A Juul

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi IGF-I measurements. Epidemiological and clinical aspects
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Front Horm Res 33:45-67. 2005
  2. ncbi Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction
    Claudia Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:4352-60. 2006
  3. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
  4. ncbi Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence
    Anders Juul
    Departments of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Endocr Dev 22:24-39. 2012
  5. ncbi 45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study
    Marie Lindhardt Johansen
    Department of Growth and Reproduction, Rigshospitalet and Copenhagen University, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:E1540-9. 2012
  6. ncbi Pubertal development in Danish children: comparison of recent European and US data
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Int J Androl 29:247-55; discussion 286-90. 2006
  7. ncbi Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:537-42. 2007
  8. ncbi A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1005-11. 2009
  9. ncbi Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
  10. ncbi A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
    M Chellakooty
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:820-6. 2006

Detail Information

Publications108 found, 100 shown here

  1. ncbi IGF-I measurements. Epidemiological and clinical aspects
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Front Horm Res 33:45-67. 2005
  2. ncbi Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction
    Claudia Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:4352-60. 2006
    ..Concern has been raised about the safety of assisted reproduction techniques for the offspring...
  3. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  4. ncbi Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence
    Anders Juul
    Departments of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Endocr Dev 22:24-39. 2012
    ..Changes in basal reproductive hormone levels in infancy, childhood and adolescence as well as the GnRH and ACTH test procedures in girls and adolescents are described in this chapter...
  5. ncbi 45,X/46,XY mosaicism: phenotypic characteristics, growth, and reproductive function--a retrospective longitudinal study
    Marie Lindhardt Johansen
    Department of Growth and Reproduction, Rigshospitalet and Copenhagen University, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:E1540-9. 2012
    ..Most previous studies of 45,X/46,XY mosaicism are case reports or have described single aspects of the disease...
  6. ncbi Pubertal development in Danish children: comparison of recent European and US data
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark
    Int J Androl 29:247-55; discussion 286-90. 2006
    ..Therefore, we believe it is crucial to monitor the pubertal development closely in Denmark in the coming decades...
  7. ncbi Age at voice break in Danish boys: effects of pre-pubertal body mass index and secular trend
    Anders Juul
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:537-42. 2007
    ..Our findings indicate that puberty, as assessed by age at voice break in boys, may be starting earlier in Denmark as it has been observed in the USA, and suggest a relationship between pre-pubertal BMI and the timing of puberty...
  8. ncbi A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1005-11. 2009
    ..The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys...
  9. ncbi Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
    ....
  10. ncbi A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
    M Chellakooty
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 91:820-6. 2006
    ..Many aspects of hormonal regulation and mechanisms of normal infancy growth are poorly understood...
  11. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ....
  12. ncbi Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number
    C Mau Kai
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 23:1669-78. 2008
    ..Deletions in the azoospermia factor (AZF) region of the Y chromosome are frequent in infertile men. The clinical consequences and the mode of inheritance of these deletions are not yet clear...
  13. ncbi High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
    ..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
  14. ncbi Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty
    A Mouritsen
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:346-59. 2010
    ..The effects may differ between boys and girls, as there are sex differences in age at onset of puberty, hormonal profiles and prevalence of precocius puberty...
  15. ncbi Serum sex hormone-binding globulin levels in healthy children and girls with precocious puberty before and during gonadotropin-releasing hormone agonist treatment
    K Sørensen
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:3189-96. 2007
    ..The regulation of SHBG is complex and influenced by sex steroids and insulin...
  16. ncbi Inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in 473 healthy infant girls
    M Chellakooty
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3515-20. 2003
    ..In conclusion, reproductive hormones showed a large variation, and concentrations corresponded to those observed in puberty. Our findings support the concept of a minipuberty in infant girls similar to that in boys...
  17. ncbi Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arch Dis Child 93:30-4. 2008
    ..To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome (KS)...
  18. ncbi Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, and Department of Biostatistics, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 95:5357-64. 2010
    ..AMH is a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism...
  19. ncbi Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome
    L Aksglaede
    University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:376-84. 2009
    ..The small semen volume supports the notion of 47,XXY patients being androgen insufficient despite serum testosterone levels within the normal range...
  20. ncbi Skin morphological changes in growth hormone deficiency and acromegaly
    M Lange
    Department of Endocrinology, National University Hospital (Rigshospitalet, Copenhagen, Denmark
    Eur J Endocrinol 145:147-53. 2001
    ..Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD...
  21. ncbi Early breast development in girls after prenatal exposure to non-persistent pesticides
    C Wohlfahrt-Veje
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 35:273-82. 2012
    ..In addition, lower serum AMH levels indicated a reduced pool of antral ovarian follicles. The long-term consequences of our findings with regard to establishment of future reproductive function still remain unknown...
  22. ncbi A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth
    M Chellakooty
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 89:384-91. 2004
    ..In addition, we found a highly significant association between the increase in placental GH and the increase in IGF-I. The gestational age at peak placental GH levels was associated with pregnancy length...
  23. ncbi The acid-labile subunit of human ternary insulin-like growth factor binding protein complex in serum: hepatosplanchnic release, diurnal variation, circulating concentrations in healthy subjects, and diagnostic use in patients with growth hormone deficienc
    A Juul
    Department of Growth and Reproduction, National University Hospital, Copenhagen, Denmark
    J Clin Endocrinol Metab 83:4408-15. 1998
    ..We suggest that ALS determination may be used in future classification of adults suspected of GHD...
  24. ncbi Hormonal changes during GnRH analogue therapy in children with central precocious puberty
    J Muller
    Clinic of Growth and Reproduction, The Juliane Marie Centre, The University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Pediatr Endocrinol Metab 13:739-46. 2000
    ..These findings are in accord with the observed decrease in height velocity in children with CPP under treatment with GnRHa, and may also play a role in the relatively small gain in final height in most patients...
  25. ncbi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010
    ..The GH/IGF-I axis influences gonadal development and function. Recently, a deletion of exon 3 in the GH receptor gene (GHRd3) has been linked to increased responsiveness to GH...
  26. ncbi Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes Care 32:909-14. 2009
    ..The aim of the present study was to evaluate SHBG as a predictor of glucose metabolism and metabolic risk during puberty...
  27. ncbi Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations
    N E Skakkebaek
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:198-204; discussion 204-5. 2007
    ....
  28. ncbi A simple screening method for detection of Klinefelter syndrome and other X-chromosome aneuploidies based on copy number of the androgen receptor gene
    A M Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, Section GR 5064, The National University Hospital of Copenhagen, DK 2100, Copenhagen, Denmark
    Mol Hum Reprod 13:745-50. 2007
    ..Our findings demonstrated that the AR-qPCR technique is a simple and reliable screening method for diagnosis of patients with Klinefelter syndrome or other chromosomal disorders involving an aberrant number of X-chromosomes...
  29. ncbi New Danish reference values for height, weight and body mass index of children aged 0-5 years
    A M Nielsen
    National Institute of Public Health, Southern University of Denmark, Copenhagen, Denmark
    Acta Paediatr 99:268-78. 2010
    ..To derive new reference values for height, weight and body mass index (BMI) of children aged 0-5 years in Denmark and to compare them with the national reference from the 1970s and the 2006 WHO standard...
  30. ncbi Adiponectin levels measured in dried blood spot samples from neonates born small and appropriate for gestational age
    A Klamer
    Department of Neonatology section 5021, National University Hospital, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 157:189-94. 2007
    ..The aim of the study was to measure adiponectin levels in routinely collected neonatal DBSS taken on day 5 (range 3-12) postnatal from infants...
  31. ncbi Age at puberty and the emerging obesity epidemic
    Lise Aksglaede
    Department of Growth and Reproduction, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8450. 2009
    ....
  32. ncbi Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies
    Ulla Lønberg
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Am J Obstet Gynecol 188:247-51. 2003
    ....
  33. ncbi Prevalence and predictive factors of post-traumatic hypopituitarism
    M Klose
    Department of Medical Endocrinology, The University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Clin Endocrinol (Oxf) 67:193-201. 2007
    ..To estimate the prevalence and predictive factors of hypopituitarism following traumatic brain injury (TBI)...
  34. ncbi Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin
    J Gyllenborg
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Metabolism 50:882-8. 2001
    ..Thus, further studies on the potential role of SHBG in the development of ischemic heart disease (IHD) should be performed...
  35. ncbi European audit of current practice in diagnosis and treatment of childhood growth hormone deficiency
    Anders Juul
    Department of Growth and Reproduction, National University Hospital, Copenhagen, Denmark
    Horm Res 58:233-41. 2002
    ..We have found much conformity but also numerous discrepancies between the recommendations of the Growth Hormone Research Society and the current practice in Europe...
  36. ncbi Recent changes in pubertal timing in healthy Danish boys: associations with body mass index
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:263-70. 2010
    ..In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data...
  37. ncbi Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:3736-44. 2010
    ..Early menarche is associated with increased risk of cardiovascular disease in adulthood. It is unknown whether metabolic risk factors are adversely affected in girls with central precocious puberty (CPP) already at time of diagnosis...
  38. ncbi Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e2728. 2008
    ..The aim of our study was to determine if the age at onset of pubertal growth spurt (OGS) and at peak height velocity (PHV) during puberty show secular trends during four decades in a large cohort of school children...
  39. ncbi High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
    ..The aim of this study was to evaluate the HPG axis in KS infants...
  40. ncbi Polysomnographic sleep, growth hormone insulin-like growth factor-I axis, leptin, and weight loss
    Michael H Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Obesity (Silver Spring) 16:1516-21. 2008
    ..We conclude that hyposomatotropism and hyperleptinemia in obesity are transient phenomena reversible with weight loss, whereas short sleep seems to persist after weight has been reduced dramatically...
  41. ncbi Effect of weight loss on free insulin-like growth factor-I in obese women with hyposomatotropism
    Michael H Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Denmark
    Obesity (Silver Spring) 15:879-86. 2007
    ....
  42. ncbi Maximum likelihood estimation for Cox's regression model under nested case-control sampling
    Thomas H Scheike
    Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 KBH N, Denmark
    Biostatistics 5:193-206. 2004
    ..We illustrate the use of the MLE for these data and show how the maximum likelihood framework can be used to obtain information additional to the relative risk estimates of covariates...
  43. ncbi Testicular function and fertility in men with Klinefelter syndrome: a review
    L Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, Section 5064, University of Copenhagen, Copenhagen, Denmark
    Eur J Endocrinol 168:R67-76. 2013
    ....
  44. ncbi Determination of insulin-like growth factor-I in the monitoring of growth hormone treatment with respect to efficacy of treatment and side effects: should potential risks of cardiovascular disease and cancer be considered?
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 51:141-8. 1999
    ..Consequently, life-time exposure to IGF-I should be considered in all patients treated with GH, and IGF-I should preferably be kept within normal age-related ranges in children as well as in adults...
  45. ncbi Determination of insulin-like growth factor I in children: normal values and clinical use
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 55:94-9. 2001
    ..Thus, an IGF-I value should always be evaluated together with auxological information and GH testing results before a decision is taken on whether or not to start GH therapy...
  46. ncbi Maternal serum placental growth hormone, but not human placental lactogen or insulin growth factor-1, is positively associated with fetal growth in the first half of pregnancy
    N G Pedersen
    Department of Fetal Medicine and Ultrasound, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Ultrasound Obstet Gynecol 36:534-41. 2010
    ..To investigate if maternal levels of human placental lactogen (hPL), placental growth hormone (PGH) and insulin-like growth factor-1 (IGF-1) are associated with growth rate of the biparietal diameter (BPD) in the first half of pregnancy...
  47. ncbi Acute and long-term pituitary insufficiency in traumatic brain injury: a prospective single-centre study
    M Klose
    Department of Medical Endocrinology, The University Hospital of Copenhagen, Denmark
    Clin Endocrinol (Oxf) 67:598-606. 2007
    ..To assess the prevalence of hypopituitarism following traumatic brain injury (TBI), describe the time-course and assess the association with trauma-related parameters and early post-traumatic hormone alterations...
  48. ncbi Fetal growth velocity, size in early life and adolescence, and prediction of bone mass: association to the GH-IGF axis
    Rikke Beck Jensen
    University Department of Growth and Reproduction Rigshospitalet, Copenhagen, Denmark
    J Bone Miner Res 23:439-46. 2008
    ..These associations were mediated by the current height and weight, but it was not confirmed that alterations of the GH-IGF axis cause this...
  49. ncbi An audit of the insulin-tolerance test in 255 patients with pituitary disease
    Martin Lange
    Department of Endocrinology, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
    Eur J Endocrinol 147:41-7. 2002
    ..It was confirmed that IGF-I is not sufficient when diagnosing GHD in adults, and reliable stimulation tests like ITT are required in the diagnosis...
  50. ncbi Improvement of semen quality in an infertile man with 21-hydroxylase deficiency, suppressed serum gonadotropins and testicular adrenal rest tumours
    Annette Mouritsen
    University Department of Growth and Reproduction, Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:518-20. 2010
    ..Optimizing the medical treatment may at least in some cases improve fecundity...
  51. ncbi Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys
    Anna Maria Andersson
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Sect GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:4696-705. 2007
    ..These secular trends may also be reflected by changes in Leydig cell function...
  52. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  53. ncbi [Pituitary insufficiency following head trauma]
    Marianne C Klose
    Rigshospitalet, Endokrinologisk Afdeling, Afdelingen for Vaekst, København Ø
    Ugeskr Laeger 169:211-3. 2007
    ..As untreated hypopituitarism is likely to delay recovery and rehabilitation, this calls for a change in the current management of patients suffering traumatic brain injury. In this article, we will review current knowledge in this field...
  54. ncbi Pituitary-gonadal function in adolescent males born appropriate or small for gestational age with or without intrauterine growth restriction
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 92:1353-7. 2007
    ..Being born small for gestational age (SGA) is suggested to influence female pituitary-gonadal axis, but only a few studies have focused on male pituitary-gonadal function...
  55. ncbi [Precocious puberty in juvenile hypothyroidism]
    Grete Teilmann
    Afdeling for Vaekst og Reproduktion, GR 5064, H:S Rigshospitalet, Blegdamsvej 9,
    Ugeskr Laeger 165:4121-3. 2003
  56. ncbi Intrauterine growth retardation and consequences for endocrine and cardiovascular diseases in adult life: does insulin-like growth factor-I play a role?
    Rikke Bodin Beck Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet, Copenhagen, Denmark
    Horm Res 60:136-48. 2003
    ..Thus IGF-I may serve as a link between fetal growth and adult-onset disease...
  57. ncbi Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight
    Marla Chellakooty
    Department of Growth and Reproduction, Righospitalet, University Hospital of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 87:2734-9. 2002
    ....
  58. ncbi High risk of adrenal insufficiency in adults previously treated for idiopathic childhood onset growth hormone deficiency
    Martin Lange
    Department of Endocrinology, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:5784-9. 2003
    ..It is imperative that pituitary axes other than the GH axis are tested at regular intervals, even in the absence of GHD in adulthood...
  59. ncbi Insulin-like growth factor I (IGF-I) and IGF-binding protein 3 as diagnostic markers of growth hormone deficiency in infancy
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Horm Res 63:15-21. 2005
    ..The diagnosis of growth hormone deficiency (GHD) in infancy is difficult, and no specific cutoff value during GH provocative testing is recommended in early life...
  60. ncbi The impact of idiopathic childhood-onset growth hormone deficiency (GHD) on bone mass in subjects without adult GHD
    Martin Lange
    Department of Endocrinology, Rigshospitalet, Glostrup, Denmark
    Clin Endocrinol (Oxf) 62:18-23. 2005
    ..The aim was to evaluate BMD and bone mineral content (BMC) in adults treated for idiopathic childhood-onset (CO) GHD, 18 years after stopping GH treatment...
  61. ncbi Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries
    Grete Teilmann
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Pediatrics 116:1323-8. 2005
    ..The aim of this study was to estimate the prevalence and incidence of precocious pubertal development in Denmark in a 9-year period...
  62. ncbi Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  63. ncbi Effects of short-term caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects
    Michael Højby Rasmussen
    Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, DK 2650 Copenhagen, Denmark
    Eur J Endocrinol 155:575-81. 2006
    ..The main purpose of this study was to determine free IGF-I, ALS, IGFBPs-1-4, and IGFBPs-1-3 protease activity in relation to 24-h GH release before and after a short-term very low-calorie diet (VLCD)...
  64. ncbi The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment
    T Zimmermann-Belsing
    Department of Endocrinology, PE 2131, University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Growth Horm IGF Res 14:235-44. 2004
    ....
  65. ncbi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
    ..Here we present new European data systematically collected from the same region and by 1 research group at the beginning and end of the recent 15-year period...
  66. ncbi Clinical and biochemical correlates of successful semen collection for cryopreservation from 12-18-year-old patients: a single-center study of 86 adolescents
    Isabella Hagenäs
    University Department of Growth and Reproduction, Copenhagen University Hospital, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:2031-8. 2010
    ..However, the experience with semen collection in adolescents is still limited. The objective of this study was to evaluate potential correlates of successful semen sampling in adolescents...
  67. ncbi The presence of the d3-growth hormone receptor polymorphism is negatively associated with fetal growth but positively associated with postnatal growth in healthy subjects
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2758-63. 2007
    ..A common polymorphism in the GH receptor (GHR) gene has been linked to increased growth response in GH-treated patients. No former study has focused on the association to prenatal growth...
  68. ncbi Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2966-9. 2009
    ..The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH...
  69. ncbi Serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in children determined by TurboFlow-LC-MS/MS
    T Søeborg
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark Electronic address
    Clin Chim Acta 419:95-101. 2013
    ..The presented method is suitable in a clinical setting for simultaneous quantification of five steroids important for management of children with disorders of sex development and steroid biosynthesis defects...
  70. ncbi Serum inhibin B, FSH, LH and testosterone levels before and after human chorionic gonadotropin stimulation in prepubertal boys with cryptorchidism
    P Christiansen
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Denmark
    Eur J Endocrinol 147:95-101. 2002
    ..It is not known if inhibin B can be used to demonstrate early damage of seminiferous tubules in prepubertal boys with cryptorchidism...
  71. ncbi The effects of oestrogens on linear bone growth
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Hum Reprod Update 7:303-13. 2001
    ..Conversely, higher levels of oestrogens stimulate secondary sexual characteristics and epiphyseal fusion...
  72. ncbi Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly
    S B Sneppen
    Department of Endocrinology, Rigshospitalet, Denmark
    Growth Horm IGF Res 11:384-91. 2001
    ..None of the parameters can at present be claimed to be superior to the others and thus all the measured parameters are recommended to be part of the evaluation of acromegalic patients...
  73. ncbi Children conceived after intracytoplasmic sperm injection (ICSI): is there a role for the paediatrician?
    C Mau
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 93:1238-44. 2004
    ..The aim of the study was to evaluate current medical knowledge about children born after intracytoplasmic sperm injection (ICSI) with respect to congenital malformations, chromosome abnormalities and postnatal growth...
  74. ncbi Dynamics and mechanisms of chemotherapy-induced ovarian follicular depletion in women of fertile age
    Mikkel Rosendahl
    The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:156-66. 2010
    ....
  75. ncbi Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study
    Anders Juul
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Circulation 106:939-44. 2002
    ..Insulin-like growth factor I (IGF-I) has been suggested to be involved in the pathogenesis of atherosclerosis. We hypothesize that low IGF-I and high IGFBP-3 levels might be associated with increased risk of ischemic heart disease (IHD)...
  76. ncbi Cartilage oligomeric matrix protein in patients with juvenile idiopathic arthritis: relation to growth and disease activity
    Birgitte Bjørnhart
    Paediatric Clinic II and Department for Growth and Reproduction, Rigshospitalet National University Hospital, University of Copenhagen, Copenhagen, Denmark
    J Rheumatol 36:1749-54. 2009
    ..COMP levels in JIA and healthy children were compared with those in healthy adults. Plasma levels of insulin-like growth factor I (IGF-1), which has been associated with COMP expression and growth velocity, were studied in parallel...
  77. ncbi Serum levels of insulin-like growth factor I and its binding proteins in health and disease
    Anders Juul
    Department of Growth and Reproduction, University of Copenhagen, Blegdamsvej 9 Rigshopitalet, Section 5064, Copenhagen 2100, Denmark
    Growth Horm IGF Res 13:113-70. 2003
  78. ncbi Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects
    Anni Larnkjaer
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    Growth Horm IGF Res 19:82-6. 2009
    ..Therefore, it has been suggested that the IGF-I axis may be programmed by diet during infancy. The association between IGF-I in infancy and later life is not known...
  79. ncbi The sensitivity of the child to sex steroids: possible impact of exogenous estrogens
    Lise Aksglaede
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
    Hum Reprod Update 12:341-9. 2006
    ..Because no lower threshold for estrogenic action has been established, caution should be taken to avoid unnecessary exposure of fetuses and children to exogenous sex steroids and endocrine disruptors, even at very low levels...
  80. ncbi Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women
    Malene Boas
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Eur J Endocrinol 161:903-10. 2009
    ....
  81. ncbi Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients
    Casper P Hagen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 95:5003-10. 2010
    ..In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls...
  82. ncbi Maturation of kisspeptinergic neurons coincides with puberty onset in male rats
    Agnete H Bentsen
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark
    Peptides 31:275-83. 2010
    ....
  83. ncbi Natural history of seminiferous tubule degeneration in Klinefelter syndrome
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod Update 12:39-48. 2006
    ....
  84. ncbi Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection
    Claudia Mau Kai
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2598-603. 2007
    ..Concern has been raised for the health of the offspring conceived by assisted reproduction technologies. Basal reproductive hormones around 3 months of age reflect the pituitary-testicular axis, which is transiently active at this age...
  85. ncbi Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality
    M Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 35:499-510. 2012
    ..In conclusion, we suggest that CYP24A1 expression at the annulus may serve as a novel marker of semen quality and an objective proxy for sperm function...
  86. ncbi Lower levels of circulating IGF-I in Type 1 diabetic women with frequent severe hypoglycaemia during pregnancy
    L Ringholm Nielsen
    Copenhagen Center for Pregnant Women with Diabetes, Departments of Endocrinology, Rigshospitalet, Faculty of Health Sciences, Copenhagen, Denmark
    Diabet Med 25:826-33. 2008
    ..We explored whether frequent severe hypoglycaemia during pregnancy in women with Type 1 diabetes is related to placental growth hormone (GH) and insulin-like growth factor I (IGF-I) levels...
  87. ncbi Putative effects of endocrine disrupters on pubertal development in the human
    Grete Teilmann
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 16:105-21. 2002
    ..While it is very plausible that endocrine disrupters may disturb pubertal development, there is very little research on this and, therefore, we do not yet have any clear cause-effect relationships in humans...
  88. ncbi Androgens and the ageing male
    Anders Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Copenhagen, Denmark
    Hum Reprod Update 8:423-33. 2002
    ..However, at this point in time, widespread use of testosterone in an elderly male population outside controlled clinical trials seems inappropriate...
  89. ncbi Subcutaneous abdominal adipose tissue lipolysis during exercise determined by arteriovenous measurements in older women
    Kai Henrik Wiborg Lange
    Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
    J Am Geriatr Soc 50:275-81. 2002
    ..To characterize the lipolytic response in the subcutaneous abdominal adipose tissue in older women to endurance exercise...
  90. ncbi Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy
    Anne Marie Ottesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Med Genet A 152:1206-12. 2010
    ..0 (-3.5 to -0.8) in 49,XXXXX (n = 3). Height increased with an increasing number of extra X or Y chromosomes, except in males with five, and in females with four or five sex chromosomes, consistent with a nonlinear effect on height...
  91. ncbi Growth hormone treatment and risk of solid tumours. A statement from the Drugs and Therapeutics Committee of the European Society for Paediatric Endocrinology (ESPE)
    Anders Juul
    University Department of Growth and Reproduction, Rigshsopitalet, Copenhagen, Denmark
    Horm Res 60:103-4. 2003
  92. ncbi Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty
    Signe Sloth Mogensen
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 96:1393-401. 2011
    ..The aim of this study was to describe a large cohort of Caucasian girls referred with signs of early puberty according to etiology and compare biochemical characteristics...
  93. ncbi The CSF and arterial to internal jugular venous hormonal differences during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Exp Physiol 89:271-7. 2004
    ..The results support the notion that the exercise-induced changes in brain metabolism are controlled by factors intrinsic to the brain...
  94. ncbi Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation
    Annette Mouritsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:521-7. 2010
    ..We conclude that TART were most frequently detected in patients with severe CYP21A2 mutations, and may occur already in early childhood in such patients...
  95. ncbi Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
    Martin Blomberg Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:1303-11. 2010
    ..Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa...
  96. ncbi Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
    ..The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes...
  97. ncbi Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children
    Camilla Hoppe
    Department of Human Nutrition and the Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg, Denmark
    Am J Clin Nutr 80:447-52. 2004
    ..Whether the same association exists in industrialized countries, where protein intake is high, is not clear...
  98. ncbi [Growth hormone treatment of short children born small for gestational age]
    Henrik B Thybo Christesen
    Odense Universitetshospital, , H:S Rigshospitalet, Afdeling for Vaekst
    Ugeskr Laeger 168:889-95. 2006
    ..The Danish consensus guidelines for diagnosis, treatment and control of short SGA children are described in this review...
  99. ncbi Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings
    Susan Y Euling
    National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA
    Pediatrics 121:S172-91. 2008
    ....
  100. ncbi Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children
    Camilla Hoppe
    Department of Human Nutrition and Centre for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Am J Clin Nutr 79:494-501. 2004
    ..A high PI probably has both endocrine and physiologic effects and may increase the risk of obesity...
  101. ncbi Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function
    Jens O L Jørgensen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus, Denmark
    J Pediatr Endocrinol Metab 15:1355-60. 2002
    ....