Bente K Pedersen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 88:1379-406. 2008
  2. ncbi Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
    Charlotte Keller
    Department of Infectious Disease, Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Appl Physiol (1985) 99:2075-9. 2005
  3. doi Muscle as a secretory organ
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark
    Compr Physiol 3:1337-62. 2013
  4. ncbi Myokines in myogenesis and health
    Tora Henriksen
    Centre of Inflammation and Metabolism Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Recent Pat Biotechnol 6:167-71. 2012
  5. doi Muscles, exercise and obesity: skeletal muscle as a secretory organ
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Section 7641, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Nat Rev Endocrinol 8:457-65. 2012
  6. doi Muscular interleukin-6 and its role as an energy sensor
    Bente Klarlund Pedersen
    The Centre of Inflammation and Metabolism at the Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    Med Sci Sports Exerc 44:392-6. 2012
  7. pmc Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
    Ronan Mg Berg
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Crit Care 14:R16. 2010
  8. ncbi Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 102:814-6. 2007
  9. ncbi Evidence for prescribing exercise as therapy in chronic disease
    B K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Copenhagen, Denmark
    Scand J Med Sci Sports 16:3-63. 2006
  10. ncbi [Fitness, physical activity and death from all causes]
    Bente Klarlund Pedersen
    H S Rigshospitalet, Center for Inflammation og Metabolisme, Epidemiklinikken og Center for Muskelforskning, og Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
    Ugeskr Laeger 168:137-44. 2006

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. doi Muscle as an endocrine organ: focus on muscle-derived interleukin-6
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 88:1379-406. 2008
    ..This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease...
  2. ncbi Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle
    Charlotte Keller
    Department of Infectious Disease, Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Appl Physiol (1985) 99:2075-9. 2005
    ..However, after the training period, IL-6R mRNA production was increased in skeletal muscle, suggesting a sensitization of skeletal muscle to IL-6 at rest...
  3. doi Muscle as a secretory organ
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark
    Compr Physiol 3:1337-62. 2013
    ..Many proteins produced by skeletal muscle are dependent upon contraction. Therefore, it is likely that myokines may contribute in the mediation of the health benefits of exercise...
  4. ncbi Myokines in myogenesis and health
    Tora Henriksen
    Centre of Inflammation and Metabolism Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Recent Pat Biotechnol 6:167-71. 2012
    ....
  5. doi Muscles, exercise and obesity: skeletal muscle as a secretory organ
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Section 7641, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Nat Rev Endocrinol 8:457-65. 2012
    ....
  6. doi Muscular interleukin-6 and its role as an energy sensor
    Bente Klarlund Pedersen
    The Centre of Inflammation and Metabolism at the Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    Med Sci Sports Exerc 44:392-6. 2012
    ....
  7. pmc Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans
    Ronan Mg Berg
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Crit Care 14:R16. 2010
    ..We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation...
  8. ncbi Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
    Bente K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 102:814-6. 2007
  9. ncbi Evidence for prescribing exercise as therapy in chronic disease
    B K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Copenhagen, Denmark
    Scand J Med Sci Sports 16:3-63. 2006
    ..The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications...
  10. ncbi [Fitness, physical activity and death from all causes]
    Bente Klarlund Pedersen
    H S Rigshospitalet, Center for Inflammation og Metabolisme, Epidemiklinikken og Center for Muskelforskning, og Københavns Universitet, Det Sundhedsvidenskabelige Fakultet
    Ugeskr Laeger 168:137-44. 2006
    ..Furthermore, there is evidence for a dose-response effect of physical activity. It is concluded that regular physical activity has health-beneficial effects which are beyond its effect on weight control...
  11. ncbi Role of myokines in exercise and metabolism
    Bente Klarlund Pedersen
    Centre of Inflammation and Metabolism, 7641 Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 103:1093-8. 2007
    ..The present review focuses on muscle-derived cytokines, their regulation by exercise, and their possible roles in metabolism and skeletal muscle function and it discusses which cytokines should be classified as true myokines...
  12. ncbi Muscle-derived interleukin-6--a possible link between skeletal muscle, adipose tissue, liver, and brain
    Bente Klarlund Pedersen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Brain Behav Immun 19:371-6. 2005
    ..Here, we review the literature on muscle- and brain-derived IL-6. We further suggest that myokines may also provide an explanation as to how regular muscle activity influences mood, performance, and cognitive function...
  13. ncbi The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Proc Nutr Soc 63:263-7. 2004
    ..Thus, it is suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines could be termed 'myokines'...
  14. ncbi [Rather fat and fit than thin and boring]
    Bente Klarlund Pedersen
    Epidemiklinik M 7641, Finsencentret, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 165:4947-50. 2003
  15. ncbi Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans
    Rikke Krogh-Madsen
    Professor of Internal Medicine, Dept of Infectious Diseases 7641, Univ Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 286:E766-72. 2004
    ....
  16. ncbi Searching for the exercise factor: is IL-6 a candidate?
    B K Pedersen
    The Copenhagen Muscle Research Centre, Copenhagen, Denmark
    J Muscle Res Cell Motil 24:113-9. 2003
    ..We propose that IL-6 and other cytokines, which are produced and released by skeletal muscles, exerting their effects in other organs of the body, should be named 'myokines'...
  17. ncbi The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control
    Bente Klarlund Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Faculty of Health Sciences, Denmark
    Essays Biochem 42:105-17. 2006
    ..Myokines may be involved in mediating the beneficial health effects against chronic diseases associated with low-grade inflammation such as diabetes and cardiovascular diseases...
  18. ncbi Beneficial health effects of exercise--the role of IL-6 as a myokine
    Bente K Pedersen
    Department of Infectious Diseases and Copenhagen Muscle Research Centre CMRC, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, Faculty of Health Sciences, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Trends Pharmacol Sci 28:152-6. 2007
    ..Newly identified myokines and their receptors could serve as targets in the treatment of metabolic disorders and other diseases...
  19. ncbi Body mass index-independent effect of fitness and physical activity for all-cause mortality
    B K Pedersen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 17:196-204. 2007
    ..Furthermore, there is evidence for a dose-response effect of physical activity. In conclusion, regular exercise has health-promoting effects, which are beyond its effect on weight control...
  20. doi Exercise-induced myokines and their role in chronic diseases
    Bente K Pedersen
    Department of Infectious Diseases, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Brain Behav Immun 25:811-6. 2011
    ..Other myokines work locally within the muscle via paracrine mechanisms, exerting their effects on signalling pathways involved in fat oxidation...
  21. doi Muscles and their myokines
    Bente Klarlund Pedersen
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Exp Biol 214:337-46. 2011
    ..It has been suggested that myokines may contribute to exercise-induced protection against several chronic diseases...
  22. pmc Calprotectin--a novel marker of obesity
    Ole Hartvig Mortensen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e7419. 2009
    ..We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes...
  23. pmc The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk
    Bente K Pedersen
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Physiol 587:5559-68. 2009
    ..Other myokines work locally within the muscle via paracrine mechanisms, exerting their effects on signalling pathways involved in fat oxidation...
  24. doi Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals
    Bente K Pedersen
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Exp Physiol 94:1153-60. 2009
    ..Brain-derived neurotrophic factor is likely to mediate some of the beneficial effects of exercise with regard to protection against dementia and type 2 diabetes...
  25. doi Edward F. Adolph distinguished lecture: muscle as an endocrine organ: IL-6 and other myokines
    Bente K Pedersen
    The Centre of Inflammation and Metabolism at the Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 107:1006-14. 2009
    ..Thus the myokine field provides a conceptual basis for the molecular mechanisms underlying, e.g., muscle-fat, muscle-liver, muscle-pancreas, and muscle-brain cross talk...
  26. pmc Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle
    Christa Broholm
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Tagensvej 20, DK 2100, Copenhagen, Denmark
    J Physiol 586:2195-201. 2008
    ....
  27. ncbi IL-6 signalling in exercise and disease
    B K Pedersen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Biochem Soc Trans 35:1295-7. 2007
    ..We suggest that IL-6 and other muscle-derived cytokines (myokines) may play a role in defending Type 2 diabetes...
  28. ncbi Physiological roles of muscle-derived interleukin-6 in response to exercise
    Bente K Pedersen
    Centre of Inflammation and Metabolism at the Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Curr Opin Clin Nutr Metab Care 10:265-71. 2007
    ..To discuss recent findings with regard to the regulation of muscle-derived interleukin-6 as well as the possible physiological and metabolic roles of interleukin-6 in response to exercise...
  29. ncbi Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects
    Bente Klarlund Pedersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Pflugers Arch 446:9-16. 2003
    ..Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise..
  30. ncbi Exercise and hypoxia: effects on leukocytes and interleukin-6-shared mechanisms?
    Bente Klarlund Pedersen
    Department of Infectious Diseases M7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Med Sci Sports Exerc 34:2004-13. 2002
    ..However, the only modest increase in IL-6 during hypoxia may be linked to hormonal changes, whereas the prolonged increase in IL-6 during chronic hypoxia is likely to be multifactorial...
  31. ncbi Training and natural immunity: effects of diets rich in fat or carbohydrate
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases M7721, Rigshospitalet, Denmark
    Eur J Appl Physiol 82:98-102. 2000
    ....
  32. ncbi Exercise and the immune system: regulation, integration, and adaptation
    B K Pedersen
    Department of Infectious Diseases and Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 80:1055-81. 2000
    ..Accordingly, drawing on the experimental, clinical, and epidemiological literature, we address the interactions between exercise and infectious diseases as well as exercise and neoplasia within the context of both aging and nutrition...
  33. ncbi Exercise and immune function: effect of ageing and nutrition
    B K Pedersen
    Copenhagen Muscle Research Centre, Denmark
    Proc Nutr Soc 58:733-42. 1999
    ..In conclusion, it is premature to make recommendations regarding nutritional supplementation to avoid post-exercise impairment of the immune system...
  34. ncbi Chemokines are elevated in plasma after strenuous exercise in humans
    K Ostrowski
    Department of Infectious Diseases M7721, Rigshospitalet, 2200 Kbh N, Denmark
    Eur J Appl Physiol 84:244-5. 2001
    ..7-fold, 3.5-fold and 4.1-fold increased, respectively. The elevated concentrations of chemokines in plasma after exercise could have implications for HIV-infected individuals; a possibility that needs further investigation...
  35. pmc Effects of exercise on lymphocytes and cytokines
    B K Pedersen
    The Copenhagen Muscle Research Centre and Department of Infectious Diseases Rigshospitalet, University of Copenhagen, Denmark
    Br J Sports Med 34:246-51. 2000
    ..To review results on exercise induced changes in the immune system following strenuous and moderate exercise...
  36. pmc Muscle-derived interleukin-6: possible biological effects
    B K Pedersen
    The Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    J Physiol 536:329-37. 2001
    ..The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis...
  37. ncbi Exercise and interleukin-6
    B K Pedersen
    The Copenhagen Muscle Research Center, Rigshospitalet, Denmark
    Curr Opin Hematol 8:137-41. 2001
    ..These facts indicate that IL-6 may represent an important link between contracting skeletal muscles and exercise-related metabolic changes...
  38. ncbi Exercise and cytokines with particular focus on muscle-derived IL-6
    B K Pedersen
    Copenhagen Muscle Research Center, Department of Infectious Diseases, University of Copenhagen, Denmark
    Exerc Immunol Rev 7:18-31. 2001
    ..This indicates that IL-6 may represent an important link between contracting skeletal muscles and exercise-related metabolic changes...
  39. ncbi Special feature for the Olympics: effects of exercise on the immune system: exercise and cytokines
    B K Pedersen
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark
    Immunol Cell Biol 78:532-5. 2000
    ....
  40. ncbi [Cytokines in internal medicine--relation to insulin resistance and exercise]
    Bente Klarlund Pedersen
    Epidemiklinikken 7641, Finsencentret, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 164:2166-71. 2002
  41. ncbi The cytokine response to strenuous exercise
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    Can J Physiol Pharmacol 76:505-11. 1998
    ..The present review also discusses the possible roles of protein breakdown, delayed onset muscle soreness, and clinical implications of the acute-phase response following exercise...
  42. ncbi Cytokines in aging and exercise
    B K Pedersen
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    Int J Sports Med 21:S4-9. 2000
    ..Therefore, in future studies, exercise is suggested as an ethically applicable model to use in studies on mechanisms underlying the age-associated altered cytokine response...
  43. doi A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
    Rikke Krogh-Madsen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet Section 7641, Blegdamsvej 9, Faculty of Health Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 108:1034-40. 2010
    ..Reduced ambulatory activity for 2 wk in healthy, nonexercising young men significantly reduced peripheral insulin sensitivity, cardiovascular fitness, and lean leg mass...
  44. ncbi Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans
    Christian P Fischer
    Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 100:1679-87. 2006
    ..The results indicate that gamma-tocopherol comprises a potent inhibitor of the exercise-induced increase of HSP72 in skeletal muscle as well as in the circulation...
  45. doi Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training
    Christina Yfanti
    Rigshospitalet, Centre of Inflammation and Metabolism, 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 300:E761-70. 2011
    ..05 for all). Our results indicate that administration of antioxidants during strenuous endurance training has no effect on the training-induced increase in insulin sensitivity in healthy individuals...
  46. pmc Plasma YKL-40: a BMI-independent marker of type 2 diabetes
    Anders R Nielsen
    Department of InfectiousDiseases, Facultyof Health Sciences, Centre of Inflammation and Metabolism, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes 57:3078-82. 2008
    ..YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation. In the present study, YKL-40 was examined in relation to obesity, inflammation, and type 2 diabetes...
  47. doi Role of vitamin C and E supplementation on IL-6 in response to training
    Christina Yfanti
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 112:990-1000. 2012
    ..In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training...
  48. doi Antioxidant supplementation does not alter endurance training adaptation
    Christina Yfanti
    Center of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 42:1388-95. 2010
    ..However, RONS production may also activate redox-sensitive signaling pathways and transcription factors, which subsequently, may promote training adaptation...
  49. ncbi Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
    Rikke Krogh-Madsen
    Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E108-14. 2006
    ....
  50. ncbi Interleukin-6 stimulates lipolysis and fat oxidation in humans
    Gerrit van Hall
    Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3005-10. 2003
    ..In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia...
  51. ncbi Tumor necrosis factor-alpha modulates human in vivo lipolysis
    Peter Plomgaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:543-9. 2008
    ..Low-grade systemic inflammation is a feature of most lifestyle-related chronic diseases. Enhanced TNF-alpha concentrations have been implicated in the development of hyperlipidemia...
  52. pmc Glucose ingestion attenuates the exercise-induced increase in circulating heat shock protein 72 and heat shock protein 60 in humans
    Mark A Febbraio
    The Copenhagen Muscle Research Center, Copenhagen, Denmark
    Cell Stress Chaperones 9:390-6. 2004
    ..We detected neither hepatosplanchnic nor contracting limb Hsp60 release in either trial. In conclusion, maintaining glucose availability during exercise attenuates the circulating Hsp response in healthy humans...
  53. doi The role of leptin in human lipid and glucose metabolism: the effects of acute recombinant human leptin infusion in young healthy males
    Emil Wolsk
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Am J Clin Nutr 94:1533-44. 2011
    ..Obese and lean humans treated with leptin have not experienced convincing weight-loss results compared with the dramatic weight losses observed in obese rodents...
  54. ncbi Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    Maria Pedersen
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Mech Ageing Dev 124:495-502. 2003
    ..Furthermore, TNF-alpha was related to lower ASM and BCM, suggesting that TNF-alpha contributes to sarcopenia in ageing...
  55. ncbi Interleukin-6 production by contracting human skeletal muscle: autocrine regulation by IL-6
    Pernille Keller
    Department of Infectious Diseases, The Copenhagen Muscle Research Centre, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 3, 2100 DK, Denmark
    Biochem Biophys Res Commun 310:550-4. 2003
    ..During rhIL-6 infusion, IL-6 mRNA increased 120-fold in muscle (p<0.05). In conclusion, the present study demonstrates that muscle IL-6 is regulated by an autocrine mechanism at the transcriptional level...
  56. ncbi Leptin gene expression and systemic levels in healthy men: effect of exercise, carbohydrate, interleukin-6, and epinephrine
    Pernille Keller
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and The Copenhagen Muscle Research Center, Faculty of Health Sciences, University Hospital of Copenhagen, Denmark
    J Appl Physiol 98:1805-12. 2005
    ..The exercise-induced decrease in circulating leptin was counteracted by CHO ingestion, suggesting a posttranscriptional regulatory mechanism of leptin involving substrate availability...
  57. pmc The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial
    Kristian Karstoft
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 36:228-36. 2013
    ....
  58. ncbi Does the aging skeletal muscle maintain its endocrine function?
    Maria Pedersen
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Exerc Immunol Rev 10:42-55. 2004
    ....
  59. ncbi Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
    Peter Plomgaard
    Department of Infectious Diseases, Rigshopitalet University of Copenhagen, Denmark
    Diabetes 54:2939-45. 2005
    ..Thus, excessive concentrations of TNF-alpha negatively regulate insulin signaling and whole-body glucose uptake in humans. Our results provide a molecular link between low-grade systemic inflammation and the metabolic syndrome...
  60. pmc Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle
    Christian P Fischer
    Copenhagen Muscle Research Centre, Copenhagen, Denmark
    J Physiol 558:633-45. 2004
    ..In conclusion, our results show that supplementation with vitamins C and E attenuated the systemic IL-6 response to exercise primarily via inhibition of the IL-6 protein release from the contracting skeletal muscle per se...
  61. pmc Muscle specific microRNAs are regulated by endurance exercise in human skeletal muscle
    Søren Nielsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 588:4029-37. 2010
    ..In conclusion, our data suggest myomiRs respond to physiological stimuli, but their role in regulating human skeletal muscle adaptation remains unknown...
  62. doi IL-6 selectively stimulates fat metabolism in human skeletal muscle
    Emil Wolsk
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 299:E832-40. 2010
    ..Our findings suggest that an acute increase in IL-6 at a normophysiological level selectively stimulates lipolysis in skeletal muscle, whereas adipose tissue is unaffected...
  63. doi Human skeletal muscle releases leptin in vivo
    Emil Wolsk
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cytokine 60:667-73. 2012
    ..An understanding of the role that leptin plays in skeletal muscle metabolism may prove important in light of several late-phase trials with recombinant leptin as an anti-obesity drug...
  64. doi Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals
    Gerrit van Hall
    Copenhagen Muscle Research Centre, Rigshospitalet, 9 Blegdamsvej, Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:2851-8. 2008
    ..IL-6 is a key modulator of immune function and suggested to be involved in skeletal muscle wasting as seen in sepsis...
  65. ncbi Low-level viremia and proviral DNA impede immune reconstitution in HIV-1-infected patients receiving highly active antiretroviral therapy
    Sisse R Ostrowski
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Infect Dis 191:348-57. 2005
    ..Immunological and virological consequences of low-level viremia in human immunodeficiency virus (HIV) type 1-infected patients receiving highly active antiretroviral therapy (HAART) remain to be determined...
  66. ncbi A low level of CD4+CD28+ T cells is an independent predictor of high mortality in human immunodeficiency virus type 1-infected patients
    Sisse R Ostrowski
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Infect Dis 187:1726-34. 2003
    ..If our results are confirmed in other studies, coexpression of CD28 on CD4(+) cells may be a useful marker to evaluate HIV progression...
  67. ncbi Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen Ø, Denmark
    Diabetes 56:2070-7. 2007
    ..The increased glucose uptake may in part be explained by increased dephosphorylation of GS (site 3a + b), resulting in increased GS activity...
  68. doi IL-6, but not TNF-α, increases plasma YKL-40 in human subjects
    Anders R Nielsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cytokine 55:152-5. 2011
    ..The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation...
  69. doi Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia
    Anne Sofie Andreasen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University Hospital Rigshospitalet, Rigshospitalet M 7641, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Intensive Care Med 36:1548-55. 2010
    ..This may partly be due to immune dysfunction. We investigated the in vivo innate immune response of type 2 diabetic persons to an intravenous injection of E. coli lipopolysaccharide (LPS)...
  70. ncbi Cytokine response to eccentric exercise in young and elderly humans
    Anders Dyhr Toft
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Am J Physiol Cell Physiol 283:C289-95. 2002
    ..Our data also suggest that aging may be associated with impaired repair mechanisms for exercise-induced muscle damage...
  71. ncbi Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans
    Rikke Krogh-Madsen
    Rigshospitalet, Section 7641, Blegdamsvej 9, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 294:E371-9. 2008
    ..Short-term hyperlipidemia enhances the inflammatory response to endotoxin, and skeletal muscle and adipose tissue are capable of producing essential inflammatory mediators after endotoxin stimulation...
  72. ncbi IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle
    Adam Steensberg
    Copenhagen Muscle Research Centre and Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 283:E1272-8. 2002
    ..In contrast, IL-6 increased throughout exercise in arterial plasma, and a net IL-6 release from the contracting limb was observed after 120 min of exercise (P < 0.05)...
  73. doi Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
    Anders Rinnov Nielsen
    Department of Infectious Diseases Rigshospitalet, Centre of Inflammation and Metabolism, University of Copenhagen, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:4486-93. 2008
    ..IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass...
  74. pmc Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation
    Adam Steensberg
    The Copenhagen Muscle Research Centre and The Department of Infectious Diseases, Rigshospitalet, The University of Copenhagen, Copenhagen, Denmark
    J Physiol 541:273-81. 2002
    ..However, this is only the case when delivery of substrates and hormones remains constant. When delivery of substrates and hormones is altered, the potential effect of glycogen on glucose uptake is negated...
  75. doi Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Denmark
    Exp Physiol 94:1062-9. 2009
    ..These results suggest that the brain is a major but not the sole contributor to circulating BDNF. Moreover, the importance of the cortex and hippocampus as a source for plasma BDNF becomes even more prominent in response to exercise...
  76. ncbi Epinephrine infusion increases adipose interleukin-6 gene expression and systemic levels in humans
    Pernille Keller
    Dept of Infectious Diseases and the Copenhagen Muscle Research Center, Univ Hospital Rigshospitalet, Tagensvej 20, Copenhagen 2200 DK, Denmark
    J Appl Physiol (1985) 97:1309-12. 2004
    ..001). However, epinephrine did not affect the IL-6 receptor mRNA. In conclusion, epinephrine acutely increases IL-6 mRNA levels in subcutaneous adipose tissue as well as circulating IL-6 levels in healthy men...
  77. pmc Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans
    Mark A Febbraio
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, DK 2100, Copenhagen Ø, Denmark
    J Physiol 549:607-12. 2003
    ..05) glucose uptake and a reduced (P < 0.05) FFA uptake in GLU. These results demonstrate that glucose ingestion during exercise attenuates leg IL-6 release but does not decrease intramuscular expression of IL-6 mRNA...
  78. doi Brain-derived neurotrophic factor predicts mortality risk in older women
    Karen S Krabbe
    Center of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Geriatr Soc 57:1447-52. 2009
    ....
  79. ncbi Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans
    Christian P Fischer
    Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Clin Immunol 117:152-60. 2005
    ..014; CON: 25%, P = 0.003) after adjustment for confounders. Our results show that plasma IL-18 was associated with HOMA-IR independent of obesity and type 2 diabetes...
  80. ncbi The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Exp Physiol 89:271-7. 2004
    ..The results support the notion that the exercise-induced changes in brain metabolism are controlled by factors intrinsic to the brain...
  81. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  82. ncbi Muscle-derived interleukin-6: mechanisms for activation and possible biological roles
    Mark A Febbraio
    The Copenhagen Muscle Research Centre, The University of Copenhagen, Copenhagen, Denmark
    FASEB J 16:1335-47. 2002
    ..It may do so via local and/or systemic effects. This review also explores the efficacy that IL-6 may be used as a therapeutic drug in treating metabolic disorders such as obesity, type 2 diabetes, and atherosclerosis...
  83. ncbi Asymptomatic bacteriuria in elderly humans is associated with increased levels of circulating TNF receptors and elevated numbers of neutrophils
    Tine Krogstrup Priø
    Department of Infectious Diseases M7641, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 N Copenhagen, Denmark
    Exp Gerontol 37:693-9. 2002
    ..Thus, the present study provides some support for the hypothesis that asymptomatic urinary infections are associated with low-grade immune activity in frail, elderly humans...
  84. ncbi Skeletal muscle adaptation: training twice every second day vs. training once daily
    Anne K Hansen
    Dept of Infectious Diseases M7641, and The Copenhagen Muscle Research Centre, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Appl Physiol 98:93-9. 2005
    ..There was a more pronounced increase in citrate synthase activity when Low was compared with High. In conclusion, the present study suggests that training twice every second day may be superior to daily training...
  85. doi Skeletal muscle as an immunogenic organ
    Søren Nielsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Faculty of Health Sciences, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Curr Opin Pharmacol 8:346-51. 2008
    ..In the present review, we focus on the myokines interleukin (IL)-6, IL-8 and IL-15 and their possible anti-inflammatory, immunoregulatory and metabolic roles...
  86. doi Erythropoietin augments the cytokine response to acute endotoxin-induced inflammation in humans
    Pernille Hojman
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cytokine 45:154-7. 2009
    ..In contrast to our hypothesis, we find that EPO augments the acute inflammatory effect...
  87. pmc IL-6 gene expression in human adipose tissue in response to exercise--effect of carbohydrate ingestion
    Charlotte Keller
    Department of Infectious Diseases, Rigshospitalet, Denmark
    J Physiol 550:927-31. 2003
    ..15.6+/-2.4 pg ml(-1) in the CHO trial). In conclusion, exercise results in an increase in IL-6 gene expression in adipose tissue in response to exercise, an effect that is significantly blunted by ingestion of carbohydrate...
  88. ncbi The anti-inflammatory effect of exercise
    Anne Marie W Petersen
    Dept of Infectious Diseases, Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    J Appl Physiol 98:1154-62. 2005
    ....
  89. ncbi Cerebral blood flow and oxidative metabolism during human endotoxemia
    Kirsten Møller
    Department of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 22:1262-70. 2002
    ..Thus, high circulating levels of TNF-alpha during human endotoxemia do not induce a direct reduction in cerebral oxidative metabolism...
  90. pmc Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia
    Pernille Hojman
    Department of Infectious Diseases, Centre of Inflammation and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes 58:2797-801. 2009
    ..Recently, FGF-21 was shown to be expressed and secreted from murine muscle cells in response to insulin stimulation...
  91. pmc Calprotectin is released from human skeletal muscle tissue during exercise
    Ole Hartvig Mortensen
    Centre of Inflammation and Metabolism at Department of Infectious, Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    J Physiol 586:3551-62. 2008
    ..In conclusion, IL-6 infusion and muscle contractions induce expression of S100A8 and S100A9 in skeletal muscle. However, IL-6 alone is not a sufficient stimulus to facilitate release of calprotectin from skeletal muscle...
  92. ncbi Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
    Christopher MacDonald
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 95:2273-7. 2003
    ..Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. In addition, leg release of IL-6 cannot alone explain the increase in plasma IL-6 during exercise...
  93. ncbi High plasma levels of intact and cleaved soluble urokinase receptor reflect immune activation and are independent predictors of mortality in HIV-1-infected patients
    Sisse Rye Ostrowski
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, DK 2100 Denmark
    J Acquir Immune Defic Syndr 39:23-31. 2005
    ..This study investigated plasma levels of suPAR(I-III), suPAR(II-III), and 1-domain suPAR [suPAR(I)] and their predictive value for survival in HIV patients...
  94. ncbi Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle
    Christian P Fischer
    Dept of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, Section M7641, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E1189-94. 2004
    ..In conclusion, the magnitude of the exercise-induced IL-6 mRNA expression in contracting human skeletal muscle was markedly reduced by 10 wk of training...
  95. ncbi Low-dose endotoxemia and human neuropsychological functions
    Karen Suarez Krabbe
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
    Brain Behav Immun 19:453-60. 2005
    ..In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis...
  96. ncbi Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise
    Lone Frydelund-Larsen
    Centre of Inflammation and Metabolism, Rigshospitalet Section 7641, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E24-31. 2007
    ..The finding that exercise enhances subcutaneous adipose tissue visfatin mRNA expression suggests that visfatin has a local metabolic role in the recovery period following exercise...
  97. pmc Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes
    Henriette Pilegaard
    Copenhagen Muscle Research Centre, The August Krogh Institute, University of Copenhagen, Denmark
    J Physiol 541:261-71. 2002
    ....
  98. pmc The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases
    Claus Brandt
    The Centre of Inflammation and Metabolism, The Department of Infectious Diseases, Copenhagen Muscle Research Centre, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Biomed Biotechnol 2010:520258. 2010
    ..In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects...
  99. ncbi Fiber type specific expression of TNF-alpha, IL-6 and IL-18 in human skeletal muscles
    Peter Plomgaard
    Centre of Inflammation and Metabolism at The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    Exerc Immunol Rev 11:53-63. 2005
    ..The specificity of cytokine expression in different muscle fiber types in healthy young males suggests that cytokines may play specific regulatory roles in normal physiology...
  100. ncbi Skeletal muscle mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy and elevated p-lactate levels
    Birgit T Røge
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    AIDS 16:973-82. 2002
    ..To investigate the skeletal muscle mitochondrial function in HIV-infected patients with lipodystrophy or elevated p-lactate levels...
  101. ncbi Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men
    Helle Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Denmark
    J Nutr 133:1170-3. 2003
    ....