J Pedersen-Bjergaard

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi request reprint Genetics of therapy-related myelodysplasia and acute myeloid leukemia
    J Pedersen-Bjergaard
    Department of Clinical Genetics, The Cytogenetic Laboratory, Rigshospitalet, Copenhagen, Denmark
    Leukemia 22:240-8. 2008
  2. ncbi request reprint Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia
    J Pedersen-Bjergaard
    The Chromosome Laboratory, Section of Hematology Oncology, Department of Clinical Genetics, Juliane Marie Center, Copenhagen, Denmark
    Leukemia 20:1943-9. 2006
  3. ncbi request reprint Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents
    M K Andersen
    Cytogenetic Laboratory, Department of Clinical Genetics, Section of Hematology Oncology, The Juliane Marie Center, University Hospital, Copenhagen, Denmark
    Genes Chromosomes Cancer 31:33-41. 2001
  4. ncbi request reprint Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis
    D H Christiansen
    Section of Hematology and Oncology, Cytogenetic Laboratory, and Department of Clinical Genetics, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 19:1405-13. 2001
  5. ncbi request reprint Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia
    D H Christiansen
    Department of Clinical Genetics, Section of Hematology Oncology 4052, Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Leukemia 19:2232-40. 2005
  6. ncbi request reprint Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia
    D H Christiansen
    Section of Hematology Oncology, Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Center, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Leukemia 17:1813-9. 2003
  7. ncbi request reprint Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML
    M K Andersen
    Department of Clinical Genetics, Section of Hematology Oncology, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Leukemia 19:197-200. 2005
  8. ncbi request reprint Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992
    M K Andersen
    Cytogenetic Laboratory, Section of Haematology Oncology, Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark
    Br J Haematol 114:539-43. 2001
  9. ncbi request reprint Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related acute myeloid leukemia with a normal karyotype and are unrelated to type of previous therapy
    D H Christiansen
    Section of Hematology and Oncology, Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Centre, Section 4052, Rigshospitalet, Blegdamsvej 9, , Denmark
    Leukemia 15:1848-51. 2001
  10. ncbi request reprint Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities
    J Pedersen-Bjergaard
    Cytogenetic Laboratory, Section of Hematology Oncology, Department of Clinical Genetics, Juliane Marie Center, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Leukemia 16:2177-84. 2002

Collaborators

Detail Information

Publications15

  1. doi request reprint Genetics of therapy-related myelodysplasia and acute myeloid leukemia
    J Pedersen-Bjergaard
    Department of Clinical Genetics, The Cytogenetic Laboratory, Rigshospitalet, Copenhagen, Denmark
    Leukemia 22:240-8. 2008
    ..As de novo and t-MDS and t-AML are biologically identical diseases, they ought to be subclassified and treated similarly...
  2. ncbi request reprint Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia
    J Pedersen-Bjergaard
    The Chromosome Laboratory, Section of Hematology Oncology, Department of Clinical Genetics, Juliane Marie Center, Copenhagen, Denmark
    Leukemia 20:1943-9. 2006
    ....
  3. ncbi request reprint Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents
    M K Andersen
    Cytogenetic Laboratory, Department of Clinical Genetics, Section of Hematology Oncology, The Juliane Marie Center, University Hospital, Copenhagen, Denmark
    Genes Chromosomes Cancer 31:33-41. 2001
    ..These results support the existence of a specific genetic pathway in t-MDS and t-AML with many previously unidentified chromosome aberrations demonstrated to represent extra copies of parts of 11q, including the unrearranged MLL gene...
  4. ncbi request reprint Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis
    D H Christiansen
    Section of Hematology and Oncology, Cytogenetic Laboratory, and Department of Clinical Genetics, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 19:1405-13. 2001
    ..To study mutations and loss of heterozygosity (LOH) of p53 in therapy-related myelodysplasia (t-MDS) and acute myeloid leukemia (t-AML)...
  5. ncbi request reprint Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia
    D H Christiansen
    Department of Clinical Genetics, Section of Hematology Oncology 4052, Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Leukemia 19:2232-40. 2005
    ..046) suggesting their cooperation in leukemogenesis...
  6. ncbi request reprint Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia
    D H Christiansen
    Section of Hematology Oncology, Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Center, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Leukemia 17:1813-9. 2003
    ..Inactivation of p15 and deletion of genes on chromosome arm 7q possibly cooperate in leukemogenesis...
  7. ncbi request reprint Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML
    M K Andersen
    Department of Clinical Genetics, Section of Hematology Oncology, The Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Leukemia 19:197-200. 2005
    ..No point mutations of the AML1 gene were observed. The results support a pivotal role of impaired TP53 function in the development of gene amplification or duplication in t-MDS and t-AML...
  8. ncbi request reprint Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992
    M K Andersen
    Cytogenetic Laboratory, Section of Haematology Oncology, Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark
    Br J Haematol 114:539-43. 2001
    ....
  9. ncbi request reprint Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related acute myeloid leukemia with a normal karyotype and are unrelated to type of previous therapy
    D H Christiansen
    Section of Hematology and Oncology, Cytogenetic Laboratory, Department of Clinical Genetics, Juliane Marie Centre, Section 4052, Rigshospitalet, Blegdamsvej 9, , Denmark
    Leukemia 15:1848-51. 2001
    ..In conclusion, FLT3/ITD and MLL/ITD are mainly observed in uncharacteristic cases of t-AML with a normal karyotype and unrelated to previous therapy for which reason they could represent sporadic cases of de novoAML...
  10. ncbi request reprint Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities
    J Pedersen-Bjergaard
    Cytogenetic Laboratory, Section of Hematology Oncology, Department of Clinical Genetics, Juliane Marie Center, University Hospital, Rigshospitalet, Copenhagen, Denmark
    Leukemia 16:2177-84. 2002
    ..Current knowledge now makes it possible to distinguish between at least seven major genetic subgroups of MDS and AML, and has directed research towards more specific causative factors also for de novo MDS and AML...
  11. doi request reprint NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features
    M T Andersen
    Department of Clinical Genetics, Hematology Oncology Section 4052, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Leukemia 22:951-5. 2008
    ..The close association to class I mutations and the inverse association to class II mutations suggest mutations of NPM1 as representing a class II mutation-like abnormality in AML...
  12. ncbi request reprint BEAM+autologous stem cell transplantation in malignant lymphoma: 100 consecutive transplants in a single centre. Efficacy, toxicity and engraftment in relation to stem-cell source and previous treatment
    C H Geisler
    Department of Haematology, The Finsen Center, Rigshospitalet, Copenhagen, Denmark
    Eur J Haematol 61:173-82. 1998
    ..We confirm that high-dose therapy with autologous stem cell transplant from blood or bone marrow in not-too-heavily pretreated patients is a safe procedure but will cure only half the patients...
  13. ncbi request reprint High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer
    M Andersson
    Department of Oncology ONA, Finsen Institute Rigshospitalet, Copenhagen, Denmark
    Cancer 65:2460-4. 1990
    ..In the light of the above results, the authors caution against the use of intensive combination chemotherapy with alkylating agents as in the current study in potentially curable patients with breast cancer...
  14. ncbi request reprint Activating mutations of JAK2V617F are uncommon in t-MDS and t-AML and are only observed in atypic cases
    F Desta
    Leukemia 20:547-8. 2006
  15. pmc Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations
    G Nucifora
    Department of Medicine, University of Chicago, IL 60637
    Proc Natl Acad Sci U S A 91:4004-8. 1994
    ..The results indicate that translocations could involve multiple genes and affect gene expression over long distances...