Research Topics
Species | L HviidSummaryAffiliation: Copenhagen University Hospital Country: Denmark Publications
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Publications
CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expressionPamela A Magistrado
Centre for Medical Parasitology at the Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Malar J 7:204. 2008..Also, unlike var genes from groups B and C, those from group A do not have sequences consistent with CD36 binding--a major cytoadhesion phenotype of P. falciparum isolates...- Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humansThomas Lavstsen
Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Malar J 4:21. 2005..Thus, severe malaria may be caused by parasites expressing PfEMP1 variants that afford parasites optimal sequestration in immunologically naive individuals and high effective multiplication rates... - Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasitesMadeleine Dahlbäck
Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Malar J 6:78. 2007..Two parasite populations were studied; an unselected population of NF54 and a selected population, NF54VAR2CSA, to compare both the transcription of var2csa and the expression pattern of the corresponding protein... - Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolatesAyman Khattab
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Malar J 3:21. 2004.... 
Naturally acquired immunity to Plasmodium falciparum malaria in AfricaLars Hviid
Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Acta Trop 95:270-5. 2005....- VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malariaL Hviid
Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Parasitology 134:1871-6. 2007..falciparum infection... - Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunityLars Hviid
Department of Infectious Diseases, Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
Microbes Infect 9:772-6. 2007..We are pursuing the development of vaccines based on antigens and immune responses that appear key in naturally acquired protection... 
Malaria vaccines: immunity, models and monoclonal antibodiesLars Hviid
Centre for Medical Parasitology at the Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen, 1014 Copenhagen K, Denmark
Trends Parasitol 24:392-5. 2008..However, recent technological advances might help overcome some of these hurdles...- [Pregnancy-associated malaria]L Hviid
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
Med Trop (Mars) 66:130-2. 2006..falciparum parasites. However, the understanding of the pathogenesis of PAM and of the acquired protective immune response to this syndrome is progressing at a rapid pace as outlined in this brief review... - Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malariaL Hviid
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Infect Immun 69:3190-6. 2001..Taken together, our data point to an immunoregulatory role of the expanded V delta 1(+) T-cell population in this group of semi-immune P. falciparum malaria patients... - The immuno-epidemiology of pregnancy-associated Plasmodium falciparum malaria: a variant surface antigen-specific perspectiveL Hviid
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen Ø, Denmark
Parasite Immunol 26:477-86. 2004..falciparum malaria operates and is acquired, have provided important insights into this enigma... - Variant-specific immunity to Plasmodium berghei in pregnant miceRosette Megnekou
Department of International Health, Immunology and Microbiology, University of Copenhagen, CSS Building 22, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark
Infect Immun 77:1827-34. 2009..falciparum malaria. The study of P. berghei malaria in pregnant, immune mice can be used to gain significant new insights regarding malaria pathogenesis and immunity in general and regarding PAM in particular... - Malaria immunity in infants: a special case of a general phenomenon?Lars Hviid
Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, 2100, Copenhagen Ø, Denmark
Trends Parasitol 20:66-72. 2004.... - Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malariaL Hviid
Center for Medical Parasitology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Denmark
Infect Immun 65:4090-3. 1997.... - The gamma/delta T-cell response to Plasmodium falciparum malaria in a population in which malaria is endemicL Hviid
Centre for Medical Parasitology at RHIMA Centre, Copenhagen University Hospital Rigshospitalet, Denmark
Infect Immun 64:4359-62. 1996..The study raises questions regarding age and degree of previous exposure as determinants of malaria-induced gamma/delta T-cell responses... - The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine developmentLars Hviid
Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Hum Vaccin 6:84-9. 2010.... - Adhesion specificities of Plasmodium falciparum-infected erythrocytes involved in the pathogenesis of pregnancy-associated malariaLars Hviid
Department of International Health, Immunology, and Microbiology, Center for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital, CSS Building 22, ster Farimagsgade 5, PO Box 2099, 1014 Copenhagen K, Denmark
Am J Pathol 170:1817-9. 2007 - Cell-mediated immune responses to soluble Plasmodium falciparum antigens in residents from an area of unstable malaria transmission in the SudanL Hviid
Department of Infectious Diseases, University Hospital, Copenhagen, Denmark
APMIS 98:594-604. 1990..This indicates that parameters outside the degree of exposure to P. falciparum influence the cellular immune responses to malaria... - Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemiaT Staalsoe
Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, 2200 Copenhagen N, Denmark
J Infect Dis 184:618-26. 2001..Data suggest that VSA(CSA) is a target for vaccination against PAM... - Human T-cell recognition of synthetic peptides representing conserved and variant sequences from the merozoite surface protein 2 of Plasmodium falciparumT G Theander
Centre for Medical Parasitology, University of Copenhagen, Denmark
Immunol Lett 58:1-8. 1997.... - Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malariaTrine Staalsoe
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Lancet 363:283-9. 2004..Our data indicate an important mechanism of clinical protection against malaria and raise hope for the clinical effectiveness of a potential VSA-based vaccine against pregnancy-associated malaria... - Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometryT Staalsoe
Centre for Medical Parasitology at RHIMA Centre, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
Cytometry 35:329-36. 1999..This protein is inserted by the parasite into the host cell membrane and mediates the adhesion to the venular endothelium of the host organism in vivo... - Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malariaK Kemp
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Clin Exp Immunol 127:151-7. 2002..However, the high proportion of pre-apoptotic cells from the time of admission suggests that apoptosis also contributes to the low frequency and number of T cells in the peripheral circulation during active disease... - Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparumH A Giha
Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, Denmark
Parasitology 119:7-17. 1999.... - Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicityM Theisen
Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
Infect Immun 69:5223-9. 2001..This indicates that synthetic peptides derived from relatively conserved epitopes of GLURP might serve as useful immunogens for vaccination against P. falciparum malaria... - Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern TanzaniaLasse S Vestergaard
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, and Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Infect Immun 76:2706-14. 2008..These differences indicate a strong and dynamic relationship between malaria exposure and functional characteristics of the variant-specific antibody response, which is likely to be important for protection against malaria... - Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malariaAli Salanti
Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
Mol Microbiol 49:179-91. 2003..falciparum malaria. This var gene thus has the properties expected of a gene encoding the parasite adhesion molecule that initiates the pathology associated with PAM... - Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparumP H Jakobsen
Department of Treponematoses, State Seruminstitute, Copenhagen, Denmark
Parasitol Res 76:657-61. 1990..Ag1 is recognized by human immune sera from six different malaria-endemic regions. Ag1 induces in vitro proliferation of lymphocytes from malaria-immune individuals in an antigen-specific manner... - Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigensJ Soerli
Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen Denmark
Parasite Immunol 31:341-6. 2009..The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA... - Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsinMorten A Nielsen
Centre for Medical Parasitology, Department of Infectious Diseases M4701, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
Exp Parasitol 117:1-8. 2007..These results support the hypothesis that VAR2CSA mediates the adhesive and antigenic phenotypes shown by parasites causing placental malaria... - Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigensMorten A Nielsen
Centre for Medical Parasitology at Department of Infectious Diseases and Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Infect Immun 72:3531-5. 2004..falciparum malaria... - Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasisK Kemp
Centre for Medical Parasitology at Laboratory Centre and RHIMA Centre, Copenhagen University Hospital Rigshospitalet, Denmark
Clin Exp Immunol 116:500-4. 1999..The third group could be a regulatory subset of T cells important for maintaining a balance between Th1- and Th2-type cells in these individuals... - West African donors have high percentages of activated cytokine producing T cells that are prone to apoptosisK Kemp
Centre for Medical Parasitology at the Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
Clin Exp Immunol 126:69-75. 2001..These results may explain why some epidemic diseases seem to have a different mode of transmission in Africa compared to the western world, and may thus be of importance when vaccine strategies are considered in Africa... - Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malariaAnja T R Jensen
Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Infect Immun 71:4193-6. 2003..Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM... - Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWoRikke N Haase
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Denmark
Infect Immun 74:3035-8. 2006..We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro... - Evidence for the involvement of VAR2CSA in pregnancy-associated malariaAli Salanti
Centre for Medical Parasitology, Dept of Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
J Exp Med 200:1197-203. 2004.... - Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestrationMadeleine Dahlbäck
Centre for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
PLoS Pathog 2:e124. 2006..These findings strengthen the vaccine candidacy of VAR2CSA and will be important for choosing epitopes and variants of DBL3X to be included in a vaccine protecting women against pregnancy-associated malaria... - Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigensN Askjaer
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Clin Diagn Lab Immunol 8:1289-91. 2001..falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN... - Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malariaTrine Staalsoe
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, M7641 Rigshospitalet, Institute for Medical Microbiology and Immunology, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
Immunol Lett 84:133-6. 2002.... - Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSALea Barfod
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Mol Microbiol 63:335-47. 2007.... - Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunityMorten A Nielsen
Center for Medical Parasitology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
J Immunol 168:3444-50. 2002..This opens the possibility of developing morbidity-reducing vaccines targeting a limited subset of common and particularly virulent VSA... - Of mice and women: rodent models of placental malariaLars Hviid
Centre for Medical Parasitology at Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen and at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Trends Parasitol 26:412-9. 2010..However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity... - The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobsLars M Joergensen
Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, CSS Øster Farimagsgade 5, Building 22 and 23, Postbox 2099, 1014 Copenhagen K, Denmark
Malar J 9:100. 2010.... - Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum malariaTrine Staalsoe
Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
Infect Immun 72:5027-30. 2004..Our data suggest that IPTp should be extended to women of all parities, in line with current World Health Organization recommendations... - Differential induction of immunoglobulin G to Plasmodium falciparum variant surface antigens during the transmission season in Daraweesh, SudanMorten A Nielsen
Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
J Infect Dis 192:520-7. 2005..Unlike VSAs expressed by parasite isolates associated with uncomplicated malaria, VSAs expressed by parasite isolates associated with severe malaria (VSA(SM)) are frequently recognized by IgG... - Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian childrenGerald K K Cham
Centre for Medical Parasitology, University of Copenhagen, Copenhagen K, Denmark
Infect Immun 78:4653-9. 2010..The results imply that anti-PfEMP1 antibodies effectively structure PfEMP1 expression and play a major role in limiting parasite multiplication in the blood... - In vivo switching between variant surface antigens in human Plasmodium falciparum infectionTrine Staalsoe
Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
J Infect Dis 186:719-22. 2002..falciparum infection. Our results suggest that VSA switching is an important survival strategy of P. falciparum, enabling the parasite to persist despite protective, parasite-specific immune responses... - Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malariaKåre Kemp
Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Clin Diagn Lab Immunol 9:720-2. 2002..These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation... - In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African childrenTrine Staalsoe
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark
Parasite Immunol 25:421-7. 2003..The described selection method appears a useful tool in the identification of genes encoding VSA involved in severe and life-threatening P. falciparum malaria... - Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigensRosette Megnekou
Center for Medical Parasitology, Department of Infectious Diseases M7641, Copenhagan University Hospital (Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Infect Immun 73:4112-8. 2005..Taken together, our data indicate that IgG1 and to a lesser extent IgG3 are the main subclasses involved in acquired VSA(PAM)-specific immunity to pregnancy-associated malaria... - Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malariaPamela A Magistrado
Centre for Medical Parasitology at Department of Medical Microbiology and Immunology, University of Copenhagen, Denmark
Infect Immun 75:2415-20. 2007..These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes... - Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytesPeter Garred
Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
Infect Immun 71:5245-53. 2003..falciparum and may thus be involved in sequestration of the parasite, which in turn may explain the association between homozygosity for MBL variant alleles and high parasite counts... - Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodesJohn P A Lusingu
Centre for Medical Parasitology, Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
Infect Immun 74:2867-75. 2006..89; P = 0.018) but not in Kwamasimba. Antibody levels to the MSP1 constructs and the control CIDR1alpha domain were not associated with morbidity protection. These data strengthen the concept of developing vaccines based on PfEMP1... - Acute P. falciparum malaria induces a loss of CD28- T IFN-gamma producing cellsKåre Kemp
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
Parasite Immunol 24:545-8. 2002..These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria... - In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into the erythrocyte membraneHanne L Ziegler
Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, Denmark
Antimicrob Agents Chemother 46:1441-6. 2002.... - VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytesPamela Magistrado
Institute of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
J Infect Dis 198:1071-4. 2008..Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA... - A sub-family of common and highly conserved Plasmodium falciparum var genesAli Salanti
Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Mol Biochem Parasitol 122:111-5. 2002 - Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytesLea Barfod
Institute for Medical Microbiology and Immunology, Panum Institute 24-2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Infect Immun 74:4357-60. 2006..These findings have implications for the development of vaccines against pregnancy-associated Plasmodium falciparum malaria... - Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malariaMichel Cot
Mother and Child Health in the Tropics, Research Institute for Development, Hopital Tenon, Paris, France
Am J Epidemiol 157:203-9. 2003.... - Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infectionMichael F Ofori
Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Infect Immun 71:1584-6. 2003..We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research... - Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responsesLars Hviid
Infect Immun 71:2296. 2003 - Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesAnja T R Jensen
Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
J Exp Med 199:1179-90. 2004..The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria... - Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malariaDavid R Cavanagh
Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Rd, EH9 3JT, Scotland, UK
Infect Immun 72:6492-502. 2004..The results support a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falciparum and, thus, a promising new candidate for the development of a malaria vaccine... - Variant surface antigens, virulence genes and the pathogenesis of malariaKirk W Deitsch
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W-704, Box 62, New York, NY 10021, USA
Trends Parasitol 20:562-6. 2004..We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004... - Elevated levels of nitric oxide and low levels of haptoglobin are associated with severe malarial anaemia in African childrenBen Gyan
Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Acta Trop 83:133-40. 2002..The low haptoglobin and high levels of NO in this SA group may contribute to haemolysis. Taken together our results support the hypothesis that immune-mediated erythrocyte destruction is involved in the pathogenesis of malarial anaemia... - Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigensMichael F Ofori
Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Infect Immun 70:2982-8. 2002..The data from this first detailed longitudinal study of acquisition of VSA antibodies support the hypothesis that naturally acquired protective immunity to P. falciparum malaria is mediated, at least in part, by VSA-specific antibodies... - Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravidsSharon E Cox
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 10:1286-97. 2005..falciparum infected red blood cells to placental chondroitin sulphate A (CSA)... - Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidaeSharon E Cox
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom
Infect Immun 73:2841-7. 2005.... - V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stabilitySéverine Loizon
Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, Departement de Parasitologie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Microbes Infect 9:1252-9. 2007..The significance of the reproducible increase of the CD4+V beta 21.3T cell subset deserves further investigations... - Malaria in pregnancy: pathogenesis and immunityStephen J Rogerson
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Lancet Infect Dis 7:105-17. 2007.... - Selective activation of TCR-gammadelta+ cells in endemic Burkitt's lymphomaGodfred Futagbi
Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Malar J 6:69. 2007..falciparum-exposed Ghanaian children with and without eBL... - Late recrudescence of Plasmodium falciparum malaria in pregnancyLars Hviid
Int J Infect Dis 10:412. 2006 - CCR3 expression induced by IL-2 and IL-4 functioning as a death receptor for B cellsTan Jinquan
Biological Allergy Research, Hørsholm, Denmark
J Immunol 171:1722-31. 2003..The apoptotic action of eotaxin/CCL11 suggests a therapeutic modality in the treatment of B cell lymphoma...