Børge G Nordestgaard

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi Lipids, atherosclerosis and CVD risk: is CRP an innocent bystander?
    B G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Nutr Metab Cardiovasc Dis 19:521-4. 2009
  2. pmc Elevated transferrin saturation and risk of diabetes: three population-based studies
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Diabetes Care 34:2256-8. 2011
  3. pmc Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population
    K H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev 2730, Denmark
    Br J Cancer 106:199-205. 2012
  4. pmc Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    David Dynnes Ørsted
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Exp Med 204:1295-301. 2007
  5. pmc Heterozygosity for E292V in ABCA3, lung function and COPD in 64,000 individuals
    Marie Bækvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Respir Res 13:67. 2012
  6. pmc S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
    Kelley M Argraves
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Lipids Health Dis 10:70. 2011
  7. pmc Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study
    Thomas Benfield
    Department of Infectious Diseases and Clinical Research Centre, Hvidovre University Hospital, Kettegaard Alle 30, Hvidovre, Denmark
    Crit Care 14:R28. 2010
  8. pmc Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study
    Kristine H Allin
    Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Breast Cancer Res 13:R55. 2011
  9. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  10. doi Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Herlev, Denmark
    Pharmacogenet Genomics 20:77-85. 2010

Detail Information

Publications119 found, 100 shown here

  1. doi Lipids, atherosclerosis and CVD risk: is CRP an innocent bystander?
    B G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Nutr Metab Cardiovasc Dis 19:521-4. 2009
    ..To evaluate recent human studies with respect to the interpretation of whether elevated plasma levels of C-reactive protein (CRP) cause cardiovascular disease (CVD), or whether elevated CRP levels more likely is an innocent bystander...
  2. pmc Elevated transferrin saturation and risk of diabetes: three population-based studies
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Diabetes Care 34:2256-8. 2011
    ..We tested the hypothesis that elevated transferrin saturation is associated with an increased risk of any form of diabetes, as well as type 1 or type 2 diabetes separately...
  3. pmc Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population
    K H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev 2730, Denmark
    Br J Cancer 106:199-205. 2012
    ..YKL-40 and C-reactive protein (CRP) are biomarkers that may reflect cancer-related subclinical inflammation. We assessed elevated YKL-40 and CRP levels as combined risk predictors for cancer...
  4. pmc Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    David Dynnes Ørsted
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    J Exp Med 204:1295-301. 2007
    ..The increased longevity may be due to increased survival after a diagnosis of cancer or other life-threatening diseases...
  5. pmc Heterozygosity for E292V in ABCA3, lung function and COPD in 64,000 individuals
    Marie Bækvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Respir Res 13:67. 2012
    ..We tested the hypothesis that individuals heterozygous for ABCA3 mutations have reduced lung function and increased risk of COPD in the general population...
  6. pmc S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
    Kelley M Argraves
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Lipids Health Dis 10:70. 2011
    ..Emerging evidence suggests that many of the effects of HDL on cardiovascular function may be attributable to its S1P cargo...
  7. pmc Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study
    Thomas Benfield
    Department of Infectious Diseases and Clinical Research Centre, Hvidovre University Hospital, Kettegaard Alle 30, Hvidovre, Denmark
    Crit Care 14:R28. 2010
    ..The objective of this study is to determine whether the Factor V Leiden (FVL) mutation is associated with susceptibility to or death from critical illness...
  8. pmc Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study
    Kristine H Allin
    Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Breast Cancer Res 13:R55. 2011
    ..We examined whether plasma C-reactive protein (CRP) levels at the time of diagnosis of breast cancer are associated with overall survival, disease-free survival, death from breast cancer, and recurrence of breast cancer...
  9. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  10. doi Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, University of Copenhagen, Herlev, Denmark
    Pharmacogenet Genomics 20:77-85. 2010
    ..These polymorphisms were chosen because they could affect blood pressure control or the pharmacological action of losartan or atenolol...
  11. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    ..Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis...
  12. pmc Lipoprotein(a) as a cardiovascular risk factor: current status
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    Eur Heart J 31:2844-53. 2010
    ..The aims of the study were, first, to critically evaluate lipoprotein(a) [Lp(a)] as a cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp(a), on desirable levels, and on therapeutic strategies...
  13. ncbi Clinical relevance of non-fasting and postprandial hypertriglyceridemia and remnant cholesterol
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Curr Vasc Pharmacol 9:281-6. 2011
    ..However, elevated remnant cholesterol may lead to cholesterol entrapment in the arterial intima and consequently to accelerated atherosclerosis and cardiovascular disease...
  14. ncbi Nonfasting hyperlipidemia and cardiovascular disease
    B G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark
    Curr Drug Targets 10:328-35. 2009
    ....
  15. doi Does elevated C-reactive protein cause human atherothrombosis? Novel insights from genetics, intervention trials, and elsewhere
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Lipidol 20:393-401. 2009
    ..To evaluate evidence from human epidemiology, mechanistic studies, animal studies, human genetics, and human intervention trials to address whether elevated C-reactive protein (CRP) causes human atherothrombotic cardiovascular disease...
  16. doi Risk factors for near-term myocardial infarction in apparently healthy men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Clin Chem 56:559-67. 2010
    ..We evaluated established cardiovascular risk factors and putative circulating biomarkers as predictors for MI within 4 years of measurement...
  17. doi Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Atherosclerosis 208:480-3. 2010
    ....
  18. ncbi Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 91:1438-45. 2006
    ..Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD)...
  19. ncbi 164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Pharmacogenet Genomics 15:633-45. 2005
    ..We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure...
  20. doi Angiotensinogen and ACE gene polymorphisms and risk of atrial fibrillation in the general population
    Lasse S Ravn
    Department of Cardiology, Danish Arrhythmia Research Center, Copenhagen, Denmark
    Pharmacogenet Genomics 18:525-33. 2008
    ..We hypothesized that polymorphisms in the angiotensinogen and angiotensin-converting enzyme (ACE) genes encoding proteins in this system predict risk of atrial fibrillation...
  21. pmc Markers of early disease and prognosis in COPD
    Morten Dahl
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Chron Obstruct Pulmon Dis 4:157-67. 2009
    ..To implement markers for COPD in clinical practice, besides those already established for the alpha(1)-antitrypsin gene, further research and validation studies are needed...
  22. ncbi Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 115:861-71. 2007
    ....
  23. pmc Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type
    Birgitte F Sode
    Department of Clinical Biochemistry, Herlev Hospital, and the Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    CMAJ 185:E229-37. 2013
    ....
  24. doi Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease
    Mette Thomsen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    JAMA 309:2353-61. 2013
    ..Exacerbations of respiratory symptoms in chronic obstructive pulmonary disease (COPD) have profound and long-lasting adverse effects on patients...
  25. ncbi Polymorphism in APOB associated with increased low-density lipoprotein levels in both genders in the general population
    Marianne Benn
    Department of Clinical Biochemistry, KB3011, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 90:5797-803. 2005
    ..Rare mutations in APOB cause hypercholesterolemia. Whether common polymorphisms in APOB have similar effects remains controversial...
  26. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension...
  27. doi C-reactive protein and the risk of cancer: a mendelian randomization study
    Kristine H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 102:202-6. 2010
    ..The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer...
  28. doi Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease
    Maria C A Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 52:369-77. 2008
    ..This study was designed to test the hypotheses that single nucleotide polymorphisms (SNPs), in zinc finger protein 202 (ZNF202), predict severe atherosclerosis and ischemic heart disease (IHD)...
  29. ncbi Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 173:858-64. 2006
    ....
  30. ncbi Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Denmark
    Circulation 107:747-52. 2003
    ....
  31. ncbi Improving prediction of ischemic cardiovascular disease in the general population using apolipoprotein B: the Copenhagen City Heart Study
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 27:661-70. 2007
    ..We tested the following hypotheses: apoB predicts ischemic cardiovascular events, and apoB is a better predictor of ischemic cardiovascular events than low-density lipoprotein cholesterol...
  32. doi Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy
    Louise S Hornstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 33:1441-7. 2013
    ..We tested the hypothesis that genetic stabilization of transthyretin associates with reduced risk of vascular disease and increased life expectancy...
  33. doi Short telomere length, cancer survival, and cancer risk in 47102 individuals
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 105:459-68. 2013
    ..We therefore tested the hypotheses that short telomere length was associated with increased risk of cancer and with increased risk of early death after cancer...
  34. doi Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease
    Louise S Hornstrup
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Circ Cardiovasc Genet 4:534-41. 2011
    ....
  35. doi C-reactive protein and risk of venous thromboembolism in the general population
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 30:1672-8. 2010
    ..To examine the robustness of the association between C-reactive protein (CRP) levels and increased risk of venous thromboembolism (VTE) and to examine whether genetically elevated CRP levels cause VTE...
  36. doi PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Coll Cardiol 55:2833-42. 2010
    ..The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality...
  37. doi Genetically elevated C-reactive protein and ischemic vascular disease
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen
    N Engl J Med 359:1897-908. 2008
    ..Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association...
  38. doi Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease
    Trine Holm Johannsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Clin Endocrinol Metab 94:1264-73. 2009
    ..Hepatic lipase influences metabolism of high-density lipoprotein (HDL), a risk factor for ischemic cardiovascular disease (ICD: ischemic heart disease and ischemic cerebrovascular disease)...
  39. pmc Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations
    Morten Dahl
    Department of Clinical Biochemistry and Copenhagen General Population Study, Herlev Hospital and Copenhagen University Hospital, Copenhagen, Denmark
    Am J Respir Crit Care Med 178:906-12. 2008
    ..Inherited change in SOD3 expression or function could affect lung matrix homeostasis and influence pulmonary function...
  40. doi CHRNA3 genotype, nicotine dependence, lung function and disease in the general population
    Diljit Kaur-Knudsen
    Dept of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark
    Eur Respir J 40:1538-44. 2012
    ..In ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity...
  41. doi Inflammatory biomarkers and comorbidities in chronic obstructive pulmonary disease
    Mette Thomsen
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 186:982-8. 2012
    ..Patients with chronic obstructive pulmonary disease (COPD) have evidence of systemic inflammation that may be implicated in the development of comorbidities...
  42. doi Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    J Natl Cancer Inst 103:508-19. 2011
    ..Low plasma levels of low-density lipoprotein (LDL) cholesterol are associated with an increased risk of cancer, but whether this association is causal is unclear...
  43. ncbi Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study
    Marianne Benn
    Department of Clinical Biochemistry, Herlev Hospital, Denmark
    J Am Coll Cardiol 59:2356-65. 2012
    ..The purpose of this study was to test whether elevated nonfasting glucose levels associate with and cause ischemic heart disease (IHD) and myocardial infarction (MI)...
  44. ncbi Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Genet 115:331-45. 2004
    ..2059T --> C and g.2197C --> T SNPs doubled the estimate of genetic variance of high-density lipoprotein and apolipoprotein Al in middle-aged females...
  45. ncbi Genetic variation in ABCA1 predicts ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 28:180-6. 2008
    ..We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population...
  46. doi Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction
    Anne Langsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Circulation 118:2047-56. 2008
    ..Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events...
  47. pmc Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, DK 2730 Herlev, Denmark
    Respir Res 6:113. 2005
    ..Carriers of cystic fibrosis intron-8 5T alleles with high exon-9 skipping could have increased annual lung function decline and increased risk for asthma or chronic obstructive pulmonary disease (COPD)...
  48. doi Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Ann Neurol 69:628-34. 2011
    ..We compared stepwise increasing levels of nonfasting triglycerides and cholesterol for their association with risk of ischemic stroke in the general population...
  49. ncbi Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study
    Maria C A Stene
    Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Atherosclerosis 188:43-50. 2006
    ..We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD)...
  50. doi Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study
    Diljit Kaur-Knudsen
    Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Oncol 29:2875-82. 2011
    ....
  51. doi Plasma YKL-40 and total and disease-specific mortality in the general population
    Julia S Johansen
    Department of Oncology, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark
    Clin Chem 56:1580-91. 2010
    ..We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population...
  52. ncbi Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Mol Cell Cardiol 46:579-86. 2009
    ..3) and 1.2 (1.0-1.5). These genotypes were not associated with risk of asthma or COPD. Leukotriene C4 synthase promoter genotypes influence risk of TIA and ischemic stroke, but not risk of IHD/coronary atherosclerosis, asthma, or COPD...
  53. doi Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 28:990-6. 2008
    ..We tested the hypothesis that the -444 A/C and -1072 G/A polymorphisms of the leukotriene C(4) synthase associate with risk of ischemic cerebrovascular disease...
  54. ncbi Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study
    Klaus Juul
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Circulation 109:59-65. 2004
    ..The secondary hypothesis was that EC-SOD-R213G offers predictive ability with respect to IHD beyond that offered by measurements of plasma EC-SOD and autoantibodies against oxidized LDL (oxLDL)...
  55. doi Pentanucleotide repeat polymorphism, lipoprotein(a) levels, and risk of ischemic heart disease
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 93:3769-76. 2008
    ..Lipoprotein(a) is a cardiovascular risk factor. Levels of lipoprotein(a) are predominantly determined by apolipoprotein(a) gene variation, including a pentanucleotide repeat promoter polymorphism...
  56. ncbi Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population
    Marianne Benn
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 93:1038-45. 2008
    ..Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels...
  57. pmc Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population: prospective cohort study
    Mette Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, DK 2100 Copenhagen, Denmark
    BMJ 343:d5497. 2011
    ..To test the hypothesis that xanthelasmata and arcus corneae, individually and combined, predict risk of ischaemic vascular disease and death in the general population...
  58. ncbi Visible age-related signs and risk of ischemic heart disease in the general population: a prospective cohort study
    Mette Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark M C, R F S, A T H The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark P S, G B J, B G N, A T H the Department of Cardiology, Hvidovre Hospital, Hvidovre, Denmark G B J Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark B G N and Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark M C, R F S, P S, G B J, B G N, A T H
    Circulation 129:990-8. 2014
    ..We tested the hypothesis that visible age-related signs associate with risk of ischemic heart disease (IHD), myocardial infarction (MI), and death in the general population, independent of chronological age...
  59. ncbi Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease
    Amar A Sethi
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Hypertension 41:1202-11. 2003
    ....
  60. ncbi C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease
    Morten Dahl
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Am J Respir Crit Care Med 175:250-5. 2007
    ..Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP)...
  61. doi Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction
    Anders Berg Jørgensen
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospitals and Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur Heart J 34:1826-33. 2013
    ....
  62. ncbi Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study
    Christina Ellervik
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    Circulation 112:185-93. 2005
    ..We tested the hypothesis that the hereditary hemochromatosis genotypes C282Y/C282Y, C282Y/H63D, or C282Y/wild-type are risk factors for ischemic heart disease (IHD) and myocardial infarction (MI)...
  63. doi β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 97:E1074-9. 2012
    ..The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes...
  64. doi Short telomere length, myocardial infarction, ischemic heart disease, and early death
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:822-9. 2012
    ..We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death...
  65. doi Genetic variation in ABCG1 and risk of myocardial infarction and ischemic heart disease
    Jesper Schou
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 32:506-15. 2012
    ..ATP binding cassette transporter G1 (ABCG1) facilitates cholesterol efflux from macrophages to mature high-density lipoprotein particles. Whether genetic variation in ABCG1 affects risk of atherosclerosis in humans remains to be determined...
  66. ncbi Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analyses
    Marianne S Nørskov
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Circ Cardiovasc Genet 4:418-28. 2011
    ..We tested the hypothesis that copy number variation (CNV) in GSTM1 and GSTT1 genes, known to be associated with stepwise decreases in catalytic activity, predict risk of IVD...
  67. doi Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital
    JAMA 299:2524-32. 2008
    ..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...
  68. doi Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:507-14. 2009
    ..We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases...
  69. ncbi Platelet glycoprotein IIb/IIIa Pl(A2)/Pl(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Am Coll Cardiol 42:661-7. 2003
    ....
  70. doi C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach
    Morten Dahl
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Thorax 66:197-204. 2011
    ..The authors tested the hypothesis that genetically elevated plasma CRP causes COPD using a Mendelian randomisation design...
  71. pmc An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease
    Greg Dyson
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA, and Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Denmark
    Genet Epidemiol 31:515-27. 2007
    ..An independent sample of 362 unrelated individuals also from the city of Copenhagen was used to test the model obtained for each of the hypothesized partitions...
  72. pmc The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    PLoS Med 9:e1001212. 2012
    ..We tested the hypothesis that positive observational associations between BMI and IHD are causal...
  73. doi Genetic variation in liver X receptor alpha and risk of ischemic vascular disease in the general population
    Stefan Stender
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 31:2990-6. 2011
    ..We tested the hypothesis that genetic variation in LXRα associates with risk of ischemic vascular disease and/or plasma lipid and lipoprotein levels in the general population...
  74. pmc Common clinical practice versus new PRIM score in predicting coronary heart disease risk
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Denmark
    Atherosclerosis 213:532-8. 2010
    ..To compare the new Patient Rule Induction Method (PRIM) Score and common clinical practice with the Framingham Point Score for classification of individuals with respect to coronary heart disease (CHD) risk...
  75. doi Elevated plasma YKL-40 levels and ischemic stroke in the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 68:672-80. 2010
    ..In contrast to C-reactive protein (CRP) produced in the liver in response to inflammation, YKL-40 is produced by lipid-laden macrophages inside the vessel wall...
  76. ncbi Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Am Coll Cardiol 46:1516-20. 2005
    ..We tested whether heterozygosity for the K776N mutation (frequency: 0.4%) in ATP-binding cassette transporter A1 (ABCA1) predicted ischemic heart disease (IHD) in the Copenhagen City Heart Study population...
  77. doi Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population
    Sarah C W Marott
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Am Coll Cardiol 56:789-95. 2010
    ..The purpose of this study was to test whether the association of C-reactive protein (CRP) with increased risk of atrial fibrillation is a robust and perhaps even causal association...
  78. doi Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Int J Cancer 128:644-52. 2011
    ..However, MTHFR c.677C>T homozygosity with lifelong hyperhomocysteinemia and hence hypomethylation associate with increased risk of esophagus and gastric cancer, and with decreased risk of colorectal cancer...
  79. doi C-reactive protein and all-cause mortality--the Copenhagen City Heart Study
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730, Herlev, Denmark
    Eur Heart J 31:1624-32. 2010
    ..We tested whether elevated levels of C-reactive protein is robustly and causally associated with all-cause mortality...
  80. ncbi Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population
    Maria C Stene
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Lipid Res 47:944-52. 2006
    ..We show that genetic variation in ZNF202 is common in the general population. However, SNPs in the protein-coding region of ZNF202 do not make a major contribution to HDL cholesterol levels...
  81. doi Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity
    Julie Lee
    Department of Clinical Biochemistry 54M1, Herlev University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Respir Med 103:1286-92. 2009
    ..These data suggest that lifelong genetically elevated ACE activity is not a major risk factor for asthma or COPD, or for ischemic heart disease, hypertension, and low physical activity in COPD patients...
  82. doi Two novel mutations in surfactant protein-C, lung function and obstructive lung disease
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, Herlev Ringvej 75, DK 2730 Herlev, Copenhagen, Denmark
    Respir Med 104:418-25. 2010
    ..A53T heterozygotes had increased asthma risk, but further research is required to conclusively determine whether this mutation is associated with asthma...
  83. doi Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease
    Julie Lee
    Department of Clinical Biochemistry K54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Stroke 41:27-33. 2010
    ..We tested whether genetically reduced soluble epoxide hydrolase activity is associated with risk of ischemic stroke, myocardial infarction, and ischemic heart disease...
  84. doi Nonfasting triglycerides and risk of ischemic stroke in the general population
    Jacob J Freiberg
    Department of Clinical Biochemistry, Herlev Hospital, DK 2730 Herlev, Denmark
    JAMA 300:2142-52. 2008
    ..Recently, a strong association was found between elevated levels of nonfasting triglycerides, which indicate the presence of remnant lipoproteins, and increased risk of ischemic heart disease...
  85. doi Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    JAMA 301:2331-9. 2009
    ..High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI)...
  86. pmc Penetrance of NOD2/CARD15 genetic variants in the general population
    Shiva Yazdanyar
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    CMAJ 182:661-5. 2010
    ..However, the importance of these genetic variants if identified in particular individuals within the general population is unknown. We undertook this study to estimate the penetrance of these variants in the general population...
  87. doi CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50,000 individuals
    Diljit Kaur-Knudsen
    Department of Clinical Biochemistry, Copenhagen University Hospital, University of Copenhagen, Denmark
    Pharmacogenet Genomics 19:685-94. 2009
    ....
  88. ncbi Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis
    Nikolaj Eldrup
    Department of Vascular Surgery, Rigshospitalet, Copenhagen University Hospital, Denmark
    Circulation 114:1847-54. 2006
    ..We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death...
  89. ncbi [Fasting and nonfasting lipids--secondary publication]
    Anne Langsted
    Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev
    Ugeskr Laeger 171:2184-7. 2009
    ..Highest versus lowest tertile of nonfasting total cholesterol, LDL cholesterol, and triglycerides, and lowest versus highest tertile of nonfasting HDL cholesterol predicted a 1.7-to 2.2-fold increased risk of cardiovascular events...
  90. pmc Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Invest 114:1343-53. 2004
    ..In conclusion, we show that at least 10% of individuals with low HDL-C in the general population are heterozygous for mutations in ABCA1 and that both mutations and SNPs in ABCA1 contribute to HDL-C levels in the general population...
  91. ncbi Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study
    Rolf V Andersen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Am Coll Cardiol 41:1972-82. 2003
    ..Our primary hypothesis was that these SNPs associate with IHD after adjustment for HDL levels...
  92. pmc A population-based study of morbidity and mortality in mannose-binding lectin deficiency
    Morten Dahl
    Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK 2730 Herlev, Denmark
    J Exp Med 199:1391-9. 2004
    ..Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population...
  93. ncbi [Nonfasting triglycerides and risk of ischemic stroke--secondary publication]
    Jacob J Freiberg
    Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev
    Ugeskr Laeger 171:2188-91. 2009
    ..3-4.8) compared with men with a nonfasting triglyceride level < 1 mmol/l. The corresponding value in women was 3.8 (1.3-11). We conclude that the level of nonfasting triglycerides is associated with risk of ischemic stroke...
  94. ncbi Mutation in apolipoprotein B associated with hypobetalipoproteinemia despite decreased binding to the low density lipoprotein receptor
    Marianne Benn
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Biol Chem 280:21052-60. 2005
    ....
  95. doi Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function, and chronic obstructive pulmonary disease in smokers
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Am J Respir Crit Care Med 181:17-20. 2010
    ..Individuals heterozygous for this mutation have partial absence of surfactant protein-B and could be at risk of lung disease when exposed to additional risk factors for impaired surfactant function such as tobacco smoking...
  96. ncbi Integrin beta3 Leu33Pro homozygosity and risk of cancer
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    J Natl Cancer Inst 95:1150-7. 2003
    ..The Leu33Pro polymorphism of the beta3 subunit modulates the function of alpha(IIb)beta3 integrin. We examined whether this polymorphism influences cancer risk...
  97. ncbi Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study
    Hans H Wittrup
    Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark
    Atherosclerosis 165:119-26. 2002
    ..97; P=0.98). The S447X mutation is associated with anti-atherogenic effects on TG and HDL cholesterol in both genders, and with a moderate protective effect on risk of ischemic heart disease in men...
  98. doi TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 31:451-7. 2011
    ..The goal of this study was to test whether TRIB1-rs2954029 and GCKR-rs1260326 associate with lipid levels and risk of ischemic heart disease (IHD) and myocardial infarction (MI) in the general population...
  99. ncbi Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals
    Julie Lee
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Cancer Epidemiol Biomarkers Prev 20:1673-82. 2011
    ..We tested whether genetically lowered mEH activity affects risk of developing cancer in the general population...
  100. doi Lipoprotein(a) and risk of myocardial infarction--genetic epidemiologic evidence of causality
    Pia R Kamstrup
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Clin Lab Invest 71:87-93. 2011
    ..The association of LPA KIV-2 genotypes raising plasma levels of lipoprotein(a) with increased risk of myocardial infarction strongly supports a causal association of lipoprotein(a) with risk of myocardial infarction...
  101. ncbi Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population
    Morten Dahl
    Department of Clinical Biochemistry 54M1, Herlev University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Ann Intern Med 136:270-9. 2002
    ..A deteriorating effect of severe alpha(1)-antitrypsin deficiency (ZZ genotype) on lung function is well known, whereas the role of intermediate deficiency (MZ genotype) remains uncertain...