Henrik Kehlet

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi request reprint Gastrointestinal transit after laparoscopic versus open colonic resection
    L Basse
    Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Surg Endosc 17:1919-22. 2003
  2. ncbi request reprint Anaesthetic practice for groin hernia repair--a nation-wide study in Denmark 1998-2003
    H Kehlet
    The Danish Hernia Database, Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Acta Anaesthesiol Scand 49:143-6. 2005
  3. ncbi request reprint Labat lecture 2005: surgical stress and postoperative outcome-from here to where?
    Henrik Kehlet
    Section for Surgical Pathophysiology, The Juliane Marie Centre, Copenhagen, Denmark
    Reg Anesth Pain Med 31:47-52. 2006
  4. ncbi request reprint [Gastrointestinal surgery--why specialisation?]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi, København Ø
    Ugeskr Laeger 168:1519-21. 2006
  5. ncbi request reprint Laparoscopic colonic surgery--mission accomplished or work in progress?
    H Kehlet
    Section of Surgical Pathophysiology, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Colorectal Dis 8:514-7. 2006
  6. ncbi request reprint [Why is surgery risky?]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi, København Ø
    Ugeskr Laeger 168:4291-2. 2006
  7. ncbi request reprint [Monitoring and surgical quality. Status and proposal for a national strategy]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centeret, Enhed for Kirurgisk Patofysiologi, 4074, København Ø
    Ugeskr Laeger 168:4324-7. 2006
  8. ncbi request reprint Groin hernia repair: anesthesia
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, The Juliane Marie Centre, Rigshospitalet, 2100 Copenhagen, Denmark
    World J Surg 29:1058-61. 2005
  9. doi request reprint Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice
    Henrik Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet Copenhagen University, Copenhagen, Denmark
    Acta Anaesthesiol Scand 55:778-84. 2011
  10. ncbi request reprint Fast-track surgery
    H Kehlet
    Section of Surgical Pathophysiology, The Juliane Marie Centre 4074, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Br J Surg 92:3-4. 2005

Detail Information

Publications180 found, 100 shown here

  1. ncbi request reprint Gastrointestinal transit after laparoscopic versus open colonic resection
    L Basse
    Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Surg Endosc 17:1919-22. 2003
    ..Gastrointestinal transit after colonic resection with laparoscopy or laparotomy was assessed...
  2. ncbi request reprint Anaesthetic practice for groin hernia repair--a nation-wide study in Denmark 1998-2003
    H Kehlet
    The Danish Hernia Database, Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Acta Anaesthesiol Scand 49:143-6. 2005
    ..Regional anaesthesia may have specific side-effects and is without documented advantages on morbidity in this small operation...
  3. ncbi request reprint Labat lecture 2005: surgical stress and postoperative outcome-from here to where?
    Henrik Kehlet
    Section for Surgical Pathophysiology, The Juliane Marie Centre, Copenhagen, Denmark
    Reg Anesth Pain Med 31:47-52. 2006
  4. ncbi request reprint [Gastrointestinal surgery--why specialisation?]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi, København Ø
    Ugeskr Laeger 168:1519-21. 2006
    ..It is concluded that reorganisation with fewer surgical departments is required to improve outcome after major gastrointestinal surgery...
  5. ncbi request reprint Laparoscopic colonic surgery--mission accomplished or work in progress?
    H Kehlet
    Section of Surgical Pathophysiology, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Colorectal Dis 8:514-7. 2006
    ....
  6. ncbi request reprint [Why is surgery risky?]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi, København Ø
    Ugeskr Laeger 168:4291-2. 2006
    ..It is emphasized that further advances require a multi-disciplinary approach with a focus on process organization and where sufficient quantity is available to secure anaesthesiological, surgical and nursing care expertise...
  7. ncbi request reprint [Monitoring and surgical quality. Status and proposal for a national strategy]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centeret, Enhed for Kirurgisk Patofysiologi, 4074, København Ø
    Ugeskr Laeger 168:4324-7. 2006
    ....
  8. ncbi request reprint Groin hernia repair: anesthesia
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, The Juliane Marie Centre, Rigshospitalet, 2100 Copenhagen, Denmark
    World J Surg 29:1058-61. 2005
    ..Surgeons and anesthesiologists should therefore adjust their anesthesia practices to fit the available scientific evidence...
  9. doi request reprint Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice
    Henrik Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet Copenhagen University, Copenhagen, Denmark
    Acta Anaesthesiol Scand 55:778-84. 2011
    ..Thus, shorter lengths of stay have been achieved by oral multimodal, non-opioid analgesia together with organisational optimisation of care according to the fast-track methodology...
  10. ncbi request reprint Fast-track surgery
    H Kehlet
    Section of Surgical Pathophysiology, The Juliane Marie Centre 4074, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Br J Surg 92:3-4. 2005
  11. ncbi request reprint PROSPECT: evidence-based, procedure-specific postoperative pain management
    Henrik Kehlet
    Section for Surgical Pathophysiology, Section 4074, The Julione Marie Centre, Rigshospitalet, Blegdomsvej 9, DK 2 100 Copenhagen ø, Denmark
    Best Pract Res Clin Anaesthesiol 21:149-59. 2007
    ..For the clinician, an evidence-based, procedure-specific guideline for perioperative pain management is therefore desirable. This chapter reviews the methodology and results of..
  12. ncbi request reprint Fast-track colonic surgery: status and perspectives
    Henrik Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet, Section 4074, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Recent Results Cancer Res 165:8-13. 2005
    ..Further data are needed from multi-national institutions on morbidity, safety, and costs...
  13. ncbi request reprint A survey of perceptions and attitudes among European surgeons towards the clinical impact and management of postoperative ileus
    H Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark
    Colorectal Dis 7:245-50. 2005
    ..The purpose of this survey was therefore to assess current attitudes of surgeons towards the clinical impact and management of POI...
  14. ncbi request reprint [The bed-less hospital--a realistic possibility?]
    Henrik Kehlet
    Afdeling for Kirurgisk Patofysiologi, Juliane Marie Centret, H S Rigshospitalet, København
    Ugeskr Laeger 166:4706-7. 2004
  15. ncbi request reprint Procedure-specific postoperative pain management
    Henrik Kehlet
    Section for Surgical Pathophysiology 4074, The Juliane Marie Centre Rigshospitalet, 2100 Copenhagen, Denmark
    Anesthesiol Clin North America 23:203-10. 2005
    ....
  16. ncbi request reprint A procedure-specific systematic review and consensus recommendations for postoperative analgesia following laparoscopic cholecystectomy
    H Kehlet
    Section for Surgical Pathophysiology, 4074, The Juliane Marie Centre, Rigshospitalet, Denmark
    Surg Endosc 19:1396-415. 2005
    ..Laparoscopic cholecystectomy has advantages over the open procedure for postoperative pain. However, a systematic review of postoperative pain management in this procedure has not been conducted...
  17. ncbi request reprint Future perspectives and research initiatives in fast-track surgery
    Henrik Kehlet
    Section for Surgical Pathophysiology, The Juliane Marie Centre, 4074, Rigshospitalet, 2100 Copenhagen, Denmark
    Langenbecks Arch Surg 391:495-8. 2006
    ..The aim of this article was to update recent data on fast-track abdominal surgery and outline future strategies for research...
  18. doi request reprint [Principles of fast track surgery. Multimodal perioperative therapy programme]
    H Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet Copenhagen University, Copenhagen, Denmark
    Chirurg 80:687-9. 2009
    ..Further improvement in postoperative outcome may be obtained by developments within each care principle with a specific focus on minimally invasive surgery, effective multimodal, non-opioid analgesia and pharmacological stress reduction...
  19. doi request reprint Evidence-based surgical care and the evolution of fast-track surgery
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 248:189-98. 2008
    ..Optimization of postoperative outcome requires the application of evidence-based principles of care carefully integrated into a multimodal rehabilitation program...
  20. doi request reprint Fast-track colorectal surgery
    Henrik Kehlet
    Section for Surgical Pathophysiology 4074, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
    Lancet 371:791-3. 2008
  21. ncbi request reprint Persistent postsurgical pain: risk factors and prevention
    Henrik Kehlet
    Section of Surgical Pathophysiology 4074, Juliane Marie Centre, Rigshospitalet, 2100 Copenhagen, Denmark
    Lancet 367:1618-25. 2006
    ..Here, we outline strategies for identification of patients at risk and for prevention and possible treatment of this important entity of chronic pain...
  22. ncbi request reprint Nationwide quality improvement of groin hernia repair from the Danish Hernia Database of 87,840 patients from 1998 to 2005
    H Kehlet
    Section for Surgical Pathophysiology, Juliane Marie Centre, 4074, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Hernia 12:1-7. 2008
    ....
  23. ncbi request reprint [Fast-track colorectal cancer surgery]
    Henrik Kehlet
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi København Ø
    Ugeskr Laeger 167:4185-6. 2005
    ..Consequently, the hospital stay may be reduced to about two to four days. Preliminary studies suggest similar improvements in more complex colorectal procedures...
  24. doi request reprint Risk of morbidity, mortality, and recurrence after parastomal hernia repair: a nationwide study
    Frederik Helgstrand
    1 The Danish Hernia Database, Copenhagen, Denmark 2 Department of Surgery, Køge Hospital, University of Copenhagen, Køge, Denmark 3 Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark 4 Section for Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 5 Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark 6 Department of Surgery, Colorectal Division, Aarhus University Hospital, Aarhus, Denmark 7 Department of Surgery, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Dis Colon Rectum 56:1265-72. 2013
    ..Surgical outcome results after repair for parastomal hernia are sparsely reported and based on small-scale studies...
  25. doi request reprint The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery
    Nicolai B Foss
    Department of Anesthesia, Hvidovre University Hospital, Denmark
    Transfusion 49:227-34. 2009
    ..Perioperative anemia leads to increased morbidity and mortality and potentially inhibits rehabilitation after hip fracture surgery. As such, the optimum transfusion threshold after hip fracture surgery is unknown...
  26. ncbi request reprint Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study
    Charlotte T Hansen
    Department of Gynecology and Obstetrics, Hvidovre University Hospital, Copenhagen, Denmark
    Am J Obstet Gynecol 196:311.e1-7. 2007
    ....
  27. ncbi request reprint Persistent pain, sensory disturbances and functional impairment after adjuvant chemotherapy for breast cancer: cyclophosphamide, epirubicin and fluorouracil compared with docetaxel + epirubicin and cyclophosphamide
    Kenneth Geving Andersen
    Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
    Acta Oncol 51:1036-44. 2012
    ....
  28. ncbi request reprint [Accelerated course after operation for ovarian cancer]
    Charlotte Iben Marx
    H S Rigshospitalet, Juliane Marie Centret, Gynaekologisk Klinik, Enhed for Kirurgisk Patofysiologi og Anaestesiafdelingen, København Ø
    Ugeskr Laeger 168:1533-6. 2006
    ..The aim of this study was to investigate the effect of a similar fast track regimen in patients operated for ovarian cancer...
  29. doi request reprint Predictive risk factors for persistent postherniotomy pain
    Eske K Aasvang
    Section of Surgical Pathophysiology, The Juliane Marie Centre, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
    Anesthesiology 112:957-69. 2010
    ..Persistent postherniotomy pain (PPP) affects everyday activities in 5-10% of patients. Identification of predisposing factors may help to identify the risk groups and guide anesthetic or surgical procedures in reducing risk for PPP...
  30. pmc Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study
    Linda Basse
    Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Ann Surg 241:416-23. 2005
    ..Since no comparative data between laparoscopic and open colonic resection with multimodal rehabilitation are available, the value of laparoscopy per se is unknown...
  31. ncbi request reprint [Perioperative care of patients with stage IIIC ovarian cancer]
    Dorthe Hjort Jakobsen
    Enhed for Perioperativ Sygepleje Afsnit 3341 Rigshospitalet, Gynakologisk Klinik, Blegdamsvej 9, 2100 København Ø, Denmark
    Ugeskr Laeger 172:2688-91. 2010
    ..The purpose of this study was to assess and discuss perioperative care principles in patients undergoing ovarian cancer surgery with stage IIIC at the six centres in Denmark performing this surgical procedure...
  32. doi request reprint Does goal-directed fluid therapy affect postoperative orthostatic intolerance?: A randomized trial
    Morten Bundgaard-Nielsen
    Research Fellow, Research Assistant, Section of Surgical Pathophysiology, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, and Department of Anesthesiology, The Abdominal Center, Copenhagen University Hospital, Rigshospitalet Research Fellow, Professor, Section of Surgical Pathophysiology, The Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet Staff Anesthesiologist, Head of Department, Professor, Department of Anesthesiology, The Abdominal Center, Copenhagen University Hospital, Rigshospitalet Professor, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Anesthesiology 119:813-23. 2013
    ....
  33. doi request reprint Acute hospitalization of the older patient: changes in muscle strength and functional performance during hospitalization and 30 days after discharge
    Ann Christine Bodilsen
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
    Am J Phys Med Rehabil 92:789-96. 2013
    ..The aim of this study was to investigate the effect of acute hospitalization as a result of medical disease on muscle strength and functional performance in older medical patients...
  34. doi request reprint Anaemia impedes functional mobility after hip fracture surgery
    Nicolai B Foss
    Department of Anaesthesia, Hvidovre University Hospital, Hvidovre, Denmark
    Age Ageing 37:173-8. 2008
    ..We therefore conducted a prospective study to establish whether anaemia affected functional mobility in the early post-operative phase after a hip fracture surgery...
  35. ncbi request reprint [Ovarian cancer in Denmark. Status of the surgical intervention]
    Charlotte Iben Marx
    H S Rigshospitalet, Juliane Marie Centret, Enhed for Kirurgisk Patofysiologi og Gynaekologisk Klinik, Sundhedsstyrelsen, Center for Evaluering og Medicinsk Teknologivurdering CEMTV, København S
    Ugeskr Laeger 168:1537-40. 2006
    ..In Denmark women have not only one of the highest risks of ovarian cancer but also the highest mortality rate. The primary surgery is a key factor in the outcome...
  36. ncbi request reprint From acute to chronic pain after laparoscopic cholecystectomy: a prospective follow-up analysis
    Thue Bisgaard
    Department of Surgical Gastroenterology, H S Hvidovre Hospital, Hvidovre, Denmark
    Scand J Gastroenterol 40:1358-64. 2005
    ..In this prospective study of 150 consecutive patients undergoing laparoscopic cholecystectomy, the preoperative clinical data, cold pressor test, state of neuroticism and early postoperative pain intensity were assessed...
  37. pmc Liberal versus restrictive fluid administration to improve recovery after laparoscopic cholecystectomy: a randomized, double-blind study
    Kathrine Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Ann Surg 240:892-9. 2004
    ..The objective of this study was to investigate the effects of 2 levels of intraoperative fluid administration on perioperative physiology and outcome after laparoscopic cholecystectomy...
  38. doi request reprint Readmissions after fast-track hip and knee arthroplasty
    Henrik Husted
    Department of Orthopedic Surgery, Hvidovre University Hospital, Copenhagen, Denmark
    Arch Orthop Trauma Surg 130:1185-91. 2010
    ..However, it has been speculated that a decrease in LOS may be associated with an increase in readmissions in general, including risk of dislocation after total hip arthroplasty (THA) or manipulation after total knee arthroplasty (TKA)...
  39. doi request reprint Heterogeneous sensory processing in persistent postherniotomy pain
    Eske Kvanner Aasvang
    Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Denmark
    Pain 150:237-42. 2010
    ..Z-score evaluation of sensory function identifies subpopulations in PPP, which may be used in selecting surgical and/or pharmacological treatment strategies...
  40. doi request reprint Nationwide prospective study of outcomes after elective incisional hernia repair
    Frederik Helgstrand
    The Danish Ventral Hernia Database, Copenhagen, Denmark
    J Am Coll Surg 216:217-28. 2013
    ..The aim of this nationwide study was to analyze surgical risk factors for early and late outcomes after incisional hernia repair...
  41. pmc Why still in hospital after fast-track hip and knee arthroplasty?
    Henrik Husted
    Department of Orthopaedic Surgery, Hvidovre University Hospital, Copenhagen, Denmark
    Acta Orthop 82:679-84. 2011
    ..Earlier studies have identified patient characteristics predicting LOS, but little is known about specific reasons for being hospitalized following fast-track THA and TKA...
  42. ncbi request reprint Self-reported arm-lymphedema and functional impairment after breast cancer treatment--a nationwide study of prevalence and associated factors
    Rune Gärtner
    Department of Breast Surgery, Rigshospitalet 3103, Copenhagen University, 2100 Copenhagen, Denmark
    Breast 19:506-15. 2010
    ..Giving up activities was associated with pain and swelling/heaviness, younger age, ALND, chemotherapy, time elapsed since surgery, and surgery on the dominant side. Radiotherapy and type of breast surgery were of no importance...
  43. doi request reprint Chronic pain after lung transplantation: a nationwide study
    Kim Wildgaard
    Department of Cardiothoracic Anesthesia double daggerDivision of Lung Transplantation, Heart Center Section for Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Denmark
    Clin J Pain 26:217-22. 2010
    ..Therefore, we investigated the nationwide incidence of chronic pain after lung transplantations...
  44. ncbi request reprint Danish Hernia Database recommendations for the management of inguinal and femoral hernia in adults
    Jacob Rosenberg
    Department of Surgical Gastroenterology, Herlev Hospital, Denmark
    Dan Med Bull 58:C4243. 2011
    ..These guidelines will also be available at the website for the Danish Hernia Database (www.herniedatabasen.dk). The guidelines will be updated when new substantial evidence becomes available...
  45. doi request reprint Fast-track surgery-an update on physiological care principles to enhance recovery
    Henrik Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet Copenhagen University, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Langenbecks Arch Surg 396:585-90. 2011
    ..The concept of fast-track surgery (enhanced recovery programs) has been evolved and been documented to be successful by decreasing length of stay, morbidity and convalescence across procedures...
  46. ncbi request reprint Can preoperative electrical nociceptive stimulation predict acute pain after groin herniotomy?
    Eske Kvanner Aasvang
    Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark
    J Pain 9:940-4. 2008
    ..Preoperative electrical pain detection threshold and electrical pain tolerance threshold did not correlate to postoperative pain (rho = -0.13, P = .09, and rho = -1.2, P = .4, respectively...
  47. ncbi request reprint Bupivacaine in microcapsules prolongs analgesia after subcutaneous infiltration in humans: a dose-finding study
    Juri L Pedersen
    Department of Surgical Gastroenterology 435, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Anesth Analg 99:912-8, table of contents. 2004
    ..No serious side effects were observed for up to 6 mo after administration. In conclusion, bupivacaine incorporated in microcapsules provided analgesia for 96 h after subcutaneous infiltration...
  48. ncbi request reprint A compression bandage improves local infiltration analgesia in total knee arthroplasty
    Lasse Ø Andersen
    Departments of Anesthesiology, Hvidovre University Hospital, Copenhagen, Denmark
    Acta Orthop 79:806-11. 2008
    ..High-volume local infiltration analgesia has been shown to be an effective pain treatment after knee replacement, but the role of bandaging to prolong analgesia has not been evaluated...
  49. ncbi request reprint Colonic surgery with accelerated rehabilitation or conventional care
    Linda Basse
    Department of Surgical Gastroenterology 435, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark
    Dis Colon Rectum 47:271-7; discussion 277-8. 2004
    ..The aim of this study was to evaluate the postoperative outcome after colonic resection with conventional care compared with fast-track multimodal rehabilitation...
  50. ncbi request reprint Anaesthesia, surgery, and challenges in postoperative recovery
    Henrik Kehlet
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    Lancet 362:1921-8. 2003
    ....
  51. doi request reprint Outcomes after emergency versus elective ventral hernia repair: a prospective nationwide study
    Frederik Helgstrand
    Danish Ventral Hernia Database, Copenhagen, Denmark
    World J Surg 37:2273-9. 2013
    ..Thus, the aim of present study was to investigate early results and risk factors for poor 30-day outcome after emergency versus elective repair for ventral hernias...
  52. ncbi request reprint Does neoadjuvant chemotherapy impair long-term survival for ovarian cancer patients? A nationwide Danish study
    Carsten Lindberg Fagö-Olsen
    Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen University Hospital, Denmark Electronic address
    Gynecol Oncol 132:292-8. 2014
    ..We aimed to evaluate the impact of first-line treatment on surgical outcome and median overall survival (MOS)...
  53. pmc A comprehensive multimodal pain treatment reduces opioid consumption after multilevel spine surgery
    Ole Mathiesen
    Section of Acute Pain Management and Palliative Medicine, Department of Anesthesia 4231, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Eur Spine J 22:2089-96. 2013
    ..This case-control study investigated if a standardized comprehensive pain and postoperative nausea and vomiting (PONV) treatment protocol would improve pain treatment in this population...
  54. ncbi request reprint Organisation and quality of primary surgical intervention for ovarian cancer in Denmark
    Charlotte Marx
    Department of Gynecology, Juliane Marie Centre, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 86:1496-502. 2007
    ..The primary aim of the present study was, therefore, to evaluate the organisation and quality of current primary surgical intervention for ovarian cancer in Denmark...
  55. ncbi request reprint Multimodal analgesic treatment in video-assisted thoracic surgery lobectomy using an intraoperative intercostal catheter
    Kim Wildgaard
    Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
    Eur J Cardiothorac Surg 41:1072-7. 2012
    ..A simple multimodal approach using an intercostal catheter (ICC) may be of benefit since acute post-operative pain following VATS lobectomy primarily originates from the chest drain area...
  56. doi request reprint Pre-operative pain and sensory function in groin hernia
    Eske K Aasvang
    Section of Surgical Pathophysiology, 4074 Rigshospitalet, Blegdamsvej 9, Copenhagen University, 2100 Copenhagen Ø, Denmark
    Eur J Pain 13:1018-22. 2009
    ..Since pre-operative pain has been demonstrated to be a risk factor for persistent postherniotomy pain, pre-operative alterations in nociceptive function may be a potential pathogenic mechanism...
  57. ncbi request reprint Ejaculatory pain: a specific postherniotomy pain syndrome?
    Eske K Aasvang
    Section of Surgical Pathophysiology, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Anesthesiology 107:298-304. 2007
    ..5% of patients. However, the specific psychosexological and neurophysiologic characteristics have not been described, thereby precluding assessment of pathogenic mechanisms and treatment strategies...
  58. ncbi request reprint Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy
    Trine Mikkelsen
    Department of Surgical Gastroenterologye, Hvidovre University Hospital, Copenhagen, Denmark
    Anesth Analg 99:146-51. 2004
    ..Factors other than nerve damage may be involved in the development of chronic posthemiotomy pain...
  59. ncbi request reprint [Surgical care guidelines]
    Kirsten Rud
    Rigshospitalet, Enhed for Perioperativ Sygepleje, Universiteternes Center for Sygepleje, København Ø
    Ugeskr Laeger 170:1559-63. 2008
    ..The aim of this study was to evaluate the availability and content of guidelines for perioperative care in all departments performing colonic resection, nephrectomy, ovarian cancer surgery, pulmonary resection and total knee replacement...
  60. doi request reprint Quantitative sensory testing in patients with postthoracotomy pain syndrome: Part 2: variability in thermal threshold assessments
    Kim Wildgaard
    Section for Surgical Pathophysiology, Copenhagen University Hospital, Copenhagen, Denmark
    Clin J Pain 29:784-90. 2013
    ..The objective of the study was to assess the test-retest variability of thermal thresholds in patients (n = 14) with the postthoracotomy pain syndrome...
  61. doi request reprint Persistent pain and sensory disturbances after treatment for breast cancer: six year nationwide follow-up study
    Mathias Kvist Mejdahl
    Section for Surgical Pathophysiology, 7621 Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 346:f1865. 2013
    ..To examine the development of persistent pain after treatment for breast cancer and to examine risk factors associated with continuing pain...
  62. ncbi request reprint Centralized treatment of advanced stages of ovarian cancer improves survival: a nationwide Danish survey
    Carsten L Fagö-Olsen
    Department of Gynecology, Juliane Marie Centre, Copenhagen, Denmark
    Acta Obstet Gynecol Scand 90:273-9. 2011
    ..This retrospective, nationwide, observational study was designed to compare treatment in tertiary referral centers vs. regional hospitals on overall survival for patients with stage IIIC and IV ovarian cancer...
  63. doi request reprint Psychological distress among women with newly diagnosed breast cancer
    Birgitte Goldschmidt Mertz
    Department of Breast Surgery, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Oncol Nurs 16:439-43. 2012
    ..Our objectives were to determine the prevalence of distress and to investigate the related problems and the characteristics of women with breast cancer who experienced psychological distress at the time of diagnosis...
  64. ncbi request reprint [Chronic pain after groin hernia repair]
    Henrik Kehlet
    Enhed for Kirurgisk Patofysiologi, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 173:45-7. 2011
    ..The choice between pharmacological intervention and re-exploration is debatable. A centralisation of the Danish patients with regard to evaluation and treatment is proposed...
  65. ncbi request reprint Liberal versus restrictive fluid management in knee arthroplasty: a randomized, double-blind study
    Kathrine Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Anesth Analg 105:465-74. 2007
    ..In this study we investigated the effects of two levels of intravascular fluid administration ("liberal" versus "restrictive") in knee arthroplasty on physiological recovery as the primary outcome variable...
  66. ncbi request reprint Painful tonic heat stimulation induces GABA accumulation in the prefrontal cortex in man
    Ron Kupers
    Department of Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark
    Pain 142:89-93. 2009
    ..The results are in line with animal findings on the role of GABA in pain processing and with studies in humans showing analgesic efficacy of GABA-related drugs in clinical pain conditions...
  67. doi request reprint Postoperative recovery profile after elective abdominal hysterectomy: a prospective, observational study of a multimodal anaesthetic regime
    Kenneth Jensen
    Department of Anaesthesiology and Intensive Care, Acute Pain Service 530, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Anaesthesiol 26:382-8. 2009
    ..To evaluate the applicability, effectiveness, immediate postoperative complaints and requirements for a postanaesthesia care unit stay after elective abdominal hysterectomy under a well defined, multimodal anaesthetic regime...
  68. ncbi request reprint Postoperative ileus: progress towards effective management
    Kathrine Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Drugs 62:2603-15. 2002
    ..A multi-modal rehabilitation programme including continuous epidural analgesia with local anaesthetics, enforced nutrition and mobilisation may reduce PI to 1-2 days after colonic surgery...
  69. doi request reprint Prevalence of and factors associated with persistent pain following breast cancer surgery
    Rune Gärtner
    Department of Breast Surgery, Rigshospitalet 2101, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    JAMA 302:1985-92. 2009
    ..The pathogenic mechanisms are complex and may be related to patient characteristics, surgical technique, and adjuvant therapy...
  70. pmc A new algorithm for hip fracture surgery. Reoperation rate reduced from 18 % to 12 % in 2,000 consecutive patients followed for 1 year
    Henrik Palm
    Department of Orthopaedics, Hvidovre University Hospital, Copenhagen, Denmark
    Acta Orthop 83:26-30. 2012
    ..Treatment of hip fracture patients is controversial. We implemented a new operative and supervision algorithm (the Hvidovre algorithm) for surgical treatment of all hip fractures, primarily based on own previously published results...
  71. ncbi request reprint Local anesthetics after total knee arthroplasty: intraarticular or extraarticular administration? A randomized, double-blind, placebo-controlled study
    Lasse Ø Andersen
    Departments of Anesthesiology, Hvidovre University Hospital, Denmark
    Acta Orthop 79:800-5. 2008
    ..e. intraarticular or extraarticular) has not been evaluated...
  72. ncbi request reprint Chronic pain after childhood groin hernia repair
    Eske Kvanner Aasvang
    Section of Surgical Pathophysiology, The Juliane Marie Centre, 2100 Copenhagen, Denmark
    J Pediatr Surg 42:1403-8. 2007
    ..Studies of other childhood surgery before the age of 3 months suggest a risk of increased pain responsiveness later in life, but its potential relationship to chronic pain in adult life is unknown...
  73. doi request reprint No evidence for generalized increased postoperative responsiveness to pain: a combined behavioral and serial functional magnetic resonance imaging study
    Ron Kupers
    Department of Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Anesth Analg 109:600-6. 2009
    ..We tested this hypothesis using a postoperative pain model, in conjunction with serial functional magnetic resonance imaging (fMRI)...
  74. doi request reprint Normovolemia defined according to cardiac stroke volume in healthy supine humans
    Morten Bundgaard-Nielsen
    Department of Anesthesiology, Rigshospitalet, University of Copenhagen, Denmark
    Clin Physiol Funct Imaging 30:318-22. 2010
    ..However, it is unknown whether stroke volume (SV) responds to an increase in preload induced by fluid administration...
  75. ncbi request reprint Prediction of postoperative pain by preoperative nociceptive responses to heat stimulation
    Mads U Werner
    Department of Anesthesiology, Hvidore University Hospital, Copenhagen, Denmark
    Anesthesiology 100:115-9; discussion 5A. 2004
    ..Therefore, the authors investigated the potential of a preoperatively induced heat injury to predict subsequent postoperative pain ratings in patients undergoing knee surgery...
  76. ncbi request reprint Room for improvement in the treatment of hip fractures in Denmark
    Ingrid Egerod
    The University Hospitals Centre for Nursing and Care Research, Rigshospitalet, København Ø, Denmark
    Dan Med Bull 57:A4199. 2010
    ..The aim of our study was to describe the quality of treatment and care related to fast-track hip fracture surgery in Denmark by external audit of patient records...
  77. pmc High-volume infiltration analgesia in bilateral hip arthroplasty. A randomized, double-blind placebo-controlled trial
    Lasse Ø Andersen
    Department of Anesthesiology, Hvidovre Hospital, Copenhagen, Denmark
    Acta Orthop 82:423-6. 2011
    ..High-volume infiltration analgesia may be effective in postoperative pain management after hip arthroplasty but methodological problems prevent exact interpretation of previous studies...
  78. doi request reprint Re-recurrence after operation for recurrent inguinal hernia. A nationwide 8-year follow-up study on the role of type of repair
    Thue Bisgaard
    The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Ann Surg 247:707-11. 2008
    ..We analyze, on a nationwide basis, the risk of re-reoperation with reference to previous inguinal hernia repair technique...
  79. ncbi request reprint Care after colonic operation--is it evidence-based? Results from a multinational survey in Europe and the United States
    Henrik Kehlet
    Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark
    J Am Coll Surg 202:45-54. 2006
    ..This survey investigated clinical practice around colonic operations across Europe and the United States...
  80. ncbi request reprint Dexamethasone prolongs local analgesia after subcutaneous infiltration of bupivacaine microcapsules in human volunteers
    Kathrine Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Anesthesiology 96:1331-5. 2002
    ..The addition of small amounts of dexamethasone to extended-release formulations of bupivacaine in microcapsules has been found to prolong local analgesia in experimental studies, but no clinical data are available...
  81. ncbi request reprint Multimodal strategies to improve surgical outcome
    Henrik Kehlet
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Am J Surg 183:630-41. 2002
    ..To evaluate the effect of modifying perioperative care in noncardiac surgical patients on morbidity, mortality, and other outcome measures...
  82. doi request reprint Local anaesthesia as a risk factor for recurrence after groin hernia repair
    H Kehlet
    Section of Surgical Pathophysiology, Copenhagen University Hospital Rigshospitalet, 4074, Copenhagen, Denmark
    Hernia 12:507-9. 2008
    ..The literature is inconclusive regarding the effect of local infiltration anaesthesia on the risk of recurrence after groin hernia repair...
  83. ncbi request reprint Anaesthesia and post-operative morbidity after elective groin hernia repair: a nation-wide study
    M Bay-Nielsen
    The Danish Hernia Database, Department of Gastroenterology, University Hospital, Hvidovre, Denmark
    Acta Anaesthesiol Scand 52:169-74. 2008
    ..However, implications and results of this evidence for general practice are not known...
  84. ncbi request reprint Combined ilioinguinal blockade and local infiltration anaesthesia for groin hernia repair--a double-blind randomized study
    F H Andersen
    Surgical Clinic Charlottenlund, Copenhagen, Denmark
    Br J Anaesth 94:520-3. 2005
    ..It is unknown whether a combined ilioinguinal blockade and local infiltration anaesthesia improves intra-operative analgesia...
  85. ncbi request reprint Physiologic effects of intravenous fluid administration in healthy volunteers
    Kathrine Holte
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Anesth Analg 96:1504-9, table of contents. 2003
    ..These findings may serve as a basis for clinical studies applying the same type of fluid in different amounts to determine the optimal amount of perioperative fluid in various surgical procedures...
  86. ncbi request reprint Does an acute pain service improve postoperative outcome?
    Mads U Werner
    Acute Pain Service, Department of Anesthesiology 532, Hvidovre University Hospital, 2650 Hvidovre, Denmark
    Anesth Analg 95:1361-72, table of contents. 2002
  87. ncbi request reprint Post-operative recovery profile after laparoscopic cholecystectomy: a prospective, observational study of a multimodal anaesthetic regime
    K Jensen
    Department of Anaesthesiology and Intensive Care, Hvidovre University Hospital, Hvidovre, Denmark
    Acta Anaesthesiol Scand 51:464-71. 2007
    ..We investigated the feasibility and efficacy of a standardized, evidence-based anaesthesia/analgesic regime to identify residual problems in the early post-operative phase...
  88. ncbi request reprint Chronic postoperative pain: the case of inguinal herniorrhaphy
    E Aasvang
    Section of Surgical Pathophysiology, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Br J Anaesth 95:69-76. 2005
  89. ncbi request reprint Late sensory function after intraoperative capsaicin wound instillation
    E K Aasvang
    Section of Surgical Pathophysiology, Copenhagen University, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:224-31. 2010
    ..However, no study has evaluated the long-term effects of wound instillation of purified capsaicin on sensory functions...
  90. ncbi request reprint Pain and convalescence after laparoscopic cholecystectomy
    T Bisgaard
    Department of Surgical Gastroenterology, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark
    Eur J Surg 167:84-96. 2001
    ..To minimise pain and the duration of convalescence, we recommend multi-modal analgesic treatment in combination with short, standardised instructions to resume work and normal activity...
  91. pmc Pain and functional impairment 1 year after inguinal herniorrhaphy: a nationwide questionnaire study
    M Bay-Nielsen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark
    Ann Surg 233:1-7. 2001
    ..To determine the incidence of groin pain 1 year after inguinal herniorrhaphy and to assess the influence of chronic groin pain on function...
  92. ncbi request reprint Fast track vaginal surgery
    Marianne Ottesen
    Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark
    Acta Obstet Gynecol Scand 81:138-46. 2002
    ..Our aim was to describe the need for postoperative hospitalization after vaginal surgery for utero-vaginal prolapse with well-defined charts for postoperative care...
  93. ncbi request reprint Perioperative medicine. The surgeons point of view
    H Kehlet
    Department of Surgical Gastroenterology, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark
    Minerva Anestesiol 67:256-7. 2001
    ..A multi-disciplinary effort is necessary to achieve this goal, and the adjustment of postoperative surgical care is as important as the supply of anesthesiological techniques...
  94. ncbi request reprint Convalescence after inguinal herniorrhaphy
    M Bay-Nielsen
    Department of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark
    Br J Surg 91:362-7. 2004
    ..The aim of this study was to describe in detail the consequences of recommending a short convalescence, including the risk of recurrence...
  95. ncbi request reprint Surgical management of chronic pain after inguinal hernia repair
    E Aasvang
    Section of Surgical Pathophysiology 4074, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    Br J Surg 92:795-801. 2005
    ..Chronic pain after inguinal hernia repair is an adverse outcome that affects about 12 per cent of patients. Principles of treatment have not been defined. This review examines neurectomy and mesh or staple removal as possible treatments...
  96. ncbi request reprint Feasibility of local infiltration anaesthesia for recurrent groin hernia repair
    T Callesen
    Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Eur J Surg 167:851-4. 2001
    ..To describe the the feasibility of and patients' satisfaction with day case repair of recurrent inguinal hernias under unmonitored local anaesthesia...
  97. ncbi request reprint One-thousand consecutive inguinal hernia repairs under unmonitored local anesthesia
    T Callesen
    Department of Surgical Gastroenterology, H S Hvidovre University Hospital, Hvidovre, Denmark
    Anesth Analg 93:1373-6, table of contents. 2001
    ..It provides a safe alternative to other anesthetic techniques with an acceptable rate of satisfaction, but intraoperative pain relief needs improvement...
  98. doi request reprint Orthostatic intolerance and the cardiovascular response to early postoperative mobilization
    M Bundgaard-Nielsen
    Section of Surgical Pathophysiology, Rigshospitalet, University of Copenhagen, Copenhagen DK 2100, Denmark
    Br J Anaesth 102:756-62. 2009
    ..We assessed orthostatic tolerance in relation to the postural cardiovascular responses before and shortly after open radical prostatectomy...
  99. ncbi request reprint Convalescence after colonic surgery with fast-track vs conventional care
    D H Jakobsen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark
    Colorectal Dis 8:683-7. 2006
    ..To compare convalescence after colonic surgery with a fast-track rehabilitation programme vs conventional care...
  100. doi request reprint Postherniotomy dysejaculation: successful treatment with mesh removal and nerve transection
    E K Aasvang
    Section of Surgical Pathophysiology, Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark
    Hernia 12:645-7. 2008
    ..At three months follow-up, there was reduced overall pain and no dysejaculation, and quantitative sensory testing showed reversal of sensory abnormalities, except for sensory loss, compared with preoperative values...