Sten Madsbad

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi [New pharmacological treatment methods of type 2 diabetes]
    Sten Madsbad
    Endokrinologisk Afdeling, Hvidovre Hospital, Kettegard Alle 30, 2650 Hvidovre, Denmark
    Ugeskr Laeger 174:2143-6. 2012
  2. ncbi Dipeptidyl peptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) agonists: no
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, 2650 Hvidovre, Denmark
    Eur J Intern Med 23:132-6. 2012
  3. doi Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, University of Copenhagen, Copenhagen N, Kettegaards Alle, Hvidovre, Denmark
    Best Pract Res Clin Endocrinol Metab 23:463-77. 2009
  4. ncbi [Long-term effects of weight-reducing drugs in hypertensive patients--a survey of a Cochrane review]
    Sten Madsbad
    Endokrinologisk Afdeling, Hvidovre Hospital, Hvidovre, Denmark
    Ugeskr Laeger 173:564-7. 2011
  5. doi An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future
    S Madsbad
    Department of Endocrinology, Copenhagen University, Hvidovre Hospital, Denmark
    Diabetes Obes Metab 13:394-407. 2011
  6. ncbi [Treatment of patients with type 2 diabetes mellitus with pioglitazone. A survey of a Cochrane review]
    Sten Madsbad
    Hvidovre Hospital, Endokrinologisk Afdeling, Hvidovre
    Ugeskr Laeger 169:4054-7. 2007
  7. ncbi Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Endocrinol 152:103-12. 2005
  8. ncbi Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass
    Carsten Dirksen
    Department of Endocrinology, Hvidovre Hospital, Kettegaard Alle 30, 2650, Hvidovre, Denmark
    Diabetologia 56:2679-87. 2013
  9. ncbi Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E677-85. 2004
  10. ncbi Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, DK 2650 Copenhagen, Denmark
    Metabolism 55:175-82. 2006

Detail Information

Publications96

  1. ncbi [New pharmacological treatment methods of type 2 diabetes]
    Sten Madsbad
    Endokrinologisk Afdeling, Hvidovre Hospital, Kettegard Alle 30, 2650 Hvidovre, Denmark
    Ugeskr Laeger 174:2143-6. 2012
    ..Proof of principle has been shown for glucagon receptor agonists, glucokinase activators and treatment with dual intestinal peptides, which all induce weight loss and improve glucose tolerance...
  2. ncbi Dipeptidyl peptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) agonists: no
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, 2650 Hvidovre, Denmark
    Eur J Intern Med 23:132-6. 2012
    ..Furthermore, the GLP-1 receptor agonists cover the whole spectrum of treatment from time of diagnosis with lifestyle treatment to combination treatment with basal insulin...
  3. doi Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, University of Copenhagen, Copenhagen N, Kettegaards Alle, Hvidovre, Denmark
    Best Pract Res Clin Endocrinol Metab 23:463-77. 2009
    ..The final place of the GLP-1 receptor agonists in the diabetes treatment algorithm will be clarified when we have long-term trials with cardiovascular end-points and data illustrating the effects on the progression of type 2 diabetes...
  4. ncbi [Long-term effects of weight-reducing drugs in hypertensive patients--a survey of a Cochrane review]
    Sten Madsbad
    Endokrinologisk Afdeling, Hvidovre Hospital, Hvidovre, Denmark
    Ugeskr Laeger 173:564-7. 2011
    ..The studies were too small and of too short duration to allow an evaluation of the effect on cardiovascular mortality and morbidity...
  5. doi An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future
    S Madsbad
    Department of Endocrinology, Copenhagen University, Hvidovre Hospital, Denmark
    Diabetes Obes Metab 13:394-407. 2011
    ..The once-weekly GLP-1 receptor analogues are promising candidates for the treatment of type 2 diabetes, although their efficacy may not be superior to once-daily analogue liraglutide...
  6. ncbi [Treatment of patients with type 2 diabetes mellitus with pioglitazone. A survey of a Cochrane review]
    Sten Madsbad
    Hvidovre Hospital, Endokrinologisk Afdeling, Hvidovre
    Ugeskr Laeger 169:4054-7. 2007
  7. ncbi Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Endocrinol 152:103-12. 2005
    ..Aiming to provide a detailed description of the metabolic adverse effects of HIV-lipodystrophy, we investigated several aspects of glucose metabolism, lipid metabolism and beta-cell function in lipodystrophic HIV-infected patients...
  8. ncbi Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass
    Carsten Dirksen
    Department of Endocrinology, Hvidovre Hospital, Kettegaard Alle 30, 2650, Hvidovre, Denmark
    Diabetologia 56:2679-87. 2013
    ..However, it is unknown whether islet cell responsiveness to i.v. glucose, non-glucose (arginine) and incretin hormones, including GLP-1, is altered...
  9. ncbi Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 287:E677-85. 2004
    ....
  10. ncbi Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, DK 2650 Copenhagen, Denmark
    Metabolism 55:175-82. 2006
    ..Furthermore, FFA may be a major determinant of LIPOX in HIV-infected patients on highly active antiretroviral therapy...
  11. pmc Exaggerated glucagon-like peptide 1 response is important for improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes
    Nils B Jørgensen
    Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
    Diabetes 62:3044-52. 2013
    ..Thus, the exaggerated effect of GLP-1 after RYGB is of major importance for the improvement in β-cell function, control of glucagon release, and glucose tolerance in patients with type 2 diabetes. ..
  12. ncbi In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Metabolism 54:171-9. 2005
    ..1). Our data suggest that HEXi and MCRi are decreased in proportion to the degree of insulin resistance in nondiabetic HIV-infected patients with lipodystrophy...
  13. doi Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss
    Rasmus Rabøl
    Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Metabolism 58:1145-52. 2009
    ....
  14. ncbi Beta-cell dysfunction and low insulin clearance in insulin-resistant human immunodeficiency virus (HIV)-infected patients with lipodystrophy
    Steen B Haugaard
    Clinical Research Unit, Hvidovre University Hospital, University of Copenhagen, Denmark
    Clin Endocrinol (Oxf) 62:354-61. 2005
    ....
  15. ncbi Early enhancements of hepatic and later of peripheral insulin sensitivity combined with increased postprandial insulin secretion contribute to improved glycemic control after Roux-en-Y gastric bypass
    Kirstine N Bojsen-Møller
    Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
    Diabetes 63:1725-37. 2014
    ..Insulin secretion increased after RYGB only in patients with T2D and only in response to oral glucose, underscoring the importance of the changed gut anatomy. ..
  16. pmc Skeletal muscle structural lipids improve during weight-maintenance after a very low calorie dietary intervention
    Steen B Haugaard
    Dept of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark
    Lipids Health Dis 8:34. 2009
    ..Special focus was addressed to SMPL omega-3 FA, which is a lipid entity that influences insulin action...
  17. doi Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
    Meena Asmar
    Department of Endocrinology, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 95:2367-75. 2010
    ..We investigated whether the effects of GLP-1 on gastric emptying, appetite, and food intake are mediated directly or indirectly via release of amylin...
  18. doi Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin
    Pernille Fog Svendsen
    Department of Obstetrics and Gynaecology, Hvidovre Hospital, Hvidovre, 2650 Hvidovre, Denmark
    Metabolism 58:586-93. 2009
    ..05), and a similar trend was seen in the obese women (P = .07). The GIP secretion is attenuated in obese women with PCOS, whereas treatment with metformin increases the levels of both GIP and GLP-1 in women with PCOS...
  19. doi Skeletal muscle mitochondrial function in polycystic ovarian syndrome
    Rasmus Rabøl
    Department of Biomedical Sciences, Faculty of Health Sciences, Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    Eur J Endocrinol 165:631-7. 2011
    ..We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry...
  20. ncbi Circulating sex hormones and gene expression of subcutaneous adipose tissue oestrogen and alpha-adrenergic receptors in HIV-lipodystrophy: implications for fat distribution
    Ove Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Clin Endocrinol (Oxf) 67:250-8. 2007
    ..Oestradiol increases subcutaneous adipose tissue in humans possibly through binding to oestrogen-receptor-alpha, which in turn activates anti-lipolytic alpha2A-adrenergic-receptor...
  21. ncbi Insulin secretion after short- and long-term low-grade free fatty acid infusion in men with increased risk of developing type 2 diabetes
    Heidi Storgaard
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark
    Metabolism 52:885-94. 2003
    ..IGT relatives appear to be more sensitive to the deleterious effects of low-grade fat infusion on insulin secretion than normal glucose tolerant control subjects...
  22. ncbi Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes
    Heidi Storgaard
    Department of Endocrinology and Clinical Research Unit, Hvidovre Hospital, University of Copenhagen, DK 2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 89:1301-11. 2004
    ..The fat-induced metabolic changes were not explained by impairment of the proximal insulin signaling transduction in skeletal muscle...
  23. ncbi Intramyocellular triglyceride content in man, influence of sex, obesity and glycaemic control
    Steen B Haugaard
    Department of Endocrinology Clinical Research Centre, Copenhagen University Hospital, Hvidovre, DK 2650 Hvidovre, Denmark
    Eur J Endocrinol 161:57-64. 2009
    ..It remains unknown whether sex impacts on intramyocellular triglyceride (IMTG) in obesity, as has been shown in non-obese subjects, and, if so, whether this may have implications on the association between IMTG and insulin sensitivity...
  24. ncbi Growth factors, glucose and insulin kinetics after low dose growth hormone therapy in HIV-lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 52:389-98. 2006
    ..Low-dose growth hormone (GH) administration has been suggested as a treatment for HIV-lipodystrophy...
  25. ncbi Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men
    Christine B Jensen
    Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, 2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 88:2775-83. 2003
    ..Moreover, insulin hypersecretion perfectly countered the free-fatty acid-induced insulin resistance. Future studies are needed to determine the role of a prolonged moderate lipid load in subjects at increased risk of developing diabetes...
  26. ncbi The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Denmark
    Regul Pept 144:123-30. 2007
    ..The incretin effect is reduced and the insulinotropic effect of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is abolished in patients with type 2 diabetes mellitus (T2DM)...
  27. ncbi Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
    ..These results suggest mechanisms for the insulin resistance greatly enhancing the risk of type 2 diabetes in HIV lipodystrophy...
  28. ncbi Different growth hormone sensitivity of target tissues and growth hormone response to glucose in HIV-infected patients with and without lipodystrophy
    Ove Andersen
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:832-9. 2004
    ..01). GHBP was inversely correlated with AUC-GH (p <0.01). Our data suggest that GH-target tissues in LIPO are at least as GH-sensitive as in HIV-infected patients without lipodystrophy...
  29. ncbi The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women
    Pernille F Svendsen
    Department of Obstetrics and Gynaecology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
    Scand J Clin Lab Invest 72:410-9. 2012
    ..Evaluation of the effect of an 8-week very low calorie diet (VLCD, 500-600 kcal daily) on weight, body fat distribution, glucose, insulin and lipid metabolism, androgen levels and incretin secretion in obese women...
  30. ncbi Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus
    Kristine J Hare
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    J Clin Endocrinol Metab 94:4679-87. 2009
    ..We investigated the dose-response relationship for GLP-1-induced glucagon suppression in patients with type 2 diabetes (T2DM) and healthy controls...
  31. ncbi Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake
    Jakob Ryskjaer
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Eur J Endocrinol 155:485-93. 2006
    ..Therefore, the aim of the present study was to investigate plasma DPP-IV activity in the fasting and the postprandial state in type-2 diabetic patients and control subjects...
  32. ncbi Desaturation of skeletal muscle structural and depot lipids in obese individuals during a very-low-calorie diet intervention
    Steen B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Copenhagen, Denmark
    Obesity (Silver Spring) 15:117-25. 2007
    ....
  33. ncbi Additive effects of glucagon-like peptide 1 and pioglitazone in patients with type 2 diabetes
    Mette Zander
    Department of Endocrinology, Hvidovre Hospital, Kettegaards Alle 30, 2650 Hvidovre, Denmark
    Diabetes Care 27:1910-4. 2004
    ..To evaluate the effect of combination therapy with pioglitazone and glucagon-like peptide (GLP)-1 in patients with type 2 diabetes...
  34. ncbi The insulin-resistant phenotype of polycystic ovary syndrome
    Pernille Fog Svendsen
    Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Copenhagen, Denmark
    Fertil Steril 94:1052-8. 2010
    ..To investigate the individual parameters included in the diagnosis of polycystic ovary syndrome (PCOS), and their impact on insulin sensitivity...
  35. doi KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    Kasper Aaboe
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Hellerup DK 2900, Denmark
    J Clin Endocrinol Metab 94:603-8. 2009
    ..With this study we therefore aimed at clarifying the role of K(ATP) channel malfunction in the impaired function of GIP...
  36. doi Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes
    Meena Asmar
    Departments of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark
    Regul Pept 160:175-80. 2010
    ..Near-normoglycaemia reduced proinsulin/C-peptide ratio during stimulation with GLP-1, suggesting that strict glycaemic control might ameliorate some of the disturbances in beta-cell function characterizing T2DM...
  37. ncbi Glucose production, oxidation and disposal correlate with plasma lactate levels in HIV-infected patients on HAART
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    J Infect 54:89-97. 2007
    ..However, the correlation between fasting lactate and mitochondrial DNA may be weak or absent, implicating that other factors e.g. glucose turnover may contribute to hyperlactatemia...
  38. ncbi Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    J Med Virol 77:29-38. 2005
    ..Further, HIV may deplete sm-mtDNA of NAIVE, which in part could be mediated through an enhanced pro-inflammatory response...
  39. pmc Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience
    Signe Schmidt
    Department of Endocrinology, Copenhagen University Hospital Hvidovre, Kettegard Alle 30, 2650 Hvidovre, Denmark
    J Diabetes Sci Technol 7:1255-64. 2013
    ..The stochastic part is identical for all patients but identified from data from a single patient. Results of the first clinical feasibility test of the algorithm are presented...
  40. doi Effects of gastric bypass surgery on glucose absorption and metabolism during a mixed meal in glucose-tolerant individuals
    Siv H Jacobsen
    Department of Endocrinology 541, Hvidovre Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Diabetologia 56:2250-4. 2013
    ....
  41. doi Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes
    Rasmus Rabøl
    Department of Biomedical Sciences, Faculty of Health Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1372-8. 2009
    ..Whether hyperglycemia inhibits mitochondrial biogenesis and/or function is unknown. This study examined the effect of different levels of glycemia on skeletal muscle mitochondrial function in patients with T2DM...
  42. ncbi Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Diabetes 56:1951-9. 2007
    ..These results suggest that the reduced incretin effect is not a primary event in the development of type 2 diabetes, but rather a consequence of the diabetic state...
  43. ncbi The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects
    Lise L Kjems
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark
    Diabetes 52:380-6. 2003
    ..Nevertheless, the results also indicate that the dose-response relation between beta-cell responsiveness to glucose and GLP-1 is severely impaired in patients with type 2 diabetes...
  44. pmc Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report
    Carsten Dirksen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Diabetes Care 33:375-7. 2010
    ..To examine after gastric bypass the effect of peroral versus gastroduodenal feeding on glucose metabolism...
  45. doi Sustained low-dose growth hormone therapy optimizes bioactive insulin-like growth factor-I level and may enhance CD4 T-cell number in HIV infection
    Ove Andersen
    Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Hvidovre, Copenhagen, Denmark
    J Med Virol 82:197-205. 2010
    ..07 and +36%, P = 0.02) compared to baseline levels. These data support the notion that low-dose rhGH regimens may increase expediently total and bioactive IGF-I and improve T-cell restoration in patients infected with HIV on HAART...
  46. ncbi Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Denmark
    Metabolism 53:1565-73. 2004
    ..Furthermore, our data suggest that IGFBP-3 protease is a significant regulator of bioactive IGF-I in HIV-lipodystrophy...
  47. pmc Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function
    Urd Kielgast
    Department of Endocrinology, Hvidovre University Hospital, Copenhagen, Denmark
    Diabetes 60:1599-607. 2011
    ....
  48. ncbi Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome
    Louise Ambye
    Department of Clinical Biochemistry, Hvidovre University Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes Res Clin Pract 67:175-9. 2005
    ..In conclusion, the Gly482Ser polymorphism of the PGC-1alpha gene is not associated with the metabolic syndrome, related quantitative traits or cardiac hypertrophy among Danish Caucasian subjects...
  49. ncbi Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
    Tina Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
    Regul Pept 114:115-21. 2003
    ....
  50. ncbi Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, Hvidovre and University of Copenhagen, Copenhagen N, Denmark
    Curr Opin Clin Nutr Metab Care 11:491-9. 2008
    ..To discuss the virtues and shortcomings of the glucagon-like peptide-1 receptor agonists and the dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes...
  51. doi Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Lancet 372:1906-13. 2008
    ..We assessed the efficacy and safety of tesofensine-an inhibitor of the presynaptic uptake of noradrenaline, dopamine, and serotonin-in patients with obesity...
  52. ncbi Obesity, body composition and metabolic disturbances in polycystic ovary syndrome
    Pernille Fog Svendsen
    Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Hum Reprod 23:2113-21. 2008
    ..We determined the impact of polycystic ovary syndrome (PCOS) and obesity on glucose and lipid metabolism and beta-cell function in women with PCOS...
  53. ncbi Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity
    Steen B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Clin Endocrinol (Oxf) 64:169-78. 2006
    ..33, p<0.01)...
  54. doi Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients
    Urd Kielgast
    Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2492-6. 2010
    ..The mechanism by which glucagon-like peptide-1 (GLP-1) suppresses glucagon secretion is uncertain, and it is not determined whether endogenous insulin is a necessary factor for this effect...
  55. doi Increased hepatic insulin clearance after Roux-en-Y gastric bypass
    Kirstine N Bojsen-Møller
    Department of Endocrinology 541, Hvidovre Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    J Clin Endocrinol Metab 98:E1066-71. 2013
    ..Roux-en-Y gastric bypass (RYGB) improves glucose tolerance and ameliorates fasting hyperinsulinemia within days after surgery. Improvements in hepatic insulin sensitivity and insulin clearance could contribute importantly to these effects...
  56. doi Adipose expression of adipocytokines in women with polycystic ovary syndrome
    Pernille Fog Svendsen
    Department of Obstetrics and Gynaecology, Copenhagen University, Hvidovre, Denmark
    Fertil Steril 98:235-41. 2012
    ..To investigate the role of adipocytokines in the pathophysiology of polycystic ovary syndrome (PCOS) by analyzing the messenger RNA (mRNA) expression and plasma levels of adipocytokines...
  57. ncbi Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function
    Ove Andersen
    Department of Infectious Diseases, Internal Medicine and Endocrinology and Clinical Psysiology, Hvidovre University Hospital, Copenhagen, Denmark
    Metabolism 52:1343-53. 2003
    ..Furthermore, in HALS patients, impaired glucose metabolism most likely relates to decreased NOGM and to defects in beta-cell function...
  58. doi Effects of everyday life events on glucose, insulin, and glucagon dynamics in continuous subcutaneous insulin infusion-treated type 1 diabetes: collection of clinical data for glucose modeling
    Signe Schmidt
    Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark
    Diabetes Technol Ther 14:210-7. 2012
    ..To obtain type 1 diabetes (T1D) data for the modeling of glucose metabolism, we designed and conducted a clinical study...
  59. pmc Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function
    Urd Kielgast
    Department of Endocrinology, Hvidovre University Hospital, and Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 34:1463-8. 2011
    ..To investigate the effect of 4 weeks of treatment with liraglutide on insulin dose and glycemic control in type 1 diabetic patients with and without residual β-cell function...
  60. doi Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes
    Mikkel Christensen
    Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Regul Pept 163:96-101. 2010
    ..In conclusion, GLP-2, but not GIP, was found to stimulate the release of glucagon in patients with T1DM, suggesting a role for GLP-2 in the postprandial hyperglucagonaemia characterising individuals with T1DM...
  61. doi Glucagon-like peptide-1, glucose homeostasis and diabetes
    Jens J Holst
    Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Trends Mol Med 14:161-8. 2008
    ..The pathophysiological basis the clinical use of these therapeutics is reviewed here...
  62. doi On the role of glucose-dependent insulintropic polypeptide in postprandial metabolism in humans
    Meena Asmar
    Department of Endocrinology, Hvidovre Hospital, Denmark
    Am J Physiol Endocrinol Metab 298:E614-21. 2010
    ..However, both insulin and GIP lower post-Intralipid FFA concentration, GIP probably via stimulation of insulin secretion, increasing FFA reesterification...
  63. ncbi Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial
    Sten Madsbad
    Department of Endocrinology, Hvidovre Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Denmark
    Diabetes Care 27:1335-42. 2004
    ..Liraglutide is a long-acting glucagon-like peptide 1 analog designed for once daily injection. This study assessed the efficacy and safety of liraglutide after 12 weeks of treatment in type 2 diabetic patients...
  64. ncbi [Weight loss treatment of obese type 2 diabetic patients]
    Sten Madsbad
    H S Hvidovre Hospital, Endokrinologisk Afdeling, Hvidovre
    Ugeskr Laeger 168:175-9. 2006
    ..Except for surgically treated patients, most patients begin to regain the weight lost four to six months after the start of the change in diet...
  65. pmc Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension
    Mogens Fenger
    Copenhagen University Hospital at Hvidovre, Department of Clinical Biochemistry, Genetics, and Molecular Biology, Kettegaard All 26, 2650 Hvidovre, Denmark
    BMC Genet 12:44. 2011
    ..Second, the genetic effects of the sphingolipid metabolism with focus on de novo synthesis of ceramide are analysed. The model does not assume a particular genetic model, but assumes that genes operate in networks...
  66. ncbi Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight
    Christine B Jensen
    Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, Hvidovre, Denmark
    Diabetes 51:1271-80. 2002
    ..We propose that reduced insulin-stimulated glycolysis precedes overt insulin resistance in LBW men. A lower insulin secretion may contribute to impaired glucose tolerance and ultimately lead to diabetes...
  67. ncbi Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists
    Urd Kielgast
    Department of Endocrinology, Hvidovre Hospital and University of Copenhagen, Denmark
    Curr Diabetes Rev 5:266-75. 2009
    ....
  68. ncbi Insulin analogues: have they changed insulin treatment and improved glycaemic control?
    Sten Madsbad
    Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark
    Diabetes Metab Res Rev 18:S21-8. 2002
    ..Surprisingly, the new fast-acting analogues have not achieved the expected commercial success, which emphasises the need for new strategies for basal insulin supplementation, exercise, diet and blood glucose monitoring...
  69. ncbi [Implementation of clinical guidelines in general practice. The effect of journal audit and continuing education for the treatment of cardiovascular risk factors in patients with and without type 2 diabetes]
    Sten Madsbad
    H S Hvidovre Hospital, Endokrinologisk Afdeling, Hvidovre
    Ugeskr Laeger 168:1640-5. 2006
    ....
  70. ncbi Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    Laura Frederiksen
    Department of Endocrinology L F, K B, S M, S A U and Clinical Biochemistry M F, Hvidovre University Hospital, Hvidovre DK 2650, Denmark
    J Clin Endocrinol Metab 87:3989-92. 2002
    ..In conclusion, homozygosity of the codon 12 variant of PPAR-gamma 2 confers a reduced risk of the IRS among Danish Caucasian subjects...
  71. ncbi Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study
    Mette Zander
    Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Lancet 359:824-30. 2002
    ..Glucagon-like peptide 1 (GLP-1) has been proposed as a treatment for type 2 diabetes. We have investigated the long-term effects of continuous administration of this peptide hormone in a 6-week pilot study...
  72. ncbi [Glycemic control and cardiovascular diseases in type 2 diabetes]
    Sten Madsbad
    Ugeskr Laeger 170:3634. 2008
  73. ncbi [The effect of metformin on late diabetic complications and cardiovascular events in obese patients with type 2 diabetes]
    Allan Lindskov Christiansen
    H S Hvidovre Hospital, Medicinsk endokrinologisk afdeling
    Ugeskr Laeger 164:2022-4. 2002
    ..The effect of metformin on various cardiovascular risk factors is briefly discussed...
  74. ncbi [Metformin. Mode of action and effect of monotherapy and combination therapy on glucose metabolism in type 2 diabetes]
    Allan Lindskov Christiansen
    H S Hvidovre Hospital, Medicinsk endokrinologisk afdeling
    Ugeskr Laeger 164:2025-8. 2002
    ..Existing evidence for the clinical use of metformin, both in monotherapy and in combination with other classes of anti-diabetics, is discussed. Overall, metformin presents a very favourable profile in the treatment of type 2 diabetes...
  75. ncbi Postprandial glycemic control with biphasic insulin aspart in patients with type 1 diabetes
    Kjeld Hermansen
    University Department of Endocrinology and Metabolism, Arhus Amtssygehus, Arhus, Denmark
    Metabolism 51:896-900. 2002
    ..We conclude that postprandial glycemic control was more effective with BIAsp 30 than with BHI 30, irrespective of timing of BHI 30 injection...
  76. ncbi No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis
    Filip K Knop
    Department of Internal Medicine F, Gentofte Hospital, Hellerup, Denmark
    Diabetes Care 26:2581-7. 2003
    ..4 +/- 1.1 according to homeostasis model assessment (HOMA). In this study, we investigated diabetic patients with normal or close to normal insulin sensitivity...
  77. ncbi [Control and treatment of HIV-associated lipodystrophy syndrome and related metabolic complications]
    Birgitte Rønde Hansen
    infektionsmedicinsk afdeling 144, H S Hvidovre Hospital, DK 2650 Hvidovre
    Ugeskr Laeger 165:4218-20. 2003
  78. ncbi Improved postprandial glycemic control with biphasic insulin aspart relative to biphasic insulin lispro and biphasic human insulin in patients with type 2 diabetes
    Kjeld Hermansen
    University Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus, Denmark
    Diabetes Care 25:883-8. 2002
    ....
  79. ncbi [Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences]
    Pernille Fog Svendsen
    H S Hvidovre Hospital, Gynaekologisk obstetrisk Afdeling og Endokrinologisk Klinik, Hvidovre
    Ugeskr Laeger 167:3147-51. 2005
    ....
  80. ncbi Young, low-birth-weight men are not more susceptible to the diabetogenic effects of a prolonged free fatty acid exposure than matched controls
    Christine B Jensen
    Steno Diabetes Center, DK 2820 Gentofte, Denmark
    Metabolism 54:1398-406. 2005
    ..We reproduced our previous finding of lower insulin-stimulated glycolysis in this population...
  81. ncbi Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
    ....
  82. ncbi Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    Tina Vilsbøll
    Department of Internal Medicine, Gentofte Hospital, Hellerup, Denmark
    Diabetes Care 30:1608-10. 2007
  83. ncbi [The place of Glitazones in the treatment of diabetes: after the PROactive study]
    Ole E Schmitz
    Arhus Universitetshospital, medicinsk endokrinologisk afdeling M
    Ugeskr Laeger 168:1750-2. 2006
    ..However, there were side effects in terms of cardial insufficiency and edema. Though this study provides some clear cut answers, it also raises a lot of questions...
  84. ncbi [The importance of physical activity and fitness in avoiding the complications of obesity]
    Tina Berentzen
    H S Institut for Sygdomsforebyggelse, Center for Sundhed og Samfund, H S Hvidovre Hospital, Medicinsk endokrinologisk afdeling, og Den Kongelige Veterinaer og Landbohøjskole, Frederiksberg, Levnedsmiddelcentret
    Ugeskr Laeger 168:144-9. 2006
    ..However, physical activity does reduce the risk of type 2 diabetes and heart disease. It is concluded that both inactivity and obesity have an adverse effect on health...
  85. ncbi Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle
    Emma Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
    Diabetes 54:3015-20. 2005
    ..Glucose-tolerant but not glucose-intolerant individuals upregulate their CAPN10 mRNA levels in response to prolonged exposure to fat...
  86. ncbi Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
    Karsten Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Diabetes 51:2514-21. 2002
    ..Our data suggest that sulfatide is important for the control of glucose-induced insulin secretion and that both an increase and a decrease in the sulfatide content have an impact on the secretory capacity of the individual beta-cells...
  87. ncbi Patients with insulin-dependent diabetes but not those with non-insulin-dependent diabetes have anti-sulfatide antibodies as determined with a new ELISA assay
    Kerstin Andersson
    Institute of Clinical Neuroscience, Section of Experimental Neuroscience, Goteborg University, Medical Faculty, Molndal, Sweden
    Autoimmunity 35:463-8. 2002
    ..The role of these autoantibodies in the disease process is not yet clarified but they can be used as a diagnostic tool in the detection of IDDM patients...
  88. ncbi Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels
    Aina S Lihn
    Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Tage Hansensgade 2, 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 285:E1072-80. 2003
    ..Increased cytokine mRNA in AT is hypothesized to exert an inhibitory effect on adiponectin gene expression and, consequently, to play a role in the reduced plasma adiponectin levels found in HALS patients...
  89. ncbi Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution
    Filip K Knop
    Dept of Internal medicine F, Gentofte Hospital, Univ of Copenhagen, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Am J Physiol Endocrinol Metab 292:E324-30. 2007
    ..These results suggest that the secretion of GLP-1 and GIP is under influence of the digestion and absorption of nutrients in the small intestine and that PES increases insulin secretion...
  90. ncbi [Postprandial hyperglycemia. Postprandial blood glucose fluctuations, cardiovascular disease and late diabetic complications]
    Sten Madsbad
    H S Hvidovre Hospital, Medicinsk Center, Endokrinologisk Klinik, DK 2650 Hvidovre
    Ugeskr Laeger 165:3149-53. 2003
    ..No randomised controlled trials have focused on specific treatment of postprandial hyperglycaemia. Therefore, the importance of postprandial hyperglycaemia for development of diabetic complications and atherosclerosis is unclear...
  91. ncbi [Obesity, the metabolic syndrome and cardiovascular disease]
    Sten Madsbad
    H S Hvidovre Hospital, Endokrinologisk Klinik, Den Kgl Veterinaer og Landbohøjskole, Levnedsmiddelcentret, Institut for Human Ernaering
    Ugeskr Laeger 166:1561-4. 2004
  92. ncbi Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
    Anthony H Barnett
    Division of Medical Sciences, University of Birmingham and Birmingham Heartlands and Solihull National Health Service Trust Teaching, Birmingham, United Kingdom
    N Engl J Med 351:1952-61. 2004
    ..Few studies have directly compared the renoprotective effects of angiotensin II-receptor blockers and angiotensin-converting-enzyme (ACE) inhibitors in persons with type 2 diabetes...
  93. ncbi IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients
    Karim Bouzakri
    Karolinska Institute, Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Stockholm, Sweden
    Diabetes 55:785-91. 2006
    ....
  94. ncbi Altered fat tissue distribution in young adult men who had low birth weight
    Eva Lind Rasmussen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes Care 28:151-3. 2005
  95. ncbi Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight
    Jakob Hagen Schou
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:4912-9. 2005
    ..Low birth weight (LBW) is associated with increased risk of type 2 diabetes mellitus. An impaired incretin effect was reported previously in type 2 diabetic patients...
  96. ncbi The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects
    Tina Vilsbøll
    Department of Internal Medicine F, Gentofte Hospital, Denmark
    Regul Pept 137:168-72. 2006
    ..The primary metabolite, GIP 3-42, generated through the action of dipeptidyl peptidase IV (DPP-IV), was eliminated with a mean half-life of 17.5 and 20.5 min in patients and healthy subjects (NS)...