Lars Vedel Kessing

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi request reprint Do young adults with bipolar disorder benefit from early intervention?
    Lars Vedel Kessing
    Copenhagen Affective Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Electronic address
    J Affect Disord 152:403-8. 2014
  2. ncbi request reprint [Genetics and stressful life events interact in depression]
    Lars Vedel Kessing
    Psykiatrisk Center København, afdeling O, Rigshospitalet, Afsnit 6233, Blegdamsvej 9, 2100 København Ø, Denmark
    Ugeskr Laeger 175:948-51. 2013
  3. doi request reprint Maternal depression, antidepressant use in pregnancy and Apgar scores in infants
    Hans Mørch Jensen
    Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Br J Psychiatry 202:347-51. 2013
  4. doi request reprint Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial
    Lars Vedel Kessing
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 202:212-9. 2013
  5. doi request reprint Depression and the risk for dementia
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Curr Opin Psychiatry 25:457-61. 2012
  6. doi request reprint An observational nationwide register based cohort study on lamotrigine versus lithium in bipolar disorder
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    J Psychopharmacol 26:644-52. 2012
  7. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
  8. pmc The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders--design of two randomised c
    Lars Vedel Kessing
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 12:32. 2011
  9. doi request reprint Treatment with antipsychotics and the risk of diabetes in clinical practice
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 197:266-71. 2010
  10. doi request reprint Volume of the adrenal and pituitary glands in depression
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark
    Psychoneuroendocrinology 36:19-27. 2011

Detail Information

Publications95

  1. doi request reprint Do young adults with bipolar disorder benefit from early intervention?
    Lars Vedel Kessing
    Copenhagen Affective Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Electronic address
    J Affect Disord 152:403-8. 2014
    ..The aim of the present report was to compare the effects of early intervention among patients with bipolar disorder aged 18-25 years to that of patients aged 26 years or older...
  2. ncbi request reprint [Genetics and stressful life events interact in depression]
    Lars Vedel Kessing
    Psykiatrisk Center København, afdeling O, Rigshospitalet, Afsnit 6233, Blegdamsvej 9, 2100 København Ø, Denmark
    Ugeskr Laeger 175:948-51. 2013
    ..Certain genetic variations in the serotonin receptor system seem to increase the risk of developing depression in relation to experiencing stressful life events...
  3. doi request reprint Maternal depression, antidepressant use in pregnancy and Apgar scores in infants
    Hans Mørch Jensen
    Psychiatric Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Br J Psychiatry 202:347-51. 2013
    ..Use of antidepressants during pregnancy has been associated with a low Apgar score in infants but a contribution from the underlying depressive disorder might influence this association...
  4. doi request reprint Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial
    Lars Vedel Kessing
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 202:212-9. 2013
    ..Little is known about whether treatment in a specialised out-patient mood disorder clinic improves long-term prognosis for patients discharged from initial psychiatric hospital admissions for bipolar disorder...
  5. doi request reprint Depression and the risk for dementia
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Curr Opin Psychiatry 25:457-61. 2012
    ....
  6. doi request reprint An observational nationwide register based cohort study on lamotrigine versus lithium in bipolar disorder
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark
    J Psychopharmacol 26:644-52. 2012
    ..It is concluded that in daily clinical practice, treatment with lithium is in general superior to treatment with lamotrigine...
  7. pmc Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    Kamilla W Miskowiak
    Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Trials 11:97. 2010
    ....
  8. pmc The effects of centralised and specialised combined pharmacological and psychological intervention compared with decentralised and non-specialised treatment in the early course of severe unipolar and bipolar affective disorders--design of two randomised c
    Lars Vedel Kessing
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 12:32. 2011
    ..It is not known whether centralised and specialised secondary care intervention initiated early after the onset of the diseases can prevent the progression and thereby improve the prognosis...
  9. doi request reprint Treatment with antipsychotics and the risk of diabetes in clinical practice
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 197:266-71. 2010
    ..Treatment with antipsychotics seems to increase the risk of developing diabetes but the association is poorly characterised in clinical practice...
  10. doi request reprint Volume of the adrenal and pituitary glands in depression
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark
    Psychoneuroendocrinology 36:19-27. 2011
    ....
  11. doi request reprint Valproate v. lithium in the treatment of bipolar disorder in clinical practice: observational nationwide register-based cohort study
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Br J Psychiatry 199:57-63. 2011
    ..Valproate is one of the most used mood stabilisers for bipolar disorder, although the evidence for the effectiveness of valproate is sparse...
  12. doi request reprint Do continued antidepressants protect against dementia in patients with severe depressive disorder?
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Int Clin Psychopharmacol 26:316-22. 2011
    ..Methodological reasons for these findings cannot be excluded because of the nonrandomized nature of data...
  13. doi request reprint Predictors of excellent response to lithium: results from a nationwide register-based study
    Lars Vedel Kessing
    Psychiatric Center Copenhagen, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Int Clin Psychopharmacol 26:323-8. 2011
    ..It is concluded that the prevalence of excellent response to lithium monotherapy is low and such patients are characterized by few earlier psychiatric hospitalizations, a manic index episode before lithium and reduced somatic comorbidity...
  14. doi request reprint No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment
    Jens Drachmann Bukh
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Eur Neuropsychopharmacol 20:327-35. 2010
    ..We found no evidence that the effects of the genetic polymorphisms on treatment outcome were dependent on stressful life events experienced by the individual prior to onset of depression...
  15. doi request reprint Risk markers for affective disorder, a seven-years follow up study of a twin cohort at low and high risk for affective disorder
    Maj Vinberg
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Psychiatr Res 47:565-71. 2013
    ..Further, they seem to experience more LEs and to be more vulnerable to these...
  16. ncbi request reprint Treatment with antidepressants in patients with dementia--a nationwide register-based study
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark
    Int Psychogeriatr 19:902-13. 2007
    ..Depression and anxiety is prevalent among patients with dementia but the extent to which these conditions are treated with antidepressants has not previously been investigated...
  17. ncbi request reprint Treatment with antiparkinson and antidepressant drugs: a register-based, pharmaco-epidemiological study
    Mette Brandt-Christensen
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Mov Disord 22:2037-42. 2007
    ....
  18. doi request reprint Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Prog Neuropsychopharmacol Biol Psychiatry 34:86-91. 2010
    ..Variations in the serotonin transporter gene (5-HTTLPR) and stressful life events are associated with affective disorders...
  19. ncbi request reprint Quality of life in unaffected twins discordant for affective disorder
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Affect Disord 99:133-8. 2007
    ..The disability and hardship associated with affective disorder is shared by the family members of affective patients and might affect the family member's quality of life...
  20. pmc Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e31980. 2012
    ..The present trial is the first to test the hypothesis that escitalopram may reduce neuroticism in healthy first-degree relatives of patients with major depressive disorder (MD)...
  21. ncbi request reprint Increased risk of treatment with antidepressants in stroke compared with other chronic illness
    Henrik Dam
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Int Clin Psychopharmacol 22:13-9. 2007
    ..It is concluded that stroke is associated with an increased rate of antidepressant treatment in clinical practice regardless of sex, age, socioeconomic group and time since diagnosis...
  22. doi request reprint Gender differences among patients with a single depressive episode
    Jens D Bukh
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Psychopathology 43:159-69. 2010
    ..The present study evaluated gender differences in sociodemographic, clinical and treatment variables among patients suffering exclusively from single-episode depression...
  23. doi request reprint Lithium treatment and risk of dementia
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Arch Gen Psychiatry 65:1331-5. 2008
    ..It has been suggested that lithium may have neuroprotective abilities, but it is not clear whether lithium reduces the risk of dementia...
  24. doi request reprint Antidepressants and dementia
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen Ø, Denmark
    J Affect Disord 117:24-9. 2009
    ..It has been suggested that antidepressants may have neuroprotective abilities but it has newer been investigated lately whether treatment with antidepressants reduces the risk of dementia...
  25. doi request reprint Does bereavement-related first episode depression differ from other kinds of first depressions?
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Rigshospitalet, Copenhagen Ø, Denmark
    Soc Psychiatry Psychiatr Epidemiol 45:801-8. 2010
    ..It has never been investigated whether first depression differs in patients who have experienced bereavement compared to patients who have not...
  26. ncbi request reprint Increased rate of treatment with antidepressants in patients with epilepsy
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Epilepsy Behav 11:39-45. 2007
    ..44 times (95% CI: 2.12-2.81) increased rate compared with the rate among the general population. It is concluded that patients with epilepsy have a moderately increased probability of being prescribed antidepressants in clinical practice...
  27. doi request reprint Impairment of executive function and attention predicts onset of affective disorder in healthy high-risk twins
    Maj Vinberg
    Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Psychiatry 74:e747-53. 2013
    ..To investigate whether measures of cognitive function can predict onset of affective disorder in individuals at heritable risk...
  28. doi request reprint Differences in the ICD-10 diagnostic subtype of depression in bipolar disorder compared to recurrent depressive disorder
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychopathology 41:141-6. 2008
    ..The aim of the study was to investigate whether patients with bipolar depression and patients with recurrent depressive disorder present with different subtypes of depressive episode as according to ICD-10...
  29. doi request reprint The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial
    Ulla Knorr
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Denmark
    Psychiatry Res 200:354-60. 2012
    ..However, change in salivary cortisol was one out of multiple outcome measures. The results of the present trial do not refute salivary cortisol as a potential endophenotype for depression...
  30. ncbi request reprint Increased rate of treatment with antidepressants in patients with multiple sclerosis
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, Denmark
    Int Clin Psychopharmacol 23:54-9. 2008
    ..The rates were increased in all subgroups of patients regardless of gender, age, socioeconomic group, and time elapsed since diagnosis...
  31. ncbi request reprint [Large differences in treatment of depression between departments of psychiatry]
    Henrik Dam
    Psykiatrisk afdeling, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 172:3183-7. 2010
    ..The purpose of this study was to develop a database for patients admitted to a psychiatric department comprising registration of central clinical parameters...
  32. ncbi request reprint Adherence to lithium in naturalistic settings: results from a nationwide pharmacoepidemiological study
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, University of Copenhagen, Denmark
    Bipolar Disord 9:730-6. 2007
    ..To estimate adherence to lithium in a nationwide sample of all patients treated with lithium and to characterize adherence according to gender and age...
  33. doi request reprint Do stressful life events predict medical treatment outcome in first episode of depression?
    Camilla Bock
    Dept of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen Ø, Denmark
    Soc Psychiatry Psychiatr Epidemiol 44:752-60. 2009
    ..It is unclear whether medical treatment outcome in first episode depression differ for patients with and without stressful life events prior to onset of depression...
  34. pmc The effects of centralised and specialised intervention in the early course of severe unipolar depressive disorder: a randomised clinical trial
    Hanne Vibe Hansen
    Mood Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 7:e32950. 2012
    ..The aim of the present study was to assess the benefits and harms of centralised and specialised secondary care intervention in the early course of severe unipolar depression...
  35. doi request reprint Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression
    Jens Drachmann Bukh
    Psychiatric Center Copenhagen, Copenhagen, Denmark
    J Affect Disord 127:199-202. 2010
    ..However, the diagnosing of personality disorder can be lengthy and requires some training. Therefore, a brief screening interview for comorbid personality disorder among patients suffering from depression would be of clinical use...
  36. ncbi request reprint Suicide risk in patients treated with lithium
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arch Gen Psychiatry 62:860-6. 2005
    ..However, these studies are biased toward patients with the most severe disorders, and the relation to sex and age has seldom been investigated...
  37. ncbi request reprint Gender differences in subtypes of late-onset depression and mania
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet and Department of Psychiatric Demography, University of Aarhus, Psychiatric Hospital, Risskov, Denmark
    Int Psychogeriatr 18:727-38. 2006
    ....
  38. doi request reprint The influence of comorbid personality disorder and neuroticism on treatment outcome in first episode depression
    Camilla Bock
    Department of Psychiatry, University Hospital of Copenhagen, Denmark
    Psychopathology 43:197-204. 2010
    ..It has never been investigated whether comorbid personality disorder or neuroticism predicts a poor treatment outcome in first episode depression...
  39. ncbi request reprint Differences in diagnostic subtypes among patients with late and early onset of a single depressive episode
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark
    Int J Geriatr Psychiatry 21:1127-31. 2006
    ....
  40. doi request reprint The effects of maternal depression and use of antidepressants during pregnancy on risk of a child small for gestational age
    Hans Mørch Jensen
    Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Psychopharmacology (Berl) 228:199-205. 2013
    ..Use of antidepressants during pregnancy has been associated with an increased rate of children small for gestational age (SGA), but it is unclear whether this is due to an effect of the underlying depressive disorder...
  41. ncbi request reprint Diagnostic stability in bipolar disorder in clinical practise as according to ICD-10
    Lars Vedel Kessing
    Department of Psychiatry, University of Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9 DK 2100 Copenhagen Ø, Denmark
    J Affect Disord 85:293-9. 2005
    ..The diagnostic stability of the ICD-10 diagnosis of mania/bipolar disorder has not been investigated in clinical practice...
  42. ncbi request reprint Increased risk of developing diabetes in depressive and bipolar disorders?
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Blegdamsvej 9, Copenhagen 2100, Denmark
    J Psychiatr Res 38:395-402. 2004
    ..There was no difference in the risks of developing Type 1 and Type 2 diabetes...
  43. doi request reprint Hysterectomy, oophorectomy and risk of dementia: a nationwide historical cohort study
    Thien Kieu Thi Phung
    Department of Neurology, Neuroscience Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 30:43-50. 2010
    ..This study aimed to determine whether there is an association between hysterectomy and dementia...
  44. pmc Repeated events and total time on test
    Kajsa Kvist
    Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
    Stat Med 27:3817-32. 2008
    ..The method is illustrated by re-analyzing Danish registry data and a long-term Swiss clinical study on recurrence in affective disorder...
  45. ncbi request reprint Diagnostic subtypes of bipolar disorder in older versus younger adults
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark
    Bipolar Disord 8:56-64. 2006
    ....
  46. doi request reprint Does lithium protect against dementia?
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen Copenhagen, Denmark
    Bipolar Disord 12:87-94. 2010
    ..To investigate whether treatment with lithium in patients with mania or bipolar disorder is associated with a decreased rate of subsequent dementia...
  47. ncbi request reprint Cognitive function in unaffected twins discordant for affective disorder
    Maj Vinberg Christensen
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Psychol Med 36:1119-29. 2006
    ..The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive impairment...
  48. doi request reprint Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events
    Eva Haastrup
    Department of Clinical Immunology, The Blood Bank, The National University Hospital, Copenhagen, Denmark
    J Affect Disord 136:134-8. 2012
    ..The proinflammatory cytokine interleukin-18 (IL-18) is less investigated in depression but highly relevant since it is produced by activated macrophages and expressed in the brain...
  49. doi request reprint Time trend in diagnosing dementia in secondary care
    Thien Kieu Thi Phung
    Memory Disorders Research Group, Department of Neurology, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 29:146-53. 2010
    ....
  50. ncbi request reprint Non-parametric estimation and model checking procedures for marginal gap time distributions for recurrent events
    Kajsa Kvist
    Department of Biostatistics, Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Stat Med 26:5394-410. 2007
    ..We conclude that the procedure only works when the recurrent event is common and when the intra-individual association between gap times is weak...
  51. doi request reprint Mood-stabilizing pharmacological treatment in bipolar disorders and risk of suicide
    Lars Søndergård
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Bipolar Disord 10:87-94. 2008
    ..This study investigated the association between continued mood-stabilizing treatment (lithium and anticonvulsants) in bipolar disorder (BD) and the risk of suicide...
  52. ncbi request reprint Diagnostic stability in depressive disorder as according to ICD-10 in clinical practice
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychopathology 38:32-7. 2005
    ..The diagnostic stability of the ICD-10 diagnosis of depressive disorder has not been investigated in clinical practice...
  53. doi request reprint Coping styles in healthy individuals at risk of affective disorder
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    J Nerv Ment Dis 198:39-44. 2010
    ..In conclusion, maladaptive coping style may represent a trait marker for mood disorder improving maladaptive coping styles may be a target for selective prevention focusing on subgroups at high risk of developing an affective disorder...
  54. ncbi request reprint Use of antiparkinsonian drugs in Denmark: results from a nationwide pharmacoepidemiological study
    Mette Brandt-Christensen
    Department of Psychiatry, University Hospital of Copenhagen Rigshospitalet, Denmark
    Mov Disord 21:1221-5. 2006
    ..However, the possibility of somewhat higher incidence and prevalence rates of PD than hitherto estimated should be considered...
  55. doi request reprint Salivary cortisol in unaffected twins discordant for affective disorder
    Maj Vinberg
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Psychiatry Res 161:292-301. 2008
    ..Future prospective family, high-risk and twin studies are needed to decide whether abnormalities in the HPA axis can be identified as an endophenotype of affective disorder...
  56. ncbi request reprint Continued antidepressant treatment and suicide in patients with depressive disorder
    Lars Søndergård
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    Arch Suicide Res 11:163-75. 2007
    ..On individualized data from a cohort of patients with a known history of depressive disorder, continued antidepressant treatment was associated with reduced risk of suicide...
  57. doi request reprint Differences in psychomotor activity in patients suffering from unipolar and bipolar affective disorder in the remitted or mild/moderate depressive state
    Maria Faurholt-Jepsen
    The Copenhagen Affective Disorder Clinic, Psychiatric Centre Copenhagen, Rigshospitalet, Denmark
    J Affect Disord 141:457-63. 2012
    ..Studies measuring differences in psychomotor activity between unipolar and bipolar disorder show divergent results and none have used a combined heart rate and movement monitor for measuring activity during free-living conditions...
  58. doi request reprint Is there a difference in subjective experience of cognitive function in patients with unipolar disorder versus bipolar disorder?
    Kamilla Miskowiak
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Nord J Psychiatry 66:389-95. 2012
    ..However, patients' subjective experience of cognitive difficulties is poorly understood, and it is unclear whether BD and UD patients experience different cognitive difficulties...
  59. ncbi request reprint Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen Rigshospitalet, Copenhagen, Denmark
    J Affect Disord 73:261-9. 2003
    ..Our aim was to investigate whether patients with unipolar or bipolar affective disorder have an increased risk of developing dementia compared to patients with other chronic illnesses...
  60. doi request reprint Cognitive deficits in the remitted state of unipolar depressive disorder
    Bo Jacob Hasselbalch
    Psychiatric Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    Neuropsychology 26:642-51. 2012
    ..Patients with unipolar depressive disorder may present with cognitive deficits in the remitted state, and the aim of the present study was to investigate whether cognitive deficits within specific cognitive domains are present...
  61. doi request reprint No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
    Eva Haastrup
    Department of Clinical Immunology, Blood Bank, National University Hospital, Copenhagen, Denmark
    J Neuroimmunol 243:69-72. 2012
    ..Our data does thus not support the hypothesis of a global anti-inflammatory effect of escitalopram on cytokines in healthy subjects...
  62. ncbi request reprint On the increased risk of developing late-onset epilepsy for patients with major affective disorder
    Flemming Mørkeberg Nilsson
    Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Affect Disord 76:39-48. 2003
    ..Based on register data we wanted to investigate whether patients with a diagnosis of affective disorder are at increased risk of developing epilepsy compared to other medically ill control groups...
  63. doi request reprint Event dependent sampling of recurrent events
    Kajsa Kvist
    Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
    Lifetime Data Anal 16:580-98. 2010
    ..Furthermore, the methods are applied to affective disease data from a register-based study (Kessing et al. Br J Psychiatry 185:372-377, 2004a) and from a long-term clinical study (Kessing et al. Acta Psychiatr Scand 109:339-344, 2004b)...
  64. doi request reprint The effect of selective serotonin reuptake inhibitors in healthy subjects. A systematic review
    Ulla Knorr
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Nord J Psychiatry 64:153-63. 2010
    ....
  65. ncbi request reprint Satisfaction with treatment among patients with depressive and bipolar disorders
    Lars Vedel Kessing
    Dept of Psychiatry, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Soc Psychiatry Psychiatr Epidemiol 41:148-55. 2006
    ..Patients' satisfaction with care may be an important factor in relation to adherence to treatment and continued psychiatric care. Few studies have focused on satisfaction in patients with depressive and bipolar disorders...
  66. ncbi request reprint Does type of first contact in depressive and bipolar disorders predict subsequent hospitalisation and risk of suicide?
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Affect Disord 83:65-71. 2004
    ..Only a few studies have investigated how the type of first contact is associated with the risk of subsequent hospitalisation and the risk of committing suicide for patients with depressive or bipolar disorders...
  67. ncbi request reprint Course of illness in depressive and bipolar disorders. Naturalistic study, 1994-1999
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 185:372-7. 2004
    ..Newer antidepressants have increasingly been used during the past decade. These drugs may increase compliance and reduce the risk of cycle acceleration in affective disorders...
  68. ncbi request reprint Predictive effects of previous episodes on the risk of recurrence in depressive and bipolar disorders
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Curr Psychiatry Rep 7:413-20. 2005
    ..Nevertheless, the course of illness in unipolar and bipolar disorders is heterogeneous, and the effect of previous episodes and its interrelation with other risk factors on the risk of relapse and recurrence warrants additional research...
  69. ncbi request reprint Validity of dementia diagnoses in the Danish hospital registers
    Thien Kieu Thi Phung
    Memory Disorders Research Group, Department of Neurology, The Centre of Neuroscience, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Dement Geriatr Cogn Disord 24:220-8. 2007
    ..The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine the value of these registers in epidemiological research about dementia...
  70. doi request reprint Hippocampal volume changes in healthy subjects at risk of unipolar depression
    William F C Baare
    Danish Centre for Magnetic Resonance, MR Department, Hvidovre Hospital, University Hospital of Copenhagen, 2650 Hvidovre, Denmark
    J Psychiatr Res 44:655-62. 2010
    ..Further studies are needed to elucidate the role of (shared) environmental and genetic factors...
  71. doi request reprint Severity of depressive episodes during the course of depressive disorder
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Br J Psychiatry 192:290-3. 2008
    ..It is not clear whether the severity of depressive episodes changes during the course of depressive disorder...
  72. ncbi request reprint General health and well-being in outpatients with depressive and bipolar disorders
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Nord J Psychiatry 60:150-6. 2006
    ..Thus, depressive symptoms seem to be the strongest predictor of general health and well-being in both disorders. As the response rate to the questionnaire was relatively low, the findings should be interpreted with caution...
  73. ncbi request reprint [Recurrence following discontinuation of 28 years of lithium therapy]
    Signe Düring Wegmann
    Psykiatrisk Center København, Region Hovedstadens Psykiatri, Blegdamsvej 9, 2100 København Ø, Denmark
    Ugeskr Laeger 173:820-1. 2011
    ..Discontinuation of lithium should be carefully evaluated in patients with a good response to lithium, and the specific reasons for discontinuation should be considered...
  74. doi request reprint Cognitive impairment in the remitted state of unipolar depressive disorder: a systematic review
    Bo Jacob Hasselbalch
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Denmark
    J Affect Disord 134:20-31. 2011
    ..It is unclear whether cognitive impairment is prevalent in the remitted state of unipolar disorder...
  75. ncbi request reprint Severity of depressive episodes according to ICD-10: prediction of risk of relapse and suicide
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Br J Psychiatry 184:153-6. 2004
    ..The ICD-10 categorisation of severity of depression into mild, moderate and severe depressive episodes has not been validated...
  76. ncbi request reprint Adherence to antidepressant treatment
    Hanne Vibe Hansen
    Amager Hospital, Department of Psychiatry, Denmark
    Expert Rev Neurother 7:57-62. 2007
    ..The patient's beliefs about the disorder and beliefs about antidepressants, including lack of conviction that the medication is needed and fear of dependence of antidepressant medicine, have a great influence on adherence to treatment...
  77. doi request reprint The risk of psychiatric disorders in individuals born prematurely in Denmark from 1974 to 1996
    Rene Mathiasen
    Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Acta Paediatr 100:691-9. 2011
    ..To investigate the risk of developing psychiatric disorders in individuals born prematurely (born before 37 weeks of gestation)...
  78. ncbi request reprint Endogenous, reactive and neurotic depression -- diagnostic stability and long-term outcome
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Psychopathology 37:124-30. 2004
    ..No larger long-term study has been conducted of outcomes of patients diagnosed with endogenous, reactive or neurotic depression and using survival methods in the analyses...
  79. pmc Validity of the diagnosis of a single depressive episode in a case register
    Camilla Bock
    Department of Psychiatry, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Clin Pract Epidemiol Ment Health 5:4. 2009
    ..To validate the ICD-10 diagnosis of a single depressive episode as used in daily clinical psychiatric practice and as recorded in the Danish Psychiatric Central Research Register...
  80. pmc Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial
    Ulla Knorr
    Department of Psychiatry Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    PLoS ONE 6:e21224. 2011
    ....
  81. ncbi request reprint Major stressful life events and other risk factors for first admission with mania
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet National Centre for Register based Research, University of Aarhus, Aarhus, Denmark
    Bipolar Disord 6:122-9. 2004
    ..To investigate whether first admission with mania is associated with the occurrence of death in the family or with major stressful life events and to explore whether the associations change with age...
  82. ncbi request reprint [Psychosis in affective disorders]
    Lars Vedel Kessing
    Psykiatrisk Center, Rigshospitalet, Afsnit 6233, DK 2100 København Ø
    Ugeskr Laeger 170:3749-50. 2008
    ..It is still being debated whether these conditions reflect independent illness entities and their relationship to schizoaffective disorder and schizophrenia is also unresolved...
  83. doi request reprint Late and very-late first-contact schizophrenia and the risk of dementia--a nationwide register based study
    Alex Kørner
    Psychogeriatric Clinic, Psychiatric Hospital, Hilleroed, Denmark
    Int J Geriatr Psychiatry 24:61-7. 2009
    ..To examine whether late and very-late first-contact schizophrenia carry a risk for later development of dementia...
  84. doi request reprint Acute and transient psychosis in old age and the subsequent risk of dementia: a nationwide register-based study
    Alex Kørner
    Unit of Psychogeriatric Research, Psychiatric Centre Nordsjaelland, Hilleroed, Denmark
    Geriatr Gerontol Int 9:62-8. 2009
    ..Using the unique Danish psychiatric and somatic health registers, we investigated the rate of subsequent dementia in patients with late-onset acute and transient psychosis...
  85. ncbi request reprint [Treatment-resistant depression is treatable]
    Maj Vinberg
    Kompetencecenter for Affektive Lidelser, Psykiatrisk Center København, Hans Kirks Vej 6, 2200 København N, Denmark
    Ugeskr Laeger 173:651-4. 2011
    ..The choice of treatment must be based on the characteristics of the depression, the severity of treatment resistance and side effects...
  86. pmc Combinations of SNPs related to signal transduction in bipolar disorder
    Pernille Koefoed
    Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e23812. 2011
    ..Different SNPs were involved in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder...
  87. pmc Differences between early and late onset adult depression
    Jens Drachmann Bukh
    Psychiatric Center Copenhagen, Denmark
    Clin Pract Epidemiol Ment Health 7:140-7. 2011
    ..It is unclear, whether age-of-onset identifies subgroups of depression...
  88. doi request reprint Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1
    Anna Secher
    Laboratory of Neuropsychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int Clin Psychopharmacol 24:199-203. 2009
    ..These new findings may aid the understanding of susceptibility to side effects such as weight gain during clinical antidepressive treatment...
  89. ncbi request reprint No increased risk of developing depression in diabetes compared to other chronic illness
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Diabetes Res Clin Pract 62:113-21. 2003
    ..It is concluded that older patients with diabetes do not seem to have an increased risk of developing severe depression compared with patients with other chronic illness...
  90. ncbi request reprint Do personality traits predict first onset in depressive and bipolar disorder?
    Maj Vinberg Christensen
    Rigshospitalet, Copenhagen, Denkark
    Nord J Psychiatry 60:79-88. 2006
    ..A connection between personality traits and development of bipolar disorder, and evidence of a personality-changing effect of affective episodes need to be further investigated...
  91. ncbi request reprint Subtypes of manic episodes according to ICD-10-prediction of time to remission and risk of relapse
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Affect Disord 81:279-85. 2004
    ..The long-term predictive ability of the ICD-10 subtypes of hypomania, mania without psychosis and mania with psychosis has not been investigated...
  92. ncbi request reprint Gender differences in the phenomenology of bipolar disorder
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Bipolar Disord 6:421-5. 2004
    ..To investigate gender differences in the phenomenology of episodes in bipolar disorder as according to ICD-10...
  93. ncbi request reprint Depressive and bipolar disorders: patients' attitudes and beliefs towards depression and antidepressants
    Lars Vedel Kessing
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Copenhagen, Denmark
    Psychol Med 35:1205-13. 2005
    ..However, these attitudes have received little study in patients whose disorders were sufficiently severe to require hospitalization...
  94. ncbi request reprint Subclinical psychopathology and socio-economic status in unaffected twins discordant for affective disorder
    Maj Vinberg Christensen
    Department of Psychiatry, Rigshospitalet University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Psychiatr Res 41:229-38. 2007
    ..It is possible to investigate the relation between risk factors and affective disorder by using a high-risk design e.g.: a study of the healthy relatives of patients with affective disorders...
  95. ncbi request reprint Subtypes of depressive episodes according to ICD-10: prediction of risk of relapse and suicide
    Lars Vedel Kessing
    Department of Psychiatry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Psychopathology 36:285-91. 2003
    ..The long-term predictive ability of the ICD-10 subtypes of depression with melancholic syndrome and depression with psychosis has not been investigated...