Christina Christoffersen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi Apolipoprotein M: bridging HDL and endothelial function
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Lipidol 24:295-300. 2013
  2. pmc The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosis
    Bas W C Arkensteijn
    Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Int J Mol Sci 14:4419-31. 2013
  3. ncbi Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 283:1839-47. 2008
  4. doi The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
    J Biol Chem 283:18765-72. 2008
  5. ncbi [Heparin-induced thrombocytopenia]
    Christina Christoffersen
    Klinisk Biokemisk Afdeling, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 171:612-5. 2009
  6. pmc The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Lipid Res 53:2198-204. 2012
  7. ncbi Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Circ Res 106:1624-34. 2010
  8. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
  9. ncbi Apolipoprotein M promotes mobilization of cellular cholesterol in vivo
    Sara Elsøe
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Biochim Biophys Acta 1831:1287-92. 2013
  10. ncbi Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL
    Sara Elsøe
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Atherosclerosis 221:91-7. 2012

Collaborators

Detail Information

Publications20

  1. doi Apolipoprotein M: bridging HDL and endothelial function
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Lipidol 24:295-300. 2013
    ..The review will address the potential roles of apolipoprotein M (apoM) as a carrier protein and modulator of sphingosine-1-phosphate (S1P) bioactivity...
  2. pmc The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosis
    Bas W C Arkensteijn
    Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Int J Mol Sci 14:4419-31. 2013
    ..This review will focus on the putative biological roles of the new apoM-S1P axis in relation to lipoprotein metabolism, lipid disorders and atherosclerosis...
  3. ncbi Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 283:1839-47. 2008
    ..The effect of apoM on atherosclerosis may be facilitated by enzymatic modulation of plasma HDL particles, increased cholesterol efflux from foam cells, and an antioxidative effect of apoM-containing HDL...
  4. doi The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
    J Biol Chem 283:18765-72. 2008
    ..The data suggest that hydrophobic signal peptide sequences, if preserved upon secretion, can anchor plasma proteins in lipoproteins. In the case of apoM, this mechanism prevents rapid loss by filtration in the kidney...
  5. ncbi [Heparin-induced thrombocytopenia]
    Christina Christoffersen
    Klinisk Biokemisk Afdeling, Rigshospitalet, DK 2100 København Ø
    Ugeskr Laeger 171:612-5. 2009
    ..When HIT is likely, treatment consists of immediate replacement of heparin with alternative anticoagulation treatment and refrainment from warfarin therapy and platelet infusion...
  6. pmc The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Lipid Res 53:2198-204. 2012
    ..38, P = 0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL receptor-mediated clearance of apoB-containing particles...
  7. ncbi Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Circ Res 106:1624-34. 2010
    ..HDL-bound apoM is antiatherogenic in vitro. However, plasma apoM is not associated with coronary heart disease in humans, perhaps because of a positive correlation with plasma low-density lipoprotein (LDL)...
  8. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
    ..Our results demonstrate that apoM, by delivering S1P to the S1P(1) receptor on endothelial cells, is a vasculoprotective constituent of HDL...
  9. ncbi Apolipoprotein M promotes mobilization of cellular cholesterol in vivo
    Sara Elsøe
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Biochim Biophys Acta 1831:1287-92. 2013
    ..ApoM increases prebeta-HDL formation. We explored whether plasma apoM affects mobilization of cholesterol from peripheral cells in mice...
  10. ncbi Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL
    Sara Elsøe
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Atherosclerosis 221:91-7. 2012
    ..Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL...
  11. ncbi Isolation and characterization of human apolipoprotein M-containing lipoproteins
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospital, University of Copenhagen, Copenhagen DK 2100, Denmark
    J Lipid Res 47:1833-43. 2006
    ..Nevertheless, apoM designates a subpopulation of HDL that protects LDL against oxidation and stimulates cholesterol efflux more efficiently than HDL lacking apoM...
  12. ncbi Endothelial and lipoprotein lipases in human and mouse placenta
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 46:2339-46. 2005
    ..Nevertheless, the two lipases might have overlapping functions in the mouse placenta. Our data also suggest that the major portions of both proteins are stored in an inactive form in human term placenta...
  13. ncbi ApoM: gene regulation and effects on HDL metabolism
    Lars B Nielsen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, DK 2100, Denmark
    Trends Endocrinol Metab 20:66-71. 2009
    ..In conclusion, it seems that apoM plays a part in lipoprotein metabolism; however, the biological impact of apoM in humans remains to be determined...
  14. doi Cardiac natriuretic Peptide gene expression and plasma concentrations during the first 72 hours of life in piglets
    Julie Smith
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Endocrinology 154:1864-72. 2013
    ..However, the cardiac gene expression does not explain plasma concentrations...
  15. doi Apolipoprotein M promotes mobilization of cellular cholesterol in vivo
    Sara Elsøe
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Biochim Biophys Acta 1831:1287-92. 2012
    ..ApoM increases preβ-HDL formation. We explored whether plasma apoM affects mobilization of cholesterol from peripheral cells in mice...
  16. doi Osteopontin deficiency dampens the pro-atherogenic effect of uraemia
    Tanja X Pedersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Cardiovasc Res 98:352-9. 2013
    ..OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice...
  17. pmc (18)F-FDG PET imaging of murine atherosclerosis: association with gene expression of key molecular markers
    Anne Mette Fisker Hag
    Cluster for Molecular Imaging, Faculty of Health and Medical Sciences and Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50908. 2012
    ..To study whether (18)F-FDG can be used for in vivo imaging of atherogenesis by examining the correlation between (18)F-FDG uptake and gene expression of key molecular markers of atherosclerosis in apoE(-/-) mice...
  18. ncbi Cardiac lipid accumulation associated with diastolic dysfunction in obese mice
    Christina Christoffersen
    Departments of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 2100
    Endocrinology 144:3483-90. 2003
    ..The results also suggest that the cardiac lipid accumulation is paralleled by cardiac diastolic dysfunction in ob/ob mice...
  19. ncbi Induction of atherosclerosis in mice and hamsters without germline genetic engineering
    Martin Maeng Bjørklund
    From the Departments of Clinical Medicine M M B, M K H, J F B and Biomedicine A K H, F D H, J G M, Aarhus University, Aarhus, Denmark Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark M M B, M K H, J F B and Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark C C
    Circ Res 114:1684-9. 2014
    ....