A Krag

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Hepatology 46:1863-71. 2007
  2. doi request reprint Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Am J Physiol Renal Physiol 295:F1295-300. 2008
  3. doi request reprint Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Adv Ther 25:1105-40. 2008
  4. doi request reprint Effects of a single dose of terlipressin on transcutaneous oxygen pressures
    Aleksander Krag
    Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre, Faculty of Health Sciences, Copenhagen, Denmark
    Scand J Gastroenterol 45:953-8. 2010
  5. doi request reprint Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 71:112-6. 2011
  6. doi request reprint Low cardiac output predicts development of hepatorenal syndrome and survival in patients with cirrhosis and ascites
    A Krag
    Department of Medical Gastroenterology 439, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Gut 59:105-10. 2010
  7. doi request reprint Treatment of acute variceal bleeding
    F Bendtsen
    Department of Medical Gastroenterology 439, Faculty of Health Sciences, Copenhagen University, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Dig Liver Dis 40:328-36. 2008
  8. doi request reprint The recent reduction in mortality from bleeding oesophageal varices is primarily observed from Days 1 to 5
    Lise Hobolth
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Science, Copenhagen University, Hvidovre, Denmark
    Liver Int 30:455-62. 2010
  9. doi request reprint Effects of a single terlipressin administration on cardiac function and perfusion in cirrhosis
    Aleksander Krag
    Departments of aClinical Physiology bGastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 22:1085-92. 2010
  10. ncbi request reprint Pulmonary dysfunction and hepatopulmonary syndrome in cirrhosis and portal hypertension
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Liver Int 29:1528-37. 2009

Detail Information

Publications18

  1. ncbi request reprint Terlipressin improves renal function in patients with cirrhosis and ascites without hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Hepatology 46:1863-71. 2007
    ..Vasoconstrictors may represent a novel future treatment modality for these patients...
  2. doi request reprint Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Am J Physiol Renal Physiol 295:F1295-300. 2008
    ..1 mmol/l (P < 0.01). An increase in AQP2 excretion and a decrease in C(H2O) and distal water excretion after terlipressin despite water loading is a clear indication of activation of the antidiuretic system (V2 receptor effect)...
  3. doi request reprint Efficacy and safety of terlipressin in cirrhotic patients with variceal bleeding or hepatorenal syndrome
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Adv Ther 25:1105-40. 2008
    ..At present, treatment with terlipressin and albumin is considered the most efficient therapy and should therefore be recommended for the treatment of type 1 HRS-1...
  4. doi request reprint Effects of a single dose of terlipressin on transcutaneous oxygen pressures
    Aleksander Krag
    Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Hvidovre, Faculty of Health Sciences, Copenhagen, Denmark
    Scand J Gastroenterol 45:953-8. 2010
    ..Side effects to TP are often related to skin hypoxaemia. The aim of the study was to investigate the transcutaneous oxygen pressures (TcPO(2) mmHg) after administration of 2 mg of TP...
  5. doi request reprint Effects of the vasopressin agonist terlipressin on plasma cAMP and ENaC excretion in the urine in patients with cirrhosis and water retention
    Aleksander Krag
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 71:112-6. 2011
    ..Stimulation of renal V2 receptors may also affect sodium transport via the Epithelial Sodium Channel (ENaC). Furthermore, endothelial V2 receptors may indirectly affect proximal sodium handling by increasing plasma cAMP...
  6. doi request reprint Low cardiac output predicts development of hepatorenal syndrome and survival in patients with cirrhosis and ascites
    A Krag
    Department of Medical Gastroenterology 439, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Gut 59:105-10. 2010
    ..In this follow-up study, we aimed to investigate the relation between cardiac and renal function in patients with cirrhosis and ascites and the impact of cardiac systolic function on survival. Patients and..
  7. doi request reprint Treatment of acute variceal bleeding
    F Bendtsen
    Department of Medical Gastroenterology 439, Faculty of Health Sciences, Copenhagen University, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Dig Liver Dis 40:328-36. 2008
    ....
  8. doi request reprint The recent reduction in mortality from bleeding oesophageal varices is primarily observed from Days 1 to 5
    Lise Hobolth
    Department of Gastroenterology, Hvidovre University Hospital, Faculty of Health Science, Copenhagen University, Hvidovre, Denmark
    Liver Int 30:455-62. 2010
    ..Several new treatments of bleeding oesophageal varices (BOV) have been introduced during the last 25 years; among these are vasoactive drugs, improved endoscopic techniques and prophylactic antibiotics...
  9. doi request reprint Effects of a single terlipressin administration on cardiac function and perfusion in cirrhosis
    Aleksander Krag
    Departments of aClinical Physiology bGastroenterology, Copenhagen University Hospital Hvidovre, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Eur J Gastroenterol Hepatol 22:1085-92. 2010
    ..The vasoconstrictor terlipressin is widely used in the treatment of the hepatorenal syndrome and variceal bleeding. However, terlipressin may compromise cardiac function and induce ischemia...
  10. ncbi request reprint Pulmonary dysfunction and hepatopulmonary syndrome in cirrhosis and portal hypertension
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Liver Int 29:1528-37. 2009
    ..Pulmonary dysfunction including the hepatopulmonary syndrome (HPS) is an important complication to cirrhosis and portal hypertension. However, the precise relation to liver dysfunction and the prevalence of HPS are unclear...
  11. doi request reprint The heart and the liver
    Søren Møller
    Department of Clinical Physiology and Nuclear Medicine, 239, Hvidovre Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Expert Rev Gastroenterol Hepatol 3:51-64. 2009
    ..Future research should focus on beneficial effects of treatment on cardiac function and mortality...
  12. ncbi request reprint Pathophysiological aspects of pulmonary complications of cirrhosis
    Søren Møller
    Department of Clinical Physiology 239, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    Scand J Gastroenterol 42:419-27. 2007
  13. doi request reprint Reduced baroreflex sensitivity and pulmonary dysfunction in alcoholic cirrhosis: effect of hyperoxia
    Søren Møller
    Dept of Clinical Physiology, Hvidovre Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 299:G784-90. 2010
    ..Acute hyperoxia does not significantly revert the low BRS or the prolonged QT interval in cirrhosis...
  14. ncbi request reprint Systematic review with meta-analysis: the effects of rifaximin in hepatic encephalopathy
    N Kimer
    Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark Department of Clinical Physiology and Nuclear Medicine, Centre of Functional Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
    Aliment Pharmacol Ther 40:123-32. 2014
    ..Rifaximin is recommended for prevention of hepatic encephalopathy (HE). The effects of rifaximin on overt and minimal HE are debated...
  15. ncbi request reprint Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices
    L L Gluud
    Department of Internal Medicine, Copenhagen University Hospital, Gentofte, Denmark
    Aliment Pharmacol Ther 32:859-71. 2010
    ..The evidence concerning the use of isosorbide-mononitrate (IsMn) for oesophageal varices is equivocal...
  16. ncbi request reprint Adherence to guidelines in bleeding oesophageal varices and effects on outcome: comparison between a specialized unit and a community hospital
    Lise Hobolth
    Department of Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Eur J Gastroenterol Hepatol 22:1221-7. 2010
    ..Our aims were to compare adherence to evidence-based guidelines in BOV between a specialized unit and a community hospital, and to investigate whether differences in adherence affected the outcome...
  17. doi request reprint Meta-analysis: the safety and efficacy of vaptans (tolvaptan, satavaptan and lixivaptan) in cirrhosis with ascites or hyponatraemia
    E Dahl
    Department of Medicine, Copenhagen University Hospital Gentofte, Denmark
    Aliment Pharmacol Ther 36:619-26. 2012
    ..Vaptans may correct hyponatraemia and mobilise ascites through an increased excretion of water. The effect on clinical outcomes is debated...
  18. ncbi request reprint Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis
    Aleksander Krag
    Department of Gastroenterology, Hvidovre Hospital, Kettegaard Alle 30, 2650 Hvidovre, Denmark
    Am J Physiol Gastrointest Liver Physiol 291:G8-15. 2006
    ..The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption...