B Lindegaard

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin
    B Lindegaard
    Centre of Inflammation and Metabolism 7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Diabetologia 56:2034-43. 2013
  2. pmc Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 8:e55632. 2013
  3. doi The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy
    B Lindegaard
    Department of Infectious Diseases, Copenhagen Muscle Research Centre, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:3860-9. 2008
  4. pmc Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients
    B Lindegaard
    Department of Infectious Diseases, University of Copenhagen, Denmark
    Clin Exp Immunol 135:273-9. 2004
  5. ncbi Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen Ø, Denmark
    Diabetes 56:2070-7. 2007
  6. ncbi High plasma level of interleukin-18 in HIV-infected subjects with lipodystrophy
    Birgitte Lindegaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    J Acquir Immune Defic Syndr 36:588-93. 2004
  7. ncbi Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes
    P Plomgaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:2562-71. 2007
  8. doi RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes
    C Erikstrup
    Centre of Inflammation and Metabolism, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Obes Metab 11:204-12. 2009
  9. ncbi Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy
    B Lindegaard
    Department of Infectious Diseases, The Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Obes (Lond) 31:449-56. 2007
  10. doi Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
    Anders Rinnov Nielsen
    Department of Infectious Diseases Rigshospitalet, Centre of Inflammation and Metabolism, University of Copenhagen, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:4486-93. 2008

Detail Information

Publications17

  1. pmc Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin
    B Lindegaard
    Centre of Inflammation and Metabolism 7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Diabetologia 56:2034-43. 2013
    ..We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy...
  2. pmc Expression of fibroblast growth factor-21 in muscle is associated with lipodystrophy, insulin resistance and lipid disturbances in patients with HIV
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 8:e55632. 2013
    ..Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that muscle FGF-21 mRNA would be altered in HIV patients with lipodystrophy...
  3. doi The effect of strength and endurance training on insulin sensitivity and fat distribution in human immunodeficiency virus-infected patients with lipodystrophy
    B Lindegaard
    Department of Infectious Diseases, Copenhagen Muscle Research Centre, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:3860-9. 2008
    ..Fat redistribution, insulin resistance, and low-grade inflammation characterize HIV-infected patients with lipodystrophy. Currently, no effective therapies exist for the combined treatment of fat redistribution and insulin resistance...
  4. pmc Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients
    B Lindegaard
    Department of Infectious Diseases, University of Copenhagen, Denmark
    Clin Exp Immunol 135:273-9. 2004
    ....
  5. ncbi Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen Ø, Denmark
    Diabetes 56:2070-7. 2007
    ..The increased glucose uptake may in part be explained by increased dephosphorylation of GS (site 3a + b), resulting in increased GS activity...
  6. ncbi High plasma level of interleukin-18 in HIV-infected subjects with lipodystrophy
    Birgitte Lindegaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    J Acquir Immune Defic Syndr 36:588-93. 2004
    ..An inverse correlation was observed between IL-18 and limb fat (P <0.05). In conclusion, the level of IL-18 is elevated in patients with LD and closely linked to limb atrophy, whereas it is not associated with cholesterol or IR...
  7. ncbi Associations between insulin resistance and TNF-alpha in plasma, skeletal muscle and adipose tissue in humans with and without type 2 diabetes
    P Plomgaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:2562-71. 2007
    ..Clear evidence exists that TNF-alpha inhibits insulin signalling and thereby glucose uptake in myocytes and adipocytes. However, conflicting results exist with regard to the role of TNF-alpha in type 2 diabetes...
  8. doi RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes
    C Erikstrup
    Centre of Inflammation and Metabolism, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Obes Metab 11:204-12. 2009
    ..We hypothesized that an imbalance between RBP and retinol might be the underlying cause for this association...
  9. ncbi Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy
    B Lindegaard
    Department of Infectious Diseases, The Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Obes (Lond) 31:449-56. 2007
    ..The objective of this study was to determine whether altered lipin gene expression is associated with HIV lipodystrophy in humans...
  10. doi Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
    Anders Rinnov Nielsen
    Department of Infectious Diseases Rigshospitalet, Centre of Inflammation and Metabolism, University of Copenhagen, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:4486-93. 2008
    ..IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass...
  11. ncbi Pronounced lipoatrophy in HIV-infected men receiving HAART for more than 6 years compared with the background population
    A B Hansen
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    HIV Med 7:38-45. 2006
    ..To establish the prevalence and quantify the severity of body fat redistribution and dyslipidaemia in HIV-infected men after long-term highly active antiretroviral therapy (HAART) compared with the background population...
  12. ncbi Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    K S Krabbe
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:431-8. 2007
    ..These disorders are associated with type 2 diabetes, and animal models suggest that BDNF plays a role in insulin resistance. We therefore explored whether BDNF plays a role in human glucose metabolism...
  13. pmc Plasma YKL-40: a BMI-independent marker of type 2 diabetes
    Anders R Nielsen
    Department of InfectiousDiseases, Facultyof Health Sciences, Centre of Inflammation and Metabolism, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes 57:3078-82. 2008
    ..YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation. In the present study, YKL-40 was examined in relation to obesity, inflammation, and type 2 diabetes...
  14. ncbi Adipose tissue expression of IL-18 and HIV-associated lipodystrophy
    Birgitte Lindegaard
    Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark
    AIDS 18:1956-8. 2004
    ..Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy...
  15. pmc Calprotectin--a novel marker of obesity
    Ole Hartvig Mortensen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e7419. 2009
    ..We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes...
  16. ncbi Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise
    Lotte Leick
    Centre of Inflammation and Metabolism, Department of Molecular Biology, The August Krogh Building, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 15:356-63. 2007
    ..Furthermore, we speculated that acute exercise and exercise training would regulate AT IL-18 mRNA expression...
  17. doi Menopause is associated with decreased whole body fat oxidation during exercise
    J Abildgaard
    Centre of Inflammation and Metabolism, Faculty of Health Sciences, Department of Infectious Diseases and CMRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 304:E1227-36. 2013
    ..06). We conclude that reduced whole body fat oxidation after menopause is associated with reduced LBM...