Niels Obel

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Soluble CD163 does not predict first-time myocardial infarction in patients infected with human immunodeficiency virus: a nested case-control study
    Andreas Knudsen
    Department of Infectious Diseases, Copenhagen University Hospital, Kettegaard Alle 30, Hvidovre 2650, Denmark
    BMC Infect Dis 13:230. 2013
  2. pmc Hepatitis C prevalence in Denmark -an estimate based on multiple national registers
    Peer Brehm Christensen
    Department of Infectious Diseases, Odense University Hospital, Odense C 29 5000, Denmark
    BMC Infect Dis 12:178. 2012
  3. pmc Retrivability in The Danish National Hospital Registry of HIV and hepatitis B and C coinfection diagnoses of patients managed in HIV centers 1995-2004
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    BMC Med Res Methodol 8:25. 2008
  4. ncbi request reprint Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    HIV Med 11:130-6. 2010
  5. pmc Genetic and environmental influences on risk of death due to infections assessed in Danish twins, 1943-2001
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Am J Epidemiol 171:1007-13. 2010
  6. ncbi request reprint A randomized trial comparing initial HAART regimens of nelfinavir/nevirapine and ritonavir/saquinavir in combination with two nucleoside reverse transcriptase inhibitors
    Ole Kirk
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark
    Antivir Ther 8:595-602. 2003
  7. doi request reprint Hospitalization for pneumonia among individuals with and without HIV infection, 1995-2007: a Danish population-based, nationwide cohort study
    Ole S Sogaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Clin Infect Dis 47:1345-53. 2008
  8. ncbi request reprint HIV-1 reverse transcriptase gene 103K/N and 184M/V combinations in tandem: detection and quantification of HIV-1 populations in the CD45RO+ T-cell compartment by a double-ARMS real-time PCR assay
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    J Acquir Immune Defic Syndr 41:160-7. 2006
  9. doi request reprint CD4 decline is associated with increased risk of cardiovascular disease, cancer, and death in virally suppressed patients with HIV
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Clin Infect Dis 57:314-21. 2013
  10. ncbi request reprint Unmeasured confounding caused slightly better response to HAART within than outside a randomized controlled trial
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, Kløvervaenget 2, Odense C, Denmark
    J Clin Epidemiol 61:87-94. 2008

Detail Information

Publications96

  1. pmc Soluble CD163 does not predict first-time myocardial infarction in patients infected with human immunodeficiency virus: a nested case-control study
    Andreas Knudsen
    Department of Infectious Diseases, Copenhagen University Hospital, Kettegaard Alle 30, Hvidovre 2650, Denmark
    BMC Infect Dis 13:230. 2013
    ....
  2. pmc Hepatitis C prevalence in Denmark -an estimate based on multiple national registers
    Peer Brehm Christensen
    Department of Infectious Diseases, Odense University Hospital, Odense C 29 5000, Denmark
    BMC Infect Dis 12:178. 2012
    ..Our aim was to estimate the prevalence of chronic hepatitis C from public registers and the proportion of these patients who received specialized healthcare...
  3. pmc Retrivability in The Danish National Hospital Registry of HIV and hepatitis B and C coinfection diagnoses of patients managed in HIV centers 1995-2004
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    BMC Med Res Methodol 8:25. 2008
    ..We examined completeness of registration of HIV infections and of chronic hepatitis B (HBV) and hepatitis C (HCV) coinfections in the Danish National Hospital Registry (DNHR) covering all Danish hospitals...
  4. ncbi request reprint Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    HIV Med 11:130-6. 2010
    ..The aim of the study was to examine whether exposure to abacavir increases the risk for myocardial infarction (MI)...
  5. pmc Genetic and environmental influences on risk of death due to infections assessed in Danish twins, 1943-2001
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Am J Epidemiol 171:1007-13. 2010
    ..The concordance rates were generally low, and, although a genetic influence on the risk of death from infectious diseases could be demonstrated, the absolute effect of the genetic component on mortality was small...
  6. ncbi request reprint A randomized trial comparing initial HAART regimens of nelfinavir/nevirapine and ritonavir/saquinavir in combination with two nucleoside reverse transcriptase inhibitors
    Ole Kirk
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark
    Antivir Ther 8:595-602. 2003
    ..A triple-class HAART regimen may be associated with a better virological effect than conventional regimens, but may also lead to toxicity and more profound resistance...
  7. doi request reprint Hospitalization for pneumonia among individuals with and without HIV infection, 1995-2007: a Danish population-based, nationwide cohort study
    Ole S Sogaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    Clin Infect Dis 47:1345-53. 2008
    ..We compared incidence rates of pneumonia among individuals with and without HIV infection and explored risk factors for pneumonia in the HIV-infected population...
  8. ncbi request reprint HIV-1 reverse transcriptase gene 103K/N and 184M/V combinations in tandem: detection and quantification of HIV-1 populations in the CD45RO+ T-cell compartment by a double-ARMS real-time PCR assay
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    J Acquir Immune Defic Syndr 41:160-7. 2006
    ..The proviral HIV-1 reverse transcriptase gene for the 103K/N and 184M/V combinations were studied in tandem. The CD45RO T (memory) cell compartment was investigated...
  9. doi request reprint CD4 decline is associated with increased risk of cardiovascular disease, cancer, and death in virally suppressed patients with HIV
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Clin Infect Dis 57:314-21. 2013
    ..We aimed to test the hypothesis that a major CD4 decline could be a marker of cardiovascular disease or undiagnosed cancer...
  10. ncbi request reprint Unmeasured confounding caused slightly better response to HAART within than outside a randomized controlled trial
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, Kløvervaenget 2, Odense C, Denmark
    J Clin Epidemiol 61:87-94. 2008
    ..To compare the outcome of highly active antiretroviral therapy (HAART) in HIV-infected patients initiating equivalent regimens within and outside a randomized controlled trial (RCT)...
  11. doi request reprint Incidence of low and high-energy fractures in persons with and without HIV infection: a Danish population-based cohort study
    Ann Brit E Hansen
    Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    AIDS 26:285-93. 2012
    ..To compare fracture risk in persons with and without HIV infection and to examine the influence of highly active antiretroviral therapy (HAART) initiation on risk of fracture...
  12. pmc Lung cancer in HIV patients and their parents: a Danish cohort study
    Frederik N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Kbh Ø, Denmark
    BMC Cancer 11:272. 2011
    ..HIV patients are known to be at increased risk of lung cancer but the risk factors behind this are unclear...
  13. ncbi request reprint Impact of hepatitis C virus coinfection on response to highly active antiretroviral therapy and outcome in HIV-infected individuals: a nationwide cohort study
    Nina Weis
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Clin Infect Dis 42:1481-7. 2006
    ..We determined the impact of HCV infection on response to highly active antiretroviral therapy and outcome among Danish patients with HIV-1 infection...
  14. pmc Cause-specific excess mortality in siblings of patients co-infected with HIV and hepatitis C virus
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    PLoS ONE 2:e738. 2007
    ..This indicates that risk factors shared by family members partially account for the excess mortality of HIV/HCV-co-infected patients. We aimed to explore the causes of death contributing to the excess sibling mortality...
  15. ncbi request reprint Use of the protease inhibitor saquinavir hard gel in human immunodeficiency virus-infected patients in the early period of highly active antiretroviral therapy: does it affect long-term treatment outcome?
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Scand J Infect Dis 35:743-9. 2003
    ..39-2.58). The insufficient suppression of viral load in patients starting with saquinavir hgc subsided during follow-up, probably owing to the earlier discontinuation of saquinavir hcg in favour of newer and more potent HAART regimens...
  16. ncbi request reprint Survival of persons with and without HIV infection in Denmark, 1995-2005
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Ann Intern Med 146:87-95. 2007
    ..The expected survival of HIV-infected patients is of major public health interest...
  17. ncbi request reprint Low mortality in HIV-infected patients starting highly active antiretroviral therapy: a comparison with the general population
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    AIDS 18:89-97. 2004
    ....
  18. pmc Impact of gender on response to highly active antiretroviral therapy in HIV-1 infected patients: a nationwide population-based cohort study
    Kristina Thorsteinsson
    Department of Infectious Diseases, Hvidovre, Copenhagen University Hospital, Kettegaards Alle 30, Hvidovre DK 2650, Denmark
    BMC Infect Dis 12:293. 2012
    ..Impact of gender on time to initiation, response to and risk of modification of highly active antiretroviral therapy (HAART) in HIV-1 infected individuals is still controversial...
  19. pmc Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study
    Frederik N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    BMC Infect Dis 10:318. 2010
    ..We aimed to identify predictors for inadequate CD4 cell recovery and estimate mortality in patients with low CD4 count but otherwise successful HAART...
  20. pmc Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e22476. 2011
    ..We also addressed the question whether prognosis differed according to age, substance abuse (alcohol abuse and injection drug use) and comorbidity...
  21. ncbi request reprint Demographics of HIV-1 infection in Denmark: results from the Danish HIV Cohort Study
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Scand J Infect Dis 37:338-43. 2005
    ..In this period 14.5% had AIDS at the time of HIV diagnosis. Our data do not confirm concerns about unmonitored evolution in the HIV epidemic in Denmark...
  22. pmc Mortality after hospitalization for pneumonia among individuals with HIV, 1995-2008: a Danish cohort study
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    PLoS ONE 4:e7022. 2009
    ..HIV-infected persons are at increased risk of pneumonia, even with highly active antiretroviral treatment (HAART). We examined the impact of pneumonia on mortality and identified prognostic factors for death among HIV-infected...
  23. pmc Risk of diabetes mellitus in persons with and without HIV: a Danish nationwide population-based cohort study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    PLoS ONE 7:e44575. 2012
    ..In a nationwide, population-based cohort study we assessed the risk of diabetes mellitus (DM) in HIV-infected individuals compared with the general population, and evaluated the impact of risk factors for DM in HIV-infected individuals...
  24. ncbi request reprint Virological control during the first 6-18 months after initiating highly active antiretroviral therapy as a predictor for outcome in HIV-infected patients: a Danish, population-based, 6-year follow-up study
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    Clin Infect Dis 42:136-44. 2006
    ....
  25. ncbi request reprint Tenofovir treatment in an unselected cohort of highly antiretroviral experienced HIV positive patients
    Anne Lerbaek
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:280-6. 2004
    ..In conclusion, we observed a significant decrease in HIV-RNA only when tenofovir was prescribed, in conjunction with other anti-retroviral drugs, to patients on a failing highly active antiretroviral drug regimen (HAART)...
  26. ncbi request reprint Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine
    Jan Gerstoft
    Department of Infectious Diseases at Rigshospitalet, Copenhagen, Denmark
    AIDS 17:2045-52. 2003
    ..Highly active antiretroviral therapy containing three nucleoside reverse transcriptase inhibitors has been somewhat successful, but the clinical efficacy is unclear...
  27. ncbi request reprint Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study
    Frederik Neess Engsig
    Department of Infectious Diseases at Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Infect Dis 199:77-83. 2009
    ....
  28. doi request reprint Anal carcinoma in HIV-infected patients in the period 1995-2009: a Danish nationwide cohort study
    Rebecca Legarth
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, DK 2100 Copenhagen Ø, Denmark
    Scand J Infect Dis 45:453-9. 2013
    ..We aimed to estimate (1) the risk of anal carcinoma among HIV patients and their parents, and (2) the mortality after a diagnosis of anal carcinoma...
  29. doi request reprint Poor CD4 response despite viral suppression is associated with increased non-AIDS-related mortality among HIV patients and their parents
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    AIDS 27:1021-6. 2013
    ..Poor CD4 response to antiretroviral treatment (HAART) is associated with increased mortality. We analyzed the impact of CD4 increase on non-AIDS-related morbidity and on mortality in HIV patients and their parents...
  30. doi request reprint Mortality attributable to smoking among HIV-1-infected individuals: a nationwide, population-based cohort study
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Infect Dis 56:727-34. 2013
    ..We assessed mortality attributable to smoking among patients with human immunodeficiency virus (HIV)...
  31. doi request reprint Molecular phylogenetics of transmitted drug resistance in newly diagnosed HIV Type 1 individuals in Denmark: a nation-wide study
    Anne Margrethe Audelin
    Statens Serum Institut, Copenhagen, Denmark
    AIDS Res Hum Retroviruses 27:1283-90. 2011
    ..The prevalence of TDR is low in Denmark and transmission of dual-drug-resistant HIV-1 is infrequent. The TDR isolates were shown to originate from local patients failing therapy...
  32. pmc Risk of myocardial infarction in parents of HIV-infected Individuals: a population-based Cohort Study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    BMC Infect Dis 10:169. 2010
    ..To establish whether the increased risk of myocardial infarction in HIV patients partly reflects an increased risk of MI in their families, we estimated the relative risk of MI in parents of HIV-infected individuals...
  33. ncbi request reprint Impact of injecting drug use on response to highly active antiretroviral treatment in HIV-1-infected patients: a nationwide population-based cohort study
    Mette Vang Larsen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
    Scand J Infect Dis 42:917-23. 2010
    ..Absolute CD4(+) cell count was lower and mortality higher among IDUs than non-IDUs...
  34. doi request reprint The incidence rate of HIV type-1 drug resistance in patients on antiretroviral therapy: a nationwide population-based Danish cohort study 1999-2005
    Anne Margrethe Audelin
    Department of Virology, Statens Serum Institut, Copenhagen, Denmark
    Antivir Ther 14:995-1000. 2009
    ..We estimated changes in incidence rates (IRs) of new mutations in HIV-infected individuals receiving highly active antiretroviral therapy (HAART)...
  35. ncbi request reprint Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naïve patients in Greenland
    Tina Vasehus Madsen
    Statens Serum Institut, Department of Virology, Copenhagen, Denmark
    AIDS Res Hum Retroviruses 24:1073-7. 2008
    ....
  36. ncbi request reprint Ischemic heart disease in HIV-infected and HIV-uninfected individuals: a population-based cohort study
    Niels Obel
    Department of Infectious Diseases, Rigshospitalet, Hvidovre, Denmark
    Clin Infect Dis 44:1625-31. 2007
    ..We examined this issue in a nationwide cohort study of patients with human immunodeficiency virus (HIV) infection and a population-based control group...
  37. ncbi request reprint Dynamics of proviral HIV-1 184M/V in circulating CD4+ T-cells: a 90 days follow-up study after initiation/switch of HAART
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    Scand J Infect Dis 38:119-23. 2006
    ..Reduction in the quantity of 184V when therapy is switched to an effective non-lamivudine regime indicates that the mutation in this compartment is dynamic...
  38. ncbi request reprint Risk of HIV or second syphilis infection in Danish men with newly acquired syphilis in the period 2000-2010
    Kirsten Salado-Rasmussen
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Sex Transm Infect 89:372-6. 2013
    ..Risk of subsequent diagnosis of HIV in persons diagnosed with newly acquired syphilis, and syphilis in HIV-infected persons, are of interest as these infections are markers of unsafe sex...
  39. ncbi request reprint Mortality in siblings of patients coinfected with HIV and hepatitis C virus
    Ann Brit Eg Hansen
    Department of Infectious Diseases, Odense University Hospital, DK 5000 Odense C, Denmark
    J Infect Dis 195:230-5. 2007
    ..We examined whether the increased mortality in these patients is partly explained by a familial excess risk of death...
  40. pmc Statin therapy and mortality in HIV-infected individuals; a Danish nationwide population-based cohort study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e52828. 2013
    ..We therefore used a Danish nationwide cohort of HIV-infected individuals to estimate the impact of statin use on mortality before and after a diagnosis of cardiovascular disease, chronic kidney disease or diabetes...
  41. doi request reprint Late presenters, repeated testing, and missed opportunities in a Danish nationwide HIV cohort
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 44:282-8. 2012
    ..We aimed to estimate the incidence and predictors of late presentation among human immunodeficiency virus (HIV)-infected individuals in Denmark...
  42. doi request reprint Liver cancer and non-Hodgkin lymphoma in hepatitis C virus-infected patients: results from the DANVIR cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    Int J Cancer 130:2310-7. 2012
    ..HCC-risk is increased substantially in HCV-infected patients compared to the general population. Chronic as opposed to cleared HCV-infection increases the risk of HCC and perhaps NHL...
  43. pmc Impact of non-HIV and HIV risk factors on survival in HIV-infected patients on HAART: a population-based nationwide cohort study
    Niels Obel
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 6:e22698. 2011
    ....
  44. ncbi request reprint Patients' answers to simple questions about treatment satisfaction and adherence and depression are associated with failure of HAART: a cross-sectional survey
    Toke S Barfod
    Rigshospitalet, University Hosital of Copenhagen, Denmark
    AIDS Patient Care STDS 19:317-25. 2005
    ..Because of the cross-sectional nature of the study, causality could not be determined. These questions, however, may be relevant screening tools in clinical practice and in follow-up studies...
  45. doi request reprint Incidence and impact on mortality of severe neurocognitive disorders in persons with and without HIV infection: a Danish nationwide cohort study
    Francois Xavier Lescure
    Department of Infectious Diseases, Copenhagen University Hospital, Blegdamsvej 9, Rigshospitalet
    Clin Infect Dis 52:235-43. 2011
    ..We aimed to compare the incidence and impact on mortality of severe neurocognitive disorders (SNCDs) in HIV-infected patients with that of the background population...
  46. ncbi request reprint Prevalence of drug resistance mutations and non-B subtypes in newly diagnosed HIV-1 patients in Denmark
    Louise B Jørgensen
    Department of Virology Statens Serum Institut, Copenhagen, Denmark
    Scand J Infect Dis 35:800-7. 2003
    ..We found 2 patients (2%) with mutations associated with resistance in the RT-gene and none in the protease gene indicating a low prevalence of resistant HIV-1 in Denmark in the year 2000...
  47. ncbi request reprint Demographics in HIV-infected children in Denmark: results from the Danish Paediatric HIV Cohort Study
    Johannes Schmid
    Department of Infectious Diseases, Odense University Hospital, Odense, Denmark
    Scand J Infect Dis 37:344-9. 2005
    ....
  48. ncbi request reprint Renal function and incidence of chronic kidney disease in HIV patients: a Danish cohort study
    Magnus G Rasch
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 44:689-96. 2012
    ..Impaired renal function is of major concern in human immunodeficiency virus (HIV)-infected patients...
  49. ncbi request reprint Impact of gender on the risk of AIDS-defining illnesses and mortality in Danish HIV-1-infected patients: a nationwide cohort study
    Kristina Thorsteinsson
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
    Scand J Infect Dis 44:766-75. 2012
    ..We aimed to assess the impact of gender on the risk of ADI and death in HIV-positive patients infected sexually...
  50. pmc Morbidity and risk of subsequent diagnosis of HIV: a population based case control study identifying indicator diseases for HIV infection
    Ole S Søgaard
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
    PLoS ONE 7:e32538. 2012
    ..Early identification of persons with undiagnosed HIV infection is an important health care issue. We examined associations between diseases diagnosed in hospitals and risk of subsequent HIV diagnosis...
  51. doi request reprint Retention in a public healthcare system with free access to treatment: a Danish nationwide HIV cohort study
    Marie Helleberg
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    AIDS 26:741-8. 2012
    ..We aimed to assess retention of HIV-infected individuals in the Danish healthcare system over a 15-year period...
  52. doi request reprint Risk of cerebrovascular events in persons with and without HIV: a Danish nationwide population-based cohort study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    AIDS 25:1637-46. 2011
    ..To assess the risk of cerebrovascular events (CVEs) in HIV-infected individuals and evaluate the impact of proven risk factors, injection drug abuse (IDU), immunodeficiency, HAART and family-related risk factors...
  53. doi request reprint Characterization of HIV-1 from patients with virological failure to a boosted protease inhibitor regimen
    Marie Rathcke Lillemark
    Department of Virology, State Serum Institute, Copenhagen, Denmark
    J Med Virol 83:377-83. 2011
    ..Gag CS mutations did not contribute significantly to resistance development and virological failure...
  54. doi request reprint Impact of injecting drug use on mortality in Danish HIV-infected patients: a nation-wide population-based cohort study
    Mette V Larsen
    Department of Infectious Diseases, Copenhagen University Hospital, DK 2650 Hvidovre, Denmark
    Addiction 105:529-35. 2010
    ..To estimate the impact of injecting drug use (IDU) on mortality in HIV-infected patients in the highly active antiretroviral therapy (HAART) era...
  55. ncbi request reprint Mortality in patients with chronic and cleared hepatitis C viral infection: a nationwide cohort study
    Lars Haukali Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    J Hepatol 53:36-42. 2010
    ..We examined the impact of chronic HCV replication on mortality among Danish patients testing positive for HCV antibodies...
  56. ncbi request reprint Long-term effectiveness of highly active antiretroviral therapy (HAART) in perinatally HIV-infected children in Denmark
    Linda Bracher
    Department of Paediatrics, Copenhagen University Hospital, Hvidovre, Denmark
    Scand J Infect Dis 39:799-804. 2007
    ..During our observation period there were no signs of a waning impact. The challenge remains to maintain a high adherence to therapy as the children grow into adolescence and develop more independence from family and health care staff...
  57. ncbi request reprint Introduction of HIV type 1 into an isolated population: molecular epidemiologic study from Greenland
    Tina V Madsen
    Department of Virology, Statens Serum Institut, Copenhagen, Denmark
    AIDS Res Hum Retroviruses 23:675-81. 2007
    ..The large diversity between the main Greenland cluster and the rest of the sequences is most likely due to a founder effect...
  58. ncbi request reprint Mortality after myocardial infarction in HIV-infected patients who have initiated HAART
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    AIDS 21:873-5. 2007
    ..Mortality in HIV-infected MI patients was not significantly different to that of MI only patients in the first 90 days post-MI and thereafter was not significantly different to that of HIV patients without MI...
  59. ncbi request reprint Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations
    Sofie Mathiesen
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    AIDS 18:1076-8. 2004
  60. ncbi request reprint The effect of race/ethnicity on the outcome of highly active antiretroviral therapy for human immunodeficiency virus type 1-infected patients
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Skejby Hospital, DK 8200 Aarhus N, Denmark
    Clin Infect Dis 35:1541-8. 2002
    ..Race and ethnic origin play no major role in the outcome associated with HAART if access to health care is free...
  61. ncbi request reprint Low effectiveness of highly active antiretroviral therapy and high mortality in the Greenland HIV-infected population
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital, 5000 Odense, Denmark
    Scand J Infect Dis 36:738-42. 2004
    ..Our findings underline the difficulties of implementing successful HIV treatment even with unlimited economic resources and free access to health care...
  62. doi request reprint Risk of cataract surgery in HIV-infected individuals: a Danish Nationwide Population-based cohort study
    Line D Rasmussen
    Department of Infectious Diseases, Odense University Hospital, Denmark
    Clin Infect Dis 53:1156-63. 2011
    ..In a nationwide, population-based cohort study we assessed the risk of cataract surgery in HIV-infected individuals compared with the general population...
  63. pmc Adherence to national guidelines for initiation of antiretroviral regimens in HIV patients: a Danish nationwide study
    Tonny S Petersen
    Department of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    Br J Clin Pharmacol 72:116-24. 2011
    ..To determine the adherence to the national guidelines for start of highly active antiretroviral treatment (HAART) in HIV infected patients...
  64. pmc Incidence, risk factors and mortality of tuberculosis in Danish HIV patients 1995-2007
    Gry A Taarnhøj
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    BMC Pulm Med 11:26. 2011
    ..We described incidence, risk factors and prognosis of TB in HIV-1 infected patients during pre (1995-1996), early (1997-1999), and late Highly Active Antiretroviral Therapy (HAART) (2000-2007) periods...
  65. ncbi request reprint Detection and quantification of proviral HIV-1 184 M/V in circulating CD4(+) T cells of patients on HAART with a viremia less than 1,000 copies/ml
    Rajesh Mohey
    Department of Infectious Diseases, Skejby University Hospital, Aarhus, Denmark
    J Clin Virol 34:257-67. 2005
    ..However, the role of low-level viremia (viral-load less than 1,000 copies/ml) on mutation genesis and incorporation of resistant forms in the long-lived CD4(+) T cellular DNA compartment is not clear...
  66. ncbi request reprint Long-term mortality in patients diagnosed with pneumococcal meningitis: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Rigshospitalet, and University of Copenhagen, Copenhagen, Denmark
    Am J Epidemiol 172:309-17. 2010
    ..To improve survival in patients surviving the acute phase of pneumococcal meningitis, physicians should meticulously screen this patient population for neurologic sequelae and comorbidity predisposing to the disease...
  67. ncbi request reprint Pharmacokinetics of two randomized trials evaluating the safety and efficacy of indinavir, saquinavir and lopinavir in combination with low-dose ritonavir: the MaxCmin1 and 2 trials
    Ulrik S Justesen
    Department of Infectious Diseases, Odense University Hospital, Odense C, Denmark
    Basic Clin Pharmacol Toxicol 101:339-44. 2007
    ..Associations between high C(min) and toxicity were identified in the saquinavir arm; therefore, dose reductions may be appropriate in certain patients with C(min) several times above the minimum effective concentration...
  68. ncbi request reprint Predictors of unsafe sex among HIV patients in Denmark: a population-based cohort study
    Tavs Qvist
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 43:181-7. 2011
    ..Abstract Background: Sexual transmission continues to be the primary mode of human immunodeficiency virus (HIV) infection in Western Europe. We aimed to describe predictors of unsafe sex and reasons given for such behaviour...
  69. pmc Socioeconomic status in HCV infected patients - risk and prognosis
    Lars Haukali Omland
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Clin Epidemiol 5:163-72. 2013
    ..It is unknown whether socioeconomic status (SES) is a risk factor for hepatitis C virus (HCV) infection or a prognostic factor following infection...
  70. doi request reprint Long-term mortality in patients diagnosed with Listeria monocytogenes meningitis: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    J Infect 64:34-40. 2012
    ..To determine the long-term mortality, the causes of death and the incidence of cancer in listeria meningitis patients...
  71. ncbi request reprint K65R with and without S68: a new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine
    Birgit T Røge
    Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Antivir Ther 8:173-82. 2003
    ..The unexpected high incidence of S68G suggests a functional role of this mutation in viruses harbouring K65R...
  72. ncbi request reprint Inpatient admissions and outpatient visits in persons with and without HIV infection in Denmark, 1995-2007
    Frederik Neess Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK2100 Copenhagen Ø, Denmark
    AIDS 24:457-61. 2010
    ..HAART has changed morbidity and mortality in the HIV-infected population dramatically. We aimed to estimate the use of healthcare facilities in HIV-infected patients after the introduction of HAART...
  73. pmc Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study
    Nanna Hansen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, 2650 Hvidovre, Denmark
    BMC Infect Dis 11:177. 2011
    ..The endpoint was sustained virological response (SVR), determined by the absence of HCV RNA 24 weeks after the end of treatment...
  74. pmc Head and neck cancer in HIV patients and their parents: a Danish cohort study
    Frederik N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    Clin Epidemiol 3:217-27. 2011
    ..We hypothesized that family-related risk factors increase the risk of HNC why we estimated the risk of this type of cancer in both HIV patients and their parents...
  75. doi request reprint Long-term mortality in children diagnosed with Haemophilus influenzae meningitis: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Pediatr Infect Dis J 30:e147-54. 2011
    ..The long-term mortality in children diagnosed with Haemophilus influenzae meningitis is poorly documented...
  76. pmc HIV-1 continues to replicate and evolve in patients with natural control of HIV infection
    Helene Mens
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
    J Virol 84:12971-81. 2010
    ..Viral diversity and adaptive events associated with immune escape were found to be restricted in HIV-1 controllers, suggesting that replication occurs in the face of less overall immune selection...
  77. pmc Clinical, virological and immunological responses in Danish HIV patients receiving raltegravir as part of a salvage regimen
    Frederik N Engsig
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    Clin Epidemiol 2:145-51. 2010
    ..Raltegravir is the first integrase inhibitor approved for treatment of HIV-infected patients harboring multiresistant viruses...
  78. pmc Long-term mortality in patients diagnosed with meningococcal disease: a Danish nationwide cohort study
    Casper Roed
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 5:e9662. 2010
    ..In contrast to the case fatality rate of patients diagnosed with meningococcal disease (MD) the long-term mortality in these patients is poorly documented...
  79. doi request reprint Increased mortality among persons infected with hepatitis C virus
    Lars Haukali Omland
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Clin Gastroenterol Hepatol 9:71-8. 2011
    ....
  80. ncbi request reprint Trends in the use of highly active antiretroviral therapy in western Denmark 1996-2000
    Søren Jensen-Fangel
    Department of Infectious Diseases, Aarhus University Hospital, Denmark
    Scand J Infect Dis 34:460-5. 2002
    ..Major new strategies implemented in the region in 1999 and 2000 included treatment with boosted protease inhibitors and non-nucleoside reverse transcriptase inhibitors...
  81. ncbi request reprint Declining risk of triple-class antiretroviral drug failure in Danish HIV-infected individuals
    Nicolai Lohse
    Odense University Hospital, and University of Southern Denmark, Odense, Denmark
    AIDS 19:815-22. 2005
    ..To analyse the incidence, prevalence, and predictors for development of triple-class antiretroviral drug failure (TCF) in individuals infected with HIV...
  82. ncbi request reprint Declining prevalence of HIV-infected individuals at risk of transmitting drug-resistant HIV in Denmark during 1997-2004
    Nicolai Lohse
    Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Antivir Ther 11:591-600. 2006
    ..5%) in our population, we estimated acquisition of HIV drug resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV...
  83. ncbi request reprint [HIV in Western Denmark. Demographic data from a population-based cohort study]
    Søren Jensen-Fangel
    Infektionsmedicinsk Afdeling Q, Skejby Sygehus, Arhus Universitetshospital, DK 8200 Arhus N
    Ugeskr Laeger 164:3964-7. 2002
    ..The course of HIV infection has changed since the introduction of highly active anti-retroviral treatment...
  84. ncbi request reprint [Changes in immunological status among newly-diagnosed HIV-infected in Denmark 1995-2005]
    Simon Høegh
    Odense Universitetshospital, Medicinsk afdeling C
    Ugeskr Laeger 170:740-4. 2008
    ....
  85. ncbi request reprint Randomized trial to evaluate indinavir/ritonavir versus saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial
    Ulrik Bak Dragsted
    Hvidovre University Hospital, Hvidovre, Denmark
    J Infect Dis 188:635-42. 2003
    ..A greater number of treatment-limiting adverse events were observed in the Idv/Rtv arm, relative to the Sqv/Rtv arm. In conclusion, Rtv-boosed Sqv and Idv were found to have comparable antiretroviral effects in the doses studied...
  86. ncbi request reprint [Post-exposure prophylaxis after sexual or occupational exposure to HIV]
    Suzanne Lunding
    epidemiafdelingen, H S Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 165:3709-12. 2003
  87. ncbi request reprint [Administration of medications. Joint charts for prescription--transcription and dispensing errors]
    Henning K Nielsen
    Randers Centralsygehus, Medicinsk afdeling
    Ugeskr Laeger 166:2800-3. 2004
  88. pmc Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care
    Anette Holm
    Department of Infectious Diseases C, Odense University Hospital, Denmark
    Br J Gen Pract 57:555-60. 2007
    ..There is no study on the value of procalcitonin measurements in adults with lower respiratory tract infection (LRTI) treated in primary care...
  89. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  90. ncbi request reprint Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study
    Jacob Sode
    Department of Infectious Medicine, Odense University Hospital, 5000, Odense C, Denmark
    Eur J Clin Pharmacol 63:499-503. 2007
    ..Several case-control studies have reported that the use of fluoroquinolone increases the risk of rupture of the Achilles tendon. Our aim was to estimate this risk by means of a population-based cohort approach...
  91. ncbi request reprint [Stable long-term effect of HIV therapy. The Danish Society for Infectious Diseases]
    Nicolai Lohse
    Klinisk Epidemiologisk Afdeling, Arhus Universitetshospital, DK 8000 Arhus C
    Ugeskr Laeger 169:1109. 2007
  92. ncbi request reprint Improved survival in HIV-infected persons: consequences and perspectives
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, DK 8000 Arhus C, Denmark
    J Antimicrob Chemother 60:461-3. 2007
    ....
  93. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  94. ncbi request reprint [Reporting chronic hepatitis B and C in Denmark]
    Nanna Hansen
    Infektionsmedicinsk Afdeling, Hvidovre Hospital, DK 2650 Hvidovre
    Ugeskr Laeger 170:1567-70. 2008
    ....
  95. pmc Implementation and effectiveness of antiretroviral therapy in Greenland
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark
    Emerg Infect Dis 14:56-9. 2008
    ..However, implementation and quality of care improved considerably in recent years...
  96. ncbi request reprint Genotypic drug resistance and long-term mortality in patients with triple-class antiretroviral drug failure
    Nicolai Lohse
    Department of Clinical Epidemiology, Arhus University Hospital, Arhus, Denmark
    Antivir Ther 12:909-17. 2007
    ..To examine the prevalence of drug-resistance-associated mutations in HIV patients with triple-drug class virological failure (TCF) and their association with long-term mortality...