Stig E Bojesen

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. pmc Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
    Stig E Bojesen
    Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Nat Genet 45:371-84, 384e1-2. 2013
  2. doi request reprint Short telomere length, myocardial infarction, ischemic heart disease, and early death
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:822-9. 2012
  3. doi request reprint Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study
    Diljit Kaur-Knudsen
    Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Oncol 29:2875-82. 2011
  4. doi request reprint Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease
    Shoaib Afzal
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Thorax 69:24-31. 2014
  5. doi request reprint Statin use and reduced cancer-related mortality
    Sune F Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    N Engl J Med 367:1792-802. 2012
  6. pmc Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study
    Sune F Nielsen
    Department of Clinical Biochemistry, 54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    BMJ 345:e5244. 2012
  7. doi request reprint Short telomere length, cancer survival, and cancer risk in 47102 individuals
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 105:459-68. 2013
  8. ncbi request reprint Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease
    Diljit Kaur-Knudsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Curr Vasc Pharmacol 10:512-20. 2012
  9. doi request reprint Plasma YKL-40 and total and disease-specific mortality in the general population
    Julia S Johansen
    Department of Oncology, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark
    Clin Chem 56:1580-91. 2010
  10. doi request reprint Plasma YKL-40 levels in healthy subjects from the general population
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark
    Clin Chim Acta 412:709-12. 2011

Detail Information

Publications35

  1. pmc Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
    Stig E Bojesen
    Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Nat Genet 45:371-84, 384e1-2. 2013
    ..3 × 10(-11)) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant...
  2. doi request reprint Short telomere length, myocardial infarction, ischemic heart disease, and early death
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:822-9. 2012
    ..We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death...
  3. doi request reprint Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study
    Diljit Kaur-Knudsen
    Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Clin Oncol 29:2875-82. 2011
    ....
  4. doi request reprint Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease
    Shoaib Afzal
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Thorax 69:24-31. 2014
    ..We examined the association of plasma 25(OH)D levels with lung function, lung function decline and risk of chronic obstructive pulmonary disease (COPD)...
  5. doi request reprint Statin use and reduced cancer-related mortality
    Sune F Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    N Engl J Med 367:1792-802. 2012
    ..We tested the hypothesis that statin use begun before a cancer diagnosis is associated with reduced cancer-related mortality...
  6. pmc Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study
    Sune F Nielsen
    Department of Clinical Biochemistry, 54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    BMJ 345:e5244. 2012
    ..To test whether elevated concentration of rheumatoid factor is associated with long term development of rheumatoid arthritis...
  7. doi request reprint Short telomere length, cancer survival, and cancer risk in 47102 individuals
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Natl Cancer Inst 105:459-68. 2013
    ..We therefore tested the hypotheses that short telomere length was associated with increased risk of cancer and with increased risk of early death after cancer...
  8. ncbi request reprint Cytochrome P450 1B1 and 2C9 genotypes and risk of ischemic vascular disease, cancer, and chronic obstructive pulmonary disease
    Diljit Kaur-Knudsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Curr Vasc Pharmacol 10:512-20. 2012
    ....
  9. doi request reprint Plasma YKL-40 and total and disease-specific mortality in the general population
    Julia S Johansen
    Department of Oncology, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev, Denmark
    Clin Chem 56:1580-91. 2010
    ..We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population...
  10. doi request reprint Plasma YKL-40 levels in healthy subjects from the general population
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark
    Clin Chim Acta 412:709-12. 2011
    ..Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects...
  11. doi request reprint Low plasma 25-hydroxyvitamin D and risk of tobacco-related cancer
    Shoaib Afzal
    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark
    Clin Chem 59:771-80. 2013
    ..We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population...
  12. doi request reprint Plasma 25-hydroxyvitamin D and risk of non-melanoma and melanoma skin cancer: a prospective cohort study
    Shoaib Afzal
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Invest Dermatol 133:629-36. 2013
    ..In conclusion, we show that increasing levels of 25-OH-vitD are associated with increased risk of non-melanoma and melanoma skin cancer...
  13. doi request reprint Prostate-specific antigen and long-term prediction of prostate cancer incidence and mortality in the general population
    David D Orsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Eur Urol 61:865-74. 2012
    ..It is largely unknown whether prostate-specific antigen (PSA) level at first date of testing predicts long-term risk of prostate cancer (PCa) incidence and mortality in the general population...
  14. pmc Associations between first and second primary cancers: a population-based study
    Sune F Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, and the Faculty of Health Sciences, University of Copenhagen, Herlev, Denmark
    CMAJ 184:E57-69. 2012
    ..We tested the hypothesis that excess risk of a second primary cancer is due mainly to excess risk of it being the same type of cancer as the first, rather than to excess risk of it being a different type...
  15. doi request reprint Long-term prostate-specific antigen velocity in improved classification of prostate cancer risk and mortality
    David D Ørsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark
    Eur Urol 64:384-93. 2013
    ..It remains unclear whether adding long-term prostate-specific antigen velocity (PSAV) to baseline PSA values improves classification of prostate cancer (PCa) risk and mortality in the general population...
  16. doi request reprint Short telomere length, lung function and chronic obstructive pulmonary disease in 46,396 individuals
    Line Rode
    Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Thorax 68:429-35. 2013
    ..A previous case-control study of 100 individuals found that short telomere length was associated with a 28-fold increased risk of chronic obstructive pulmonary disease (COPD)...
  17. doi request reprint Risk of thyroid cancer, brain cancer, and non-Hodgkin lymphoma after adult leukemia: a nationwide study
    Sune F Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Blood 118:4062-9. 2011
    ..4-223) for thyroid cancer, 7.2 (95% CI, 2.0-26) for brain cancer, and 6.5 (95% CI, 0.4-110) for NHL. Patients with adult leukemia have excess risk of thyroid cancer, brain cancer, and NHL, similar to patients with childhood leukemia...
  18. pmc Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study
    Kristine H Allin
    Department of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Breast Cancer Res 13:R55. 2011
    ..We examined whether plasma C-reactive protein (CRP) levels at the time of diagnosis of breast cancer are associated with overall survival, disease-free survival, death from breast cancer, and recurrence of breast cancer...
  19. doi request reprint Association of clinical benign prostate hyperplasia with prostate cancer incidence and mortality revisited: a nationwide cohort study of 3,009,258 men
    David D Ørsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Denmark
    Eur Urol 60:691-8. 2011
    ..Although benign prostate hyperplasia (BPH) and prostate cancer (PCa) share features such as hormone-dependent growth and response to treatment with antiandrogen therapy, BPH is generally not considered a premalignant lesion...
  20. ncbi request reprint Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia
    Shoaib Afzal
    The Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Alzheimers Dement 10:296-302. 2014
    ..We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population...
  21. ncbi request reprint Risk of cancer among HIV-infected individuals compared to the background population: impact of smoking and HIV
    Marie Helleberg
    aDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen bThe Copenhagen General Population Study and Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev Hospital, Herlev cDepartment of Infectious Diseases, Copenhagen University Hospital, Hvidovre dDepartment of Infectious Diseases, Aarhus University Hospital, Skejby eDepartment of Infectious Diseases, Odense University Hospital, Odense fFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    AIDS 28:1499-508. 2014
    ..We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency...
  22. ncbi request reprint Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study
    Shoaib Afzal
    The Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Lancet Diabetes Endocrinol 2:298-306. 2014
    ....
  23. pmc Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements 10 years apart
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 10:e1004191. 2014
    ..Also, change in telomere length did not associate prospectively with mortality or morbidity in the general population...
  24. ncbi request reprint Splice site mutations in mismatch repair genes and risk of cancer in the general population
    Mette Thomsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark
    Fam Cancer 12:567-72. 2013
    ..These findings are novel and important in the counseling of HNPCC patients and their relatives...
  25. pmc CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer
    Maren Weischer
    University of Copenhagen, Copenhagen, Denmark
    J Clin Oncol 30:4308-16. 2012
    ..We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific death, and risk of a second breast cancer in women with a first breast cancer...
  26. doi request reprint Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis
    Shoaib Afzal
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    Clin Chem 59:381-91. 2013
    ..We tested the hypothesis that low plasma 25-hydroxyvitamin D [25(OH)D] is associated with increased risk of type 2 diabetes in the general population...
  27. ncbi request reprint [C-reactive protein, risk of and survival after cancer--secondary publication]
    Kristine H Allin
    Herlev Hospital, Klinisk Biokemisk Afdeling, Herlev, Denmark
    Ugeskr Laeger 171:3510-3. 2009
    ..1 (1.2-3.8) for lung cancer, 1.7 (0.8-3.2) for colorectal cancer, and 0.9 (0.5-1.7) for breast cancer. Multifactorially adjusted hazard ratios for early death in patients with cancer were 1.8 (1.2-2.7) for CRP > 3 versus < 1 mg/L...
  28. doi request reprint CHRNA3 genotype, nicotine dependence, lung function and disease in the general population
    Diljit Kaur-Knudsen
    Dept of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark
    Eur Respir J 40:1538-44. 2012
    ..In ever-smokers, the CHRNA3 rs1051730 genotype associated with reduced lung function and increased COPD severity...
  29. doi request reprint CHRNA3 and CYP3A5*3 genotype, lung function and chronic obstructive pulmonary disease in the general population
    Diljit Kaur-Knudsen
    aDepartment of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital bCopenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital cInstitute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark
    Pharmacogenet Genomics 24:220-9. 2014
    ....
  30. ncbi request reprint Genetic variants in CHI3L1 influencing YKL-40 levels: resequencing 900 individuals and genotyping 9000 individuals from the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Herlev, Denmark
    J Med Genet 50:831-7. 2013
    ..Therefore, we aimed at identifying genetic variants in CHI3L1 influencing plasma YKL-40 levels in the general population...
  31. doi request reprint Diagnostic value of JAK2 V617F somatic mutation for myeloproliferative cancer in 49 488 individuals from the general population
    Camilla Nielsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev, Denmark
    Br J Haematol 160:70-9. 2013
    ..In conclusion, in the general population the JAK2 V617F somatic mutation has a high diagnostic value for myeloproliferative cancer when combined with conventional haematological parameters...
  32. doi request reprint The link between benign prostatic hyperplasia and prostate cancer
    David D Ørsted
    54N5 Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Nat Rev Urol 10:49-54. 2013
    ..Establishing BPH as a causal factor for prostate cancer development could improve the accuracy of prognostication and expedite intervention, potentially reducing the number of men who die from prostate cancer...
  33. doi request reprint CHEK2*1100delC and risk of malignant melanoma: Danish and German studies and meta-analysis
    Maren Weischer
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark
    J Invest Dermatol 132:299-303. 2012
    ..81 (95% CI, 1.07-3.05). Stratifications did not alter these results. CHEK2*1100delC heterozygotes have a twofold risk of malignant melanoma compared with noncarriers...
  34. doi request reprint Elevated plasma YKL-40 levels and ischemic stroke in the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 68:672-80. 2010
    ..In contrast to C-reactive protein (CRP) produced in the liver in response to inflammation, YKL-40 is produced by lipid-laden macrophages inside the vessel wall...
  35. doi request reprint Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Int J Cancer 128:644-52. 2011
    ..However, MTHFR c.677C>T homozygosity with lifelong hyperhomocysteinemia and hence hypomethylation associate with increased risk of esophagus and gastric cancer, and with decreased risk of colorectal cancer...