H Bruunsgaard

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage
    H Bruunsgaard
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, Denmark
    J Physiol 499:833-41. 1997
  2. ncbi request reprint Proinflammatory cytokines, antibodies to Chlamydia pneumoniae and age-associated diseases in Danish centenarians: is there a link?
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Infect Dis 34:493-9. 2002
  3. ncbi request reprint Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Eur Cytokine Netw 13:389-91. 2002
  4. pmc Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Glostrup University Hospital, Denmark
    Clin Exp Immunol 132:24-31. 2003
  5. ncbi request reprint Decreased natural killer cell activity is associated with atherosclerosis in elderly humans
    H Bruunsgaard
    Department of Infectious Diseases M7641, H S, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 N, Copenhagen, Denmark
    Exp Gerontol 37:127-36. 2001
  6. ncbi request reprint Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men
    Helle Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Denmark
    J Nutr 133:1170-3. 2003
  7. ncbi request reprint Elevated levels of tumor necrosis factor alpha and mortality in centenarians
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Am J Med 115:278-83. 2003
  8. ncbi request reprint TNF-alpha, leptin, and lymphocyte function in human aging
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Life Sci 67:2721-31. 2000
  9. ncbi request reprint Special feature for the Olympics: effects of exercise on the immune system: effects of exercise on the immune system in the elderly population
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Immunol Cell Biol 78:523-31. 2000
  10. pmc Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Immunol 121:255-60. 2000

Detail Information

Publications44

  1. pmc Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage
    H Bruunsgaard
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, Denmark
    J Physiol 499:833-41. 1997
    ..However, as eccentric exercise caused a more pronounced increase in the concentration of NK cells and CD8+ cells, factors involved in muscle damage may also contribute to the recruitment of these cells...
  2. ncbi request reprint Proinflammatory cytokines, antibodies to Chlamydia pneumoniae and age-associated diseases in Danish centenarians: is there a link?
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Scand J Infect Dis 34:493-9. 2002
    ..pneumoniae infection and these disorders...
  3. ncbi request reprint Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Eur Cytokine Netw 13:389-91. 2002
    ....
  4. pmc Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Glostrup University Hospital, Denmark
    Clin Exp Immunol 132:24-31. 2003
    ..These findings indicate that at least in old populations chronic elevated levels of TNF-alpha and IL-6 have different biological functions that trigger age-associated pathology and cause mortality...
  5. ncbi request reprint Decreased natural killer cell activity is associated with atherosclerosis in elderly humans
    H Bruunsgaard
    Department of Infectious Diseases M7641, H S, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 N, Copenhagen, Denmark
    Exp Gerontol 37:127-36. 2001
    ..Elderly people with severe medical disorders had low numbers of circulating NK cells. Furthermore, elderly people with atherosclerosis had low cytotoxicity per NK cell and a high number of circulating neutrophils...
  6. ncbi request reprint Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men
    Helle Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Denmark
    J Nutr 133:1170-3. 2003
    ....
  7. ncbi request reprint Elevated levels of tumor necrosis factor alpha and mortality in centenarians
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Am J Med 115:278-83. 2003
    ..We hypothesized that TNF-alpha was also a prognostic marker for all-cause mortality in these persons...
  8. ncbi request reprint TNF-alpha, leptin, and lymphocyte function in human aging
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Life Sci 67:2721-31. 2000
    ..In conclusion, increased plasma levels of TNF-alpha in aging is associated with poor IL-2 production ex vivo and lymphocyte activation in vivo. These associations do not seem to involve leptin...
  9. ncbi request reprint Special feature for the Olympics: effects of exercise on the immune system: effects of exercise on the immune system in the elderly population
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Immunol Cell Biol 78:523-31. 2000
    ..However, highly conditioned elderly humans seem to have a relatively better preserved immune system, although it is not possible to conclude if this is linked to training or other lifestyle-related factors...
  10. pmc Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Immunol 121:255-60. 2000
    ..In conclusion, the present study shows that in a cohort of 81-year-old humans, high levels of TNF-alpha in the blood were associated with a high prevalence of atherosclerosis...
  11. ncbi request reprint Physical activity and modulation of systemic low-level inflammation
    Helle Bruunsgaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, Faculty of Health Sciences, University of Copenhagen, DK 2100 Copenhagen East, Denmark
    J Leukoc Biol 78:819-35. 2005
    ..It is discussed how this fits the consistent observation that enhanced plasma levels of IL-6 represent a strong risk marker in chronic disorders associated with systemic low-level inflammation and all-cause mortality...
  12. pmc Proliferative responses of blood mononuclear cells (BMNC) in a cohort of elderly humans: role of lymphocyte phenotype and cytokine production
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Denmark
    Clin Exp Immunol 119:433-40. 2000
    ..Accordingly, a minimum of true naive CD4+ cells was required for a normal proliferative response to PHA, perhaps by providing sufficient IL-2 which is critical for growth of naive as well as memory cells...
  13. ncbi request reprint Exercise induces recruitment of lymphocytes with an activated phenotype and short telomeres in young and elderly humans
    H Bruunsgaard
    Department of Infectious Diseases, University of Copenhagen, Denmark
    Life Sci 65:2623-33. 1999
    ..Furthermore, elderly humans fulfilling the Senieur protocol have a preserved ability to recruit T lymphocytes in response to acute physical stress...
  14. ncbi request reprint A high plasma concentration of TNF-alpha is associated with dementia in centenarians
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    J Gerontol A Biol Sci Med Sci 54:M357-64. 1999
    ....
  15. pmc Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans
    H Bruunsgaard
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, Copenhagen
    Clin Exp Immunol 118:235-41. 1999
    ..However, the clinical relevance is questionable in healthy elderly people because decreased levels were found compared with young men but not compared with young women...
  16. pmc Ageing is associated with a prolonged fever response in human endotoxemia
    K S Krabbe
    Department of Infectious Diseases M7641, Laboratory B2014, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen O, Denmark
    Clin Diagn Lab Immunol 8:333-8. 2001
    ..In conclusion, ageing is associated with an altered acute-phase response including initial hyperreactivity, prolonged inflammatory activity, and prolonged fever response...
  17. ncbi request reprint Genetic priming of a proinflammatory profile predicts low IQ in octogenarians
    K S Krabbe
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Neurobiol Aging 30:769-81. 2009
    ..Only the IL-18 haplotype was associated with inflammation in the peripheral blood and only with regard to circulating TNF-alpha...
  18. pmc High serum YKL-40 level in a cohort of octogenarians is associated with increased risk of all-cause mortality
    J S Johansen
    Department of Rheumatology and Geriatric Medicine, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Immunol 151:260-6. 2008
    ..These results suggest that serum YKL-40 is a prognostic and sensitive biomarker of all-cause mortality in octogenarians...
  19. ncbi request reprint Strenuous exercise decreases the percentage of type 1 T cells in the circulation
    A Steensberg
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
    J Appl Physiol 91:1708-12. 2001
    ..Furthermore, IL-6 may stimulate type 2 T cells, thereby maintaining a relatively unaltered percentage of these cells in the circulation compared with total circulating lymphocyte number...
  20. ncbi request reprint Hypotension during endotoxemia in aged humans
    K S Krabbe
    The Department of Infectious Medicine M7721, Rigshospitalet, University of Copenhagen, Denmark
    Eur J Anaesthesiol 18:572-5. 2001
    ..CONCLUSION: In conclusion, healthy elderly subjects fail to maintain a constant mean arterial pressure in response to the immunological challenge of endotoxemia...
  21. pmc Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans
    S Taudorf
    Department of Infectious Diseases, Centre of Inflammation and Metabolism, Rigshiospitalet, Unviersity of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark
    Clin Exp Immunol 152:147-52. 2008
    ..Previous reports of a major heritability factor in the inflammatory response may be due to other target genes or effects in older age groups or women...
  22. ncbi request reprint The cytokine response to strenuous exercise
    B K Pedersen
    Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    Can J Physiol Pharmacol 76:505-11. 1998
    ..The present review also discusses the possible roles of protein breakdown, delayed onset muscle soreness, and clinical implications of the acute-phase response following exercise...
  23. pmc Activated T lymphocytes disappear from circulation during endotoxemia in humans
    K S Krabbe
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:731-5. 2002
    ..In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis...
  24. pmc Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?
    M Sandmand
    The Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Clin Exp Immunol 127:107-14. 2002
    ..Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile...
  25. ncbi request reprint Exercise and immune function: effect of ageing and nutrition
    B K Pedersen
    Copenhagen Muscle Research Centre, Denmark
    Proc Nutr Soc 58:733-42. 1999
    ..In conclusion, it is premature to make recommendations regarding nutritional supplementation to avoid post-exercise impairment of the immune system...
  26. ncbi request reprint Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
    K S Krabbe
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 50:431-8. 2007
    ..These disorders are associated with type 2 diabetes, and animal models suggest that BDNF plays a role in insulin resistance. We therefore explored whether BDNF plays a role in human glucose metabolism...
  27. ncbi request reprint Possible beneficial role of exercise in modulating low-grade inflammation in the elderly
    B K Pedersen
    Department of Infectious Diseases and Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Med Sci Sports 13:56-62. 2003
    ..We suggest that muscle-derived IL-6 contributes to mediate the beneficial metabolic effects of exercise and may contribute to inhibit TNF-production and thereby insulin resistance...
  28. ncbi request reprint Cytokines in aging and exercise
    B K Pedersen
    The Copenhagen Muscle Research Centre, Department of Infectious Diseases, University of Copenhagen, Denmark
    Int J Sports Med 21:S4-9. 2000
    ..Therefore, in future studies, exercise is suggested as an ethically applicable model to use in studies on mechanisms underlying the age-associated altered cytokine response...
  29. ncbi request reprint Aging and proinflammatory cytokines
    H Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Curr Opin Hematol 8:131-6. 2001
    ..However, a causal relation between the acute phase response and the increased mortality because of bacterial infections in older patients remains to be demonstrated...
  30. pmc Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients
    B Lindegaard
    Department of Infectious Diseases, University of Copenhagen, Denmark
    Clin Exp Immunol 135:273-9. 2004
    ....
  31. ncbi request reprint Identification of IFN-gamma-producing CD4+ T cells following PMA stimulation
    K Kemp
    Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    J Interferon Cytokine Res 21:503-6. 2001
    ..01). Our data suggest that intracellular staining of CD4 together with cytokine staining will make identification of CD4(+) cells possible and facilitate the procedure of intracellular staining of cytokines...
  32. ncbi request reprint Low-dose endotoxemia and human neuropsychological functions
    Karen Suarez Krabbe
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
    Brain Behav Immun 19:453-60. 2005
    ..In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis...
  33. ncbi request reprint The tumor necrosis factor alpha -308G>A polymorphism is associated with dementia in the oldest old
    Helle Bruunsgaard
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Geriatr Soc 52:1361-6. 2004
    ..To test the hypothesis that the tumor necrosis factor (TNF) -308 G>A promoter gene polymorphism is a risk factor in age-related dementia and longevity...
  34. ncbi request reprint The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality
    Helle Bruunsgaard
    The laboratory of the BKP group presently Centre of inflammation and Metabolism, Department of Infectious Diseases, H S Rigshospitalet, Denmark
    Dan Med Bull 53:285-309. 2006
  35. ncbi request reprint Inflammatory mediators in the elderly
    Karen Suarez Krabbe
    Department of Infectious Diseases, H S, Rigshospitalet, University of Copenhagen, M7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Exp Gerontol 39:687-99. 2004
    ..Several studies support indeed this hypothesis but, unfortunately, findings in this area are conflicting, which probably reflects the complexity of the effect of cytokine polymorphisms and their interaction with the lifestyle and sex...
  36. ncbi request reprint The IL-6 -174G>C polymorphism is associated with cardiovascular diseases and mortality in 80-year-old humans
    Helle Bruunsgaard
    Institute of Public Health, Epidemiology, University of Southern Denmark, Odense, Denmark
    Exp Gerontol 39:255-61. 2004
    ..This effect was not detected among smokers. We conclude that the IL-6 -174G>C polymorphism was an independent predictor of all-cause mortality in octogenarians but the effect was complex and interacted with the smoking status...
  37. ncbi request reprint Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old
    Helle Bruunsgaard
    Department of Infectious Diseases, Hovedstadens Sygehusfćlleskab, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Am Geriatr Soc 52:237-41. 2004
    ....
  38. ncbi request reprint Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    Maria Pedersen
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Mech Ageing Dev 124:495-502. 2003
    ..Furthermore, TNF-alpha was related to lower ASM and BCM, suggesting that TNF-alpha contributes to sarcopenia in ageing...
  39. ncbi request reprint Asymptomatic bacteriuria in elderly humans is associated with increased levels of circulating TNF receptors and elevated numbers of neutrophils
    Tine Krogstrup Priø
    Department of Infectious Diseases M7641, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 N Copenhagen, Denmark
    Exp Gerontol 37:693-9. 2002
    ..Thus, the present study provides some support for the hypothesis that asymptomatic urinary infections are associated with low-grade immune activity in frail, elderly humans...
  40. pmc Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells
    Kåre Kemp
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Infect Immun 70:5019-25. 2002
    ..In conclusion, these data suggest that activated T lymphocytes with a type 1 cytokine profile are highly engaged in the in vivo immune response to S. pneumoniae...
  41. ncbi request reprint Prolonged exercise, lymphocyte apoptosis and F2-isoprostanes
    Adam Steensberg
    The Copenhagen Muscle Research Centre, and The Department of Infectious Diseases Rigshospitalet, University of Copenhagen, Rigshospitalet 7641, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Eur J Appl Physiol 87:38-42. 2002
    ....
  42. ncbi request reprint Cytokine response to eccentric exercise in young and elderly humans
    Anders Dyhr Toft
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Am J Physiol Cell Physiol 283:C289-95. 2002
    ..Our data also suggest that aging may be associated with impaired repair mechanisms for exercise-induced muscle damage...
  43. ncbi request reprint High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes
    Marie Sandmand
    The Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark
    Gerontology 49:155-60. 2003
    ..High plasma levels of tumor necrosis factor (TNF)-alpha are strongly associated with morbidity and mortality in elderly humans. However, the cellular source and mechanisms for the increased circulating TNF-alpha levels are unknown...
  44. ncbi request reprint Exercise-induced change in type 1 cytokine-producing CD8+ T cells is related to a decrease in memory T cells
    Tobias Ibfelt
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Appl Physiol 93:645-8. 2002
    ..94; P < or = 0.002). In conclusion, this study demonstrates that the exercise-induced change in type 1 cytokine-producing T cells is related to a decline in memory cells...