Pär I Johansson

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr
    Sulman Rafiq
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 13:48. 2012
  2. pmc Current management of massive hemorrhage in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 20:47. 2012
  3. doi Coagulopathy and hemostatic monitoring in cardiac surgery: an update
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 46:194-202. 2012
  4. doi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012
  5. doi Coagulation monitoring of the bleeding traumatized patient
    Pär I Johansson
    Section for Transfusion Medicine, Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Anaesthesiol 25:235-41. 2012
  6. ncbi High circulating adrenaline levels at admission predict increased mortality after trauma
    Pär Ingemar Johansson
    Section forTransfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    J Trauma Acute Care Surg 72:428-36. 2012
  7. pmc Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
  8. doi High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    J Thromb Haemost 10:207-16. 2012
  9. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
  10. pmc Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009

Collaborators

Detail Information

Publications79

  1. pmc Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr
    Sulman Rafiq
    Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Trials 13:48. 2012
    ....
  2. pmc Current management of massive hemorrhage in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 20:47. 2012
    ..The aim of the goal-directed therapy should be to maintain a normal hemostatic competence until surgical hemostasis is achieved, as this appears to be associated with reduced mortality...
  3. doi Coagulopathy and hemostatic monitoring in cardiac surgery: an update
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 46:194-202. 2012
    ..Excessive transfusion and surgical re-exploration after cardiac surgery are potentially associated with a number of adverse outcomes including increased mortality...
  4. doi Elderly trauma patients have high circulating noradrenaline levels but attenuated release of adrenaline, platelets, and leukocytes in response to increasing injury severity
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen, Denmark
    Crit Care Med 40:1844-50. 2012
    ....
  5. doi Coagulation monitoring of the bleeding traumatized patient
    Pär I Johansson
    Section for Transfusion Medicine, Regional Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Anaesthesiol 25:235-41. 2012
    ..On admission, 25-35% of trauma patients present with coagulopathy, which is associated with a several-fold increase in morbidity and mortality...
  6. ncbi High circulating adrenaline levels at admission predict increased mortality after trauma
    Pär Ingemar Johansson
    Section forTransfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    J Trauma Acute Care Surg 72:428-36. 2012
    ..Although its pathophysiology is unclear, severe injury and shock(hypoperfusion) are proposed drivers. This study investigated the association between sympathoadrenal activation (circulating catecholamines) and biomarkers of coagulopathy...
  7. pmc Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Crit Care 15:R272. 2011
    ..This study investigated the prevalence of overt DIC and ACoTS in trauma patients and characterized these conditions based on their biomarker profiles...
  8. doi High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    J Thromb Haemost 10:207-16. 2012
    ..Soluble CD40L is a platelet-derived mediator that links inflammation, hemostasis and vascular dysfunction...
  9. pmc Reappraising the concept of massive transfusion in trauma
    Simon J Stanworth
    NHS Blood and Transplant, Oxford Radcliffe Hospitals Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK
    Crit Care 14:R239. 2010
    ..We also examined whether the concept was useful in that early prediction of massive transfusion requirements could allow early activation of blood bank protocols...
  10. pmc Thrombelastography and tromboelastometry in assessing coagulopathy in trauma
    Pär I Johansson
    Regional Blood Bank, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 17:45. 2009
    ....
  11. ncbi Hemostatic strategies for minimizing mortality in surgery with major blood loss
    Pär I Johansson
    Regional Blood Bank, Section for Transfusion Service, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Hematol 16:509-14. 2009
    ..This article reviews recent advances that impact the use and effectiveness of massive transfusion...
  12. doi Hemostatic resuscitation for massive bleeding: the paradigm of plasma and platelets--a review of the current literature
    Pär I Johansson
    Department of Clinical Immunology, Section for Transfusion Service, Centre of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Transfusion 50:701-10. 2010
    ..Recent studies indicate a possible survival benefit in patients receiving a higher ratio of plasma and platelets (PLTs) to red blood cells (RBCs) than what is recommended in current transfusion guidelines...
  13. doi Goal-directed hemostatic resuscitation for massively bleeding patients: the Copenhagen concept
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfus Apher Sci 43:401-5. 2010
    ..A review of transfusion practice for these patients at our hospital revealed that a significant proportion received suboptimal transfusion therapy. Survivors had higher platelets count than non-survivors...
  14. pmc Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders
    Pär I Johansson
    Capital Region Blood Bank, Section for Transfusion Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Drug Des Devel Ther 4:107-16. 2010
    ..Recombinant activated factor VII (rFVIIa, NovoSeven) was introduced in 1996 for the treatment of hemophilic patients with antibodies against coagulation factor VIII or IX...
  15. doi Hypocoagulability, as evaluated by thrombelastography, at admission to the ICU is associated with increased 30-day mortality
    Pär I Johansson
    Department of Clinical Immunology, and Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 21:168-74. 2010
    ..Hypocoagulability is an independent risk factor for 30-day mortality...
  16. ncbi Investigation of the effect of kaolin and tissue-factor-activated citrated whole blood, on clot-forming variables, as evaluated by thromboelastography
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 48:2377-83. 2008
    ..Implementing TEG as a routine laboratory-based analysis, however, requires validation of the activators employed and the effect of storage of the WB sample in citrate before analysis...
  17. pmc Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study
    P I Johansson
    Department of Clinical Immunology, Blood Bank, Copenhagen University Hospital, Copenhagen, Denmark
    Vox Sang 96:111-8. 2009
    ..Current consensus guidelines recommend restrictive use. Our aim was to determine the effect of changing the transfusion practice on 30-day survival in massively bleeding patients...
  18. doi Off-label use of recombinant factor VIIa for treatment of haemorrhage: results from randomized clinical trials
    P I Johansson
    Section for Transfusion Service, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Vox Sang 95:1-7. 2008
    ..The aim of the present study was to review the randomized clinical trials (RCT) for evidence of such an approach...
  19. ncbi Investigation of the thrombin-generating capacity, evaluated by thrombogram, and clot formation evaluated by thrombelastography of platelets stored in the blood bank for up to 7 days
    P I Johansson
    Department of Clinical Immunology, Blood Bank, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Vox Sang 94:113-8. 2008
    ..Taking the pivotal role of thrombin generation in the coagulation process into consideration, the clinical utility of the TEG may, in part, depend on its reflection of the dynamics of thrombin generation...
  20. doi A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Ann Surg 254:194-200. 2011
    ..To investigate the association between markers of acute endothelial glycocalyx degradation, inflammation, coagulopathy, and mortality after trauma...
  21. doi Transfusion packages for massively bleeding patients: the effect on clot formation and stability as evaluated by Thrombelastograph (TEG)
    Pär I Johansson
    Transfusion Service, Department of Clinical Immunology, University of Copenhagen, Rigshospitalet 2034, Blegdamsvej 9, Copenhagen, Denmark
    Transfus Apher Sci 39:3-8. 2008
    ..01). In 8 patients damage control surgery was successful and 6 of these patients survived. The result indicates that an early balanced transfusion strategy maintains haemostatic competence in massively bleeding patients...
  22. doi Intraoperative platelet and plasma improves survival in patients operated for a rAAA: a follow-up evaluation
    P I Johansson
    Department of Clinical Immunology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Vasc Endovasc Surg 36:397-400. 2008
    ..The aim of the present evaluation was to evaluate whether reduced mortality in rAAA patients related to a pro-active transfusion therapy is maintained...
  23. doi Management of major blood loss: an update
    P I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Anaesthesiol Scand 54:1039-49. 2010
    ..The aim of the goal-directed therapy should be to maintain a normal haemostatic competence until surgical haemostasis is achieved, as this appears to be associated with reduced mortality...
  24. doi Hemostatic function of buffy coat platelets in additive solution treated with pathogen reduction technology
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 51:344-56. 2011
    ..To investigate this, buffy coat PLTs (BCPs) stored in PLT additive solution (SSP+) with or without Mirasol PRT treatment (CaridianBCT Biotechnologies) were compared by functional hemostatic assays...
  25. doi Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, the Department of Anesthesia and TraumaCenter 3193, Centre for Head and Orthopedic, and the Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research, CETIR, University of Texas Medical School at Houston, Houston, Texas
    Transfusion 53:3088-99. 2013
    ..Hemorrhage accounts for most preventable trauma deaths, but still the optimal strategy for hemostatic resuscitation remains debated...
  26. ncbi Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma
    Martin Sillesen
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care M S, C H J, A I, J O H, D D, M Du, M De, G C V, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts Department of Anesthesia M S, L S R, Center of Head and Orthopedics, and Capital Region Blood Bank P I J, C H J, Copenhagen University Hospital, Rigshospitalet, Denmark Department of Surgery P I J, University of Texas Medical School at Houston, Texas and Department of Surgery G J, H B A, University of Michigan, Ann Arbor, Michigan
    J Trauma Acute Care Surg 76:998-1007. 2014
    ..Platelet dysfunction following trauma has been identified as an independent predictor of mortality. We hypothesized that fresh frozen plasma (FFP) resuscitation would attenuate platelet dysfunction compared with 0.9% normal saline (NS)...
  27. pmc Discrepant fibrinolytic response in plasma and whole blood during experimental endotoxemia in healthy volunteers
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 8:e59368. 2013
    ....
  28. pmc High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, Copenhagen DK 2100, Denmark
    Scand J Trauma Resusc Emerg Med 20:27. 2012
    ..Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome...
  29. ncbi Assessment of coagulopathy, endothelial injury, and inflammation after traumatic brain injury and hemorrhage in a porcine model
    Martin Sillesen
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care M S, C H J, A I, J O H, M D, G V, Department of Surgery, Massachusetts GeneralHospital Harvard Medical School, Boston, Massachusetts Department of surgery G J, I H, H B A, University of Michigan, Ann Arbor, Michigan and Department of Surgery P I J, University of Texas Medical School, Houston, Texas and Department of Anesthesia M S, L S R, Center of Head and Orthopedics, and Capital Region Blood Bank C H J, P I J, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Trauma Acute Care Surg 76:12-9; discussion 19-20. 2014
    ..We hypothesized that a combination of TBI and HS would disturb coagulation, damage the endothelium, and activate inflammatory and complement systems...
  30. ncbi Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity
    Bo Wiinberg
    The Small Animal Hospital, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    Vet J 185:292-8. 2010
    ..3%, specificity 77.3%). Based on commonly used, plasma-based coagulation assays, it was possible to design an objective diagnostic scoring system for canine DIC with a high sensitivity and specificity...
  31. ncbi Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: evaluating a change in transfusion practice
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:593-8. 2007
    ..It was considered that early substitution with PLTs and fresh-frozen plasma (FFP) would prevent development of coagulopathy and thus improve survival...
  32. doi The in vitro effect of recombinant factor VIIa on coated platelet formation and clot dynamics of stored platelet concentrates
    Mette S Svendsen
    Blood Bank, Department of Clinical Immunology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark
    Transfusion 49:2186-94. 2009
    ..We investigated whether activated recombinant factor VII (rFVIIa, NovoSeven, Novo Nordisk A/S) could improve the ability of stored PLTs to support coagulation under conditions that promote the formation of coated PLTs...
  33. doi Hypercoagulability in response to elevated body temperature and central hypovolemia
    Martin A S Meyer
    Section for Transfusion Medicine, Capital Regional Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas Electronic address
    J Surg Res 185:e93-100. 2013
    ..The objective of this study was to evaluate whether experimentally elevated body temperature and reduced central blood volume (CBV) per se affects hemostasis and endothelial activation...
  34. ncbi Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Electronic address
    J Crit Care 28:586-96. 2013
    ..The aim of this study was to investigate associations between circulating catecholamines, endothelial damage, and coagulopathy in experimental human endotoxemia and septic patients...
  35. doi Thrombelastography and rotational thromboelastometry early amplitudes in 182 trauma patients with clinical suspicion of severe injury
    Anna Sina P Meyer
    From the Section for Transfusion Medicine A S P M, M A S M, M B H, s r o, P I J, Capital Region Blood Bank, The Trauma Centre A M S, Centre of Head and Orthopaedics, and Department of Anaesthesia A M S, L S R, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Department of Surgery A S P M, M A S M, J H B, B A C, C E W, P I J, Center for Translational Injury Research CeTIR, University of Texas Medical School at Houston, Houston, Texas
    J Trauma Acute Care Surg 76:682-90. 2014
    ..Viscoelastic hemostatic assays may provide means for earlier detection of trauma-induced coagulopathy (TIC)...
  36. pmc Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:64. 2011
    ..Severe injury induces an acute coagulopathy associated with increased mortality. This study compared the Thrombelastography (TEG) and biomarker profiles upon admission in trauma patients...
  37. doi Hydroxyethyl starch reduces coagulation competence and increases blood loss during major surgery: results from a randomized controlled trial
    Kirsten C Rasmussen
    Department of Anesthesiology, The Abdominal Centre Section for Transfusion Medicine Department of Urology and Center of Head and Ortopaedic Surgery, Rigshospitalet, University of Copenhagen, Denmark
    Ann Surg 259:249-54. 2014
    ..This study evaluated whether administration of hydroxyethyl starch (HES) 130/0.4 affects coagulation competence and influences the perioperative blood loss...
  38. doi Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy
    Sisse R Ostrowski
    Section for Transfusion Medicine, Copenhagen University Hospital, Copenhagen, Denmark
    J Trauma Acute Care Surg 73:60-6. 2012
    ..This study evaluated if degradation of the endothelial glycocalyx and ensuing release of its heparin-like substances induce autoheparinization and thereby contributes to TIC...
  39. doi In-vitro comparison of free oscillation rheometry (ReoRox) and rotational thromboelastometry (ROTEM) in trauma patients upon hospital admission
    Sacha Sølbeck
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 23:688-92. 2012
    ..ROTEM EXTEM did not correlate with COT1, COT2 or COT2-1 of Fibscreen1 and this warrants further investigation...
  40. doi The influence of low platelet count on whole blood aggregometry assessed by Multiplate
    Trine Stissing
    Department of Clinical Immunology, Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet 2034, University of Copenhagen, Denmark
    Clin Appl Thromb Hemost 17:E211-7. 2011
    ..In conclusion, platelet concentration of <150 × 10(9)/L may influence Multiplate which should be considered in clinical settings. Furthermore, the findings emphasize the importance of evaluating haemostasis in its natural matrix, WB...
  41. ncbi Platelet hyperreactivity in response to on- and off-pump coronary artery bypass grafting
    Louise Bochsen
    Department of Clinical Immunology 2032, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Extra Corpor Technol 41:15-9. 2009
    ..These results suggest that a more aggressive antithrombotic treatment might be warranted for patients undergoing coronary artery bypass grafting, both OPCAB and CABG, presenting with a high MA pre- and postsurgery...
  42. doi The prognostic value of thrombelastography in identifying neurosurgical patients with worse prognosis
    Nis A Windeløv
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:416-9. 2011
    ..Low concordance with conventional coagulation assays indicates that TEG might be valuable in identifying patients with clinically relevant coagulopathy...
  43. doi The influence of platelets, plasma and red blood cells on functional haemostatic assays
    Louise Bochsen
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:167-75. 2011
    ..The results emphasize that the concentrations of all cellular and plasmatic components in whole blood should be taken into account when interpreting results obtained by TEG and multiplate...
  44. doi Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage
    Martin Sillesen
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    J Trauma Acute Care Surg 74:1252-9. 2013
    ..We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers...
  45. ncbi The blood bank: from provider to partner in treatment of massively bleeding patients
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 47:176S-181S; discussion 182S-183S. 2007
    ..We therefore investigated whether the blood bank could improve its service and hence improve the outcome...
  46. pmc Blood product ratio in acute traumatic coagulopathy--effect on mortality in a Scandinavian level 1 trauma centre
    Jesper Dirks
    Department of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 18:65. 2010
    ..Several studies report that higher ratios improve survival in massively bleeding patients. Here, the aim was to investigate the potential effect of increased FFP and PLT to RBC on mortality in trauma patients...
  47. doi Differential clot stabilising effects of rFVIIa and rFXIII-A2 in whole blood from thrombocytopenic patients and healthy volunteers
    Pär I Johansson
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Br J Haematol 143:559-69. 2008
    ..These data illustrate that rFVIIa and rFXIII-A2 contribute to clot formation and stability by different mechanisms suggesting enhanced haemostatic efficacy by combining these agents...
  48. doi Interindividual variation in platelets and the cardiovascular response to haemorrhage in the pig
    Morten Zaar
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Blood Coagul Fibrinolysis 22:92-7. 2011
    ..These results support that platelets exert functions during bleeding beyond their importance for clot formation...
  49. ncbi Platelet aggregation following trauma: a prospective study
    Nis A Windeløv
    aDepartment of Anaesthesia bTrauma Centre, Centre of Head and Orthopaedics, cDepartment of Intensive Care, The Abdominal Centre dDepartment of Cardiothoracic Anaesthesia and Intensive Care, The Heart Centre eSection for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark fDepartment of Surgery, Centre for Translational Injury Research, University of Texas Medical School, Houston, Texas, USA
    Blood Coagul Fibrinolysis 25:67-73. 2014
    ..01). We concluded there was no simple relationship between platelet aggregation and injury severity. Our results indicate that high platelet aggregation values are associated with fatality of cerebral injury. ..
  50. doi A pilot study to assess the hemostatic function of pathogen-reduced platelets in patients with thrombocytopenia
    Pär I Johansson
    Department of Clinical Immunology, Section of Transfusion Medicine, Copenhagen, Denmark Department of Hematology, University of Copenhagen, Copenhagen, Denmark Terumo BCT, Lakewood, Colorado
    Transfusion 53:2043-52. 2013
    ..This clinical pilot study assessed the effect of pathogen reduction technology with riboflavin plus ultraviolet light using thrombelastography (TEG)...
  51. doi Hypercoagulability in relation to coronary artery bypass graft patency and clinical outcome
    Mette Zacho
    Department of Radiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand Cardiovasc J 47:104-8. 2013
    ..The objective of this study was to test the hypothesis that graft patency and post-CABG thrombembolic events are related to the pre-surgical TEG status...
  52. doi Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: a prospective study
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Crit Care 28:317.e1-11. 2013
    ..The aim of this study was to assess associations between consecutive thrombelastography (TEG) profiles and standard coagulation tests and disease severity and mortality in patients with severe sepsis...
  53. ncbi Tissue factor activated thromboelastography correlates to clinical signs of bleeding in dogs
    Bo Wiinberg
    The Small Animal Hospital, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Frederiksberg DK 1870, Denmark
    Vet J 179:121-9. 2009
    ..The findings strongly suggest that TF- activated TEG may be of value in the workup of dogs suspected of having a haemostatic disorder...
  54. pmc Reduced clot strength upon admission, evaluated by thrombelastography (TEG), in trauma patients is independently associated with increased 30-day mortality
    Kristin B Nystrup
    Department of Clinical Immunology, Section for Transfusion Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Trauma Resusc Emerg Med 19:52. 2011
    ..Thrombelastographic (TEG) clot strength has previously been shown to predict outcome in critically ill patients. The aim of the present study was to investigate this relation in the trauma setting...
  55. doi Role of preoperative anemia for risk of transfusion and postoperative morbidity in fast-track hip and knee arthroplasty
    Øivind Jans
    Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark Section for Transfusion Medicine, Rigshospitalet, Lundbeck Foundation Centre for Fast track Hip and Knee Arthroplasty, Copenhagen, Denmark
    Transfusion 54:717-26. 2014
    ..We aimed to evaluate the prevalence of preoperative anemia in elective fast-track THA and TKA and its association with risk of perioperative transfusion, prolonged length of hospital stay (LOS), and postoperative readmission...
  56. pmc Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial
    Lars B Holst
    Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Trials 14:150. 2013
    ..However, benefit and harm of RBCs have not been established in this group of high-risk patients...
  57. doi Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion
    Martin Sillesen
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Surgery 154:197-205. 2013
    ....
  58. ncbi Transfusion requirements and clinical outcome in intensive care patients receiving continuous renal replacement therapy: comparison of prostacyclin vs. heparin prefilter administration
    Nis A Windeløv
    Capital Region Blood Bank, Rigshospitalet, Copenhagen University Hospital, Denmark
    Blood Coagul Fibrinolysis 21:414-9. 2010
    ..Despite this, a trend towards lower mortality was observed in the PGI(2) group suggesting beneficial effects of PGI(2) administration in ICU patients undergoing CRRT...
  59. ncbi Transfusion of 7-day-old amotosalen photochemically treated buffy-coat platelets to patients with thrombocytopenia: a pilot study
    Anne C Simonsen
    Copenhagen University Hospital, Copenhagen, Denmark
    Transfusion 46:424-33. 2006
    ..Photochemical treatment (PCT) of platelets (PLTs) with amotosalen and ultraviolet A light to inactivate bacteria may facilitate extension of storage from 5 to 7 days...
  60. doi Equally increased hypercoagulability irrespective of using minimized or conventional ECC systems
    Ann S Steinbrüchel
    Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Denmark
    Scand Cardiovasc J 46:233-8. 2012
    ..The aim of this study was to investigate whether the use of mini systems does result in an increased postoperative hypercoagulative status...
  61. doi Rethinking platelet function: thrombocytopenia induced immunodeficiency in critical illness
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet 2032, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Med Hypotheses 77:798-802. 2011
    ....
  62. doi In vitro cell quality of buffy coat platelets in additive solution treated with pathogen reduction technology
    Sisse R Ostrowski
    Section for Transfusion Medicine, Capital Region Blood Bank, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Transfusion 50:2210-9. 2010
    ..To investigate this, buffy coat PLTs (BCPs) in PLT additive solution (AS; SSP+) with or without Mirasol PRT (CaridianBCT Biotechnologies) were assessed by quality control tests and four-color flow cytometry...
  63. pmc Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage
    Lars Heslet
    Department of Intensive Care ITA 4131, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Denmark
    Crit Care 10:R177. 2006
    ..Tissue factor is expressed in the lung alveoli during inflammation and therefore pulmonary administration of human recombinant activated factor VIIa (rFVIIa) could be a rational treatment option...
  64. ncbi Higher Thrombelastograph platelet reactivity in cardiac surgery patients than in blood donors
    Louise Bochsen
    Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand Cardiovasc J 41:321-4. 2007
    ..The aim of this study was to investigate the platelet hyperreactivity and the variability in platelet reactivity due to ADP in cardiac surgery patients and donors...
  65. ncbi [Resuscitation and abdominal surgical aspects of damage control surgery]
    Jens G Hillingsø
    Kirurgisk Klinik C 2122, Rigshospitalet, Blegdamsvej 7 9, 2100 København Ø
    Ugeskr Laeger 173:1271-3. 2011
    ....
  66. ncbi Transfusion practice in massively bleeding patients: time for a change?
    P I Johansson
    Department of Clinical Immunology, University Hospital of Copenhagen, Copenhagen, Denmark
    Vox Sang 89:92-6. 2005
    ..We identified some fatal cases where massively bleeding patients received inadequate transfusion therapy. The aim of this study was to review and evaluate the transfusion practice in acutely multitransfused patients...
  67. ncbi Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury
    Cecilie Heerdegen Jepsen
    From the Department of Surgery C H J, M A D, M S, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts Capital Region Blood Bank C H J, M S, s r o, P I J and Department of Intensive Care A P, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery H B A, University of Michigan, Ann Arbor, Michigan and Department of Surgery P I J, University of Texas Medical School at Houston, Houston, Texas
    J Trauma Acute Care Surg 77:292-7. 2014
    ..We further hypothesized that VPA treatment would reduce this response and reduce lesion size volume...
  68. ncbi Association between sympathoadrenal activation, fibrinolysis, and endothelial damage in septic patients: A prospective study
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Surgery, Division of Acute Care Surgery, Centre for Translational Injury Research CeTIR, University of Texas Medical School at Houston, TX, USA Electronic address
    J Crit Care 29:327-33. 2014
    ..The purpose of this study is to investigate potential associations between sympathoadrenal activation and/or vasopressor/inotropic therapy and endothelial activation, damage, and coagulopathy in septic patients...
  69. pmc A review of the clinical utility of INR to monitor and guide administration of prothrombin complex concentrate to orally anticoagulated patients
    Sacha Sølbeck
    Section for Transfusion Medicine, Capital Region Blood Bank, Rigshospitalet University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen, Denmark
    Thromb J 10:5. 2012
    ....
  70. ncbi [Blood transfusion in major orthopaedic surgery]
    Øivind Jans
    Enhed for Kirurgisk Patofysiologi, 4074, Rigshospitalet, 2100 København Ø, Denmark
    Ugeskr Laeger 173:815-7. 2011
    ..Thus, large randomised studies evaluating a restrictive versus a liberal transfusion strategy in a procedure-specific setup are needed...
  71. doi Effects of nucleotides and nucleosides on coagulation
    Laurids T Bune
    Copenhagen Muscle Research Centre, Rigshospitalet, Denmark
    Blood Coagul Fibrinolysis 21:436-41. 2010
    ..The potential clinical significance of these findings should be investigated further because ADP discharged systemically may possibly contribute to the coagulopathy observed in severe sepsis...
  72. ncbi Rescue treatment with recombinant factor VIIa is effective in patients with life-threatening bleedings secondary to major wound excision: a report of four cases
    Pär I Johansson
    Department of Clinical Immunology, University Hospital of Copenhagen, Copenhagen, Denmark
    J Trauma 61:1016-8. 2006
    ..We conclude that rFVIIa may be an effective hemostatic treatment for patients undergoing major wound excision developing life-threatening bleedings...
  73. doi Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig
    M Zaar
    Department of Anaesthesia, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Br J Anaesth 103:840-7. 2009
    ..v. vs i.m. administration of the coagulation factor VIIa analogue NN1731 on haemorrhage after a liver trauma in the pig...
  74. pmc Hemostatic resuscitation with plasma and platelets in trauma
    Pär I Johansson
    Section for Transfusion Medicine, Capital Region Blood Bank, Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Denmark
    J Emerg Trauma Shock 5:120-5. 2012
    ..The aim of the present review was to investigate the potential effect on survival of proactive administration of plasma and/or platelets (PLT) in trauma patients with massive bleeding...
  75. doi Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pig
    M Zaar
    Department of Anaesthesia, Faculty of Health Sciences, University of Copenhagen, Denmark
    Br J Anaesth 102:221-6. 2009
    ..This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringer's solution (RL)...
  76. pmc Early activation of the coagulation system during lower body negative pressure
    M Zaar
    Department of Anesthesia, Rigshospitalet, University of Copenhagen, Denmark
    Clin Physiol Funct Imaging 29:427-30. 2009
    ..05), reflecting reduced vagal activity. In conclusion, thrombin generation was activated by a modest decrease in CBV by LBNP in healthy humans independent of the vagal activity...
  77. doi Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation
    B Wiinberg
    Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Small Animal Hospital, University of Copenhagen, Frederiksberg, Denmark
    J Vet Intern Med 22:357-65. 2008
    ..There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function...
  78. pmc Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven)
    D Viuff
    Hemostasis Pharmacology, Novo Nordisk A S, Novo Nordisk Park, 2760 Måløv, Denmark
    Br J Anaesth 101:324-31. 2008
    ..The haemostatic agent, recombinant activated factor VII (rFVIIa, NovoSeven), may be used to improve haemostasis but potential interactions with different volume expanders are poorly understood...