Børge G Nordestgaard

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    PLoS Med 9:e1001212. 2012
  2. pmc Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK 2730 Herlev, Copenhagen, Denmark
    Eur Heart J 34:3478-90a. 2013
  3. pmc Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 10:e1004191. 2014
  4. ncbi request reprint Only a fraction of patients with ischaemic diseases or diabetes are treated to recommended target values for plasma lipids
    Niels Siggaard-Andersen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Herlev Ringvej 75, Herlev, Denmark
    Dan Med J 59:A4470. 2012
  5. doi request reprint Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis
    Pia R Kamstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
    Arterioscler Thromb Vasc Biol 32:1732-41. 2012
  6. doi request reprint Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Atherosclerosis 208:480-3. 2010
  7. ncbi request reprint Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
  8. pmc Markers of early disease and prognosis in COPD
    Morten Dahl
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Chron Obstruct Pulmon Dis 4:157-67. 2009
  9. ncbi request reprint 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Pharmacogenet Genomics 15:633-45. 2005
  10. doi request reprint Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population
    Lasse S Ravn
    Department of Cardiology, Danish Arrhythmia Research Center, Copenhagen, Denmark
    Pharmacogenet Genomics 18:525-33. 2008

Detail Information

Publications126 found, 100 shown here

  1. pmc The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    PLoS Med 9:e1001212. 2012
    ..We tested the hypothesis that positive observational associations between BMI and IHD are causal...
  2. pmc Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK 2730 Herlev, Copenhagen, Denmark
    Eur Heart J 34:3478-90a. 2013
    ..The second aim was to provide guidance for screening and treatment of FH, in order to prevent coronary heart disease (CHD)...
  3. pmc Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 10:e1004191. 2014
    ..Also, change in telomere length did not associate prospectively with mortality or morbidity in the general population...
  4. ncbi request reprint Only a fraction of patients with ischaemic diseases or diabetes are treated to recommended target values for plasma lipids
    Niels Siggaard-Andersen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Herlev Ringvej 75, Herlev, Denmark
    Dan Med J 59:A4470. 2012
    ..We tested the hypothesis that individuals in the general population with and without ischaemic cardiovascular disease, or with diabetes, are treated to recommended target values for plasma lipids...
  5. doi request reprint Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis
    Pia R Kamstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
    Arterioscler Thromb Vasc Biol 32:1732-41. 2012
    ..The aim of the present study was to determine whether lipoprotein(a) [Lp(a)], considered a causal risk factor for cardiovascular disease, primarily promotes thrombosis or atherosclerosis...
  6. doi request reprint Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Atherosclerosis 208:480-3. 2010
    ....
  7. ncbi request reprint Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
    ..Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  8. pmc Markers of early disease and prognosis in COPD
    Morten Dahl
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Chron Obstruct Pulmon Dis 4:157-67. 2009
    ..To implement markers for COPD in clinical practice, besides those already established for the alpha(1)-antitrypsin gene, further research and validation studies are needed...
  9. ncbi request reprint 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Pharmacogenet Genomics 15:633-45. 2005
    ..We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure...
  10. doi request reprint Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population
    Lasse S Ravn
    Department of Cardiology, Danish Arrhythmia Research Center, Copenhagen, Denmark
    Pharmacogenet Genomics 18:525-33. 2008
    ..We hypothesized that polymorphisms in the angiotensinogen and angiotensin-converting enzyme (ACE) genes encoding proteins in this system predict risk of atrial fibrillation...
  11. pmc Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type
    Birgitte F Sode
    Department of Clinical Biochemistry, Herlev Hospital, and the Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    CMAJ 185:E229-37. 2013
    ....
  12. doi request reprint Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease
    Mette Thomsen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    JAMA 309:2353-61. 2013
    ..Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients...
  13. ncbi request reprint Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population
    Marianne Benn
    Department of Clinical Biochemistry, KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 90:5797-803. 2005
    ..Rare mutations in APOB cause hypercholesterolemia. Whether common polymorphisms in APOB have similar effects remains controversial...
  14. doi request reprint C-reactive protein and the risk of cancer: a mendelian randomization study
    Kristine H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 102:202-6. 2010
    ..The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer...
  15. ncbi request reprint Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 115:861-71. 2007
    ....
  16. doi request reprint Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease
    Maria C A Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 52:369-77. 2008
    ..This study was designed to test the hypotheses that single nucleotide polymorphisms (SNPs), in zinc finger protein 202 (ZNF202), predict severe atherosclerosis and ischemic heart disease (IHD)...
  17. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension...
  18. doi request reprint Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease
    Trine Holm Johannsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Clin Endocrinol Metab 94:1264-73. 2009
    ..Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease)...
  19. doi request reprint Genetically elevated C-reactive protein and ischemic vascular disease
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen
    N Engl J Med 359:1897-908. 2008
    ..Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association...
  20. pmc Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations
    Morten Dahl
    Department of Clinical Biochemistry and Copenhagen General Population Study, Herlev Hospital and Copenhagen University Hospital, Copenhagen, Denmark
    Am J Respir Crit Care Med 178:906-12. 2008
    ..Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function...
  21. ncbi request reprint Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B: the Copenhagen City Heart Study
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 27:661-70. 2007
    ..We tested the following hypotheses: apoB predicts ischemic cardiovascular events, and apoB is a better predictor of ischemic cardiovascular events than low-density lipoprotein cholesterol...
  22. doi request reprint Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy
    Louise S Hornstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 33:1441-7. 2013
    ..We tested the hypothesis that genetic stabilization of transthyretin associates with reduced risk of vascular disease and increased life expectancy...
  23. doi request reprint Short telomere length, cancer survival, and cancer risk in 47102 individuals
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 105:459-68. 2013
    ..We therefore tested the hypotheses that short telomere length was associated with increased risk of cancer and with increased risk of early death after cancer...
  24. doi request reprint PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 55:2833-42. 2010
    ..The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality...
  25. doi request reprint Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease
    Louise S Hornstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 4:534-41. 2011
    ....
  26. doi request reprint Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease
    Mette Thomsen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 186:982-8. 2012
    ..Patients with chronic obstructive pulmonary disease (COPD) have evidence of systemic inflammation that may be implicated in the development of comorbidities...
  27. doi request reprint CHRNA3 genotype, nicotine dependence, lung function and disease in the general population
    Diljit Kaur-Knudsen
    Dept of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark
    Eur Respir J 40:1538-44. 2012
    ..In ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity...
  28. doi request reprint Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    J Natl Cancer Inst 103:508-19. 2011
    ..Low plasma levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of cancer, but whether this association is causal is unclear...
  29. doi request reprint Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction
    Anne Langsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Circulation 118:2047-56. 2008
    ..Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events...
  30. ncbi request reprint Genetic variation in ABCA1 predicts ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 28:180-6. 2008
    ..We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population...
  31. ncbi request reprint Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Denmark
    J Am Coll Cardiol 59:2356-65. 2012
    ..The purpose of this study was to test whether elevated nonfasting glucose levels associate with and cause ischemic heart disease (IHD) and myocardial infarction (MI)...
  32. doi request reprint Pentanucleotide repeat polymorphism, lipoprotein(a) levels, and risk of ischemic heart disease
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 93:3769-76. 2008
    ..Lipoprotein(a) is a cardiovascular risk factor. Levels of lipoprotein(a) are predominantly determined by apolipoprotein(a) gene variation, including a pentanucleotide repeat promoter polymorphism...
  33. doi request reprint Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study
    Diljit Kaur-Knudsen
    Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Oncol 29:2875-82. 2011
    ....
  34. doi request reprint Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 28:990-6. 2008
    ..We tested the hypothesis that the -444 A/C and -1072 G/A polymorphisms of the leukotriene C(4) synthase associate with risk of ischemic cerebrovascular disease...
  35. doi request reprint Plasma YKL-40 and total and disease-specific mortality in the general population
    Julia S Johansen
    Department of Oncology, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark
    Clin Chem 56:1580-91. 2010
    ..We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population...
  36. ncbi request reprint Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Mol Cell Cardiol 46:579-86. 2009
    ..3) and 1.2 (1.0-1.5). These genotypes were not associated with risk of asthma or COPD. Leukotriene C4 synthase promoter genotypes influence risk of TIA and ischemic stroke, but not risk of IHD/coronary atherosclerosis, asthma, or COPD...
  37. ncbi request reprint Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 173:858-64. 2006
    ....
  38. ncbi request reprint Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Denmark
    Circulation 107:747-52. 2003
    ....
  39. ncbi request reprint Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study
    Maria C A Stene
    Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Atherosclerosis 188:43-50. 2006
    ..We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD)...
  40. ncbi request reprint Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Genet 115:331-45. 2004
    ..2059T --> C and g.2197C --> T SNPs doubled the estimate of genetic variance of high-density lipoprotein and apolipoprotein Al in middle-aged females...
  41. ncbi request reprint Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 109:59-65. 2004
    ..The secondary hypothesis was that EC-SOD-R213G offers predictive ability with respect to IHD beyond that offered by measurements of plasma EC-SOD and autoantibodies against oxidized LDL (oxLDL)...
  42. pmc Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, DK 2730 Herlev, Denmark
    Respir Res 6:113. 2005
    ..Carriers of cystic fibrosis intron-8 5T alleles with high exon-9 skipping could have increased annual lung function decline and increased risk for asthma or chronic obstructive pulmonary disease (COPD)...
  43. pmc Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study
    Mette Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, DK 2100 Copenhagen, Denmark
    BMJ 343:d5497. 2011
    ..To test the hypothesis that xanthelasmata and arcus corneae, individually and combined, predict risk of ischaemic vascular disease and death in the general population...
  44. ncbi request reprint Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population
    Marianne Benn
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:1038-45. 2008
    ..Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels...
  45. doi request reprint Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Ann Neurol 69:628-34. 2011
    ..We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population...
  46. doi request reprint C-reactive protein and risk of venous thromboembolism in the general population
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 30:1672-8. 2010
    ..To examine the robustness of the association between C-reactive protein (CRP) levels and increased risk of venous thromboembolism (VTE) and to examine whether genetically elevated CRP levels cause VTE...
  47. doi request reprint Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction
    Anders Berg Jørgensen
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur Heart J 34:1826-33. 2013
    ....
  48. doi request reprint Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:507-14. 2009
    ..We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases...
  49. ncbi request reprint Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Circulation 112:185-93. 2005
    ..We tested the hypothesis that the hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, or C282Y/wild-type are risk factors for ischemic heart disease (IHD) and myocardial infarction (MI)...
  50. doi request reprint β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:E1074-9. 2012
    ..The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes...
  51. ncbi request reprint Visible age-related signs and risk of ischemic heart disease in the general population: a prospective cohort study
    Mette Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark M C, R F S, A T H The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark P S, G B J, B G N, A T H the Department of Cardiology, Hvidovre Hospital, Hvidovre, Denmark G B J Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark B G N and Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark M C, R F S, P S, G B J, B G N, A T H
    Circulation 129:990-8. 2014
    ..We tested the hypothesis that visible age-related signs associate with risk of ischemic heart disease (IHD), myocardial infarction (MI), and death in the general population, independent of chronological age...
  52. doi request reprint Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital
    JAMA 299:2524-32. 2008
    ..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...
  53. doi request reprint C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach
    Morten Dahl
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Thorax 66:197-204. 2011
    ..The authors tested the hypothesis that genetically elevated plasma CRP causes COPD using a Mendelian randomisation design...
  54. pmc An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genet Epidemiol 31:515-27. 2007
    ..An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions...
  55. doi request reprint Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease
    Jesper Schou
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 32:506-15. 2012
    ..ATP binding cassette transporter G1 (ABCG1) facilitates cholesterol efflux from macrophages to mature high-density lipoprotein particles. Whether genetic variation in ABCG1 affects risk of atherosclerosis in humans remains to be determined...
  56. doi request reprint Short telomere length, myocardial infarction, ischemic heart disease, and early death
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:822-9. 2012
    ..We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death...
  57. ncbi request reprint Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
    Marianne S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Circ Cardiovasc Genet 4:418-28. 2011
    ..We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD...
  58. pmc Penetrance of NOD2/CARD15 genetic variants in the general population
    Shiva Yazdanyar
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    CMAJ 182:661-5. 2010
    ..However, the importance of these genetic variants if identified in particular individuals within the general population is unknown. We undertook this study to estimate the penetrance of these variants in the general population...
  59. doi request reprint Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity
    Julie Lee
    Department of Clinical Biochemistry 54M1, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Respir Med 103:1286-92. 2009
    ..These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients...
  60. doi request reprint Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    JAMA 301:2331-9. 2009
    ..High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI)...
  61. pmc AT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general population
    Sarah C W Marott
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Br J Clin Pharmacol 76:114-24. 2013
    ....
  62. pmc Population-based resequencing of APOA1 in 10,330 individuals: spectrum of genetic variation, phenotype, and comparison with extreme phenotype approach
    Christiane L Haase
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    PLoS Genet 8:e1003063. 2012
    ..Population-based resequencing of APOA1 identified a majority of rare NS variants associated with reduced apoA-1 and HDL cholesterol levels and/or predisposing to amyloidosis. In addition, NS variants associated with increased risk of MI...
  63. doi request reprint Low-density lipoprotein cholesterol and risk of gallstone disease: a Mendelian randomization study and meta-analyses
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Denmark
    J Hepatol 58:126-33. 2013
    ..Whether plasma levels of LDL-C per se predict risk of gallstone disease remains unclear. We tested the hypothesis that elevated LDL-C is a causal risk factor for symptomatic gallstone disease...
  64. ncbi request reprint C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 175:250-5. 2007
    ..Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP)...
  65. doi request reprint Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58 434 individuals from the Copenhagen General Population Study
    Anne Langsted
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Chem 57:482-9. 2011
    ..We examined the influence of normal food intake on lipid profiles in diabetic and nondiabetic individuals...
  66. ncbi request reprint Platelet glycoprotein IIb/IIIa Pl(A2)/Pl(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Am Coll Cardiol 42:661-7. 2003
    ....
  67. ncbi request reprint Factor V leiden homozygosity, dyspnea, and reduced pulmonary function
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Arch Intern Med 165:2032-6. 2005
    ..We tested the hypothesis that factor V Leiden homozygosity is associated with pulmonary symptoms and signs...
  68. ncbi request reprint Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 46:1516-20. 2005
    ..We tested whether heterozygosity for the K776N mutation (frequency: 0.4%) in ATP-binding cassette transporter A1 (ABCA1) predicted ischemic heart disease (IHD) in the Copenhagen City Heart Study population...
  69. ncbi request reprint Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population
    Maria C Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Lipid Res 47:944-52. 2006
    ..We show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels...
  70. doi request reprint Elevated plasma YKL-40 levels and ischemic stroke in the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 68:672-80. 2010
    ..In contrast to C-reactive protein (CRP) produced in the liver in response to inflammation, YKL-40 is produced by lipid-laden macrophages inside the vessel wall...
  71. doi request reprint CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals
    Diljit Kaur-Knudsen
    Department of Clinical Biochemistry, Copenhagen University Hospital, University of Copenhagen, Denmark
    Pharmacogenet Genomics 19:685-94. 2009
    ....
  72. doi request reprint Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease
    Julie Lee
    Department of Clinical Biochemistry K54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Stroke 41:27-33. 2010
    ..We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemic heart disease...
  73. doi request reprint Genetic variation in liver X receptor alpha and risk of ischemic vascular disease in the general population
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 31:2990-6. 2011
    ..We tested the hypothesis that genetic variation in LXRα associates with risk of ischemic vascular disease and/or plasma lipid and lipoprotein levels in the general population...
  74. doi request reprint Short telomere length, lung function and chronic obstructive pulmonary disease in 46,396 individuals
    Line Rode
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Thorax 68:429-35. 2013
    ..A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD)...
  75. doi request reprint Remnant cholesterol as a causal risk factor for ischemic heart disease
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Am Coll Cardiol 61:427-36. 2013
    ..The aim of this study was to test the hypothesis that elevated nonfasting remnant cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-density lipoprotein (HDL) cholesterol...
  76. doi request reprint 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies
    Peter Brøndum-Jacobsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:2794-802. 2012
    ..We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death...
  77. pmc Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Invest 114:1343-53. 2004
    ..In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1 and that both mutations and SNPs in ABCA1 contribute to HDL-C levels in the general population...
  78. ncbi request reprint Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  79. doi request reprint Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Hepatology 53:640-8. 2011
    ..001)...
  80. doi request reprint Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population
    Sarah C W Marott
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Am Coll Cardiol 56:789-95. 2010
    ..The purpose of this study was to test whether the association of C-reactive protein (CRP) with increased risk of atrial fibrillation is a robust and perhaps even causal association...
  81. doi request reprint Statin use and reduced cancer-related mortality
    Sune F Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    N Engl J Med 367:1792-802. 2012
    ..We tested the hypothesis that statin use begun before a cancer diagnosis is associated with reduced cancer-related mortality...
  82. doi request reprint Two novel mutations in surfactant protein-C, lung function and obstructive lung disease
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, Herlev Ringvej 75, DK 2730 Herlev, Copenhagen, Denmark
    Respir Med 104:418-25. 2010
    ..A53T heterozygotes had increased asthma risk, but further research is required to conclusively determine whether this mutation is associated with asthma...
  83. doi request reprint Plasma 25-hydroxyvitamin D and risk of non-melanoma and melanoma skin cancer: a prospective cohort study
    Shoaib Afzal
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Invest Dermatol 133:629-36. 2013
    ..In conclusion, we show that increasing levels of 25-OH-vitD are associated with increased risk of non-melanoma and melanoma skin cancer...
  84. doi request reprint C-reactive protein and all-cause mortality--the Copenhagen City Heart Study
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730, Herlev, Denmark
    Eur Heart J 31:1624-32. 2010
    ..We tested whether elevated levels of C-reactive protein is robustly and causally associated with all-cause mortality...
  85. ncbi request reprint [Nonfasting triglycerides and risk of ischemic stroke--secondary publication]
    Jacob J Freiberg
    Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev
    Ugeskr Laeger 171:2188-91. 2009
    ..3-4.8) compared with men with a nonfasting triglyceride level < 1 mmol/l. The corresponding value in women was 3.8 (1.3-11). We conclude that the level of nonfasting triglycerides is associated with risk of ischemic stroke...
  86. pmc Common clinical practice versus new PRIM score in predicting coronary heart disease risk
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Denmark
    Atherosclerosis 213:532-8. 2010
    ..To compare the new Patient Rule Induction Method (PRIM) Score and common clinical practice with the Framingham Point Score for classification of individuals with respect to coronary heart disease (CHD) risk...
  87. doi request reprint LCAT, HDL cholesterol and ischemic cardiovascular disease: a Mendelian randomization study of HDL cholesterol in 54,500 individuals
    Christiane L Haase
    Department of Clinical Biochemistry, Rigshospitalet, The Copenhagen City Heart Study, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:E248-56. 2012
    ..Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is unclear...
  88. pmc Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study
    Sune F Nielsen
    Department of Clinical Biochemistry, 54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    BMJ 345:e5244. 2012
    ..To test whether elevated concentration of rheumatoid factor is associated with long term development of rheumatoid arthritis...
  89. ncbi request reprint Genetic variation in the scavenger receptor MARCO and its association with chronic obstructive pulmonary disease and lung infection in 10,604 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark
    Respiration 85:144-53. 2013
    ..Reduced function of this receptor due to genetic variation may be associated with susceptibility to chronic obstructive pulmonary disease (COPD) and lung infection...
  90. doi request reprint Low plasma 25-hydroxyvitamin D and risk of tobacco-related cancer
    Shoaib Afzal
    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark
    Clin Chem 59:771-80. 2013
    ..We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population...
  91. doi request reprint 25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis
    Peter Brøndum-Jacobsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Ann Neurol 73:38-47. 2013
    ..We tested the hypothesis that low plasma concentrations of 25-hydroxyvitamin D are associated with increased risk of symptomatic ischemic stroke in the general population...
  92. doi request reprint Elevated fibrinogen levels are associated with risk of pulmonary embolism, but not with deep venous thrombosis
    Jolanta Klovaite
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark
    Am J Respir Crit Care Med 187:286-93. 2013
    ..It is unclear whether elevated plasma fibrinogen is associated with both deep venous thrombosis (DVT) and its complication, pulmonary embolism (PE), and whether elevated fibrinogen is a direct cause of these disorders...
  93. doi request reprint Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication
    Marianne Benn
    Chief Physician, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:3956-64. 2012
    ..This employs the personal and family history of premature coronary artery disease and hypercholesterolemia and the presence of a pathogenic mutation in the low-density lipoprotein receptor (LDLR) and apolipoprotein B (APOB) genes...
  94. doi request reprint Extreme lipoprotein(a) levels and improved cardiovascular risk prediction
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 61:1146-56. 2013
    ..The study tested whether extreme lipoprotein(a) levels and/or corresponding LPA risk genotypes improve myocardial infarction (MI) and coronary heart disease (CHD) risk prediction beyond conventional risk factors...
  95. ncbi request reprint Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease
    Diljit Kaur-Knudsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Curr Vasc Pharmacol 10:512-20. 2012
    ....
  96. doi request reprint Nonfasting triglycerides and risk of ischemic stroke in the general population
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, DK 2730 Herlev, Denmark
    JAMA 300:2142-52. 2008
    ..Recently, a strong association was found between elevated levels of nonfasting triglycerides, which indicate the presence of remnant lipoproteins, and increased risk of ischemic heart disease...
  97. ncbi request reprint Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Curr Vasc Pharmacol 9:281-6. 2011
    ..However, elevated remnant cholesterol may lead to cholesterol entrapment in the arterial intima and consequently to accelerated atherosclerosis and cardiovascular disease...
  98. doi request reprint Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Int J Cancer 128:644-52. 2011
    ..However, MTHFR c.677C>T homozygosity with lifelong hyperhomocysteinemia and hence hypomethylation associate with increased risk of esophagus and gastric cancer, and with decreased risk of colorectal cancer...
  99. ncbi request reprint [Fasting and nonfasting lipids--secondary publication]
    Anne Langsted
    Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev
    Ugeskr Laeger 171:2184-7. 2009
    ..Highest versus lowest tertile of nonfasting total cholesterol, LDL cholesterol, and triglycerides, and lowest versus highest tertile of nonfasting HDL cholesterol predicted a 1.7-to 2.2-fold increased risk of cardiovascular events...
  100. doi request reprint Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function, and chronic obstructive pulmonary disease in smokers
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Am J Respir Crit Care Med 181:17-20. 2010
    ..Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking...
  101. doi request reprint TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 31:451-7. 2011
    ..The goal of this study was to test whether TRIB1-rs2954029 and GCKR-rs1260326 associate with lipid levels and risk of ischemic heart disease (IHD) and myocardial infarction (MI) in the general population...