Niels Jørgensen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Recent adverse trends in semen quality and testis cancer incidence among Finnish men
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 34:e37-48. 2011
  2. doi Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:298-303. 2010
  3. doi Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men
    Niels Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:2128-34. 2010
  4. doi PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men
    Ulla Nordström Joensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Hum Reprod 28:599-608. 2013
  5. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
  6. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
  7. ncbi Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 159:49-58. 2004
  8. ncbi Fertility treatment and reproductive health of male offspring: a study of 1,925 young men from the general population
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 165:583-90. 2007
  9. ncbi Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
  10. pmc Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality
    Tina Harmer Lassen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 122:478-84. 2014

Detail Information

Publications49

  1. pmc Recent adverse trends in semen quality and testis cancer incidence among Finnish men
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 34:e37-48. 2011
    ..Our findings necessitate not only further surveillance of male reproductive health but also research to detect and remove the underlying factors...
  2. doi Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
    N Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:298-303. 2010
    ....
  3. doi Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men
    Niels Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 94:2128-34. 2010
    ..To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported...
  4. doi PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men
    Ulla Nordström Joensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Hum Reprod 28:599-608. 2013
    ..Is exposure to perfluorinated compounds (PFCs) associated with testicular function (reproductive hormone levels and semen quality) in healthy men?..
  5. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  6. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  7. ncbi Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 159:49-58. 2004
    ..Maternal smoking may have long-term implications for the reproductive health of the offspring. This is another good reason to advise pregnant women to avoid smoking...
  8. ncbi Fertility treatment and reproductive health of male offspring: a study of 1,925 young men from the general population
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Epidemiol 165:583-90. 2007
    ..Although the cause of these findings is unknown, they raise concern about possible late effects of fertility treatment. Larger-scale studies of children born after fertility treatment should be performed...
  9. ncbi Is human fecundity declining?
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:2-11. 2006
    ..This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists...
  10. pmc Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality
    Tina Harmer Lassen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 122:478-84. 2014
    ..Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent...
  11. doi Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer
    Camilla Nymann Rud
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark University Department of Oncology, Rigshospitalet, Copenhagen, Denmark
    J Urol 190:2074-80. 2013
    ..We investigated whether semen quality or some easily attainable clinical parameters might be used to estimate the risk of contralateral carcinoma in situ in patients with unilateral testicular germ cell tumors...
  12. ncbi Self-rated health and semen quality among 3,457 young Danish men
    Tina K Jensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 88:1366-73. 2007
    ..To study the relationship between self-rated health (SRH) and semen quality...
  13. doi Caffeine intake and semen quality in a population of 2,554 young Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Epidemiol 171:883-91. 2010
    ..Therefore, the authors cannot exclude the possibility of a threshold above which cola, and possibly caffeine, negatively affects semen quality. Alternatively, the less healthy lifestyle of these men may explain these findings...
  14. ncbi Testicular carcinoma in situ in subfertile Danish men
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen
    Int J Androl 30:406-11; discussion 412. 2007
    ....
  15. pmc Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men
    Ulla Nordström Joensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Environ Health Perspect 120:1397-403. 2012
    ..In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function...
  16. ncbi Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern
    Niels Jørgensen
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    Int J Androl 29:54-61; discussion 105-8. 2006
    ..In Denmark, the situation is of concern and a continued surveillance of semen quality in young men was established in 2001 by a government-supported programme...
  17. doi Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome
    Grete Lottrup
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, University Hospital of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:2223-9. 2013
    ....
  18. doi Regional differences and temporal trends in male reproductive health disorders: semen quality may be a sensitive marker of environmental exposures
    Loa Nordkap
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Mol Cell Endocrinol 355:221-30. 2012
    ....
  19. pmc A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
    Marlene D Dalgaard
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Med Genet 49:58-65. 2012
    ..The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population...
  20. doi Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index
    Trine L Ravnborg
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 26:1000-11. 2011
    ..The aim of this study was to investigate the associations between these factors while controlling for the effects of current smoking in young adulthood...
  21. ncbi Clinical and biochemical correlates of successful semen collection for cryopreservation from 12-18-year-old patients: a single-center study of 86 adolescents
    Isabella Hagenäs
    University Department of Growth and Reproduction, Copenhagen University Hospital, GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:2031-8. 2010
    ..However, the experience with semen collection in adolescents is still limited. The objective of this study was to evaluate potential correlates of successful semen sampling in adolescents...
  22. doi Testosterone production is better preserved after 16 than 20 Gray irradiation treatment against testicular carcinoma in situ cells
    Anne K Bang
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Int J Radiat Oncol Biol Phys 75:672-6. 2009
    ..To study the effect of 16 Gy radiotherapy (RT) vs. 20 Gy RT on Leydig cell function in men treated with radiotherapy against carcinoma in situ (CIS) of the testis...
  23. ncbi Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation
    Annette Mouritsen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:521-7. 2010
    ..We conclude that TART were most frequently detected in patients with severe CYP21A2 mutations, and may occur already in early childhood in such patients...
  24. ncbi Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis
    Niels E Skakkebaek
    University Department of Growth and Reproduction, Rigshospitalet, DK 2100 Copenhagen, Denmark
    APMIS 111:1-9; discussion 9-11. 2003
    ..We speculate that most of these abnormalities are caused by adverse environmental effects rather than specific gene mutations...
  25. doi Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012
    Hanne Frederiksen
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Reproduction 147:555-65. 2014
    ..The exposure to other non-persistent chemicals was also widespread. Our data indicate decreasing excretion of two common phthalates (di-n-butyl phthalate and di-(2-ethylhexyl) phthalate) over time. ..
  26. doi Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Sci Technol 47:958-67. 2013
    ..The only slightly higher ICCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools...
  27. doi Association between organic dietary choice during pregnancy and hypospadias in offspring: a study of mothers of 306 boys operated on for hypospadias
    Jeppe Schultz Christensen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Urol 189:1077-82. 2013
    ..We examined the association between organic dietary choice during pregnancy and presence of hypospadias in the offspring...
  28. pmc Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA
    Tina Kold Jensen
    Department of Environmental Epidemiology, University of Southern Denmark, Winsløwsparken 17, Odense, Denmark Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark
    Hum Reprod 29:1801-9. 2014
    ..Is there an association between alcohol intake and semen quality and serum reproductive hormones among healthy men from the USA and Europe?..
  29. doi 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management
    Lise Aksglaede
    Department of Growth and Reproduction GR, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Am J Med Genet C Semin Med Genet 163:55-63. 2013
    ..The aim of this review is to present the clinical aspects of XXY and the age-specific recommendations for medical management. © 2013 Wiley Periodicals, Inc...
  30. doi High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population
    Tina K Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Clin Nutr 97:411-8. 2013
    ..Saturated fat intake has been associated with both cardiovascular disease and cancer risk, and a newly published study found an association between saturated fat intake and a lower sperm concentration in infertile men...
  31. ncbi [Male infertility]
    Loa Nordkap
    Afdelingen for Vækst og Reproduktion, Rigshospitalet, Blegdamsvej 9, Copenhagen
    Ugeskr Laeger 174:2444-8. 2012
    ..It is important to elucidate possible reasons for male infertility as low semen quality might be a symptom of pituitary dysfunction, genetic disorders or testicular cancer...
  32. doi Testicular dysgenesis syndrome and Leydig cell function
    Ulla Nordström Joensen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 102:155-61. 2008
    ..We present our view of the emerging role of Leydig cell dysfunction with subsequent decreased testosterone levels in the pathogenesis of TDS...
  33. ncbi Improvement of semen quality in an infertile man with 21-hydroxylase deficiency, suppressed serum gonadotropins and testicular adrenal rest tumours
    Annette Mouritsen
    University Department of Growth and Reproduction, Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:518-20. 2010
    ..Optimizing the medical treatment may at least in some cases improve fecundity...
  34. ncbi Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Anal Toxicol 34:400-10. 2010
    ..In seminal plasma, only MEP levels correlated significantly to levels in urine and in serum...
  35. doi Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa
    Martin Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 26:1307-17. 2011
    ..We investigated the role of activated VD (1,25(OH)(2)D(3)) in human spermatozoa and whether VD serum levels are associated with semen quality...
  36. ncbi Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads
    Ewa Rajpert-De Meyts
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 19:1338-44. 2004
    ....
  37. doi Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Expo Sci Environ Epidemiol 21:262-71. 2011
    ..In all the three matrices significant correlations between the parabens were seen. Furthermore, urinary paraben concentrations correlate to the paraben concentrations in both serum and seminal plasma...
  38. pmc Do perfluoroalkyl compounds impair human semen quality?
    Ulla Nordström Joensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 117:923-7. 2009
    ..There are no previous reports of PFAA levels in adult men from Denmark or of a possible association between semen quality and PFAA exposure...
  39. doi Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract
    Martin Blomberg Jensen
    University Department of Growth and Reproduction GR, Rigshospitalet Section 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 25:1303-11. 2010
    ..Therefore, we performed a comprehensive analysis of the expression of VDR, VD activating (CYP2R1, CYP27A1, CYP27B1) and inactivating (CYP24A1) enzymes in the testis, epididymis, seminal vesicle (SV), prostate and spermatozoa...
  40. pmc Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men
    Ulla Nordström Joensen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 122:345-50. 2014
    ..Objectives: We investigated urinary excretion of phthalate metabolites and testicular function in young men with and without FLG loss-of-function variants in a cross-sectional study of 861 young men from the general Danish population...
  41. ncbi The 2014 Danish references from birth to 20 years for height, weight and body mass index
    Jeanette Tinggaard
    Department of Growth and Reproduction, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Acta Paediatr 103:214-24. 2014
    ....
  42. doi Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men
    Selma K Kranich
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Sci Technol 48:706-12. 2014
    ..Besides the phthalates investigated here, humans are exposed to numerous other chemicals that also may contribute to a cumulative antiandrogenic exposure. ..
  43. ncbi [Antioxidants and male subfertility--a survey of a Cochrane review]
    Tina Kold Jensen
    Klinik for Vækst og Reproduktion, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark
    Ugeskr Laeger 173:3253-5. 2011
    ..Future studies should be large, randomized placebo-controlled trials...
  44. doi Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy
    Anne Marie Ottesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Med Genet A 152:1206-12. 2010
    ..0 (-3.5 to -0.8) in 49,XXXXX (n = 3). Height increased with an increasing number of extra X or Y chromosomes, except in males with five, and in females with four or five sex chromosomes, consistent with a nonlinear effect on height...
  45. ncbi East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland
    Niels Jørgensen
    Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Copenhagen, Denmark
    Hum Reprod 17:2199-208. 2002
    ....
  46. pmc UGT2B17 Genotype and the Pharmacokinetic Serum Profile of Testosterone during Substitution Therapy with Testosterone Undecanoate. A Retrospective Experience from 207 Men with Hypogonadism
    Anne Kirstine Bang
    Department of Growth and Reproduction, Faculty of Health and Medical Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Front Endocrinol (Lausanne) 4:94. 2013
    ..Only subtle differences in serum T and LH were noted according to UGT2B17 genotype, which however suggest that the UGT2B17 genotype exert modest influence on the pharmacokinetic profile of T after TU treatment. ..
  47. ncbi Meat intake and reproductive parameters among young men
    Myriam C Afeiche
    From the aDepartment of Nutrition, bDepartment of Biostatistics, and cDepartment of Epidemiology, Harvard School of Public Health, Boston, MA d Division of Preventive Medicine and Public Health, University of Murcia School of Medicine, Murcia, Spain eUniversity Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark fDepartment of Obstetrics and Gynecology, School of Medicine, University of Rochester, Rochester, NY gDepartment of Preventive Medicine, Mount Sinai School of Medicine, New York, NY and hChanning Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Epidemiology 25:323-30. 2014
    ..There is concern regarding the reproductive consequences of this practice in men who eat beef. We investigated whether meat consumption was associated with semen quality parameters and reproductive hormone levels in young men...
  48. ncbi Poor semen quality may contribute to recent decline in fertility rates
    Tina Kold Jensen
    Department of Growth and Reproduction, Rigshospitalet, The Juliane Marie Centre, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 17:1437-40. 2002
    ..We propose that researchers in other countries with low and falling fertility rates among young women should consider the possibility that semen quality of their younger male cohorts may also have deteriorated...