Anders Perner

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
  2. ncbi Red blood cell transfusion during septic shock in the ICU
    A Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 56:718-23. 2012
  3. ncbi [Septic shock in intensive care]
    Anders Perner
    Intensiv Terapiklinik 4131, Rigshospitalet, DK 2100 København Ø, Denmark
    Ugeskr Laeger 172:1206-10. 2010
  4. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
  5. ncbi [Maximal engagement. Working at an Australian national university hospital]
    Anders Perner
    Rigshospitalet, Abdominalcentret, Intensiv Terapiklinik 4131
    Ugeskr Laeger 169:4466-8. 2007
  6. pmc Attitudes to drug trials among relatives of unconscious intensive care patients
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    BMC Anesthesiol 10:6. 2010
  7. doi Central venous oxygen saturation for the diagnosis of low cardiac output in septic shock patients
    A Perner
    Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:98-102. 2010
  8. doi Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, the Department of Anesthesia and TraumaCenter 3193, Centre for Head and Orthopedic, and the Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research, CETIR, University of Texas Medical School at Houston, Houston, Texas
    Transfusion 53:3088-99. 2013
  9. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
  10. doi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012

Collaborators

Detail Information

Publications44

  1. doi Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    N Engl J Med 367:124-34. 2012
    ..Hydroxyethyl starch (HES) [corrected] is widely used for fluid resuscitation in intensive care units (ICUs), but its safety and efficacy have not been established in patients with severe sepsis...
  2. ncbi Red blood cell transfusion during septic shock in the ICU
    A Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 56:718-23. 2012
    ..Our aim was to evaluate RBC transfusion practice in septic shock in the intensive care unit (ICU), and patient characteristics and outcome associated with RBC transfusion...
  3. ncbi [Septic shock in intensive care]
    Anders Perner
    Intensiv Terapiklinik 4131, Rigshospitalet, DK 2100 København Ø, Denmark
    Ugeskr Laeger 172:1206-10. 2010
    ..Patients in septic shock have a 33-42% 30-day mortality, but characteristics and outcome have not been assessed in Danish intensive care units (ICUs)...
  4. pmc Comparing the effect of hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis (6S--Scandinavian Starch for Severe Sepsis/Septic Shock trial): study protocol, design and rationale for
    Anders Perner
    Department of Intensive Care, Centre of Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 12:24. 2011
    ..Now lower molecular weight HES 130/0.4 is the preferred colloid in Scandinavian intensive care units (ICUs) and 1st choice fluid for patients with severe sepsis. However, HES 130/0.4 is largely unstudied in patients with severe sepsis...
  5. ncbi [Maximal engagement. Working at an Australian national university hospital]
    Anders Perner
    Rigshospitalet, Abdominalcentret, Intensiv Terapiklinik 4131
    Ugeskr Laeger 169:4466-8. 2007
  6. pmc Attitudes to drug trials among relatives of unconscious intensive care patients
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    BMC Anesthesiol 10:6. 2010
    ..In many countries relatives are asked to consent on behalf of ICU patients prior to inclusion in clinical trials. However, the attitudes to drug trials among relatives of unconscious ICU patients are largely unknown...
  7. doi Central venous oxygen saturation for the diagnosis of low cardiac output in septic shock patients
    A Perner
    Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:98-102. 2010
    ..We assessed the diagnostic value of central venous oxygen saturation in the superior vena cava (ScvO(2)) for detecting low cardiac output in patients with septic shock...
  8. doi Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, the Department of Anesthesia and TraumaCenter 3193, Centre for Head and Orthopedic, and the Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research, CETIR, University of Texas Medical School at Houston, Houston, Texas
    Transfusion 53:3088-99. 2013
    ..Hemorrhage accounts for most preventable trauma deaths, but still the optimal strategy for hemostatic resuscitation remains debated...
  9. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
    ..However, benefit and harm of RBCs have not been established in this group of high-risk patients...
  10. doi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012
    ....
  11. pmc High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Scand J Trauma Resusc Emerg Med 20:27. 2012
    ..Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome...
  12. ncbi Bleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark
    Intensive Care Med 39:2126-34. 2013
    ..We aimed to characterize the degree and clinical importance of bleeding in patients treated with hydroxyethyl starch (HES)...
  13. doi Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Crit Care 28:317.e1-11. 2013
    ..The aim of this study was to assess associations between consecutive thrombelastography (TEG) profiles and standard coagulation tests and disease severity and mortality in patients with severe sepsis...
  14. ncbi Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate
    Anders Perner
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, 2100, Copenhagen, Denmark
    Intensive Care Med 40:927-34. 2014
    ..We assessed long-term mortality and hospitalisation in patients with severe sepsis resuscitated with hydroxyethyl starch (HES) or Ringer's acetate...
  15. ncbi Effects of hydroxyethyl starch in subgroups of patients with severe sepsis: exploratory post-hoc analyses of a randomised trial
    Rasmus G Müller
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen, Denmark
    Intensive Care Med 39:1963-71. 2013
    ..It has been speculated that certain subgroups of sepsis patients may benefit from treatment with hydroxyethyl starch (HES) 130/0.42, specifically in the earlier resuscitation of patients with more severely impaired circulation...
  16. doi Hydroxyethyl starch for resuscitation
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Curr Opin Crit Care 19:321-5. 2013
    ..Resuscitation with hydroxyethyl starch (HES) is controversial. In this review, we will present the current evidence for the use of HES solutions including data from recent high-quality randomized clinical trials...
  17. ncbi Platelet aggregation following trauma: a prospective study
    Nis A Windeløv
    aDepartment of Anaesthesia bTrauma Centre, Centre of Head and Orthopaedics, cDepartment of Intensive Care, The Abdominal Centre dDepartment of Cardiothoracic Anaesthesia and Intensive Care, The Heart Centre eSection for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark fDepartment of Surgery, Centre for Translational Injury Research, University of Texas Medical School, Houston, Texas, USA
    Blood Coagul Fibrinolysis 25:67-73. 2014
    ..01). We concluded there was no simple relationship between platelet aggregation and injury severity. Our results indicate that high platelet aggregation values are associated with fatality of cerebral injury. ..
  18. ncbi High dosage of dextran 70 is associated with severe bleeding in patients admitted to the intensive care unit for septic shock
    Lisa Nebelin Hvidt
    Intensiv Terapiklinik, Abdominalcentret, Rigshospitalet, Copenhagen, Denmark
    Dan Med J 59:A4531. 2012
    ..As practice has changed, we performed a before-and-after study of fluid resuscitation and outcome in patients with septic shock...
  19. pmc Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 346:f839. 2013
    ..To assess the effects of fluid therapy with hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin on mortality, kidney injury, bleeding, and serious adverse events in patients with sepsis...
  20. doi Provision of protein and energy in relation to measured requirements in intensive care patients
    Matilde Jo Allingstrup
    Department of Intensive Care 4131, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Clin Nutr 31:462-8. 2012
    ..Adequacy of nutritional support in intensive care patients is still a matter of investigation. This study aimed to relate mortality to provision, measured requirements and balances for energy and protein in ICU patients...
  21. ncbi The majority of patients in septic shock are transfused with fresh-frozen plasma
    Nanna Reiter
    Intensive Care Unit, Rigshospitalet, 2100 Copenhagen, Denmark
    Dan Med J 60:A4606. 2013
    ..Fresh-frozen plasma (FFP) transfusion may be widely used in patients in septic shock, but the use is not well-described. Our aim was to describe the current use of FFP transfusion in medical patients with septic shock...
  22. pmc Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort
    Ragnhild G Rosland
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Scand J Trauma Resusc Emerg Med 22:14. 2014
    ..Treating anaemia with red blood cell (RBC) transfusion is frequent, but controversial, in patients with septic shock. Therefore we assessed characteristics and outcome associated with RBC transfusion in this group of high risk patients...
  23. doi Perioperative treatment of patients with sepsis
    Michael Ibsen
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Curr Opin Anaesthesiol 26:348-53. 2013
    ..This review will primarily discuss fluid, vasopressor and antibiotic therapy because these have been the subject of the recent large clinical trials...
  24. doi Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality
    Pär I Johansson
    Department of Clinical Immunology, and Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 21:168-74. 2010
    ..Hypocoagulability is an independent risk factor for 30-day mortality...
  25. ncbi Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration
    Nis A Windeløv
    Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark
    Blood Coagul Fibrinolysis 21:414-9. 2010
    ..Despite this, a trend towards lower mortality was observed in the PGI(2) group suggesting beneficial effects of PGI(2) administration in ICU patients undergoing CRRT...
  26. doi Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock
    Jesper B Poulsen
    Department of Intensive Care, the Section for Surgical Pathophysiology, Rigshospitalet, University Hospital of Copenhagen, and the Laboratory of Biological Anthropology, Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark
    Crit Care Med 39:456-61. 2011
    ..Intensive care unit admission is associated with muscle wasting and impaired physical function. We investigated the effect of early transcutaneous electrical muscle stimulation on quadriceps muscle volume in patients with septic shock...
  27. doi Incidence, staff awareness and mortality of patients at risk on general wards
    Lone Fuhrmann
    Danish Institute for Medical Simulation, Herlev Hospital, Capital Region of Copenhagen, Denmark
    Resuscitation 77:325-30. 2008
    ..The aim of this study was to estimate the incidence, staff awareness and subsequent mortality of patients with abnormal vital signs on general wards in a Danish university hospital...
  28. ncbi [Observation of critically ill patients]
    Lone Fuhrmann
    Dansk Institut for Medicinsk Simulation, Herlev Hospital, DK 2730 Herlev
    Ugeskr Laeger 171:502-6. 2009
    ....
  29. ncbi Association between sympathoadrenal activation, fibrinolysis, and endothelial damage in septic patients: A prospective study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research CeTIR, University of Texas Medical School at Houston, TX, USA Electronic address
    J Crit Care 29:327-33. 2014
    ..The purpose of this study is to investigate potential associations between sympathoadrenal activation and/or vasopressor/inotropic therapy and endothelial activation, damage, and coagulopathy in septic patients...
  30. pmc Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
    ..This study investigated the prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker profiles...
  31. ncbi Data from clinical database on septic shock are valid
    Lars Grønlykke
    Department of Intensive Care, Rigshospitalet, Denmark
    Dan Med J 59:A4522. 2012
    ..The purpose of this study was to evaluate the reliability and accuracy of a clinical database on intensive care unit (ICU) patients...
  32. doi Biomechanical and nonfunctional assessment of physical capacity in male ICU survivors
    Jesper B Poulsen
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Crit Care Med 41:93-101. 2013
    ..The underlying mechanisms responsible for this muscle function impairment are undescribed. The aim of this study was to describe the biomechanical properties of the quadriceps muscle in ICU survivors 12 months after ICU discharge...
  33. pmc Central venous oxygen saturation in septic shock--a marker of cardiac output, microvascular shunting and/or dysoxia?
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:184. 2011
    ....
  34. ncbi [Critical care research]
    Anders Perner
    Rigshospitalet, Abdominalcentret, Intensiv Terapiklinik 4131, København Ø
    Ugeskr Laeger 169:677-9. 2007
    ..Clinicians, researchers, public officials and politicians at all levels must work together towards this aim...
  35. ncbi [Early identification and treatment of cardiovascular failure in severe sepsis]
    Nicolai Haase
    Intensiv Terapiklinik 4131, Rigshospitalet, Blegdamsvej 9, DK 2100 København Ø, Denmark
    Ugeskr Laeger 172:210-4. 2010
    ..The treatment involves focus control, broad-spectrum antibiotics, target-oriented fluid therapy and vasopressor and inotropic agents guided by frequent reassessments of the patient's response to treatment...
  36. ncbi Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury
    Cecilie Heerdegen Jepsen
    From the Department of Surgery C H J, M A D, M S, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts Capital Region Blood Bank C H J, M S, s r o, P I J and Department of Intensive Care A P, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery H B A, University of Michigan, Ann Arbor, Michigan and Department of Surgery P I J, University of Texas Medical School at Houston, Houston, Texas
    J Trauma Acute Care Surg 77:292-7. 2014
    ..We further hypothesized that VPA treatment would reduce this response and reduce lesion size volume...
  37. ncbi Variable assessment of the circulation in intensive care unit patients with shock
    Louise Inkeri Hennings
    Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark
    Dan Med J 60:A4676. 2013
    ..This study describes current clinical practice regarding circulatory assessment in ICU patients with shock...
  38. pmc Consecutive daily measurements of luminal concentrations of lactate in the rectum in septic shock patients
    Michael Ibsen
    Intensive CareUnit 4131, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Crit Care Res Pract 2012:504096. 2012
    ..Conclusion. There was no change in the concentration of lactate in the rectal lumen over time in patients with septic shock. Also, there was no difference between nonsurvivors and survivors...
  39. ncbi [Convalescence and decline in physical function level following intensive therapy]
    Jesper B Poulsen
    Intensiv Terapi Afsnit 4131, Abdominalcenteret, Rigshospitalet, DK 2100 København Ø, Denmark
    Ugeskr Laeger 171:2916-9. 2009
    ..This review describes the most common predisposing factors and discusses preventative measures and interventions...
  40. ncbi Acceptable long-term outcome in elderly intensive care unit patients
    Morten A Schrøder
    Intensive Care Unit, 4131, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark
    Dan Med Bull 58:A4297. 2011
    ..The number of elderly intensive care unit (ICU) patients is increasing. We therefore assessed the long-term outcome in the elderly following intensive care...
  41. pmc Is hydroxyethyl starch 130/0.4 safe?
    Nicolai Haase
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 16:116. 2012
    ....
  42. doi Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
    Mette Krag
    Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Intensive Care Med 40:11-22. 2014
    ....
  43. ncbi Increased colorectal permeability in patients with severe sepsis and septic shock
    Vibeke L Jørgensen
    Department of Anaesthesia and Intensive Care, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Intensive Care Med 32:1790-6. 2006
    ..To develop a method for the assessment of colorectal permeability in septic patients...
  44. ncbi [Synthetic colloid to intensive care patients--SAFE?]
    Anders Perner
    Ugeskr Laeger 168:2265-6. 2006