Lars S Rasmussen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Postoperative cognitive dysfunction: incidence and prevention
    Lars S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Section 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Anaesthesiol 20:315-30. 2006
  2. ncbi Postoperative cognitive dysfunction: true deterioration versus random variation
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 48:1137-43. 2004
  3. ncbi Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients
    L S Rasmussen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 47:260-6. 2003
  4. ncbi Neuron loss after coronary artery bypass detected by SPECT estimation of benzodiazepine receptors
    Lars S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Ann Thorac Surg 74:1576-80. 2002
  5. ncbi [Detection of postoperative cognitive dysfunction]
    Kamilia S Funder
    Anaestesi og Operationsklinikken, HOC 4231, Rigshospitalet, DK 2100 København Ø, Denmark
    Ugeskr Laeger 172:449-52. 2010
  6. ncbi Biochemical markers for brain damage after carbon monoxide poisoning
    L S Rasmussen
    Department of Anesthesia, Center of Head and Orthopedics, Statens Serum Institut, Copenhage, Denmark
    Acta Anaesthesiol Scand 48:469-73. 2004
  7. ncbi Comparison of xenon with propofol for supplementary general anaesthesia for knee replacement: a randomized study
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Br J Anaesth 97:154-9. 2006
  8. ncbi Normothermic versus hypothermic cardiopulmonary bypass during repair of congenital heart disease
    L S Rasmussen
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cardiothorac Vasc Anesth 15:563-6. 2001
  9. ncbi The assessment of postoperative cognitive function
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Acta Anaesthesiol Scand 45:275-89. 2001
  10. ncbi Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma
    Martin Sillesen
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care M S, C H J, A I, J O H, D D, M Du, M De, G C V, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts Department of Anesthesia M S, L S R, Center of Head and Orthopedics, and Capital Region Blood Bank P I J, C H J, Copenhagen University Hospital, Rigshospitalet, Denmark Department of Surgery P I J, University of Texas Medical School at Houston, Texas and Department of Surgery G J, H B A, University of Michigan, Ann Arbor, Michigan
    J Trauma Acute Care Surg 76:998-1007. 2014

Detail Information

Publications86

  1. ncbi Postoperative cognitive dysfunction: incidence and prevention
    Lars S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Section 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Anaesthesiol 20:315-30. 2006
    ..Regional anaesthesia does not seem to reduce the incidence of POCD, and cognitive function does not seem to improve after carotid surgery as has previously been suggested...
  2. ncbi Postoperative cognitive dysfunction: true deterioration versus random variation
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 48:1137-43. 2004
    ..The aim of this study was to describe how variability in neuropsychological testing could lead to the detection of cognitive improvement and poor consistency of POCD between postoperative test sessions...
  3. ncbi Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients
    L S Rasmussen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 47:260-6. 2003
    ..We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general...
  4. ncbi Neuron loss after coronary artery bypass detected by SPECT estimation of benzodiazepine receptors
    Lars S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Ann Thorac Surg 74:1576-80. 2002
    ..In addition, we correlated the findings with neuropsychological test results...
  5. ncbi [Detection of postoperative cognitive dysfunction]
    Kamilia S Funder
    Anaestesi og Operationsklinikken, HOC 4231, Rigshospitalet, DK 2100 København Ø, Denmark
    Ugeskr Laeger 172:449-52. 2010
    ..Aspects like baseline performance, practice effects and time interval between test sessions all influence the assessment of cognitive function...
  6. ncbi Biochemical markers for brain damage after carbon monoxide poisoning
    L S Rasmussen
    Department of Anesthesia, Center of Head and Orthopedics, Statens Serum Institut, Copenhage, Denmark
    Acta Anaesthesiol Scand 48:469-73. 2004
    ..We hypothesized that increased serum concentrations of Neuron-specific enolase (NSE) and S-100beta protein could be detected after carbon monoxide poisoning and that the concentration would correlate with the severity of intoxication...
  7. ncbi Comparison of xenon with propofol for supplementary general anaesthesia for knee replacement: a randomized study
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Br J Anaesth 97:154-9. 2006
    ..The aim of this study was to compare xenon with propofol for supplementary general anaesthesia in patients undergoing knee replacement in spinal anaesthesia...
  8. ncbi Normothermic versus hypothermic cardiopulmonary bypass during repair of congenital heart disease
    L S Rasmussen
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Cardiothorac Vasc Anesth 15:563-6. 2001
    ..To compare normothermic cardiopulmonary bypass (CPB) versus hypothermic CPB in pediatric patients undergoing repair of congenital heart disease with focus on biochemical markers for brain damage...
  9. ncbi The assessment of postoperative cognitive function
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Acta Anaesthesiol Scand 45:275-89. 2001
    ..In this review article, we present a number of recommendations for the design and execution of studies within this area. In addition, the critical reader may use these recommendations in the evaluation of the literature...
  10. ncbi Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma
    Martin Sillesen
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care M S, C H J, A I, J O H, D D, M Du, M De, G C V, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts Department of Anesthesia M S, L S R, Center of Head and Orthopedics, and Capital Region Blood Bank P I J, C H J, Copenhagen University Hospital, Rigshospitalet, Denmark Department of Surgery P I J, University of Texas Medical School at Houston, Texas and Department of Surgery G J, H B A, University of Michigan, Ann Arbor, Michigan
    J Trauma Acute Care Surg 76:998-1007. 2014
    ..Platelet dysfunction following trauma has been identified as an independent predictor of mortality. We hypothesized that fresh frozen plasma (FFP) resuscitation would attenuate platelet dysfunction compared with 0.9% normal saline (NS)...
  11. ncbi Quality differences in postoperative sleep between propofol-remifentanil and sevoflurane anesthesia in infants
    Jacob Steinmetz
    Department of Anesthesia, Centre of Head and Orthopedics 4231, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesth Analg 104:779-83. 2007
    ..In the present study we focus on postoperative sleep disturbances, which we hypothesized would be more common after sevoflurane anesthesia than propofol-remifentanil anesthesia...
  12. ncbi Pre-hospital diagnosis and transfer of patients with acute myocardial infarction--a decade long experience from one of Europe's largest STEMI networks
    Peter Clemmensen
    Department of Cardiology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark Electronic address
    J Electrocardiol 46:546-52. 2013
    ..These organizational changes are likely to contribute to the improved mortality rate for STEMI patients...
  13. ncbi Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model
    Martin Sillesen
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care M S, C H J, A I, J O H, M D, G V, Department of Surgery, Massachusetts GeneralHospital Harvard Medical School, Boston, Massachusetts Department of surgery G J, I H, H B A, University of Michigan, Ann Arbor, Michigan and Department of Surgery P I J, University of Texas Medical School, Houston, Texas and Department of Anesthesia M S, L S R, Center of Head and Orthopedics, and Capital Region Blood Bank C H J, P I J, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Trauma Acute Care Surg 76:12-9; discussion 19-20. 2014
    ..We hypothesized that a combination of TBI and HS would disturb coagulation, damage the endothelium, and activate inflammatory and complement systems...
  14. ncbi Cognitive outcomes in elderly high-risk patients 1 year after off-pump versus on-pump coronary artery bypass grafting. A randomized trial
    Birte Østergaard Jensen
    Department of Cardio Thoracic Surgery, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Cardiothorac Surg 34:1016-21. 2008
    ..Coronary artery bypass grafting (CABG) without the use of cardiopulmonary bypass is considered to be less harmful to the patient, especially in terms of neurological complications...
  15. ncbi Hemodynamic differences between propofol-remifentanil and sevoflurane anesthesia for repair of cleft lip and palate in infants
    Jacob Steinmetz
    Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Copenhagen, Denmark
    Paediatr Anaesth 17:32-7. 2007
    ..We aimed at comparing the hemodynamic effects of propofol-remifentanil vs sevoflurane-fentanyl anesthesia. In addition, we sought to investigate recovery and whether remifentanil induced acute opioid tolerance...
  16. doi Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, the Department of Anesthesia and TraumaCenter 3193, Centre for Head and Orthopedic, and the Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research, CETIR, University of Texas Medical School at Houston, Houston, Texas
    Transfusion 53:3088-99. 2013
    ..Hemorrhage accounts for most preventable trauma deaths, but still the optimal strategy for hemostatic resuscitation remains debated...
  17. ncbi Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial
    Christian S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesth Analg 115:849-54. 2012
    ..In this follow-up study of the PROXI trial we assessed the association between long-term mortality and perioperative oxygen fraction in patients undergoing abdominal surgery...
  18. ncbi Disseminating cardiopulmonary resuscitation training by distributing 35,000 personal manikins among school children
    Dan L Isbye
    Department of Anesthesia, Section 4231, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Circulation 116:1380-5. 2007
    ..The aim of this study was to evaluate the effect of mass distribution of CPR instructional materials among schoolchildren...
  19. doi Voice advisory manikin versus instructor facilitated training in cardiopulmonary resuscitation
    Dan L Isbye
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Resuscitation 79:73-81. 2008
    ..It has been suggested to replace instructor facilitated (IF) training with an automated voice advisory manikin (VAM), which increases skill level by continuous verbal feedback during individual training...
  20. ncbi Depth of anaesthesia and post-operative cognitive dysfunction
    J Steinmetz
    Department of Anaesthesia, Centre of Head and Orthopaedics, University Hospital of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:162-8. 2010
    ..The purpose of the present study was to assess the possible effect of the level of anaesthesia on post-operative cognitive dysfunction (POCD) 1 week after surgery, as assessed by a neuropsychological test battery...
  21. doi Thrombelastography and rotational thromboelastometry early amplitudes in 182 trauma patients with clinical suspicion of severe injury
    Anna Sina P Meyer
    From the Section for Transfusion Medicine A S P M, M A S M, M B H, s r o, P I J, Capital Region Blood Bank, The Trauma Centre A M S, Centre of Head and Orthopaedics, and Department of Anaesthesia A M S, L S R, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Surgery A S P M, M A S M, J H B, B A C, C E W, P I J, Center for Translational Injury Research CeTIR, University of Texas Medical School at Houston, Houston, Texas
    J Trauma Acute Care Surg 76:682-90. 2014
    ..Viscoelastic hemostatic assays may provide means for earlier detection of trauma-induced coagulopathy (TIC)...
  22. doi Delirium in the fast-track surgery setting
    Lene Krenk
    Rigshospitalet, Section of Surgical Pathophysiology, The Lundbeck Centre for Fast track Hip and Knee Arthroplasty, Copenhagen O, Denmark
    Best Pract Res Clin Anaesthesiol 26:345-53. 2012
    ..In conclusion, the fast-track methodology may reduce the incidence of postoperative cognitive decline after surgery...
  23. doi In-hospital mortality pattern of severely injured children
    Hien Quoc Do
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Injury 43:2060-4. 2012
    ..The aim of this study was to describe the mortality pattern of severely injured children admitted to a Danish level I trauma centre...
  24. doi Rational use of oxygen in medical disease and anesthesia
    Christian S Meyhoff
    Department of Anaesthesiology, Copenhagen University Hospital, Herlev, Denmark
    Curr Opin Anaesthesiol 25:363-70. 2012
    ..The aim of this article is to review the recent findings regarding benefits and harms of oxygen therapy in anesthesia and acute medical conditions...
  25. doi The impact of therapeutic hypothermia on neurological function and quality of life after cardiac arrest
    John Bro-Jeppesen
    Department of Cardiology, The Heart Centre, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Resuscitation 80:171-6. 2009
    ..To assess the impact of therapeutic hypothermia on cognitive function and quality of life in comatose survivors of out of Hospital Cardiac arrest (OHCA)...
  26. ncbi Health-related quality of life following off-pump versus on-pump coronary artery bypass grafting in elderly moderate to high-risk patients: a randomized trial
    Birte Østergaard Jensen
    Department of Cardiothoracic Surgery, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Section 9441, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Cardiothorac Surg 30:294-9. 2006
    ..Patient-reported health-related quality of life has not been significantly different. We compared health-related quality of life in elderly moderate to high-risk patients randomized to either off-pump or on-pump surgery...
  27. ncbi Anesthesia for the patient with dementia
    Kamilia S Funder
    Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Alzheimers Dis 22:129-34. 2010
    ..This review reflects on both general considerations concerning geriatric patients but also on the specific features of perioperatively used drugs and anesthetics that might have an impact on patients with Alzheimer's disease (AD)...
  28. ncbi A helicopter emergency medical service may allow faster access to highly specialised care
    Monika Afzali
    Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet
    Dan Med J 60:A4647. 2013
    ..The aim of this study was to describe activity and possible beneficial effect of a physician-staffed helicopter in a one-year trial period in eastern Denmark...
  29. ncbi Platelet aggregation following trauma: a prospective study
    Nis A Windeløv
    aDepartment of Anaesthesia bTrauma Centre, Centre of Head and Orthopaedics, cDepartment of Intensive Care, The Abdominal Centre dDepartment of Cardiothoracic Anaesthesia and Intensive Care, The Heart Centre eSection for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark fDepartment of Surgery, Centre for Translational Injury Research, University of Texas Medical School, Houston, Texas, USA
    Blood Coagul Fibrinolysis 25:67-73. 2014
    ..01). We concluded there was no simple relationship between platelet aggregation and injury severity. Our results indicate that high platelet aggregation values are associated with fatality of cerebral injury. ..
  30. pmc How does extracerebral trauma affect the clinical value of S100B measurements?
    Søren Ohrt-Nissen
    Department of Orthopaedic Surgery, Rigshospitalet, University of Copenhagen, Denmark
    Emerg Med J 28:941-4. 2011
    ..The primary aim was to assess if a significant difference in serum levels of S100B could be found between IHI and MTHI patients...
  31. doi Inspiratory oxygen fraction and postoperative complications in obese patients: a subgroup analysis of the PROXI trial
    Anne K Staehr
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesthesiology 114:1313-9. 2011
    ..Our aim was to evaluate the effect of a high inspiratory oxygen fraction (80%) on SSI and pulmonary complications in obese patients undergoing laparotomy...
  32. ncbi Cognitive outcomes in elderly high-risk patients after off-pump versus conventional coronary artery bypass grafting: a randomized trial
    Birte Ostergaard Jensen
    Department of Cardiothoracic Surgery, The Heart Center, Copenhagen University Hospital, Section 9441, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Circulation 113:2790-5. 2006
    ..However, evidence for this statement is preliminary, and additional insight is needed...
  33. doi Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion
    Martin Sillesen
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Surgery 154:197-205. 2013
    ....
  34. doi Patients' experience of awake versus anaesthetised orotracheal intubation: a controlled study
    Didde T Schnack
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Anaesthesiol 28:438-42. 2011
    ....
  35. ncbi Methodological issues of postoperative cognitive dysfunction research
    Kamilia S Funder
    Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Semin Cardiothorac Vasc Anesth 14:119-22. 2010
    ..Issues, such as baseline performance, learning effects, and the interval between test sessions, also influence test results and must be considered when designing and interpreting POCD data...
  36. doi Should dosing of rocuronium in obese patients be based on ideal or corrected body weight?
    Christian S Meyhoff
    Department of Anaesthesia, Section 4231, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesth Analg 109:787-92. 2009
    ..In this study, we compared onset time, conditions for tracheal intubation, and duration of action in obese patients when the intubation dose of rocuronium was based on three different weight corrections...
  37. ncbi Long-term survival after out-of-hospital cardiac arrest
    Nana G Holler
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Resuscitation 75:23-8. 2007
    ..The purpose of this study was to assess the long-term survival after OHCA...
  38. ncbi Is peri-operative cortisol secretion related to post-operative cognitive dysfunction?
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 49:1225-31. 2005
    ..We hypothesized that the incidence of POCD would be related to changes in cortisol level...
  39. ncbi Trauma-induced coagulopathy: standard coagulation tests, biomarkers of coagulopathy, and endothelial damage in patients with traumatic brain injury
    Gustav Folmer Genét
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Neurotrauma 30:301-6. 2013
    ..The coagulopathy identified thus reflected the severity of injury rather than its localization...
  40. pmc Influence of perioperative oxygen fraction on pulmonary function after abdominal surgery: a randomized controlled trial
    Anne K Staehr
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark
    BMC Res Notes 5:383. 2012
    ..Our aim was to assess if a high FiO2 is associated with impaired oxygenation and decreased pulmonary functional residual capacity (FRC)...
  41. doi Short-term practice effects and variability in cognitive testing in a healthy elderly population
    Lene Krenk
    Section of Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Denmark
    Exp Gerontol 47:432-6. 2012
    ..The aim of this study was to collect cognitive test results with repeated testing in an elderly healthy population...
  42. ncbi Cerebral blood flow and cognitive dysfunction after coronary surgery
    Hanne Abildstrom
    Department of Anesthesia, Rigshospitalet, Copenhagen University Hospital, Denmark
    Ann Thorac Surg 73:1174-8; discussion 1178-9. 2002
    ..We investigated whether cognitive dysfunction after coronary surgery is associated with changes in regional cerebral blood flow (CBF) using single photon emission computed tomography...
  43. doi Anaesthesia for the patient with dementia undergoing outpatient surgery
    Kamilia S Funder
    Department of Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Curr Opin Anaesthesiol 22:712-7. 2009
    ..The aim of this article is to highlight some of the most important perioperative issues relating to demented patients, both regarding anaesthesia and other aspects that should be considered to ensure a quick and uncomplicated recovery...
  44. ncbi Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery
    Hanne Abildstrom
    Department of Anesthesia 4132, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Anesthesiology 101:855-61. 2004
    ..The authors hypothesized that patients with the epsilon4 allele would have an increased risk of postoperative cognitive dysfunction (POCD) after noncardiac surgery...
  45. ncbi Skill retention in adults and in children 3 months after basic life support training using a simple personal resuscitation manikin
    Dan L Isbye
    Department of Anaesthesia, Section 4231, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Resuscitation 74:296-302. 2007
    ..Teaching BLS in public schools has been recommended to achieve this...
  46. ncbi The use of bispectral index monitoring in education - a tool to improve nurse-anaesthetists practice
    Jakob I Vedtofte
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark
    J Adv Nurs 59:577-82. 2007
    ..This paper is a report of a study to investigate whether monitoring depth of anaesthesia by bispectral index would reduce recovery time and consumption of anaesthetic drugs in anaesthetics performed by student nurse-anaesthetists...
  47. ncbi Long-term prognosis after out-of-hospital cardiac arrest
    Tina I Horsted
    Department of Anaesthesia, Centre of Head and Orthopaedics 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Resuscitation 72:214-8. 2007
    ..In this study we aimed to report survival beyond 6 months, including quality of life, for patients after out-of-hospital cardiac arrest (OHCA) with a physician-based EMS in an urban area...
  48. ncbi Long-term consequences of postoperative cognitive dysfunction
    Jacob Steinmetz
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesthesiology 110:548-55. 2009
    ..Postoperative cognitive dysfunction (POCD) is common in elderly patients after noncardiac surgery, but the consequences are unknown. The authors' aim was to determine the effects of POCD on long-term prognosis...
  49. ncbi Cognitive dysfunction after cardiovascular surgery
    K S Funder
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Minerva Anestesiol 75:329-32. 2009
    ..A highly sensitive neuropsychological test battery must be used to detect POCD and a well-matched control group is very useful for the analysis and interpretation of the test..
  50. ncbi Biphasic cardiac output changes during onset of spinal anaesthesia in elderly patients
    C S Meyhoff
    Copenhagen University Hospital, Centre of Head and Orthopaedics, Department of Anaesthesia, Rigshospitalet, Denmark
    Eur J Anaesthesiol 24:770-5. 2007
    ..The aim of this study was to demonstrate cardiac output changes with high time-resolution during onset of spinal anaesthesia in elderly patients...
  51. ncbi Inter-observer agreement of tests used for prediction of difficult laryngoscopy/tracheal intubation
    C Rosenstock
    Academic Department of Anaesthesia Department of Anaesthesia and Intensive Care, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 49:1057-62. 2005
    ..We determined the inter-observer agreement of the specific test combinations included in SARI as well as of the total score...
  52. ncbi Choice reaction time in patients with post-operative cognitive dysfunction
    J Steinmetz
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 52:95-8. 2008
    ..We hypothesized that CRT could be used as a screening tool for POCD...
  53. ncbi Residents lack knowledge and practical skills in handling the difficult airway
    C Rosenstock
    Academic Department of Anaesthesia, Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Acta Anaesthesiol Scand 48:1014-8. 2004
    ..We aimed at assessing Danish anaesthesia residents' knowledge and management of a standardized difficult airway situation in an advanced airway simulator. The reliability of the assessment was also determined...
  54. ncbi The former preterm infant and risk of post-operative apnoea: recommendations for management
    S Walther-Larsen
    Department of Anaesthesia, Section 4013 Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Acta Anaesthesiol Scand 50:888-93. 2006
    ..The risk of apnoea in former preterm infants can be further reduced by the administration of intravenous caffeine (10 mg/kg). All of these patients should be referred to a tertiary centre for anaesthesia and surgery...
  55. ncbi Biochemical markers for brain damage after cardiac surgery -- time profile and correlation with cognitive dysfunction
    L S Rasmussen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 46:547-51. 2002
    ..The aim of the study was to determine the optimal timing of blood sampling...
  56. ncbi Cognitive dysfunction 1-2 years after non-cardiac surgery in the elderly. ISPOCD group. International Study of Post-Operative Cognitive Dysfunction
    H Abildstrom
    Department of Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Denmark
    Acta Anaesthesiol Scand 44:1246-51. 2000
    ..We recently showed that POCD was present in 9.9% of elderly patients 3 months after major non-cardiac surgery. The aim of the present study was to investigate whether POCD persists for 1-2 years after operation...
  57. doi Paediatric airway management: basic aspects
    R J Holm-Knudsen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 53:1-9. 2009
    ..A slightly different technique during laryngoscopy is suggested. The treatment of airway oedema and laryngospasm is described...
  58. ncbi Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil
    C S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 53:369-75. 2009
    ..We hypothesized that depth of anaesthesia monitoring would reduce recovery time and use of anaesthetics in obese patients receiving propofol and remifentanil...
  59. ncbi Qualitative analysis of unanticipated difficult airway management
    C Rosenstock
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 50:290-7. 2006
    ..Anaesthesiologists' opinions, as well as environmental factors of importance for DAM proficiency, were also assessed...
  60. doi Is air transport of stroke patients faster than ground transport? A prospective controlled observational study
    Rasmus Hesselfeldt
    Department of Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Emerg Med J 31:268-72. 2014
    ..Helicopters are widely used for interhospital transfers of stroke patients, but the benefit is sparsely documented. We hypothesised that helicopter transport would reduce system delay to thrombolytic treatment at the regional stroke centre...
  61. ncbi Implementation of a physician-staffed helicopter: impact on time to primary PCI
    Rasmus Hesselfeldt
    Departments of Anaesthesia, Centre of Head and Orthopaedics, and Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark
    EuroIntervention 9:477-83. 2013
    ..This study aimed to compare air (AIR) and ground transport (GRD) of STEMI patients bound for primary percutaneous coronary intervention (pPCI)...
  62. ncbi Risk factors for 48-hours mortality after prehospital treatment of opioid overdose
    Sine Wichmann
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Emerg Med J 30:223-5. 2013
    ..The authors describe the short-term outcome and identify risk factors for death within 48 h after prehospital treatment of opioid overdose in Copenhagen, the capital of Denmark...
  63. doi Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage
    Martin Sillesen
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Trauma Acute Care Surg 74:1252-9. 2013
    ..We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers...
  64. doi Emergency airway access in children--transtracheal cannulas and tracheotomy assessed in a porcine model
    Rolf J Holm-Knudsen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Copenhagen, Denmark
    Paediatr Anaesth 22:1159-65. 2012
    ..In the rare scenario when it is impossible to oxygenate or intubate a child, no evidence exists on what strategy to follow...
  65. ncbi Is it possible to predict hypotension during onset of spinal anesthesia in elderly patients?
    Christian S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Anesth 21:23-9. 2009
    ..To evaluate the sensitivity and specificity of various predictors of hypotension during onset of spinal anesthesia in elderly patients...
  66. doi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
    ..To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma...
  67. ncbi Resuscitation, prolonged cardiac arrest, and an automated chest compression device
    Martin Risom
    Department of Anaesthesia, Centre of Head and Orthopaedics, Section 4231, Copenhagen University Hospital, Copenhagen, Denmark
    J Emerg Med 38:481-3. 2010
    ..The European Resuscitation Council's 2005 guidelines for cardiopulmonary resuscitation (CPR) emphasize the delivery of uninterrupted chest compressions of adequate depth during cardiac arrest...
  68. ncbi [Cognitive deterioration after surgery]
    Jacob Steinmetz
    Anaestesi og Operationsklinikken, HovedOrtoCentret 4231, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 170:4032-4. 2008
    ..Mortality is higher among patients with cognitive dysfunction than among patients without such dysfunction...
  69. doi New insights into the pathophysiology of postoperative cognitive dysfunction
    L Krenk
    Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:951-6. 2010
    ..Potential prophylactic intervention may include minimal invasive surgery, multi-modal non-opioid pain management and pharmacological manipulation of the inflammatory response and sleep architecture...
  70. ncbi Evaluation of the airway of the SimMan full-scale patient simulator
    R Hesselfeldt
    Department of Anesthesia and Operating Theatre Services, Copenhagen University Hospital, Rigs hospitalet Copenhagen, Denmark
    Acta Anaesthesiol Scand 49:1339-45. 2005
    ..SimMan is a full-scale patient simulator, capable of simulating normal and pathological airways. The performance of SimMan has never been critically evaluated...
  71. doi Treatment of opioid overdose in a physician-based prehospital EMS: frequency and long-term prognosis
    Karina Nielsen
    Department of Anaesthesia, Centre of Head and Orthopaedics 4231, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Resuscitation 82:1410-3. 2011
    ....
  72. ncbi Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial
    Christian S Meyhoff
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    JAMA 302:1543-50. 2009
    ..Use of 80% oxygen during surgery has been suggested to reduce the risk of surgical wound infections, but this effect has not been consistently identified. The effect of 80% oxygen on pulmonary complications has not been well defined...
  73. ncbi Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction
    L S Rasmussen
    Department of Anaesthesia, Copenhagen University Hospital, Denmark
    Br J Anaesth 83:585-9. 1999
    ..01). The postoperative cognitive dysfunction we found in elderly patients after operation could not be explained by benzodiazepine concentrations detected in blood...
  74. ncbi A comparison of the AMBU ISCOPE and Macintosh laryngoscopes: first experience with a new device for tracheal intubation: a manikin study
    Anne G Vedel
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Anaesthesiol 30:175-9. 2013
    ..The new AMBU ISCOPE intubation device combines features from the laryngeal mask airway with video laryngoscopy enabling visual control of tracheal intubation without the use of a stylet...
  75. ncbi Using a nasopharyngeal airway during fiberoptic intubation in small children with a difficult airway
    Rolf Holm-Knudsen
    Department of Anaesthesia and Operating Theatre Services, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej, Copenhagen, Denmark
    Paediatr Anaesth 15:839-45. 2005
    ..A pediatric fiberscope is used to perform a nasotracheal intubation via the opposite nostril...
  76. ncbi Tetranectin in cerebrospinal fluid: biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF
    Birgitte Stoevring
    Department of Clinical Biochemistry, Statens Serum Institut, 5 Artillerivej, Copenhagen DK 2300 S, Denmark
    Clin Chim Acta 359:65-71. 2005
    ..The TN concentration in serum is approximately 10 mg/l and is reduced in patients with several cancers. The TN concentration in the normal CSF has not been examined...
  77. ncbi Long-term prognosis for patients with COPD treated in the prehospital setting: Is it influenced by hospital admission?
    Jacob Steinmetz
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Chest 130:676-80. 2006
    ..We specifically sought to examine whether mortality was different among patients released before hospital admission and those admitted to the hospital...
  78. ncbi Triage and mortality in 2875 consecutive trauma patients
    R Meisler
    Department of Anaesthesia, HOC 4231, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:218-23. 2010
    ..Most studies on trauma and trauma systems have been conducted in the United States. We aimed to describe the factors predicting mortality in European trauma patients, with focus on triage...
  79. ncbi Increasing compression depth during manikin CPR using a simple backboard
    L Ø Andersen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 51:747-50. 2007
    ..The aim of this study was to compare chest compression depth with and without a rigid backboard. The authors hypothesized that the presence of a backboard would result in an increased depth of chest compressions...
  80. ncbi Tetranectin in cerebrospinal fluid of patients with multiple sclerosis
    B Stoevring
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Scand J Clin Lab Invest 66:577-83. 2006
    ..The aim of this study was to determine the TN serum and cerebrospinal fluid (CSF) concentration in patients with multiple sclerosis (MS) and controls...
  81. ncbi Improved survival after an out-of-hospital cardiac arrest using new guidelines
    J Steinmetz
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 52:908-13. 2008
    ..An out-of-hospital cardiac arrest (OHCA) is associated with a poor prognosis. We hypothesized that the implementations of 2005 European Resuscitation Council resuscitation guidelines were associated with improved 30-day survival after OHCA...
  82. ncbi Prediction of post-operative pain by an electrical pain stimulus
    P R Nielsen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Acta Anaesthesiol Scand 51:582-6. 2007
    ..Our aim was to assess the predictive value of pre-caesarean section pain threshold on intensity of post-caesarean section pain using the PM...
  83. ncbi Postoperative cognitive dysfunction in patients with preoperative cognitive impairment: which domains are most vulnerable?
    Jeffrey H Silverstein
    Departments of Anesthesiology, Mount Sinai School of Medicine, New York, New York 10027 6574, USA
    Anesthesiology 106:431-5. 2007
    ....
  84. ncbi Postoperative cognitive dysfunction in middle-aged patients
    Tim Johnson
    Department of Anaesthesia, Hope Hospital, Salford, United Kingdom
    Anesthesiology 96:1351-7. 2002
    ....
  85. ncbi [The Danish Difficult Airway Registry and preoperative respiratory airway assessment]
    Charlotte Rosenstock
    Ugeskr Laeger 167:2543-4; author reply 2544. 2005
  86. ncbi Independent vascular and cognitive risk factors for postoperative delirium
    James L Rudolph
    Geriatric Research, Education, and Clinical Center, VA Boston Healthcare System, Boston, Mass 02130, USA lt
    Am J Med 120:807-13. 2007
    ..We hypothesized that vascular risk factors and mildly impaired cognitive performance would independently predispose nondemented patients to develop delirium after noncardiac surgery...