individual prediction of methotrexate toxicity: a review
    Kjeld Schmiegelow
    The Faculty of Medicine, Institute of Gynaecology, Obstetrics and Paediatrics, University of Copenhagen, Copenhagen, Denmark
    Br J Haematol 146:489-503. 2009
    ..This paper discusses the pharmacology of methotrexate and reviews studies on haematological malignancies that have attempted to predict the risk of toxicity by specific clinical or genetic features...
  9. pmc Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    Kjeld Schmiegelow
    Faculty of Medicine, Institute of Gynecology, Obstetrics, and Pediatrics, University of Copenhagen, Copenhagen, Denmark
    Blood 113:6077-84. 2009
    ..7 vs 60.4 mg/m2; P = .03). This study indicates that the duration and intensity of 6MP/MTX maintenance therapy of childhood ALL may influence the risk of SMNs in childhood ALL...
  10. doi request reprint Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    K Schmiegelow
    The Institute of Gynecology, Obstetrics, and Pediatrics, The Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark
    Leukemia 23:557-64. 2009
    ..These data suggest that children with ALL and TPMT wild type might have their cure rate improved, if the pharmacokinetics/-dynamics of TPMT low-activity patients could be mimicked without a concurrent excessive risk of second cancers...
  11. doi request reprint Etiology of common childhood acute lymphoblastic leukemia: the adrenal hypothesis
    K Schmiegelow
    The Pediatric Clinic, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 22:2137-41. 2008
    ....
  12. doi request reprint Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
    K Schmiegelow
    Faculty of Medicine, The Institute of Gynaecology, Obstetrics, and Paediatrics, University of Copenhagen, Copenhagen, Denmark
    Leukemia 24:345-54. 2010
    ....
  13. ncbi request reprint [Cancer in childhood and inheritance]
    Kjeld Schmiegelow
    H S Rigshospitalet, Juliane Marie Centret, Paediatrisk klinik, Blegdamsvej 9, DK 2100 København Ø
    Ugeskr Laeger 168:2373-6. 2006
    ....
  14. doi request reprint The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse
    K Schmiegelow
    Department of Pediatric Oncology, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 24:715-20. 2010
    ..38, P=0.02), which was not the case for those who developed a relapse (r(S)=0.15, P=0.60). Thus, compliance to maintenance therapy may influence the risk of relapse for adolescents with ALL...
  15. doi request reprint A 10-year follow up of reproductive function in women treated for childhood cancer
    S N Nielsen
    The Fertility Clinic, The Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Reprod Biomed Online 27:192-200. 2013
    ..However, if the ovarian function is preserved in the early to mid-twenties, it is likely to persist until the mid-thirties, giving a good chance of childbearing...
  16. ncbi request reprint Competitive PCR for quantification of minimal residual disease in acute lymphoblastic leukaemia
    C Nyvold
    Department of Clinical Immunology, The National University Hospital, Rigshospitalet, Tagensvej 20, DK 2200, Copenhagen, Denmark
    J Immunol Methods 233:107-18. 2000
    ..The method is very sensitive with a detection limit of at least one malignant cell in 10(5) normal cells. This method may be used for treatment stratification based on the early response to antileukaemic therapy...
  17. ncbi request reprint Growth hormone response to a growth hormone-releasing hormone stimulation test in a population-based study following cranial irradiation of childhood brain tumors
    M Schmiegelow
    Department of Growth and Reproduction, Juliane Marie Centre, National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Horm Res 54:53-9. 2000
    ....
  18. ncbi request reprint 6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia
    K Schmiegelow
    The Laboratory for Pediatric Oncology, The Pediatric Clinic II, The Juliane Marie Centre, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Leukemia 15:74-9. 2001
    ..0057, P = 0.046). In conclusion, the study indicates that reductions of the dose of concurrently given oral 6MP could be one way of reducing the risk of significant myelotoxicity following HDM during maintenance therapy of childhood ALL...
  19. ncbi request reprint Cryopreservation of semen from pubertal boys with cancer
    J Muller
    Clinic of Growth and Reproduction, Juliane Marie Centre, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Med Pediatr Oncol 34:191-4. 2000
    ..The possibility of cryopreservation of semen from adolescents has until now received only little attention. Therefore, we have investigated the possibility of cryopreservation of semen in adolescent boys with cancer...
  20. ncbi request reprint Gonadal status in male survivors following childhood brain tumors
    M Schmiegelow
    Department of Growth and Reproduction, Juliane Marie Centre, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 86:2446-52. 2001
    ..However, because the number of patients with RT + CT and RT only are small, these data must be confirmed in further studies...
  21. ncbi request reprint Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia
    U Nygaard
    The Pediatric Clinic II, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Leukemia 17:1344-8. 2003
    ..001). The reduction of 6MP dosage during HDM can significantly reduce the risk of severe myelotoxicity and prevent treatment interruptions...
  22. ncbi request reprint Glucagon-like peptide-2 (GLP-2) response to enteral intake in children during anti-cancer treatment
    B U Andreassen
    Paediatric Nutrition Unit, Rigshospitalet, Coppenhagen, Denmark
    J Pediatr Gastroenterol Nutr 40:48-53. 2005
    ..Lack of GLP-2 may increase the risk of malabsorption and intestinal bacterial translocation. The aim of this study is to evaluate meal stimulated secretion of GLP-2 in children with cancer undergoing anti-cancer treatment...
  23. ncbi request reprint The role of parvovirus B19 infection in childhood acute lymphoblastic leukemia
    E D Heegaard
    Department of Clinical Microbiology, University State Hospital, Copenhagen, Denmark
    Pediatr Hematol Oncol 16:329-34. 1999
    ..The results suggest that there is an insignificant chance of finding a parvovirus B19 infection in pediatric patients with ALL at the time of diagnosis. However, parvovirus B19 infection may infrequently serve as a prodrome to ALL...
  24. ncbi request reprint [Individualized cancer treatment. Illustrated by acute lymphoblastic leukemia in children]
    K Schmiegelow
    H S Righospitalet, Juliane Marie Centret, paediatrisk klinik II
    Ugeskr Laeger 163:1062-6. 2001
    ....
  25. doi request reprint Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia
    C Bohnstedt
    Pediatrics and Adolescent Medicine, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark
    Leukemia 27:866-70. 2013
    ..31 and 0.72 (P=0.02), and the mWBC hazard ratio for DS-ALL patients was 2.0 (P<0.0005). We conclude that insufficient treatment intensity during maintenance therapy of DS-ALL patients may contribute to their poor prognosis...
  26. pmc Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia
    K Schmiegelow
    Department of Paediatrics, University Hospital, Copenhagen, Denmark
    Br J Cancer 61:767-72. 1990
    ..5 year CCR: 0.70 and 0.50, P = 0.06; and 4.5 year haematological remission: 0.83 and 0.63, P = 0.03). The favourable outcome for patients with hepatoxicity could be demonstrated for all risk groups...
  27. ncbi request reprint Pneumocystis carinii pneumonia during maintenance treatment of childhood acute lymphoblastic leukemia
    A Poulsen
    Section of Pediatric Hematology and Oncology, Pediatric Clinic II, The Juliane Marie Center, The Copenhagen University Hospital, Rigshospitalet, Denmark
    Med Pediatr Oncol 37:20-3. 2001
    ..The very low incidence of PCP during the later part of MT emphasizes that methotrexate/6-mercaptopurine MT have more impact on B-cell than on T-cell function. TMP/SMX prophylaxis should be recommended for all children treated for ALL...
  28. ncbi request reprint Transient pancytopenia preceding acute lymphoblastic leukaemia (pre-ALL) precipitated by parvovirus B19
    E D Heegaard
    Department of Clinical Microbiology, University State Hospital, Rigshospitalet, Denmark
    Br J Haematol 114:810-3. 2001
    ..In this patient the observed cytopenias were probably the result of B19 acting in concert with the failing BM and B19 is possibly one of several factors capable of triggering the onset of pre-ALL...
  29. doi request reprint Hepatoblastoma in the Nordic countries
    S de Fine Licht
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 131:E555-61. 2012
    ..These may include low birth weight and asphyxia leading to neonatal intensive care. Alternatively, the factors may be a consequence of hepatoblastoma developing in utero...
  30. doi request reprint Estimation of dynamic treatment strategies for maintenance therapy of children with acute lymphoblastic leukaemia: an application of history-adjusted marginal structural models
    S Rosthøj
    Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
    Stat Med 31:470-88. 2012
    ..The implementation is complicated, and we touch upon the limitations of the methods in relation to the formulation of alternative dosing strategies for the maintenance therapy...
  31. doi request reprint Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in Denmark
    H Hansson
    The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    Eur J Cancer Care (Engl) 21:59-66. 2012
    ..In future studies, interviews with children and siblings could be an important source of information for planning and delivering care suited to the families' perceived needs...
  32. ncbi request reprint Post-induction residual leukemia in childhood acute lymphoblastic leukemia quantified by PCR correlates with in vitro prednisolone resistance
    K Schmiegelow
    Department of Pediatrics, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Leukemia 15:1066-71. 2001
    ....
  33. ncbi request reprint Evaluation of plasma 3,4-dihydroxyphenylacetic acid (DOPAC) and plasma 3,4-dihydroxyphenylalanine (DOPA) as tumor markers in children with neuroblastoma
    E Eldrup
    Department of Internal Medicine E Herlev Hospital, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 61:479-90. 2001
    ..Plasma analyses of DOPA and DOPAC seem to be useful alternatives in the diagnosis and follow-up of NB if urine sampling is to be avoided. Plasma DOPAC may be an index of nutritional status in various diseases...
  34. ncbi request reprint Diminished ovarian reserve in female childhood cancer survivors with regular menstrual cycles and basal FSH <10 IU/l
    E C Larsen
    Fertility Clinic, Department of Growth and Reproduction, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 18:417-22. 2003
    ..The aim of the present study was to assess ovarian reserve in women with an apparently normal ovarian function, who were cured of cancer in childhood...
  35. ncbi request reprint High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia
    Arend von Stackelberg
    Department of Pediatric Oncology Hematology, University of Berlin Charité Universitätsmedizin Berlin, Augustenburgerplatz 1, Berlin, Germany
    Blood 111:2573-80. 2008
    ..In conclusion, methotrexate infusions at 5 g/m(2) per 24 hours, compared with 1 g/m(2) per 36 hours, are not associated with increased disease control in relapsed childhood PBC acute lymphoblastic leukemia...
  36. ncbi request reprint Post-induction residual disease in translocation t(12;21)-positive childhood ALL
    Jeanette Seyfarth
    Department of Clinical Immunology, The National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Med Pediatr Oncol 40:82-7. 2003
    ..t(12;21)(p1 3;q22), the most frequent chromosomal translocation found in childhood acute lymphoblastic leukemia (ALL), occurs in approximately 25% of B-lineage ALL cases and has been claimed to carry a good prognosis...
  37. ncbi request reprint [Chromosome changes associated with childhood leukaemia occur prenatally]
    Marianne Olsen
    H S Rigshospitalet, Juliane Marie Centret, paediatrisk klinik II
    Ugeskr Laeger 168:2152-7. 2006
    ..The findings provide a basic understanding of the natural history of childhood leukaemia and may make the development of preventive measures feasible...
  38. ncbi request reprint Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion
    Lise Borgwardt
    Positron Emission Tomography and Cyclotron Unit, Department of Clinical Physiology, Nuclear Medicine and Positron Emission Tomography, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Clin Oncol 23:3030-7. 2005
    ..CONCLUSION FDG PET of the brain with MRI coregistration can be used to obtain a more specific diagnosis with respect to malignancy grading. Improved PET/MRI imaging of the benign hypermetabolic tumors is needed to optimize clinical use...
  39. ncbi request reprint The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations
    Erik Forestier
    Department of Clinical Sciences, Pediatrics, University of Umea, Sweden, and Pediatric Clinic II, The University Hospital Rigshospitalet, Copenhagen, Denmark
    J Pediatr Hematol Oncol 28:486-95. 2006
    ..Further research is needed to explore whether the 2 to 7 years age incidence peak in childhood ALL harbor yet unidentified cytogenetic subsets with the same natural history as the high-hyperdiploid and t(12;21)-positive leukemias...
  40. ncbi request reprint Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia
    Britt Marie Frost
    Department of Women s and Children s Health, University Children s Hospital, Uppsala, Sweden
    Br J Haematol 122:376-85. 2003
    ..In conclusion, our data indicate that in vitro testing of cellular drug resistance can be used to predict the clinical outcome in HR ALL, while the final evaluation of the results in IR and SR patients must await longer follow-up...
  41. ncbi request reprint Leaving home after cancer in childhood: a measure of social independence in early adulthood
    Susanne Vinkel Koch
    Section of Pediatric Hematology and Oncology, Pediatric Clinic II, Juliane Marie Center, University Hospital, H S Rigshospitalet, Copenhagen, Denmark
    Pediatr Blood Cancer 47:61-70. 2006
    ..As a measure of social independence, we investigated whether cancer survivors displayed the same patterns of leaving home as population-based control group...
  42. ncbi request reprint Cognitive deficits in long-term survivors of childhood brain tumors: Identification of predictive factors
    Tonny Solveig Reimers
    Department of Psychology, Play Therapy, and Social Work, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Denmark
    Med Pediatr Oncol 40:26-34. 2003
    ..To describe cognitive function and to evaluate the association between potentially predictive factors and cognitive outcome in an unselected population of survivors of childhood brain tumors...
  43. ncbi request reprint Infections during induction therapy of childhood acute lymphoblastic leukemia--no association to mannose-binding lectin deficiency
    Birgitte Lausen
    Pediatric Clinic II, Juliane Marie Centre, H S Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Haematol 76:481-7. 2006
    ..Thus, these patients have been proposed to be candidates for MBL replacement therapy...
  44. ncbi request reprint Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland
    Lisa Lyngsie Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    J Natl Cancer Inst 96:1549-56. 2004
    ..We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia...
  45. ncbi request reprint Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity
    Ulrikka Nygaard
    The Pediatric Clinic II, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Clin Pharmacol Ther 75:274-81. 2004
    ....
  46. ncbi request reprint [Individual monitoring of thiopurine and methotrexate treatment]
    Bo Baslund
    H S Rigshospitalet, reumatologisk klinik, Klinisk Farmakologisk Afdeling
    Ugeskr Laeger 167:2177-9. 2005
  47. ncbi request reprint Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia
    Päivi Halonen
    Paediatric Research Centre, Medical School, University of Tampere, Tampere, Finland
    Pediatr Blood Cancer 46:762-6. 2006
    ..Whether they are associated with hepatotoxicity manifested as histological liver changes is not known. We studied the association of the metabolites and cumulative doses of 6MP and MTX with histological liver disease...
  48. ncbi request reprint [Trimethoprim-sulfamethoxazole as antibacterial prophylaxis during induction therapy of children with acute lymphatic leukemia]
    Kirstine E Agger
    Arhus Universitetshospital, Skejby Sygehus, børneonkologisk afdeling, DK 8200 Arhus N
    Ugeskr Laeger 164:488-92. 2002
    ..This gave us the opportunity to describe the effect of TMP/SMX on bacterial infections in children with ALL during the induction therapy...
  49. ncbi request reprint Anti-Erwinia asparaginase antibodies during treatment of childhood acute lymphoblastic leukemia and their relationship to outcome: a case-control study
    Birgitte Klug Albertsen
    Department of Pharmacology, The Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
    Cancer Chemother Pharmacol 50:117-20. 2002
    ....
  50. ncbi request reprint Long-term neurological outcome of childhood brain tumors treated by surgery only
    Signe Sønderkaer
    Pediatric Clinic II and the Department of Growth and Reproduction, Juliane Marie Center, H S Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:1347-51. 2003
    ..To evaluate the pattern of neurological late effects in patients who have received surgery only for a brain tumor in childhood and to identify possible risk factors for neurological sequelae...
  51. ncbi request reprint Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia
    Kamilla B Petersen
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
    Cancer Chemother Pharmacol 51:465-73. 2003
    ..To evaluate the plasma protein binding and pharmacokinetics of prednisolone during therapeutic use in children with acute lymphoblastic leukemia (ALL) using the population approach...
  52. ncbi request reprint High-resolution comparative genomic hybridisation yields a high detection rate of chromosomal aberrations in childhood acute lymphoblastic leukaemia
    Tim D Kristensen
    Department of Pediatrics, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Haematol 70:363-72. 2003
    ..Cytogenetic aberrations are of prognostic significance in childhood acute lymphoblastic leukaemias and a high detection rate could improve the biological understanding and classification of these diseases...
  53. ncbi request reprint [Beta-thalassemia major in children and adolescents in Denmark]
    Anne Jung
    H S Rigshospitalet, Juliane Marie Centret, paediatrisk klinik II, afsnit for vaekst og reproduktion
    Ugeskr Laeger 164:5803-6. 2002
    ..The aim of the study was to estimate the occurrence of beta-thalassemia major in Denmark, analyse the treatment and organ functions, and identify areas for an improved treatment strategy...
  54. ncbi request reprint Precise quantification of minimal residual disease at day 29 allows identification of children with acute lymphoblastic leukemia and an excellent outcome
    Charlotte Nyvold
    Department of Clinical Immunology and Department of Pediatrics, National University Hospital, Rigshospitalet, Copenhagen, Denmark
    Blood 99:1253-8. 2002
    ..Further trials are needed to reveal whether such patients with D29 MRD less than 0.01% can be cured with less intensive chemotherapy, which would reduce the risk of serious late effects as well as the costs of therapy...
  55. ncbi request reprint Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer
    Elisabeth C Larsen
    The Fertility Clinic, The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:5307-14. 2003
    ..Consequently, cessation of fertility may occur much earlier than anticipated. Adult survivors with spontaneous cycles should be informed hereof to plan childbearing...
  56. ncbi request reprint Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia
    Britt Marie Frost
    Department of Women s and Children s Health, University Children s Hospital, SE 751 85 Uppsala, Sweden
    Blood 104:2452-7. 2004
    ..High throughput techniques should now be used to elucidate the cellular mechanisms by which ETV6/RUNX1 gene fusion is linked to increased sensitivity to these drugs...
  57. ncbi request reprint Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
    Anders Castor
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, 221 84 Lund, Sweden
    Nat Med 11:630-7. 2005
    ....
  58. ncbi request reprint Multiplex reverse transcription polymerase chain reaction screening in acute myeloid leukemia detects cytogenetically unrevealed abnormalities of prognostic significance
    Marianne Hutchings Hoffmann
    Haematologica 90:984-6. 2005
    ..In five patients, a cytogenetically unrevealed fusion gene of prognostic importance was detected, while the assay failed to detect one case of t(15;17)...
  59. ncbi request reprint [Central nervous system tumours in children. An evaluation of the completeness and validity of the Cancer Registry]
    Rikke Thorsteinsson
    Kraeftens Bekaempelse, København
    Ugeskr Laeger 167:3782-5. 2005
    ..The aim of this study was to evaluate the registration of childhood CNS tumours in the Danish Cancer Registry (CR) from 1980 to 1996, based on completeness and validity...
  60. ncbi request reprint Memory deficits in long-term survivors of childhood brain tumors may primarily reflect general cognitive dysfunctions
    Tonny Solveig Reimers
    Clinic of Psychology, Play Therapy and Social Work, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Pediatr Blood Cancer 48:205-12. 2007
    ..To analyze the impact of potential predictors on memory performance in survivors of childhood brain tumors and to examine whether deficits in memory after radiotherapy (RT) should be considered part of a more global mental dysfunction...
  61. ncbi request reprint Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries
    Lisa Lyngsie Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 95:1539-44. 2003
    ....
  62. ncbi request reprint Flow cytometric DNA index, G-band karyotyping, and comparative genomic hybridization in detection of high hyperdiploidy in childhood acute lymphoblastic leukemia
    Ulrikka Nygaard
    Department of Pediatrics, The University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Pediatr Hematol Oncol 28:134-40. 2006
    ..In addition, FCM detects patients with high hyperdiploid subclones, not detected by either GBK or HR-CGH, and the challenge remains to determine the prognosis of patients with such high hyperdiploid subclones...
  63. ncbi request reprint Radiotherapy at a young age reduces uterine volume of childhood cancer survivors
    Elisabeth C Larsen
    The Fertility Clinic, Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Acta Obstet Gynecol Scand 83:96-102. 2004
    ..We measured uterine volume in a cohort of childhood cancer survivors, and assessed uterine response to a high-dose estrogen replacement regimen...
  64. ncbi request reprint Preleukemic TEL-AML1-positive clones at cell level of 10(-3) to 10(-4) do not persist into adulthood
    Marianne Olsen
    Copenhagen University Hospital Rigshospitalet, Juliane Marie Center, Bonkolab 5704, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Pediatr Hematol Oncol 28:734-40. 2006
    ..The findings are compatible with the risk of t(12;21)(p13;q22) ALL correlating with the total number of TEL-AML1-positive cells in peripheral blood in both childhood and adulthood...
  65. ncbi request reprint Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations
    Nina Toft
    Bonkolab 5704, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 95:1665-7. 2006
    ..To determine the frequency of thiopurine methyltransferase (TPMT) low-activity alleles in the Greenlandic and Danish populations...
  66. ncbi request reprint [Procalcitonin for early diagnosis of bacteraemia in children with cancer]
    Bo Lund Chawes
    Paediatrisk Klinik II og Klinisk Mikrobiologisk Afdeling, Diagnostisk Center
    Ugeskr Laeger 169:138-42. 2007
    ..Furthermore, we compared the usefulness of procalcitonin with that of C-reactive protein (CRP)...
  67. ncbi request reprint Intensive chemotherapy without radiotherapy gives more than 85% event-free survival for non-Hodgkin lymphoma without central nervous involvement: a 6-year population-based study from the nordic society of pediatric hematology and oncology
    Ildiko Marky
    Department of Pediatrics, The Queen Silivia Children s Hospital, Goteborg, Sweden
    J Pediatr Hematol Oncol 26:555-60. 2004
    ..The authors report the results from a 6-year population-based study of clinical characteristics and treatment results of NHL from the five Nordic countries...
  68. doi request reprint Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detection
    Karen Marie Olesen
    Department of Pharmaceuticals and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Chromatogr B Analyt Technol Biomed Life Sci 864:149-55. 2008
    ..8 to 15.5%. In a small cohort of eight children with acute lymphoblastic leukaemia (ALL), a median of one 6-thioguanine base was found for each 3000 normal bases (range 1:2000-1:11000)...
  69. doi request reprint ETV6-RUNX1 transcript is not frequent in early human haematopoiesis
    Ulrik Lausten-Thomsen
    Eur J Haematol 81:161-2. 2008