Hanne Frederiksen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi Metabolism of phthalates in humans
    Hanne Frederiksen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Nutr Food Res 51:899-911. 2007
  2. doi High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
  3. doi Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake
    Hanne Frederiksen
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Res 111:656-63. 2011
  4. doi Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Expo Sci Environ Epidemiol 21:262-71. 2011
  5. doi Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Toxicol Sci 106:376-83. 2008
  6. ncbi Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Anal Toxicol 34:400-10. 2010
  7. ncbi Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits
    Hanne Frederiksen
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade, Søborg, Denmark
    Mol Nutr Food Res 51:564-71. 2007
  8. doi Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Androl 35:227-35. 2012
  9. ncbi Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark Electronic address
    Int J Hyg Environ Health 216:710-20. 2013
  10. ncbi Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples
    Tina Harmer Lassen
    Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark Electronic address
    Environ Res 126:164-70. 2013

Collaborators

Detail Information

Publications29

  1. ncbi Metabolism of phthalates in humans
    Hanne Frederiksen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Nutr Food Res 51:899-911. 2007
    ..This differential distribution is of special concern as, in particular, the hydrophobic phthalates and their metabolites are shown to have adverse effects following in utero and lactational exposures in animal studies...
  2. doi High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
    ..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
  3. doi Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake
    Hanne Frederiksen
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Res 111:656-63. 2011
    ..They are suspected to be involved in male reproductive health problems and have also been associated with several other health problems in children including obesity and asthma...
  4. doi Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    J Expo Sci Environ Epidemiol 21:262-71. 2011
    ..In all the three matrices significant correlations between the parabens were seen. Furthermore, urinary paraben concentrations correlate to the paraben concentrations in both serum and seminal plasma...
  5. doi Higher levels of ethyl paraben and butyl paraben in rat amniotic fluid than in maternal plasma after subcutaneous administration
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    Toxicol Sci 106:376-83. 2008
    ....
  6. ncbi Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Anal Toxicol 34:400-10. 2010
    ..In seminal plasma, only MEP levels correlated significantly to levels in urine and in serum...
  7. ncbi Effects of red grape skin and seed extract supplementation on atherosclerosis in Watanabe heritable hyperlipidemic rabbits
    Hanne Frederiksen
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade, Søborg, Denmark
    Mol Nutr Food Res 51:564-71. 2007
    ....
  8. doi Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia
    Mikkel G Mieritz
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Healthy Sciences, University of Copenhagen, Copenhagen, Denmark
    Int J Androl 35:227-35. 2012
    ..However, longitudinal studies are needed to evaluate possible perinatal or long-term postnatal effects of phthalates on healthy boys...
  9. ncbi Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark Electronic address
    Int J Hyg Environ Health 216:710-20. 2013
    ..Small children were relatively more exposed to BPA than older children, while higher exposures to TCS, BP-3 and ∑DCP were seen among adolescents. ..
  10. ncbi Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples
    Tina Harmer Lassen
    Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark Electronic address
    Environ Res 126:164-70. 2013
    ..Our data do not support that collection of 24-h samples will improve individual exposure assessment for any of the analysed phenols. ..
  11. ncbi Longitudinal Changes in Circulating Testosterone Levels Determined by LC-MS/MS and by a Commercially Available Radioimmunoassay in Healthy Girls and Boys during the Pubertal Transition
    Annette Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Horm Res Paediatr 82:12-7. 2014
    ..Accurate and selective assessment of testosterone requires use of a sensitive LC-MS/MS method, especially at low levels as those seen in young children...
  12. pmc Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality
    Tina Harmer Lassen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 122:478-84. 2014
    ..Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent...
  13. ncbi Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs
    Hanne Frederiksen
    Department of Growth and Reproduction, Section 5064, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark Electronic address
    Int J Hyg Environ Health 216:772-83. 2013
    ..A high individual exposure to one chemical was often associated with a high exposure to other of the chemicals and the possibility of combination effects of multiple simultaneous exposures cannot be excluded. ..
  14. doi Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012
    Hanne Frederiksen
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Reproduction 147:555-65. 2014
    ..The exposure to other non-persistent chemicals was also widespread. Our data indicate decreasing excretion of two common phthalates (di-n-butyl phthalate and di-(2-ethylhexyl) phthalate) over time. ..
  15. doi Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence
    Anders Juul
    Departments of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Endocr Dev 22:24-39. 2012
    ..Changes in basal reproductive hormone levels in infancy, childhood and adolescence as well as the GnRH and ACTH test procedures in girls and adolescents are described in this chapter...
  16. doi Endocrine potency of wastewater: contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays
    Kresten Ole Kusk
    Technical University of Denmark, Kgs Lyngby, Denmark
    Environ Toxicol Chem 30:413-26. 2011
    ..Our data suggest that the wastewater treatment processes are not efficient enough to prevent contamination of environmental surface waters...
  17. ncbi Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans
    Nadeem Rezaq Janjua
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 31:118-30. 2008
    ..The three chemicals are systemically absorbed, metabolized and excreted in urine following application on the skin in a cream preparation. More DEP than DBP was absorbed, presumably because of a faster absorption rate for DEP...
  18. pmc Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men
    Ulla Nordström Joensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Environ Health Perspect 120:1397-403. 2012
    ..In animals, some phthalates impair male reproductive development and function. Epidemiological studies have reported inconsistent evidence of associations between phthalates and markers of human testicular function...
  19. doi Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies
    Hanne Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Sci Technol 47:958-67. 2013
    ..The only slightly higher ICCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools...
  20. doi Do parabens have the ability to interfere with steroidogenesis?
    Camilla Taxvig
    National Food Institute, Technical University of Denmark, Department of Toxicology and Risk Assessment, DK 2860 Søborg, Denmark
    Toxicol Sci 106:206-13. 2008
    ....
  21. pmc Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men
    Ulla Nordström Joensen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 122:345-50. 2014
    ..Objectives: We investigated urinary excretion of phthalate metabolites and testicular function in young men with and without FLG loss-of-function variants in a cross-sectional study of 861 young men from the general Danish population...
  22. doi Current exposure of 200 pregnant Danish women to phthalates, parabens and phenols
    Katrine Tefre de Renzy-Martin
    University Department of Growth and Reproduction, Section 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Reproduction 147:443-53. 2014
    ..The true cumulative risk for the foetus may therefore be underestimated. ..
  23. doi Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men
    Selma K Kranich
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Environ Sci Technol 48:706-12. 2014
    ..Besides the phthalates investigated here, humans are exposed to numerous other chemicals that also may contribute to a cumulative antiandrogenic exposure. ..
  24. pmc Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth
    Malene Boas
    Department of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 118:1458-64. 2010
    ..Phthalates are widely used chemicals, and human exposure is extensive. Recent studies have indicated that phthalates may have thyroid-disrupting properties...
  25. pmc Many putative endocrine disruptors inhibit prostaglandin synthesis
    David M Kristensen
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Environ Health Perspect 119:534-41. 2011
    ..However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural similarity with mild analgesics...
  26. doi Considerations for estimating daily intake values of nonpersistent environmental endocrine disruptors based on urinary biomonitoring data
    Tue Søeborg
    Department of Growth and Reproduction, GR 5064, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Reproduction 147:455-63. 2014
    ..Several knowledge gaps are identified and new studies are suggested. The route of administration used in toxicokinetic studies often does not match realistic scenarios. ..
  27. ncbi Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits
    Hanne Frederiksen
    Danish Institute for Food and Veterinary Research, Bygade, Soborg, Denmark
    Br J Nutr 97:6-10. 2007
    ..In conclusion, the tomato extract increased plasma levels of lycopene in rabbits, but had no effect on hypercholesterolaemia, oxidation of plasma lipids or aortic atherosclerosis...
  28. ncbi Urinary excretion of total isothiocyanates from cruciferous vegetables shows high dose-response relationship and may be a useful biomarker for isothiocyanate exposure
    Mette Kristensen
    Dept of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, Soborg 2860, Denmark
    Eur J Nutr 46:377-82. 2007
    ..Many ITCs are assumed to have cancer preventive effects and to further evaluate these potential health effects, reliable biomarkers of ITC exposure are needed...
  29. ncbi Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease
    Salka Elbøl Rasmussen
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Soeborg, Denmark
    Mol Nutr Food Res 49:159-74. 2005
    ....