P Plenge

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Prophylactic efficacy of lithium administered every second day: a WHO multicentre study
    P Plenge
    Department of Pharmacology, University of Copenhagen, Denmark
    Bipolar Disord 1:109-16. 1999
  2. ncbi request reprint Pindolol and the acceleration of the antidepressant response
    Per Plenge
    Laboratory of Neuropsychiatry, Righospitalet 6102, DK 2100, Copenhagen, Denmark
    J Affect Disord 75:285-9. 2003
  3. ncbi request reprint Effects of white spirits on rat brain 5-HT receptor functions and synaptic remodeling
    H R Lam
    Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration, DK 2860 Søborg, Copenhagen, Denmark
    Neurotoxicol Teratol 23:603-8. 2001
  4. ncbi request reprint Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients
    E Mellerup
    Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark
    Acta Psychiatr Scand 103:229-33. 2001
  5. ncbi request reprint Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
    Per Plenge
    Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Rigshospitalet 6102, Blegdamsvej, DK 2100 Copenhagen, Denmark
    Eur J Pharmacol 567:1-9. 2007
  6. ncbi request reprint High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions
    Per Plenge
    Department of Pharmacology, Laboratory of Neuropsychiatry, Rigshospitalet 6102, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neurosci Lett 383:203-8. 2005
  7. ncbi request reprint Characterization of an allosteric citalopram-binding site at the serotonin transporter
    Fenghua Chen
    Laboratory of Molecular Neurobiology, Department of Biological Psychiatry, Aarhus Psychiatric University Hospital, Risskov, Denmark
    J Neurochem 92:21-8. 2005
  8. ncbi request reprint The serotonin transporter and 5HT2A receptor in rat brain after localized lesions
    Henrik Dam
    Department of Psychiatry, H S Rigshospitalet, Copenhagen, Denmark
    Neurol Res 29:717-22. 2007
  9. ncbi request reprint Serotonin, locomotion, exploration, and place recall in the rat
    Jesper Mogensen
    Department of Psychology, University of Copenhagen, Amager, Njalsgade 88, DK 2300 Copenhagen S, Denmark
    Pharmacol Biochem Behav 75:381-95. 2003
  10. ncbi request reprint Characterization of epibatidine binding to medial habenula: potential role in analgesia
    Per Plenge
    Laboratory of Neuropsychiatry, University Hospital, Rigshospitalet 6102, DK 2100 Copenhagen, Denmark
    J Pharmacol Exp Ther 302:759-65. 2002

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Prophylactic efficacy of lithium administered every second day: a WHO multicentre study
    P Plenge
    Department of Pharmacology, University of Copenhagen, Denmark
    Bipolar Disord 1:109-16. 1999
    ..To study the prophylactic efficacy of lithium administered every second day to patients with bipolar disorder or recurrent unipolar depressive disorder...
  2. ncbi request reprint Pindolol and the acceleration of the antidepressant response
    Per Plenge
    Laboratory of Neuropsychiatry, Righospitalet 6102, DK 2100, Copenhagen, Denmark
    J Affect Disord 75:285-9. 2003
    ..Some studies, most using paroxetine, show an acceleration of the antidepressant response, whereas studies with other SSRIs find no marked latency reduction...
  3. ncbi request reprint Effects of white spirits on rat brain 5-HT receptor functions and synaptic remodeling
    H R Lam
    Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration, DK 2860 Søborg, Copenhagen, Denmark
    Neurotoxicol Teratol 23:603-8. 2001
    ..The affected 5-HT receptor expression and synaptic plasticity marker proteins indicate that inhalation exposure to high concentrations of white spirit may be neurotoxic to rats, especially the aromatic white spirit type...
  4. ncbi request reprint Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients
    E Mellerup
    Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark
    Acta Psychiatr Scand 103:229-33. 2001
    ....
  5. ncbi request reprint Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites
    Per Plenge
    Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Rigshospitalet 6102, Blegdamsvej, DK 2100 Copenhagen, Denmark
    Eur J Pharmacol 567:1-9. 2007
    ..2: The allosteric effects of R-citalopram on the dissociation of [(3)H]-imipramine from hSERT indicate that R-citalopram introduces a conformational change in hSERT...
  6. ncbi request reprint High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions
    Per Plenge
    Department of Pharmacology, Laboratory of Neuropsychiatry, Rigshospitalet 6102, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neurosci Lett 383:203-8. 2005
    ..g., Q562A). It is concluded that the allosteric binding site is independent of the high-affinity-binding site; it may therefore represent a new drug target...
  7. ncbi request reprint Characterization of an allosteric citalopram-binding site at the serotonin transporter
    Fenghua Chen
    Laboratory of Molecular Neurobiology, Department of Biological Psychiatry, Aarhus Psychiatric University Hospital, Risskov, Denmark
    J Neurochem 92:21-8. 2005
    ..A species-scanning mutagenesis study comparing human and bovine SERT revealed that Met180, Tyr495 and Ser513 are important residues in mediating the allosteric effect, as well as contributing to high-affinity binding at the primary site...
  8. ncbi request reprint The serotonin transporter and 5HT2A receptor in rat brain after localized lesions
    Henrik Dam
    Department of Psychiatry, H S Rigshospitalet, Copenhagen, Denmark
    Neurol Res 29:717-22. 2007
    ..The purpose of the present study was to examine whether serotonin transporter density or 5HT2A serotonin receptor density is changed in specific brain areas following anterior or posterior lesions in the two hemispheres...
  9. ncbi request reprint Serotonin, locomotion, exploration, and place recall in the rat
    Jesper Mogensen
    Department of Psychology, University of Copenhagen, Amager, Njalsgade 88, DK 2300 Copenhagen S, Denmark
    Pharmacol Biochem Behav 75:381-95. 2003
    ..At 14 days postsurgery, the 5,7-DHT-treated animals demonstrated an impaired habituation of the exploratory behaviour...
  10. ncbi request reprint Characterization of epibatidine binding to medial habenula: potential role in analgesia
    Per Plenge
    Laboratory of Neuropsychiatry, University Hospital, Rigshospitalet 6102, DK 2100 Copenhagen, Denmark
    J Pharmacol Exp Ther 302:759-65. 2002
    ..This leads us to suggest that the medial habenular epibatidine binding site might be a valuable target for the development of non-opiate analgesics...
  11. ncbi request reprint Binding characteristics of the 5-HT2A receptor antagonists altanserin and MDL 100907
    Heidi Kristiansen
    Neurobiology Research Unit, University Hospital Rigshospitalet, Copenhagen, Denmark
    Synapse 58:249-57. 2005
    ..Overall, the binding of [(18)F]altanserin and [(3)H]MDL 100907 to the 5-HT(2A) receptor was very comparable, showing selective high affinity binding in the subnanomolar range...
  12. ncbi request reprint Associative and nonassociative learning after chronic imipramine in rats
    Jesper Mogensen
    Department of Psychology, University of Copenhagen, Amager, Njalsgade 88, DK 2300, Copenhagen S, Denmark
    Pharmacol Biochem Behav 76:197-212. 2003
    ....