P Bech

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. doi request reprint Psychometric validation of the Hopkins Symptom Checklist (SCL-90) subscales for depression, anxiety, and interpersonal sensitivity
    P Bech
    Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University, Hillerød, Denmark Electronic address
    J Affect Disord 160:98-103. 2014
  2. pmc Screening for depressed mood in an adolescent psychiatric context by brief self-assessment scales--testing psychometric validity of WHO-5 and BDI-6 indices by latent trait analyses
    Eva Henje Blom
    Department of Clinical Neuroscience, Karolinska Institutet, Retzius vag 8, A2 3, Stockholm 17177, Sweden
    Health Qual Life Outcomes 10:149. 2012
  3. pmc Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)
    Yaacov G Bachner
    Department of Public Health and the Center for Multidisciplinary Research in Aging, Faculty of Health Sciences, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel
    BMC Psychiatry 13:2. 2013
  4. doi request reprint The predictive validity of atypical neurovegetative depressive symptoms identified by the first principal component in the DUAG trial of moclobemide versus clomipramine
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    J Affect Disord 140:253-9. 2012
  5. doi request reprint Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trial
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    Acta Psychiatr Scand 125:342-8. 2012
  6. doi request reprint Psychometric validation and clinical validity of the Minor Melancholia Mood Checklist (MMCL-32)
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    J Affect Disord 137:79-86. 2012
  7. ncbi request reprint [Stress and psychometrics]
    Per Bech
    Psykiatrisk Forskningsenhed, Psykiatrisk Center Nordsjælland, Dyrehavevej 48, 3400 Hillerød, Denmark
    Ugeskr Laeger 174:195-7. 2012
  8. pmc Effect of a multidisciplinary stress treatment programme on the return to work rate for persons with work-related stress. A non-randomized controlled study from a stress clinic
    Bo Netterstrøm
    The Stress Clinic, Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, DK 2400 Copenhagen, Denmark
    BMC Public Health 10:658. 2010
  9. doi request reprint HAM-D17 and HAM-D6 sensitivity to change in relation to desvenlafaxine dose and baseline depression severity in major depressive disorder
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Pharmacopsychiatry 43:271-6. 2010
  10. doi request reprint Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, University of Copenhagen, Hillerød, Denmark
    Acta Psychiatr Scand 123:154-61. 2011

Collaborators

Detail Information

Publications50

  1. doi request reprint Psychometric validation of the Hopkins Symptom Checklist (SCL-90) subscales for depression, anxiety, and interpersonal sensitivity
    P Bech
    Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University, Hillerød, Denmark Electronic address
    J Affect Disord 160:98-103. 2014
    ....
  2. pmc Screening for depressed mood in an adolescent psychiatric context by brief self-assessment scales--testing psychometric validity of WHO-5 and BDI-6 indices by latent trait analyses
    Eva Henje Blom
    Department of Clinical Neuroscience, Karolinska Institutet, Retzius vag 8, A2 3, Stockholm 17177, Sweden
    Health Qual Life Outcomes 10:149. 2012
    ..The aim of the study is to test the psychometric validity of two such scales, which may be used in a two-step screening procedure, the WHO-Five Well-being Index (WHO-5) and the six-item version of Beck's Depression Inventory (BDI-6)...
  3. pmc Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)
    Yaacov G Bachner
    Department of Public Health and the Center for Multidisciplinary Research in Aging, Faculty of Health Sciences, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel
    BMC Psychiatry 13:2. 2013
    ..The current study compares both self-report and clinician-rated versions of the Hebrew version of this scale...
  4. doi request reprint The predictive validity of atypical neurovegetative depressive symptoms identified by the first principal component in the DUAG trial of moclobemide versus clomipramine
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    J Affect Disord 140:253-9. 2012
    ....
  5. doi request reprint Outcomes on the pharmacopsychometric triangle in bupropion-SR vs. buspirone augmentation of citalopram in the STAR*D trial
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    Acta Psychiatr Scand 125:342-8. 2012
    ..buspirone in the acute therapy of major depression in the STAR*D study. The triangle provides a composite view in three domains of antidepressive activity, side effects, and quality of life...
  6. doi request reprint Psychometric validation and clinical validity of the Minor Melancholia Mood Checklist (MMCL-32)
    P Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, Copenhagen University, Hillerød, Denmark
    J Affect Disord 137:79-86. 2012
    ..The Minor Melancholia Mood Checklist (MMCL-32) was developed to identify sub-threshold states of major depression. The MMCL-32 can be considered as the counterpole to the Hypomanic Check List (HCL-32)...
  7. ncbi request reprint [Stress and psychometrics]
    Per Bech
    Psykiatrisk Forskningsenhed, Psykiatrisk Center Nordsjælland, Dyrehavevej 48, 3400 Hillerød, Denmark
    Ugeskr Laeger 174:195-7. 2012
    ..In PTSD patients the unspecific arousal syndrome (HAM-D9) is the first syndrome to emerge, typically after the two first weeks...
  8. pmc Effect of a multidisciplinary stress treatment programme on the return to work rate for persons with work-related stress. A non-randomized controlled study from a stress clinic
    Bo Netterstrøm
    The Stress Clinic, Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, DK 2400 Copenhagen, Denmark
    BMC Public Health 10:658. 2010
    ..The aim of this study was to test the effect of a multidisciplinary stress treatment programme on the return to work (RTW) rate in persons with work-related stress and establish predictive factors for this outcome...
  9. doi request reprint HAM-D17 and HAM-D6 sensitivity to change in relation to desvenlafaxine dose and baseline depression severity in major depressive disorder
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Pharmacopsychiatry 43:271-6. 2010
    ..This retrospective analysis compared sensitivity to change on the 17-item and 6-item Hamilton Rating Scales For Depression (HAM-D (17) and HAM-D (6), respectively) in relation to antidepressant dose and baseline depression severity...
  10. doi request reprint Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, University of Copenhagen, Hillerød, Denmark
    Acta Psychiatr Scand 123:154-61. 2011
    ..e., the important pharmacopsychometric triangle domains...
  11. doi request reprint From items to syndromes in the Hypomania Checklist (HCL-32): psychometric validation and clinical validity analysis
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Copenhagen University, Hillerød, Denmark
    J Affect Disord 132:48-54. 2011
    ..The Hypomania Checklist (HCL-32) was developed to identify subthreshold bipolarity in patients with major depression. An HCL-32 version with fewer items has been suggested...
  12. doi request reprint Factor structure and dimensionality of the two depression scales in STAR*D using level 1 datasets
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Copenhagen University, Hillerød, Denmark
    J Affect Disord 132:396-400. 2011
    ....
  13. doi request reprint Mood and anxiety in the medically ill
    Per Bech
    Psychiatric Research Unit, Mental Health Centre North Zealand, University of Copenhagen, Hillerød, Denmark
    Adv Psychosom Med 32:118-32. 2012
    ..The Clinical Interview for Depression and Related Syndromes (CIDRS) is included in the appendix as this CIDRS covers many of the rating scales measuring mood and anxiety...
  14. ncbi request reprint Adjunctive bright light in non-seasonal major depression: results from clinician-rated depression scales
    K Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 112:117-25. 2005
    ..To investigate the use of bright light therapy as an adjunct treatment to sertraline in non-seasonal major depression...
  15. ncbi request reprint Psychiatric outcome studies (POS): does treatment help the patients? A Popperian approach to research in clinical psychiatry
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, 48, Dyrehavevej, DK 3400 Hillerød, Denmark
    Nord J Psychiatry 61:4-34. 2007
  16. doi request reprint Identifying patients with therapy-resistant depression by using factor analysis
    K Andreasson
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Pharmacopsychiatry 43:252-6. 2010
    ..Attempts to identify the factor structure in patients with treatment-resistant depression have been very limited...
  17. doi request reprint High cortisol awakening response is associated with an impairment of the effect of bright light therapy
    K Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, DK 3400 Hillerød, Denmark
    Acta Psychiatr Scand 120:196-202. 2009
    ..We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression...
  18. ncbi request reprint Modafinil augmentation in depressed patients with partial response to antidepressants: a pilot study on self-reported symptoms covered by the Major Depression Inventory (MDI) and the Symptom Checklist (SCL-92)
    N A Rasmussen
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej, Hillerød, Denmark
    Nord J Psychiatry 59:173-8. 2005
    ..Modafinil thus appears to be an appropriate augmentation to antidepressant treatment, leading to a remission rate of 43%. However, the results from this open-label study need ot be confirmed in a placebo-controlled trial...
  19. ncbi request reprint The Major Depression Rating Scale (MDS). Inter-rater reliability and validity across different settings in randomized moclobemide trials. Danish University Antidepressant Group
    P Bech
    Psychiatric Institute, Frederiksborg General Hospital, Hillerød, Denmark
    J Affect Disord 42:39-48. 1997
    ..However, studies are needed to standardize the scale, especially in the general practice setting...
  20. doi request reprint Repetitive transcranial magnetic stimulation (rTMS) in combination with escitalopram in patients with treatment-resistant major depression: a double-blind, randomised, sham-controlled trial
    L G Bretlau
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Pharmacopsychiatry 41:41-7. 2008
    ..However, because a recent meta-analysis showed only a small effect size of rTMS over sham TMS in the acute treatment phase of depressed patients, we decided to make an interim analysis...
  21. ncbi request reprint Mental distress in the Danish general population
    L R Olsen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 113:477-84. 2006
    ..To evaluate associations between mental distress and biopsychosocial factors...
  22. pmc Fatigue in the Danish general population. Influence of sociodemographic factors and disease
    T Watt
    Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200 NV Copenhagen, Denmark
    J Epidemiol Community Health 54:827-33. 2000
    ..To measure the levels of fatigue in the general population, and to examine how disease and sociodemographic factors influence fatigue...
  23. ncbi request reprint The WHO Quality of Life (WHOQOL) Questionnaire: Danish validation study
    V Nørholm
    Psychiatric Research Institute, WHO Collaborating Centre, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hillerød, Denmark
    Nord J Psychiatry 55:229-35. 2001
    ..The abbreviated version of WHOQOL-100, the WHOQOL-BREF, was analysed separately and was also found psychometrically valid. The WHOQOL is a questionnaire that is easy to administer, and it seems applicable for use...
  24. ncbi request reprint The internalising and externalising dimensions of affective symptoms in depressed (unipolar) and bipolar patients
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerod, Denmark
    Psychother Psychosom 75:362-9. 2006
    ..To analyse the internalising and externalising dimensions of affective states in depressed (unipolar) and bipolar patients approximately 2 years after discharge from psychiatric hospitals in Denmark...
  25. doi request reprint A validation analysis of two self-reported HAM-D6 versions
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Copenhagen University Hospitals, Hilleroed, Denmark
    Acta Psychiatr Scand 119:298-303. 2009
    ..In this study, the two self-reported versions of the HAM-D(6) have been psychometrically validated to ensure the unidimensionality of this administration form in patients with mild-to-moderate depression...
  26. ncbi request reprint Anxiety and depression in breast cancer patients at low risk of recurrence compared with the general population: a valid comparison?
    M Groenvold
    Department of Health Services Research, Institute of Public Health, University of Copenhagen, Denmark
    J Clin Epidemiol 52:523-30. 1999
    ..However, we question the validity of this comparison. The HADS may not be suitable for use in the general population and there may be methodological problems in comparisons of groups whose life situations are very different...
  27. ncbi request reprint Adjunctive bright light in non-seasonal major depression: results from patient-reported symptom and well-being scales
    K Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 111:453-9. 2005
    ..In this study, we tested the efficacy of bright light therapy as an adjunct to antidepressant treatment (sertraline) in patients with non-seasonal major depression...
  28. ncbi request reprint The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, DK 3400 Hilleroed, Denmark
    J Affect Disord 66:159-64. 2001
    ..This Major Depression Inventory (MDI) can be scored both according to the DSM-IV and the ICD-10 algorithms for depressive symptomatology and according to severity scales by the simple total sum of the items...
  29. ncbi request reprint Validity of HoNOS in identifying frequently hospitalized patients with ICD-10 mental disorders
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej, Hillerød, Denmark
    Acta Psychiatr Scand 113:485-91. 2006
    ....
  30. ncbi request reprint Effective dose of escitalopram in moderate versus severe DSM-IV major depression
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, 3400 Hillerød, Denmark
    Pharmacopsychiatry 39:128-34. 2006
    ..The hypothesis tested was that escitalopram 10 mg/d might be an effective dose in moderate MDD, whereas escitalopram 20 mg/d might be needed in severe depression...
  31. ncbi request reprint Work-related stressors, depression and quality of life in Danish managers
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, DK 3400 Hilleroed, Denmark
    Eur Psychiatry 20:S318-25. 2005
    ..By use of valid questionnaires to investigate work-related stress and distress in Danish managers...
  32. ncbi request reprint Citalopram dose-response revisited using an alternative psychometric approach to evaluate clinical effects of four fixed citalopram doses compared to placebo in patients with major depression
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Dyrehavevej 48, 3400 Hillerød, Denmark
    Psychopharmacology (Berl) 163:20-5. 2002
    ..Among the many problems in interpreting dose-response studies with antidepressants are the psychometric problems in the identification of true antidepressive effect versus true adverse drug effect...
  33. ncbi request reprint Quality of life in the Danish general population--normative data and validity of WHOQOL-BREF using Rasch and item response theory models
    V Noerholm
    Psychiatric Research Unit, WHO Collaborating Center, Frederiksborg General Hospital, Hilleroed, Denmark
    Qual Life Res 13:531-40. 2004
    ..Furthermore, the objective of the study was to estimate the reference data for the quality of life questionnaire WHOQOL-BREF in the general Danish population and in subgroups defined by age, gender, and education...
  34. ncbi request reprint Dimensionality, responsiveness and standardization of the Bech-Rafaelsen Mania Scale in the ultra-short therapy with antipsychotics in patients with severe manic episodes
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Denmark
    Acta Psychiatr Scand 104:25-30. 2001
    ..The difference was statistically significant. CONCLUSION: The MAS has been found to be a valid scale to measure early onset of action and response in the ultra-short antimanic treatment with typical antipsychotics...
  35. ncbi request reprint Association between clinically depressed subgroups, type of treatment and patient retention in the LIDO study
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Psychol Med 33:1051-9. 2003
    ..Few data are available with which to evaluate the association between depressed subgroups, type of treatment and patient retention during episodes of major depression...
  36. ncbi request reprint Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss
    T H Andersen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Nord J Psychiatry 59:205-8. 2005
    ..In addition, we observed a medium weight reduction of 10.5 kg (range 1-20 kg)...
  37. ncbi request reprint Prevalence of major depression and stress indicators in the Danish general population
    L R Olsen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 109:96-103. 2004
    ....
  38. ncbi request reprint Monitoring improvement using a patient-rated depression scale during treatment with anti-depressants in general practice. A validation study on the Goldberg Depression Scale
    J Holm
    Department of Psychiatry, Frederiksborg General Hospital, Hillerød, Denmark
    Scand J Prim Health Care 19:263-6. 2001
    ..To perform a pilot study on the value of the Goldberg Depression Scale as an instrument for monitoring improvement in depressed patients treated with anti-depressants in general practice...
  39. ncbi request reprint Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Nord J Psychiatry 60:181-2. 2006
    ..In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity...
  40. ncbi request reprint The SCL-90 and SCL-90R versions validated by item response models in a Danish community sample
    L R Olsen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 110:225-9. 2004
    ..To evaluate the internal validity of the subscales of the combined SCL-90 and SCL-90R, the SCL-92, by item response analyses as compared with several previously reported factor analyses of this questionnaire in the literature...
  41. doi request reprint Fifty years with the Hamilton scales for anxiety and depression. A tribute to Max Hamilton
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Psychother Psychosom 78:202-11. 2009
    ..Max Hamilton therefore belongs to the very exclusive family of eminent physicians celebrated by this journal with a tribute...
  42. ncbi request reprint Meta-analysis of placebo-controlled trials with mirtazapine using the core items of the Hamilton Depression Scale as evidence of a pure antidepressive effect in the short-term treatment of major depression
    P Bech
    Psychiatric Research Unit, WHO Collaborating Center for Mental Health, Frederiksberg General Hospital, Hillerød, Denmark
    Int J Neuropsychopharmacol 4:337-45. 2001
    ..In conclusion, a purely antidepressive effect of mirtazapine has been demonstrated concerning both improvement after the acute therapy of major depression and early onset of action...
  43. doi request reprint Applied psychometrics in clinical psychiatry: the pharmacopsychometric triangle
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, University of Copenhagen, Hillerød, Denmark
    Acta Psychiatr Scand 120:400-9. 2009
    ..To consider applied psychometrics in psychiatry as a discipline focusing on pharmacopsychology rather than psychopharmacology as illustrated by the pharmacopsychometric triangle...
  44. ncbi request reprint Relapse prevention by citalopram in SAD patients responding to 1 week of light therapy. A placebo-controlled study
    K Martiny
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Acta Psychiatr Scand 109:230-4. 2004
    ..We have tested the relapse-preventive effect of citalopram when compared with placebo in 282 patients with Seasonal Affective Disorder (SAD) responding to 1 week of light therapy...
  45. ncbi request reprint Reliability and validity of the Danish version of the Calgary Depression Scale for Schizophrenia
    T Schuetze
    Psychiatric Research Unit, Frederiksborg General Hospital, , Denmark
    Nord J Psychiatry 55:119-22. 2001
    ..For the inter-observer reliability the intra-class coefficients have been calculated. It was shown that a subscale of the Calgary scale has sufficient reliability and validity...
  46. ncbi request reprint Clomipramine and mianserin in the treatment of chronic tension headache. A double-blind, controlled study
    M Langemark
    Department of Neurology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
    Headache 30:118-21. 1990
    ..Although the trend was the same for the other parameters, the changes relative to placebo did not reach statistical significance...
  47. pmc The Pharmacopsychometric Triangle to Illustrate the Effectiveness of T-PEMF Concomitant with Antidepressants in Treatment Resistant Patients: A Double-Blind, Randomised, Sham-Controlled Trial Revisited with Focus on the Patient-Reported Outcomes
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, 3400 Hillerød, Denmark
    Depress Res Treat 2011:806298. 2011
    ..41. The advantage of active over sham T-PEMF obtained an effect size of 0.48. Conclusion. Active T-PEMF was found superior to sham T-PEMF within the pharmacopsychometric triangle with a clinically significant effect size level above 0.40...
  48. ncbi request reprint The Bech-Rafaelsen Melancholia Scale (MES) in clinical trials of therapies in depressive disorders: a 20-year review of its use as outcome measure
    P Bech
    Psychiatric Research, Unit WHO Collaborating Centre for Mental Health, Frederiksborg General Hospital, Denmark
    Acta Psychiatr Scand 106:252-64. 2002
    ..To evaluate the psychometric properties of the Bech-Rafaelsen Melancholia Scale (MES) by reviewing clinical trials in which it has been used as outcome measure...
  49. ncbi request reprint The internal and external validity of the Major Depression Inventory in measuring severity of depressive states
    L R Olsen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Psychol Med 33:351-6. 2003
    ..We aimed to evaluate this as a scale measuring severity of depressive states with reference to both internal and external validity...
  50. ncbi request reprint Dose-response relationship of pregabalin in patients with generalized anxiety disorder. A pooled analysis of four placebo-controlled trials
    P Bech
    Psychiatric Research Unit, Frederiksborg General Hospital, Hillerød, Denmark
    Pharmacopsychiatry 40:163-8. 2007
    ..Four of the available six placebo-controlled trials were found acceptable for a pooled analysis of dose-response relationship...