Pär I Johansson

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Current management of massive hemorrhage in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 20:47. 2012
  2. ncbi Coagulopathy and hemostatic monitoring in cardiac surgery: an update
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 46:194-202. 2012
  3. ncbi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012
  4. ncbi Coagulation monitoring of the bleeding traumatized patient
    Pär I Johansson
    Section for Transfusion Medicine, Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Anaesthesiol 25:235-41. 2012
  5. ncbi High circulating adrenaline levels at admission predict increased mortality after trauma
    Pär Ingemar Johansson
    Section forTransfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    J Trauma Acute Care Surg 72:428-36. 2012
  6. ncbi Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
  7. ncbi High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    J Thromb Haemost 10:207-16. 2012
  8. ncbi Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
  9. ncbi Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets--a review of the current literature
    Pär I Johansson
    Department of Clinical Immunology, Section for Transfusion Service, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Transfusion 50:701-10. 2010
  10. ncbi Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders
    Pär I Johansson
    Capital Region Blood Bank, Section for Transfusion Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Drug Des Devel Ther 4:107-16. 2010

Collaborators

Detail Information

Publications61

  1. ncbi Current management of massive hemorrhage in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 20:47. 2012
    ..The aim of the goal-directed therapy should be to maintain a normal hemostatic competence until surgical hemostasis is achieved, as this appears to be associated with reduced mortality...
  2. ncbi Coagulopathy and hemostatic monitoring in cardiac surgery: an update
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 46:194-202. 2012
    ..Excessive transfusion and surgical re-exploration after cardiac surgery are potentially associated with a number of adverse outcomes including increased mortality...
  3. ncbi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012
    ....
  4. ncbi Coagulation monitoring of the bleeding traumatized patient
    Pär I Johansson
    Section for Transfusion Medicine, Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Anaesthesiol 25:235-41. 2012
    ..On admission, 25-35% of trauma patients present with coagulopathy, which is associated with a several-fold increase in morbidity and mortality...
  5. ncbi High circulating adrenaline levels at admission predict increased mortality after trauma
    Pär Ingemar Johansson
    Section forTransfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    J Trauma Acute Care Surg 72:428-36. 2012
    ..Although its pathophysiology is unclear, severe injury and shock(hypoperfusion) are proposed drivers. This study investigated the association between sympathoadrenal activation (circulating catecholamines) and biomarkers of coagulopathy...
  6. ncbi Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
    ..This study investigated the prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker profiles...
  7. ncbi High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    J Thromb Haemost 10:207-16. 2012
    ..Soluble CD40L is a platelet-derived mediator that links inflammation, hemostasis and vascular dysfunction...
  8. ncbi Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
    ..We also examined whether the concept was useful in that early prediction of massive transfusion requirements could allow early activation of blood bank protocols...
  9. ncbi Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets--a review of the current literature
    Pär I Johansson
    Department of Clinical Immunology, Section for Transfusion Service, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Transfusion 50:701-10. 2010
    ..Recent studies indicate a possible survival benefit in patients receiving a higher ratio of plasma and platelets (PLTs) to red blood cells (RBCs) than what is recommended in current transfusion guidelines...
  10. ncbi Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders
    Pär I Johansson
    Capital Region Blood Bank, Section for Transfusion Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Drug Des Devel Ther 4:107-16. 2010
    ..Recombinant activated factor VII (rFVIIa, NovoSeven) was introduced in 1996 for the treatment of hemophilic patients with antibodies against coagulation factor VIII or IX...
  11. ncbi Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009
    ....
  12. ncbi Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality
    Pär I Johansson
    Department of Clinical Immunology, and Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 21:168-74. 2010
    ..Hypocoagulability is an independent risk factor for 30-day mortality...
  13. ncbi Hemostatic strategies for minimizing mortality in surgery with major blood loss
    Pär I Johansson
    Regional Blood Bank, Section for Transfusion Service, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Hematol 16:509-14. 2009
    ..This article reviews recent advances that impact the use and effectiveness of massive transfusion...
  14. ncbi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
    ..To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma...
  15. ncbi Management of major blood loss: an update
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:1039-49. 2010
    ..The aim of the goal-directed therapy should be to maintain a normal haemostatic competence until surgical haemostasis is achieved, as this appears to be associated with reduced mortality...
  16. ncbi Goal-directed hemostatic resuscitation for massively bleeding patients: the Copenhagen concept
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfus Apher Sci 43:401-5. 2010
    ..A review of transfusion practice for these patients at our hospital revealed that a significant proportion received suboptimal transfusion therapy. Survivors had higher platelets count than non-survivors...
  17. ncbi Investigation of the thrombin-generating capacity, evaluated by thrombogram, and clot formation evaluated by thrombelastography of platelets stored in the blood bank for up to 7 days
    P I Johansson
    Department of Clinical Immunology, Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Vox Sang 94:113-8. 2008
    ..Taking the pivotal role of thrombin generation in the coagulation process into consideration, the clinical utility of the TEG may, in part, depend on its reflection of the dynamics of thrombin generation...
  18. ncbi Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study
    P I Johansson
    Department of Clinical Immunology, Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    Vox Sang 96:111-8. 2009
    ..Current consensus guidelines recommend restrictive use. Our aim was to determine the effect of changing the transfusion practice on 30-day survival in massively bleeding patients...
  19. ncbi Investigation of the effect of kaolin and tissue-factor-activated citrated whole blood, on clot-forming variables, as evaluated by thromboelastography
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 48:2377-83. 2008
    ..Implementing TEG as a routine laboratory-based analysis, however, requires validation of the activators employed and the effect of storage of the WB sample in citrate before analysis...
  20. ncbi Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)
    Pär I Johansson
    Transfusion Service, Department of Clinical Immunology, University of Copenhagen, Rigshospitalet 2034, Blegdamsvej 9, Copenhagen, Denmark
    Transfus Apher Sci 39:3-8. 2008
    ..01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients...
  21. ncbi Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation
    P I Johansson
    Department of Clinical Immunology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Vasc Endovasc Surg 36:397-400. 2008
    ..The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active transfusion therapy is maintained...
  22. ncbi Off-label use of recombinant factor VIIa for treatment of haemorrhage: results from randomized clinical trials
    P I Johansson
    Section for Transfusion Service, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Vox Sang 95:1-7. 2008
    ..The aim of the present study was to review the randomized clinical trials (RCT) for evidence of such an approach...
  23. ncbi Hemostatic function of buffy coat platelets in additive solution treated with pathogen reduction technology
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 51:344-56. 2011
    ..To investigate this, buffy coat PLTs (BCPs) stored in PLT additive solution (SSP+) with or without Mirasol PRT treatment (CaridianBCT Biotechnologies) were compared by functional hemostatic assays...
  24. ncbi High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Scand J Trauma Resusc Emerg Med 20:27. 2012
    ..Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome...
  25. ncbi Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:593-8. 2007
    ..It was considered that early substitution with PLTs and fresh-frozen plasma (FFP) would prevent development of coagulopathy and thus improve survival...
  26. ncbi The in vitro effect of recombinant factor VIIa on coated platelet formation and clot dynamics of stored platelet concentrates
    Mette S Svendsen
    Blood Bank, Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Transfusion 49:2186-94. 2009
    ..We investigated whether activated recombinant factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S) could improve the ability of stored PLTs to support coagulation under conditions that promote the formation of coated PLTs...
  27. ncbi Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:64. 2011
    ..Severe injury induces an acute coagulopathy associated with increased mortality. This study compared the Thrombelastography (TEG) and biomarker profiles upon admission in trauma patients...
  28. ncbi Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity
    Bo Wiinberg
    The Small Animal Hospital, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Vet J 185:292-8. 2010
    ..3%, specificity 77.3%). Based on commonly used, plasma-based coagulation assays, it was possible to design an objective diagnostic scoring system for canine DIC with a high sensitivity and specificity...
  29. ncbi Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy
    Sisse R Ostrowski
    Section for Transfusion Medicine, Copenhagen University Hospital, Copenhagen, Denmark
    J Trauma Acute Care Surg 73:60-6. 2012
    ..This study evaluated if degradation of the endothelial glycocalyx and ensuing release of its heparin-like substances induce autoheparinization and thereby contributes to TIC...
  30. ncbi In-vitro comparison of free oscillation rheometry (ReoRox) and rotational thromboelastometry (ROTEM) in trauma patients upon hospital admission
    Sacha Sølbeck
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 23:688-92. 2012
    ..ROTEM EXTEM did not correlate with COT1, COT2 or COT2-1 of Fibscreen1 and this warrants further investigation...
  31. ncbi The influence of low platelet count on whole blood aggregometry assessed by Multiplate
    Trine Stissing
    Department of Clinical Immunology, Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet 2034, University of Copenhagen, Denmark
    Clin Appl Thromb Hemost 17:E211-7. 2011
    ..In conclusion, platelet concentration of <150 × 10(9)/L may influence Multiplate which should be considered in clinical settings. Furthermore, the findings emphasize the importance of evaluating haemostasis in its natural matrix, WB...
  32. ncbi Platelet hyperreactivity in response to on- and off-pump coronary artery bypass grafting
    Louise Bochsen
    Department of Clinical Immunology 2032, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Extra Corpor Technol 41:15-9. 2009
    ..These results suggest that a more aggressive antithrombotic treatment might be warranted for patients undergoing coronary artery bypass grafting, both OPCAB and CABG, presenting with a high MA pre- and postsurgery...
  33. ncbi The prognostic value of thrombelastography in identifying neurosurgical patients with worse prognosis
    Nis A Windeløv
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:416-9. 2011
    ..Low concordance with conventional coagulation assays indicates that TEG might be valuable in identifying patients with clinically relevant coagulopathy...
  34. ncbi The influence of platelets, plasma and red blood cells on functional haemostatic assays
    Louise Bochsen
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:167-75. 2011
    ..The results emphasize that the concentrations of all cellular and plasmatic components in whole blood should be taken into account when interpreting results obtained by TEG and multiplate...
  35. ncbi The blood bank: from provider to partner in treatment of massively bleeding patients
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:176S-181S; discussion 182S-183S. 2007
    ..We therefore investigated whether the blood bank could improve its service and hence improve the outcome...
  36. ncbi Blood product ratio in acute traumatic coagulopathy--effect on mortality in a Scandinavian level 1 trauma centre
    Jesper Dirks
    Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 18:65. 2010
    ..Several studies report that higher ratios improve survival in massively bleeding patients. Here, the aim was to investigate the potential effect of increased FFP and PLT to RBC on mortality in trauma patients...
  37. ncbi Interindividual variation in platelets and the cardiovascular response to haemorrhage in the pig
    Morten Zaar
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:92-7. 2011
    ..These results support that platelets exert functions during bleeding beyond their importance for clot formation...
  38. ncbi Differential clot stabilising effects of rFVIIa and rFXIII-A2 in whole blood from thrombocytopenic patients and healthy volunteers
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Br J Haematol 143:559-69. 2008
    ..These data illustrate that rFVIIa and rFXIII-A2 contribute to clot formation and stability by different mechanisms suggesting enhanced haemostatic efficacy by combining these agents...
  39. ncbi Tissue factor activated thromboelastography correlates to clinical signs of bleeding in dogs
    Bo Wiinberg
    The Small Animal Hospital, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg DK 1870, Denmark
    Vet J 179:121-9. 2009
    ..The findings strongly suggest that TF- activated TEG may be of value in the workup of dogs suspected of having a haemostatic disorder...
  40. ncbi Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality
    Kristin B Nystrup
    Department of Clinical Immunology, Section for Transfusion Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:52. 2011
    ..Thrombelastographic (TEG) clot strength has previously been shown to predict outcome in critically ill patients. The aim of the present study was to investigate this relation in the trauma setting...
  41. ncbi Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration
    Nis A Windeløv
    Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark
    Blood Coagul Fibrinolysis 21:414-9. 2010
    ..Despite this, a trend towards lower mortality was observed in the PGI(2) group suggesting beneficial effects of PGI(2) administration in ICU patients undergoing CRRT...
  42. ncbi Equally increased hypercoagulability irrespective of using minimized or conventional ECC systems
    Ann S Steinbrüchel
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Scand Cardiovasc J 46:233-8. 2012
    ..The aim of this study was to investigate whether the use of mini systems does result in an increased postoperative hypercoagulative status...
  43. ncbi Rethinking platelet function: thrombocytopenia induced immunodeficiency in critical illness
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet 2032, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 77:798-802. 2011
    ....
  44. ncbi In vitro cell quality of buffy coat platelets in additive solution treated with pathogen reduction technology
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 50:2210-9. 2010
    ..To investigate this, buffy coat PLTs (BCPs) in PLT additive solution (AS; SSP+) with or without Mirasol PRT (CaridianBCT Biotechnologies) were assessed by quality control tests and four-color flow cytometry...
  45. ncbi Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage
    Lars Heslet
    Department of Intensive Care ITA 4131, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Denmark
    Crit Care 10:R177. 2006
    ..Tissue factor is expressed in the lung alveoli during inflammation and therefore pulmonary administration of human recombinant activated factor VIIa (rFVIIa) could be a rational treatment option...
  46. ncbi Higher Thrombelastograph platelet reactivity in cardiac surgery patients than in blood donors
    Louise Bochsen
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand Cardiovasc J 41:321-4. 2007
    ..The aim of this study was to investigate the platelet hyperreactivity and the variability in platelet reactivity due to ADP in cardiac surgery patients and donors...
  47. ncbi [Resuscitation and abdominal surgical aspects of damage control surgery]
    Jens G Hillingsø
    Kirurgisk Klinik C 2122, Rigshospitalet, Blegdamsvej 7 9, 2100 København Ø
    Ugeskr Laeger 173:1271-3. 2011
    ....
  48. ncbi Transfusion practice in massively bleeding patients: time for a change?
    P I Johansson
    Department of Clinical Immunology, University Hospital of Copenhagen, Copenhagen, Denmark
    Vox Sang 89:92-6. 2005
    ..We identified some fatal cases where massively bleeding patients received inadequate transfusion therapy. The aim of this study was to review and evaluate the transfusion practice in acutely multitransfused patients...
  49. ncbi Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: A prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark Electronic address
    J Crit Care 28:317.e1-317.e11. 2013
    ..The aim of this study was to assess associations between consecutive thrombelastography (TEG) profiles and standard coagulation tests and disease severity and mortality in patients with severe sepsis...
  50. ncbi Discrepant Fibrinolytic Response in Plasma and Whole Blood during Experimental Endotoxemia in Healthy Volunteers
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 8:e59368. 2013
    ....
  51. ncbi Hypercoagulability in relation to coronary artery bypass graft patency and clinical outcome
    Mette Zacho
    Department of Radiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand Cardiovasc J 47:104-8. 2013
    ..The objective of this study was to test the hypothesis that graft patency and post-CABG thrombembolic events are related to the pre-surgical TEG status...
  52. ncbi A review of the clinical utility of INR to monitor and guide administration of prothrombin complex concentrate to orally anticoagulated patients
    Sacha Sølbeck
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Thromb J 10:5. 2012
    ....
  53. ncbi Effects of nucleotides and nucleosides on coagulation
    Laurids T Bune
    Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    Blood Coagul Fibrinolysis 21:436-41. 2010
    ..The potential clinical significance of these findings should be investigated further because ADP discharged systemically may possibly contribute to the coagulopathy observed in severe sepsis...
  54. ncbi [Blood transfusion in major orthopaedic surgery]
    Øivind Jans
    Enhed for Kirurgisk Patofysiologi, 4074, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 173:815-7. 2011
    ..Thus, large randomised studies evaluating a restrictive versus a liberal transfusion strategy in a procedure-specific setup are needed...
  55. ncbi Rescue treatment with recombinant factor VIIa is effective in patients with life-threatening bleedings secondary to major wound excision: a report of four cases
    Pär I Johansson
    Department of Clinical Immunology, University Hospital of Copenhagen, Copenhagen, Denmark
    J Trauma 61:1016-8. 2006
    ..We conclude that rFVIIa may be an effective hemostatic treatment for patients undergoing major wound excision developing life-threatening bleedings...
  56. ncbi Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig
    M Zaar
    Department of Anaesthesia, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Br J Anaesth 103:840-7. 2009
    ..v. vs i.m. administration of the coagulation factor VIIa analogue NN1731 on haemorrhage after a liver trauma in the pig...
  57. ncbi Hemostatic resuscitation with plasma and platelets in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Denmark
    J Emerg Trauma Shock 5:120-5. 2012
    ..The aim of the present review was to investigate the potential effect on survival of proactive administration of plasma and/or platelets (PLT) in trauma patients with massive bleeding...
  58. ncbi Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pig
    M Zaar
    Department of Anaesthesia, Faculty of Health Sciences, University of Copenhagen, Denmark
    Br J Anaesth 102:221-6. 2009
    ..This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringer's solution (RL)...
  59. ncbi Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation
    B Wiinberg
    Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Small Animal Hospital, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 22:357-65. 2008
    ..There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function...
  60. ncbi Early activation of the coagulation system during lower body negative pressure
    M Zaar
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Clin Physiol Funct Imaging 29:427-30. 2009
    ..05), reflecting reduced vagal activity. In conclusion, thrombin generation was activated by a modest decrease in CBV by LBNP in healthy humans independent of the vagal activity...
  61. ncbi Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven)
    D Viuff
    Hemostasis Pharmacology, Novo Nordisk A S, Novo Nordisk Park, 2760 Måløv, Denmark
    Br J Anaesth 101:324-31. 2008
    ..The haemostatic agent, recombinant activated factor VII (rFVIIa, NovoSeven), may be used to improve haemostasis but potential interactions with different volume expanders are poorly understood...