Jes Olesen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Detoxification for medication overuse headache is the primary task
    Jes Olesen
    University of Copenhagen, Denmark
    Cephalalgia 32:420-2. 2012
  2. ncbi Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1
    Anne Francke Christensen
    Department of Neurology, Danish Headache Center, University of Copenhagen, Glostrup University Hospital, Nordre Ringvej 57, Glostrup, 2600, Copenhagen, Denmark
    J Headache Pain 13:21-7. 2012
  3. ncbi The economic cost of brain disorders in Europe
    J Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Eur J Neurol 19:155-62. 2012
  4. ncbi Collaboration to promote neurological research--the European Brain Council experience
    Jes Olesen
    Department of Neurology N39, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, Glostrup, Denmark
    Nat Clin Pract Neurol 3:298-9. 2007
  5. ncbi Funding of headache research in Europe
    J Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 27:995-9. 2007
  6. ncbi Cost of disorders of the brain in Denmark
    Jes Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Glostrup, Denmark
    Nord J Psychiatry 62:114-20. 2008
  7. ncbi The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
    Jes Olesen
    University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pharmacol Ther 120:157-71. 2008
  8. ncbi Origin of pain in migraine: evidence for peripheral sensitisation
    Jes Olesen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Lancet Neurol 8:679-90. 2009
  9. ncbi Proposals for new standardized general diagnostic criteria for the secondary headaches
    J Olesen
    Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 29:1331-6. 2009
  10. ncbi Nitric oxide-related drug targets in headache
    Jes Olesen
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Copenhagen, DK 2600 Denmark
    Neurotherapeutics 7:183-90. 2010

Collaborators

Detail Information

Publications91

  1. ncbi Detoxification for medication overuse headache is the primary task
    Jes Olesen
    University of Copenhagen, Denmark
    Cephalalgia 32:420-2. 2012
    ..Common practice in patients overusing medication is to place major emphasis on detoxification...
  2. ncbi Genotype-phenotype correlation in migraine without aura focusing on the rs1835740 variant on 8q22.1
    Anne Francke Christensen
    Department of Neurology, Danish Headache Center, University of Copenhagen, Glostrup University Hospital, Nordre Ringvej 57, Glostrup, 2600, Copenhagen, Denmark
    J Headache Pain 13:21-7. 2012
    ..Comparison of carriers with non-carriers showed no significant difference in any of the parameters studied. In conclusion, the rs1835740 variant has no significant influence on the clinical expression of MO...
  3. ncbi The economic cost of brain disorders in Europe
    J Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Eur J Neurol 19:155-62. 2012
    ..This new report presents updated, more accurate, and comprehensive 2010 estimates for 30 European countries...
  4. ncbi Collaboration to promote neurological research--the European Brain Council experience
    Jes Olesen
    Department of Neurology N39, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, Glostrup, Denmark
    Nat Clin Pract Neurol 3:298-9. 2007
  5. ncbi Funding of headache research in Europe
    J Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 27:995-9. 2007
    ..Considering the huge economic impact of these disorders, public funding of research into migraine and other headaches should be greatly increased in the future...
  6. ncbi Cost of disorders of the brain in Denmark
    Jes Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Glostrup, Denmark
    Nord J Psychiatry 62:114-20. 2008
    ..Expenses to brain diseases constituted 3% of the gross domestic product. Brain disorders are very prevalent in Denmark and they cause high societal and personal cost...
  7. ncbi The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
    Jes Olesen
    University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pharmacol Ther 120:157-71. 2008
    ..Indeed, selective n-NOS and i-NOS inhibitors are already in early clinical development...
  8. ncbi Origin of pain in migraine: evidence for peripheral sensitisation
    Jes Olesen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Lancet Neurol 8:679-90. 2009
    ..We suggest that migraine can be explained to patients as a disorder of the brain, and that the headache originates in the sensory fibres that convey pain signals from intracranial and extracranial blood vessels...
  9. ncbi Proposals for new standardized general diagnostic criteria for the secondary headaches
    J Olesen
    Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 29:1331-6. 2009
    ..We issue a plea to the headache community to use and study these proposed general criteria for the secondary headaches in order to provide more evidence for their utility-before their incorporation in the main body of the classification...
  10. ncbi Nitric oxide-related drug targets in headache
    Jes Olesen
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Copenhagen, DK 2600 Denmark
    Neurotherapeutics 7:183-90. 2010
    ..It is more unlikely that antagonism of cGMP or its formation will be feasible, but augmenting its breakdown via phosphodiesterase activation is a possibility, as well as other ways of inhibiting the NO-cGMP pathway...
  11. ncbi Emerging migraine treatments and drug targets
    Jes Olesen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Ndr Ringvej 57, DK 2600 Glostrup, Denmark
    Trends Pharmacol Sci 32:352-9. 2011
    ..The greatest need is for new prophylactic drugs, and it seems likely that such compounds will be developed in the coming decade...
  12. ncbi Molecular studies of BKCa channels in intracranial arteries: presence and localization
    Helle Wulf
    Department of Neurology and Danish Headache Centre, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 69, 2600, Glostrup, Denmark
    Cell Tissue Res 334:359-69. 2008
    ..The data thus suggest the presence and localization of both mRNA and protein expression of the BK(Ca) channel in the smooth muscle cell layer in rat basilar, middle cerebral, and middle meningeal arteries...
  13. ncbi PACAP38 induces migraine-like attacks in patients with migraine without aura
    Henrik Winther Schytz
    Department of Neurology, Faculty of Health Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Brain 132:16-25. 2009
    ..In migraine sufferers, PACAP38 caused delayed migraine-like attacks. The findings stimulate further investigation of the neuronal and vascular mechanisms of PACAP38...
  14. ncbi Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
    Faisal Mohammad Amin
    University of Copenhagen, Denmark
    Cephalalgia 32:140-9. 2012
    ....
  15. ncbi Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig
    Christina Kruuse
    Department of Clinical Experimental Research, Glostrup University Hospital, University of Copenhagen, Glostrup, Denmark
    Eur J Pharmacol 521:105-14. 2005
    ..Sildenafil in vitro is a poor dilator of guinea pig cerebral arteries unless a nitric oxide donor is co-administered, corresponding to the previous findings in vivo...
  16. ncbi BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation
    Kenneth A Petersen
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, KAS Glostrup, DK 2600 Glostrup, Denmark
    Clin Pharmacol Ther 77:202-13. 2005
    ..We investigated the ability of BIBN4096BS to inhibit human alphaCGRP (h-alphaCGRP)-induced headache and cerebral hemodynamic changes in healthy volunteers...
  17. ncbi PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system
    Lars S Kruse
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Nordre Ringvej 57, Glostrup, Denmark
    Brain Res 1281:25-34. 2009
    ..The functional implications are yet unknown, but their localisation indicates that they may have a role in the pain pathway of migraine as well as trigeminal neuralgia and trigeminal autonomic cephalalgias...
  18. ncbi K ATP channels in pig and human intracranial arteries
    Kenneth Beri Ploug
    Department of Neurology and Danish Headache Center, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur J Pharmacol 601:43-9. 2008
    ..Specific blocking of Kir6.1 or SUR2B K(ATP) channel subunits in large cerebral and meningeal arteries may be a future anti-migraine strategy...
  19. ncbi Molecular investigations of BK(Ca) channels and the modulatory beta-subunits in porcine basilar and middle cerebral arteries
    Helle Wulf
    Department of Neurology and Danish Headache Center, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
    J Mol Histol 40:87-97. 2009
    ..The mRNA transcript for beta1-, beta2- and beta4-subunit were shown by RT-PCR in porcine basilar and middle cerebral arteries. However, at the protein level, only, the beta1-subunit protein was found by western blotting...
  20. ncbi The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers
    Steffen Birk
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Regul Pept 140:185-91. 2007
    ..The marked increase in heart rate and the reduction in rCBF caused by decreased P(et)CO(2) are important dose-limiting factors to consider in future clinical studies...
  21. ncbi Effect of two novel CGRP-binding compounds in a closed cranial window rat model
    Louise Juhl
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, University of Copenhagen, DK 2600, Glostrup, Denmark
    Eur J Pharmacol 567:117-24. 2007
    ..05). In conclusion, the CGRP scavengers effectively inhibited the effect of circulating CGRP but do not modify the effect of electrical stimulation and the consequent liberation of CGRP from perivascular sensory nerve fibres...
  22. ncbi The phosphodiesterase 3 inhibitor cilostazol dilates large cerebral arteries in humans without affecting regional cerebral blood flow
    Steffen Birk
    Danish Headache Center and Department of Neurology, University of Copenhagen, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    J Cereb Blood Flow Metab 24:1352-8. 2004
    ..6 +/- 8.6% (P < 0.001 vs. baseline). Adverse events, especially headache, were common. The findings suggest that cilostazol is an interesting candidate for future clinical trials of delayed cerebral vasospasm...
  23. ncbi Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects
    Messoud Ashina
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 31:683-90. 2011
    ..Given that substances used in all these experiments were vasodilators we examined a possible correlation between headache scores and increases in arterial diameter...
  24. ncbi Prostaglandin E2 receptor expression in the rat trigeminal-vascular system and other brain structures involved in pain
    Maja Myren
    Danish Headache Center, Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Denmark
    Neurosci Lett 506:64-9. 2012
    ..In conclusion, all four receptors are located in areas implicated in migraine supporting the possible involvement of PGE(2) in this disease...
  25. ncbi Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate
    Ingelise Christiansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:215-20. 2008
    ..Due to a variety of other possible pain-inducing effects of nitric oxide our results do not exclude cerebral arteries...
  26. ncbi Neuronal fast activating and meningeal silent modulatory BK channel splice variants cloned from rat
    Asser Nyander Poulsen
    Department of Animal and Veterinary Basic Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, Frederiksberg C, Denmark
    Pflugers Arch 461:65-75. 2011
    ....
  27. ncbi Differential expression of BK channel isoforms and beta-subunits in rat neuro-vascular tissues
    Asser Nyander Poulsen
    Department of Physiology and Biochemistry, IBHV, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 7, 1870 Frederiksberg C, Denmark
    Biochim Biophys Acta 1788:380-9. 2009
    ..In conclusion a great number of splice variant and beta-subunit combinations likely exist, being differentially expressed among nervous and vascular tissues...
  28. ncbi Activation of PAR-2 elicits NO-dependent and CGRP-independent dilation of the dural artery
    Deepak K Bhatt
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    Headache 50:1017-30. 2010
    ..The goal of this study was to determine the vascular effects of protease-activated receptor-2 (PAR-2) activation in the rat cranial vasculature...
  29. ncbi No effect of pure oxygen inhalation on headache induced by glyceryl trinitrate
    Dorthe Daugaard
    Department of Neurology, Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    J Headache Pain 11:93-5. 2010
    ..Oxygen inhalation did not have effect on GTN-induced headache, most likely because the theoretical decrease in NO levels, due to faster metabolism of NO, is too small to be detected in the GTN headache model...
  30. ncbi Migraine can be induced by sildenafil without changes in middle cerebral artery diameter
    Christina Kruuse
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Brain 126:241-7. 2003
    ..However, other sites of action may also be possible and future studies are needed to elucidate this. In the clinical use of sildenafil, patients who have migraine should be informed about the risk of migraine attacks...
  31. ncbi mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system
    Dipak V Amrutkar
    Department of Neurology and Danish Headache Center, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
    Pain 153:830-8. 2012
    ..The 5-HT(1F) receptor agonist was effective only in peripheral terminals in dura mater, whereas the 5-HT(1D) agonist had a preferential effect on central terminals in the TNC...
  32. ncbi A naturalistic glyceryl trinitrate infusion migraine model in the rat
    Roshni Ramachandran
    University of Copenhagen, Denmark
    Cephalalgia 32:73-84. 2012
    ..Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose...
  33. ncbi Pharmacological characterization and expression of VIP and PACAP receptors in isolated cranial arteries of the rat
    Michael Baun
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Eur J Pharmacol 670:186-94. 2011
    ..In conclusion, migraine-like headache induced by PACAP-38 infusion is unlikely to be caused by direct vasodilator action on intracranial vessels...
  34. ncbi Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine
    Maja Myren
    Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 30:1110-22. 2010
    ....
  35. ncbi Nitric oxide synthase (NOS) in the trigeminal vascular system and other brain structures related to pain in rats
    Roshni Ramachandran
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Science, University of Copenhagen, Ndr Ringvej 69, DK 2600, Glostrup, Denmark
    Neurosci Lett 484:192-6. 2010
    ..The same pattern of expression was also observed with the eNOS protein. In conclusion, we found both nNOS and eNOS located to areas relevant to migraine supporting the involvement of NO in migraine mechanisms...
  36. ncbi Role of K ATP channels in cephalic vasodilatation induced by calcitonin gene-related peptide, nitric oxide, and transcranial electrical stimulation in the rat
    Aydin Gozalov
    Danish Headache Center and Department of Neurology, Faculty of Life Sciences, University of Copenhagen, Denmark
    Headache 48:1202-13. 2008
    ..The objective of this study was to explore the role of K(ATP) channels in vasodilatation induced by calcitonin gene-related peptide (CGRP), nitric oxide (NO), and transcranial electrical stimulation (TES) in intracranial arteries of rat...
  37. ncbi Presence and vascular pharmacology of KATP channel subtypes in rat central and peripheral tissues
    Kenneth Beri Ploug
    Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur J Pharmacol 637:109-17. 2010
    ..However, a SUR2B blocker may not discriminate between cranial and peripheral arteries...
  38. ncbi Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system
    Maja Myren
    Danish Headache Center, Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Denmark
    Vascul Pharmacol 55:50-8. 2011
    ..Together, these results demonstrate that the IP receptor mediates the dilatory effect of PGI(2) in the cranial vasculature in rats. Antagonism of this receptor might be of therapeutic relevance in acute migraine treatment...
  39. ncbi Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study
    Faisal Mohammad Amin
    Danish Headache Center and Department of Neurology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Lancet Neurol 12:454-61. 2013
    ..To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura...
  40. ncbi Effect of CGRP and sumatriptan on the BOLD response in visual cortex
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Faculty of Health Sciences, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, Glostrup, 2600 Copenhagen, Denmark
    J Headache Pain 13:159-66. 2012
    ..98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier...
  41. ncbi The in vivo effect of adrenomedullin on rat dural and pial arteries
    Louise Juhl
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Eur J Pharmacol 538:101-7. 2006
    ..In conclusion, we suggest that adrenomedullin in the rat cranial circulation dilates dural and pial arteries, reduces mean arterial blood pressure and increases LCBF(Flux), probably via a CGRP1-receptor...
  42. ncbi The pharmacological effect of BGC20-1531, a novel prostanoid EP4 receptor antagonist, in the prostaglandin E2 human model of headache
    Maria Antonova
    Danish Headache Center and Department of Neurology, Faculty of Health Sciences, Glostrup Hospital, University of Copenhagen, Ndr Ringvej 67, Glostrup, Denmark
    J Headache Pain 12:551-9. 2011
    ..In conclusion, these data suggest that the other EP receptors may be involved in PGE(2) induced headache and dilatation in normal subjects...
  43. ncbi Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries
    Steffen Birk
    Department of Clinical Experimental Research, University of Copenhagen, Glostrup University Hospital, Glostrup, Copenhagen 2600, Denmark
    Eur J Pharmacol 489:93-100. 2004
    ..This suggests that phosphodiesterase 3 inhibitors are still effective under conditions with possible dysfunctional nitric oxide-cGMP pathway, such as in ischemic stroke or cerebral vasospasm...
  44. ncbi Pharmacological and molecular comparison of K(ATP) channels in rat basilar and middle cerebral arteries
    Kenneth Beri Ploug
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Eur J Pharmacol 553:254-62. 2006
    ..Furthermore, the results indicate that Kir6.1/SUR2B is the major K(ATP) channel complex in rat basilar and middle cerebral arteries...
  45. ncbi Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38
    Michael Baun
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 32:337-45. 2012
    ..In the present study we examine the hypothesis that PACAP-38 and its truncated version PACAP-27 but not VIP cause degranulation of mast cells in peritoneum and in dura mater...
  46. ncbi Pro-inflammatory and vasoconstricting prostanoid PGF2α causes no headache in man
    Maria Antonova
    University of Copenhagen, Denmark
    Cephalalgia 31:1532-41. 2011
    ....
  47. ncbi Evidence for CGRP re-uptake in rat dura mater encephali
    Saurabh Gupta
    Department of Neurology, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Science, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Br J Pharmacol 161:1885-98. 2010
    ..Such release may be a mechanism underlying migraine headache. Based on data from guinea pig basilar artery preparations, we have here studied CGRP release and uptake in an organ preparation of the hemisected rat skull...
  48. ncbi Coexisting typical migraine in familial hemiplegic migraine
    Jakob Møller Hansen
    Danish Headache Center and Department of Neurology N01, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Neurology 74:594-600. 2010
    ....
  49. ncbi Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat
    Kenneth A Petersen
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Denmark
    Br J Pharmacol 143:697-704. 2004
    ..The CGRP induced increase in LCBF(Flux) was similar not prevented by the antagonist. We suggest that systemic BIBN4096BS exerts its inhibitory action mainly on large dural blood vessels (MMA)...
  50. ncbi Discrepancy between strong cephalic arterial dilatation and mild headache caused by prostaglandin D₂ (PGD₂)
    Troels Wienecke
    Danish Headache Centre and Department ofNeurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Glostrup, Copenhagen, Denmark
    Cephalalgia 31:65-76. 2011
    ..Prostaglandins (PGs) are involved in nociception and mast cell degranulation. Prostaglandin D₂ (PGD₂) is a vasodilatator released during mast cell degranulation. The headache-eliciting effect of PGD₂ has not been studied in man...
  51. ncbi No release of interstitial glutamate in experimental human model of muscle pain
    Messoud Ashina
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Eur J Pain 9:337-43. 2005
    ..05). In conclusion, the present study demonstrates no signs of increased release of glutamate from myofascial nociceptors during and after acute experimentally induced muscle pain and tenderness...
  52. ncbi A dose-response study of nitric oxide synthase inhibition in different vascular beds in man
    Lisbeth Hjorth Lassen
    Danish Headache Center, Department of Neurology, Glostrup University Hospital, 2600 Glostrup, Denmark
    Eur J Clin Pharmacol 59:499-505. 2003
    ..The present study was performed to evaluate the dose-response relation of L-NMMA to improve the design and interpretation of studies in migraine sufferers and other diseases...
  53. ncbi Sources of variability of resting cerebral blood flow in healthy subjects: a study using (133)Xe SPECT measurements
    Otto M Henriksen
    1 Functional Imaging Unit, Department of Diagnostics, Glostrup University Hospital, Glostrup, Denmark 2 Section of Clinical Physiology and Nuclear Medicine, Department of Diagnostics, Glostrup University Hospital, Glostrup, Denmark 3 Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Cereb Blood Flow Metab 33:787-92. 2013
    ..This implies that a large fraction of CBF variability may be due to unknown factors such as differences in neuron density or metabolism that could be subject for further studies...
  54. ncbi Taking the negative view of current migraine treatments: the unmet needs
    Peer Tfelt-Hansen
    Danish Headache Center, Health Science Faculty, University of Copenhagen, Department of Neurology, Glostrup Hospital, Glostrup, Denmark
    CNS Drugs 26:375-82. 2012
    ..For prophylactic migraine drugs there is an even greater need for new drugs than for acute drug treatment...
  55. ncbi Association between migraine, lifestyle and socioeconomic factors: a population-based cross-sectional study
    Han Le
    Department of Neurology, The Danish Headache Centre, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
    J Headache Pain 12:157-72. 2011
    ..Most associations such as low education and employment status were probably due to the negative effects of having migraine while others such as smoking were risk factors for migraine...
  56. ncbi Cutaneous nociception and neurogenic inflammation evoked by PACAP38 and VIP
    Henrik Winther Schytz
    Department of Neurology, Faculty of Health Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup 2600, Copenhagen, Denmark
    J Headache Pain 11:309-16. 2010
    ..This suggests that acute pain and vasomotor responses following intradermal injections of PACAP38 and VIP are primarily mediated by VPAC receptors...
  57. ncbi Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
    ..Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra- and intracranial vessels in migraine without aura patients...
  58. ncbi Basilar-type migraine: clinical, epidemiologic, and genetic features
    Malene Kirchmann
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 66:880-6. 2006
    ..It remains uncertain whether basilar-type migraine (BM) is a subtype of migraine with typical aura (MTA) or a distinct phenotype or genotype...
  59. ncbi Consensus document on European brain research
    Jes Olesen
    European Brain Council, University of Copenhagen, Department of Neurology, Glostrup Hospital, Nordre Ringvej, Glostrup, Copenhagen, 2600 Denmark
    J Neurol Neurosurg Psychiatry 77:i1-49. 2006
    ..The human and social returns of such an investment are inestimable. And the time to act is now...
  60. ncbi Prostacyclin (epoprostenol) induces headache in healthy subjects
    Troels Wienecke
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pain 139:106-16. 2008
    ..001), but no significant dilatation of the MCA (AUC, p=0.508). These data indicate that PGI(2) induced headache might be due to activation and sensitization of sensory afferents around extracranial arteries...
  61. ncbi The phosphodiesterase 5 inhibitor sildenafil has no effect on cerebral blood flow or blood velocity, but nevertheless induces headache in healthy subjects
    Christina Kruuse
    Department of Neurology, Glostrop Hospital, University of Copenhagen, Denmark
    J Cereb Blood Flow Metab 22:1124-31. 2002
    ..The present results show that sildenafil 100 mg does not dilate cerebral or extracerebral arteries but nevertheless causes headache, which may be attributed to nonvascular mechanisms...
  62. ncbi Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype
    Jakob Møller Hansen
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Bolig 23 24, DK 2600 Glostrup, Copenhagen, Denmark
    Neurology 71:841-7. 2008
    ..FHM shares many phenotypical similarities with common types of migraine, indicating common neurobiological pathways. We tested the hypothesis that the FHM genotype confers a CGRP hypersensitive phenotype...
  63. ncbi Phosphodiesterase 3 and 5 and cyclic nucleotide-gated ion channel expression in rat trigeminovascular system
    Lars S Kruse
    Department of Neurology, Glostrup Hospital, Nordre Ringvej 57, Denmark
    Neurosci Lett 404:202-7. 2006
    ..This suggests that modulation of cAMP and cGMP levels by PDE and activation of CNG may play a role in trigeminovascular pain signalling leading to migraine headache...
  64. ncbi Towards a reliable animal model of migraine
    Jes Olesen
    Danish Headache Centre, Department of Neurology at Glostrup Hospital, Ndr Ringvej 57, 2600 Glostrup, Denmark
    Cephalalgia 32:578-80. 2012
    ..Several attempts have been made to transfer this model to animals. The different variants of this model are discussed as well as other recent models...
  65. ncbi Probable medication-overuse headache: the effect of a 2-month drug-free period
    Peter Zeeberg
    Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Neurology 66:1894-8. 2006
    ..To describe the emerging profile of headache frequency following a 2-month drug-free period in patients with medication overuse...
  66. ncbi Predictors of outcome of the treatment programme in a multidisciplinary headache centre
    Rigmor Jensen
    Danish Headache Centre, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 30:1214-24. 2010
    ..Despite the high prevalence of headaches, multidisciplinary headache clinics are few and their efficacy still needs validation. The objective was to characterise patients and treatment results in a tertiary headache centre...
  67. ncbi Expression of BK Ca channels and the modulatory beta-subunits in the rat and porcine trigeminal ganglion
    Helle Wulf-Johansson
    Department of Neurology and Danish Headache Center, Glostrup Research Institute, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
    Brain Res 1292:1-13. 2009
    ..The present study showed BK(Ca) channel expression in rat and porcine TG. The main modulatory beta-subunits detected in TG of both species were beta2- and beta 4-subunits...
  68. ncbi Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study
    Anne W Hauge
    Danish Headache Center, Department of Neurology, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Lancet Neurol 8:718-23. 2009
    ..Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and we therefore investigated whether tonabersat has a preventive effect in migraine with aura...
  69. ncbi Possible site of action of CGRP antagonists in migraine
    Peer Tfelt-Hansen
    University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 31:748-50. 2011
    ..This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS)...
  70. ncbi The relative influence of environment and genes in episodic tension-type headache
    Vibeke Ulrich
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 62:2065-9. 2004
    ..To examine the relative importance of genetic and environmental influence for the development of tension-type headache by analyses of twins...
  71. ncbi Co-morbidity of migraine with somatic disease in a large population-based study
    Han Le
    University of Copenhagen, Denmark
    Cephalalgia 31:43-64. 2011
    ..The aim of this study was to determine sex specific co-morbidity of migraine and its subtypes migraine without aura (MO) and migraine with aura (MA) with a number of common somatic diseases...
  72. ncbi The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura
    Malene Kirchmann
    Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Am J Med Genet B Neuropsychiatr Genet 141:250-6. 2006
    ..Our study shows that the CACNA1A or ATP1A2 genes are probably not involved in MA. To identify the genes involved in the common forms of migraine, future genetic studies should focus on MA and migraine without aura (MO) and not FHM...
  73. ncbi Headache classification update 2004
    Jes Olesen
    Danish Headache Center, University of Copenhagen, Denmark
    Curr Opin Neurol 17:275-82. 2004
  74. ncbi The PACAP receptor: a novel target for migraine treatment
    Henrik W Schytz
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
    Neurotherapeutics 7:191-6. 2010
    ..This review summarizes the current evidence supporting the involvement of PACAP in migraine pathophysiology and the PAC(1) receptor as a possible novel target for migraine treatment...
  75. ncbi Trigger factors for familial hemiplegic migraine
    Jakob Møller Hansen
    Faculty of Health Sciences, University of Copenhagen, Nordre Ringvej 57, Glostrup, Copenhagen, Denmark
    Cephalalgia 31:1274-81. 2011
    ..The aim was to identify and describe migraine trigger factors in patients with familial hemiplegic migraine (FHM) from a population-based sample...
  76. ncbi [Clinical symptoms and pathophysiology of migraine]
    Peer Tfelt-Hansen
    Neurologisk afdeling N, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 170:3231-4. 2008
    ..Allodynia, most likely caused by central sensitization, often develops during the attack. In conclusion, the migraine attack is a complex neurobiological and neurovascular process...
  77. ncbi Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine
    Jes Olesen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 350:1104-10. 2004
    ..Calcitonin gene-related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks...
  78. ncbi Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine
    Lise L Thomsen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 60:595-601. 2003
    ..To compare clinical characteristics of patients with sporadic hemiplegic migraine (SHM) with those of patients with migraine with typical aura (MA) and patients with familial hemiplegic migraine (FHM)...
  79. ncbi Experimental muscle pain and tenderness following infusion of endogenous substances in humans
    Hanne Mørk
    Department of Neurology, Copenhagen Headache Center, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Eur J Pain 7:145-53. 2003
    ....
  80. ncbi Migraine without aura and migraine with aura are distinct disorders. A population-based twin survey
    Michael Bjørn Russell
    Department of Neurology, University of Copenhagen, Gentofte Hospital, Denmark
    Headache 42:332-6. 2002
    ..To investigate the co-occurrence of migraine without aura (MWOA) and migraine with aura (MWA) in a population-based twin survey...
  81. ncbi Implications of clinical subtypes of migraine with aura
    Malene Kirchmann Eriksen
    Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark
    Headache 46:286-97. 2006
    ..In future studies FHM, SHM, and NHMA therefore should be analyzed as separate entities and patients with NHMA may be stratified by ICHD-2 subtype of NHMA...
  82. ncbi No increase of calcitonin gene-related peptide in jugular blood during migraine
    Jesper Filtenborg Tvedskov
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    Ann Neurol 58:561-8. 2005
    ..Our finding strongly suggests that CGRP is not increased in jugular venous blood during migraine without aura. CGRP cannot be used as a biomarker to validate human or animal models of migraine...
  83. ncbi Increasing the effect of triptans in migraine
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK-2600 Glostrup, Denmark
    Lancet 368:1313-4. 2006
  84. ncbi Cost of disorders of the brain in Europe
    Patrik Andlin-Sobocki
    Stockholm Health Economics, Stockholm, Sweden
    Eur J Neurol 12:1-27. 2005
  85. ncbi [Headache]
    Sait Ashina
    Hovedpinecenter og Neurologisk Afdeling, Amtssygehuset i Glostrup, DK-2600 Glostrup
    Ugeskr Laeger 167:3192. 2005
  86. ncbi Towards a better understanding of the size and burden and cost of brain disorders in Europe
    Hans-Ulrich Wittchen
    Eur Neuropsychopharmacol 15:355-6. 2005
  87. ncbi European Brain Council: partnership to promote European and national brain research
    Jes Olesen
    Trends Neurosci 29:493-5. 2006
  88. ncbi A review of European studies on the economic burden of brain diseases
    Bengt Jonsson
    Department of Health Economics, Stockholm School of Economics, Stockholm, Sweden
    Eur J Health Econ 5:S4. 2004
  89. ncbi Large recurrent microdeletions associated with schizophrenia
    Hreinn Stefansson
    CNS Division, deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Nature 455:232-6. 2008
    ..CNV analysis may also point the way to the identification of additional and more prevalent risk variants in genes and pathways involved in schizophrenia...
  90. ncbi Are headache disorders caused by neurobiological mechanisms?
    Jes Olesen
    Curr Opin Neurol 19:277-80. 2006
  91. ncbi [Interdisciplinary treatment of headache. The Danish Society of Headache]
    Jes Olesen
    Neurologisk Afdeling N01, Amtssygehuset i Glostrup, Nordre Ringvej 57, DK-2600 Glostrup
    Ugeskr Laeger 165:1235. 2003