L Hviid

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression
    Pamela A Magistrado
    Centre for Medical Parasitology at the Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 7:204. 2008
  2. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
  3. pmc Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
    Madeleine Dahlbäck
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Malar J 6:78. 2007
  4. pmc Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates
    Ayman Khattab
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Malar J 3:21. 2004
  5. ncbi request reprint Naturally acquired immunity to Plasmodium falciparum malaria in Africa
    Lars Hviid
    Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Trop 95:270-5. 2005
  6. ncbi request reprint VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria
    L Hviid
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Parasitology 134:1871-6. 2007
  7. ncbi request reprint Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity
    Lars Hviid
    Department of Infectious Diseases, Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Microbes Infect 9:772-6. 2007
  8. doi request reprint Malaria vaccines: immunity, models and monoclonal antibodies
    Lars Hviid
    Centre for Medical Parasitology at the Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen, 1014 Copenhagen K, Denmark
    Trends Parasitol 24:392-5. 2008
  9. ncbi request reprint [Pregnancy-associated malaria]
    L Hviid
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    Med Trop (Mars) 66:130-2. 2006
  10. pmc Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria
    L Hviid
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 69:3190-6. 2001

Detail Information

Publications73

  1. pmc CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression
    Pamela A Magistrado
    Centre for Medical Parasitology at the Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 7:204. 2008
    ..Also, unlike var genes from groups B and C, those from group A do not have sequences consistent with CD36 binding--a major cytoadhesion phenotype of P. falciparum isolates...
  2. pmc Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans
    Thomas Lavstsen
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Malar J 4:21. 2005
    ..Thus, severe malaria may be caused by parasites expressing PfEMP1 variants that afford parasites optimal sequestration in immunologically naive individuals and high effective multiplication rates...
  3. pmc Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites
    Madeleine Dahlbäck
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Malar J 6:78. 2007
    ..Two parasite populations were studied; an unselected population of NF54 and a selected population, NF54VAR2CSA, to compare both the transcription of var2csa and the expression pattern of the corresponding protein...
  4. pmc Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates
    Ayman Khattab
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Malar J 3:21. 2004
    ....
  5. ncbi request reprint Naturally acquired immunity to Plasmodium falciparum malaria in Africa
    Lars Hviid
    Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Trop 95:270-5. 2005
    ....
  6. ncbi request reprint VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria
    L Hviid
    Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Parasitology 134:1871-6. 2007
    ..falciparum infection...
  7. ncbi request reprint Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity
    Lars Hviid
    Department of Infectious Diseases, Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    Microbes Infect 9:772-6. 2007
    ..We are pursuing the development of vaccines based on antigens and immune responses that appear key in naturally acquired protection...
  8. doi request reprint Malaria vaccines: immunity, models and monoclonal antibodies
    Lars Hviid
    Centre for Medical Parasitology at the Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen, 1014 Copenhagen K, Denmark
    Trends Parasitol 24:392-5. 2008
    ..However, recent technological advances might help overcome some of these hurdles...
  9. ncbi request reprint [Pregnancy-associated malaria]
    L Hviid
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
    Med Trop (Mars) 66:130-2. 2006
    ..falciparum parasites. However, the understanding of the pathogenesis of PAM and of the acquired protective immune response to this syndrome is progressing at a rapid pace as outlined in this brief review...
  10. pmc Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria
    L Hviid
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 69:3190-6. 2001
    ..Taken together, our data point to an immunoregulatory role of the expanded V delta 1(+) T-cell population in this group of semi-immune P. falciparum malaria patients...
  11. ncbi request reprint The immuno-epidemiology of pregnancy-associated Plasmodium falciparum malaria: a variant surface antigen-specific perspective
    L Hviid
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen Ø, Denmark
    Parasite Immunol 26:477-86. 2004
    ..falciparum malaria operates and is acquired, have provided important insights into this enigma...
  12. pmc Variant-specific immunity to Plasmodium berghei in pregnant mice
    Rosette Megnekou
    Department of International Health, Immunology and Microbiology, University of Copenhagen, CSS Building 22, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark
    Infect Immun 77:1827-34. 2009
    ..falciparum malaria. The study of P. berghei malaria in pregnant, immune mice can be used to gain significant new insights regarding malaria pathogenesis and immunity in general and regarding PAM in particular...
  13. ncbi request reprint Malaria immunity in infants: a special case of a general phenomenon?
    Lars Hviid
    Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, 2100, Copenhagen Ø, Denmark
    Trends Parasitol 20:66-72. 2004
    ....
  14. pmc Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria
    L Hviid
    Center for Medical Parasitology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Denmark
    Infect Immun 65:4090-3. 1997
    ....
  15. pmc The gamma/delta T-cell response to Plasmodium falciparum malaria in a population in which malaria is endemic
    L Hviid
    Centre for Medical Parasitology at RHIMA Centre, Copenhagen University Hospital Rigshospitalet, Denmark
    Infect Immun 64:4359-62. 1996
    ..The study raises questions regarding age and degree of previous exposure as determinants of malaria-induced gamma/delta T-cell responses...
  16. ncbi request reprint The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development
    Lars Hviid
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Hum Vaccin 6:84-9. 2010
    ....
  17. pmc Adhesion specificities of Plasmodium falciparum-infected erythrocytes involved in the pathogenesis of pregnancy-associated malaria
    Lars Hviid
    Department of International Health, Immunology, and Microbiology, Center for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital, CSS Building 22, Øster Farimagsgade 5, PO Box 2099, 1014 Copenhagen K, Denmark
    Am J Pathol 170:1817-9. 2007
  18. ncbi request reprint Cell-mediated immune responses to soluble Plasmodium falciparum antigens in residents from an area of unstable malaria transmission in the Sudan
    L Hviid
    Department of Infectious Diseases, University Hospital, Copenhagen, Denmark
    APMIS 98:594-604. 1990
    ..This indicates that parameters outside the degree of exposure to P. falciparum influence the cellular immune responses to malaria...
  19. ncbi request reprint Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia
    T Staalsoe
    Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, 2200 Copenhagen N, Denmark
    J Infect Dis 184:618-26. 2001
    ..Data suggest that VSA(CSA) is a target for vaccination against PAM...
  20. ncbi request reprint Human T-cell recognition of synthetic peptides representing conserved and variant sequences from the merozoite surface protein 2 of Plasmodium falciparum
    T G Theander
    Centre for Medical Parasitology, University of Copenhagen, Denmark
    Immunol Lett 58:1-8. 1997
    ....
  21. ncbi request reprint Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria
    Trine Staalsoe
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Lancet 363:283-9. 2004
    ..We looked for a possible relation between VSA-specific antibody concentrations, placental infection, and protection from low birthweight and maternal anaemia...
  22. ncbi request reprint Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometry
    T Staalsoe
    Centre for Medical Parasitology at RHIMA Centre, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Cytometry 35:329-36. 1999
    ..This protein is inserted by the parasite into the host cell membrane and mediates the adhesion to the venular endothelium of the host organism in vivo...
  23. pmc Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria
    K Kemp
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Immunol 127:151-7. 2002
    ..However, the high proportion of pre-apoptotic cells from the time of admission suggests that apoptosis also contributes to the low frequency and number of T cells in the peripheral circulation during active disease...
  24. ncbi request reprint Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparum
    H A Giha
    Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, Denmark
    Parasitology 119:7-17. 1999
    ....
  25. pmc Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity
    M Theisen
    Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark
    Infect Immun 69:5223-9. 2001
    ..This indicates that synthetic peptides derived from relatively conserved epitopes of GLURP might serve as useful immunogens for vaccination against P. falciparum malaria...
  26. pmc Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania
    Lasse S Vestergaard
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, and Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 76:2706-14. 2008
    ..These differences indicate a strong and dynamic relationship between malaria exposure and functional characteristics of the variant-specific antibody response, which is likely to be important for protection against malaria...
  27. ncbi request reprint Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24 2, and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Mol Microbiol 49:179-91. 2003
    ..falciparum malaria. This var gene thus has the properties expected of a gene encoding the parasite adhesion molecule that initiates the pathology associated with PAM...
  28. ncbi request reprint Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparum
    P H Jakobsen
    Department of Treponematoses, State Seruminstitute, Copenhagen, Denmark
    Parasitol Res 76:657-61. 1990
    ..Ag1 is recognized by human immune sera from six different malaria-endemic regions. Ag1 induces in vitro proliferation of lymphocytes from malaria-immune individuals in an antigen-specific manner...
  29. pmc Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens
    J Soerli
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen Denmark
    Parasite Immunol 31:341-6. 2009
    ..The results corroborate current efforts to develop PAM-specific vaccines based on VAR2CSA...
  30. ncbi request reprint Plasmodium falciparum: VAR2CSA expressed during pregnancy-associated malaria is partially resistant to proteolytic cleavage by trypsin
    Morten A Nielsen
    Centre for Medical Parasitology, Department of Infectious Diseases M4701, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Exp Parasitol 117:1-8. 2007
    ..These results support the hypothesis that VAR2CSA mediates the adhesive and antigenic phenotypes shown by parasites causing placental malaria...
  31. pmc Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens
    Morten A Nielsen
    Centre for Medical Parasitology at Department of Infectious Diseases and Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 72:3531-5. 2004
    ..falciparum malaria...
  32. pmc Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis
    K Kemp
    Centre for Medical Parasitology at Laboratory Centre and RHIMA Centre, Copenhagen University Hospital Rigshospitalet, Denmark
    Clin Exp Immunol 116:500-4. 1999
    ..The third group could be a regulatory subset of T cells important for maintaining a balance between Th1- and Th2-type cells in these individuals...
  33. pmc West African donors have high percentages of activated cytokine producing T cells that are prone to apoptosis
    K Kemp
    Centre for Medical Parasitology at the Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Denmark
    Clin Exp Immunol 126:69-75. 2001
    ..These results may explain why some epidemic diseases seem to have a different mode of transmission in Africa compared to the western world, and may thus be of importance when vaccine strategies are considered in Africa...
  34. pmc Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria
    Anja T R Jensen
    Centre for Medical Parasitology, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 71:4193-6. 2003
    ..Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM...
  35. pmc Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo
    Rikke N Haase
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Denmark
    Infect Immun 74:3035-8. 2006
    ..We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and that the BeWo line can be used to efficiently select for VSA(PAM) expression in vitro...
  36. pmc Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
    Ali Salanti
    Centre for Medical Parasitology, Dept of Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 200:1197-203. 2004
    ....
  37. pmc Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration
    Madeleine Dahlbäck
    Centre for Medical Parasitology, University of Copenhagen and Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    PLoS Pathog 2:e124. 2006
    ..These findings strengthen the vaccine candidacy of VAR2CSA and will be important for choosing epitopes and variants of DBL3X to be included in a vaccine protecting women against pregnancy-associated malaria...
  38. pmc Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens
    N Askjaer
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Diagn Lab Immunol 8:1289-91. 2001
    ..falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN...
  39. ncbi request reprint Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria
    Trine Staalsoe
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, M7641 Rigshospitalet, Institute for Medical Microbiology and Immunology, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Immunol Lett 84:133-6. 2002
    ....
  40. pmc Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
    Lea Barfod
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Mol Microbiol 63:335-47. 2007
    ....
  41. ncbi request reprint Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity
    Morten A Nielsen
    Center for Medical Parasitology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
    J Immunol 168:3444-50. 2002
    ..This opens the possibility of developing morbidity-reducing vaccines targeting a limited subset of common and particularly virulent VSA...
  42. doi request reprint Of mice and women: rodent models of placental malaria
    Lars Hviid
    Centre for Medical Parasitology at Department for International Health, Immunology, and Microbiology ISIM, University of Copenhagen and at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Trends Parasitol 26:412-9. 2010
    ..However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity...
  43. pmc The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
    Lars M Joergensen
    Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet, CSS Øster Farimagsgade 5, Building 22 and 23, Postbox 2099, 1014 Copenhagen K, Denmark
    Malar J 9:100. 2010
    ....
  44. pmc Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum malaria
    Trine Staalsoe
    Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Infect Immun 72:5027-30. 2004
    ..Our data suggest that IPTp should be extended to women of all parities, in line with current World Health Organization recommendations...
  45. ncbi request reprint Differential induction of immunoglobulin G to Plasmodium falciparum variant surface antigens during the transmission season in Daraweesh, Sudan
    Morten A Nielsen
    Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    J Infect Dis 192:520-7. 2005
    ..Unlike VSAs expressed by parasite isolates associated with uncomplicated malaria, VSAs expressed by parasite isolates associated with severe malaria (VSA(SM)) are frequently recognized by IgG...
  46. pmc Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children
    Gerald K K Cham
    Centre for Medical Parasitology, University of Copenhagen, Copenhagen K, Denmark
    Infect Immun 78:4653-9. 2010
    ..The results imply that anti-PfEMP1 antibodies effectively structure PfEMP1 expression and play a major role in limiting parasite multiplication in the blood...
  47. ncbi request reprint In vivo switching between variant surface antigens in human Plasmodium falciparum infection
    Trine Staalsoe
    Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Infect Dis 186:719-22. 2002
    ..falciparum infection. Our results suggest that VSA switching is an important survival strategy of P. falciparum, enabling the parasite to persist despite protective, parasite-specific immune responses...
  48. pmc Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria
    Kåre Kemp
    Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:720-2. 2002
    ..These data suggest that CD30(+) cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation...
  49. ncbi request reprint In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African children
    Trine Staalsoe
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark
    Parasite Immunol 25:421-7. 2003
    ..The described selection method appears a useful tool in the identification of genes encoding VSA involved in severe and life-threatening P. falciparum malaria...
  50. pmc Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigens
    Rosette Megnekou
    Center for Medical Parasitology, Department of Infectious Diseases M7641, Copenhagan University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Infect Immun 73:4112-8. 2005
    ..Taken together, our data indicate that IgG1 and to a lesser extent IgG3 are the main subclasses involved in acquired VSA(PAM)-specific immunity to pregnancy-associated malaria...
  51. pmc Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria
    Pamela A Magistrado
    Centre for Medical Parasitology at Department of Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Infect Immun 75:2415-20. 2007
    ..These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes...
  52. pmc Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes
    Peter Garred
    Tissue Typing Laboratory 7631, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
    Infect Immun 71:5245-53. 2003
    ..falciparum and may thus be involved in sequestration of the parasite, which in turn may explain the association between homozygosity for MBL variant alleles and high parasite counts...
  53. pmc Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodes
    John P A Lusingu
    Centre for Medical Parasitology, Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
    Infect Immun 74:2867-75. 2006
    ..89; P = 0.018) but not in Kwamasimba. Antibody levels to the MSP1 constructs and the control CIDR1alpha domain were not associated with morbidity protection. These data strengthen the concept of developing vaccines based on PfEMP1...
  54. ncbi request reprint Acute P. falciparum malaria induces a loss of CD28- T IFN-gamma producing cells
    Kåre Kemp
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Parasite Immunol 24:545-8. 2002
    ..These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria...
  55. pmc In vitro Plasmodium falciparum drug sensitivity assay: inhibition of parasite growth by incorporation of stomatocytogenic amphiphiles into the erythrocyte membrane
    Hanne L Ziegler
    Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Copenhagen, Denmark
    Antimicrob Agents Chemother 46:1441-6. 2002
    ....
  56. doi request reprint VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes
    Pamela Magistrado
    Institute of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
    J Infect Dis 198:1071-4. 2008
    ..Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA...
  57. ncbi request reprint A sub-family of common and highly conserved Plasmodium falciparum var genes
    Ali Salanti
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Biochem Parasitol 122:111-5. 2002
  58. pmc Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes
    Lea Barfod
    Institute for Medical Microbiology and Immunology, Panum Institute 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Infect Immun 74:4357-60. 2006
    ..These findings have implications for the development of vaccines against pregnancy-associated Plasmodium falciparum malaria...
  59. ncbi request reprint Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria
    Michel Cot
    Mother and Child Health in the Tropics, Research Institute for Development, Hopital Tenon, Paris, France
    Am J Epidemiol 157:203-9. 2003
    ....
  60. pmc Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection
    Michael F Ofori
    Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Infect Immun 71:1584-6. 2003
    ..We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research...
  61. pmc Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responses
    Lars Hviid
    Infect Immun 71:2296. 2003
  62. pmc Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
    Anja T R Jensen
    Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
    J Exp Med 199:1179-90. 2004
    ..The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria...
  63. pmc Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria
    David R Cavanagh
    Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Rd, EH9 3JT, Scotland, UK
    Infect Immun 72:6492-502. 2004
    ..The results support a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falciparum and, thus, a promising new candidate for the development of a malaria vaccine...
  64. ncbi request reprint Variant surface antigens, virulence genes and the pathogenesis of malaria
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W 704, Box 62, New York, NY 10021, USA
    Trends Parasitol 20:562-6. 2004
    ..We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004...
  65. ncbi request reprint Elevated levels of nitric oxide and low levels of haptoglobin are associated with severe malarial anaemia in African children
    Ben Gyan
    Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Acta Trop 83:133-40. 2002
    ..The low haptoglobin and high levels of NO in this SA group may contribute to haemolysis. Taken together our results support the hypothesis that immune-mediated erythrocyte destruction is involved in the pathogenesis of malarial anaemia...
  66. pmc Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens
    Michael F Ofori
    Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Infect Immun 70:2982-8. 2002
    ..The data from this first detailed longitudinal study of acquisition of VSA antibodies support the hypothesis that naturally acquired protective immunity to P. falciparum malaria is mediated, at least in part, by VSA-specific antibodies...
  67. ncbi request reprint Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids
    Sharon E Cox
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 10:1286-97. 2005
    ..falciparum infected red blood cells to placental chondroitin sulphate A (CSA)...
  68. pmc Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae
    Sharon E Cox
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom
    Infect Immun 73:2841-7. 2005
    ....
  69. ncbi request reprint V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stability
    Séverine Loizon
    Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, Departement de Parasitologie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbes Infect 9:1252-9. 2007
    ..The significance of the reproducible increase of the CD4+V beta 21.3T cell subset deserves further investigations...
  70. ncbi request reprint Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ....
  71. pmc Selective activation of TCR-gammadelta+ cells in endemic Burkitt's lymphoma
    Godfred Futagbi
    Immunology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
    Malar J 6:69. 2007
    ..falciparum-exposed Ghanaian children with and without eBL...
  72. ncbi request reprint Late recrudescence of Plasmodium falciparum malaria in pregnancy
    Lars Hviid
    Int J Infect Dis 10:412. 2006
  73. ncbi request reprint CCR3 expression induced by IL-2 and IL-4 functioning as a death receptor for B cells
    Tan Jinquan
    Biological Allergy Research, Hørsholm, Denmark
    J Immunol 171:1722-31. 2003
    ..The apoptotic action of eotaxin/CCL11 suggests a therapeutic modality in the treatment of B cell lymphoma...