L Aksglaede

Summary

Affiliation: Copenhagen University Hospital
Country: Denmark

Publications

  1. ncbi A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1005-11. 2009
  2. doi Testicular function and fertility in men with Klinefelter syndrome: a review
    L Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, Section 5064, University of Copenhagen, Copenhagen, Denmark
    Eur J Endocrinol 168:R67-76. 2013
  3. doi 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management
    Lise Aksglaede
    Department of Growth and Reproduction GR, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Am J Med Genet C Semin Med Genet 163:55-63. 2013
  4. ncbi High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
  5. ncbi Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, and Department of Biostatistics, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 95:5357-64. 2010
  6. pmc Age at puberty and the emerging obesity epidemic
    Lise Aksglaede
    Department of Growth and Reproduction, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8450. 2009
  7. doi Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:839-45. 2011
  8. ncbi Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arch Dis Child 93:30-4. 2008
  9. doi Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:793-806. 2011
  10. doi Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period: associations with adrenal androgen levels and puberty
    A Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:3755-64. 2013

Detail Information

Publications31

  1. ncbi A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys
    A Juul
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 94:1005-11. 2009
    ..The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys...
  2. doi Testicular function and fertility in men with Klinefelter syndrome: a review
    L Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, Section 5064, University of Copenhagen, Copenhagen, Denmark
    Eur J Endocrinol 168:R67-76. 2013
    ....
  3. doi 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management
    Lise Aksglaede
    Department of Growth and Reproduction GR, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Am J Med Genet C Semin Med Genet 163:55-63. 2013
    ..The aim of this review is to present the clinical aspects of XXY and the age-specific recommendations for medical management. © 2013 Wiley Periodicals, Inc...
  4. ncbi High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    Eur J Endocrinol 157:345-50. 2007
    ..The aim of this study was to evaluate the HPG axis in KS infants...
  5. ncbi Changes in anti-Müllerian hormone (AMH) throughout the life span: a population-based study of 1027 healthy males from birth (cord blood) to the age of 69 years
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, and Department of Biostatistics, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Clin Endocrinol Metab 95:5357-64. 2010
    ..AMH is a testis-specific marker used for diagnosis in infants with ambiguous genitalia or bilateral cryptorchidism...
  6. pmc Age at puberty and the emerging obesity epidemic
    Lise Aksglaede
    Department of Growth and Reproduction, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e8450. 2009
    ....
  7. doi Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:839-45. 2011
    ..We therefore aimed at determining circulating AMH concentrations in patients with 47,XXY Klinefelter syndrome (KS) with or without cryptorchidism...
  8. ncbi Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome
    L Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Arch Dis Child 93:30-4. 2008
    ..To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome (KS)...
  9. doi Clinical and biological parameters in 166 boys, adolescents and adults with nonmosaic Klinefelter syndrome: a Copenhagen experience
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Acta Paediatr 100:793-806. 2011
    ..We aimed at describing the phenotypic characteristics throughout life from clinical follow-up of our large cohort of patients with KS...
  10. doi Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period: associations with adrenal androgen levels and puberty
    A Mouritsen
    Department of Growth and Reproduction, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 98:3755-64. 2013
    ..Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in children...
  11. doi High urinary phthalate concentration associated with delayed pubarche in girls
    H Frederiksen
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Int J Androl 35:216-26. 2012
    ..We demonstrated that delayed pubarche, but not thelarche, was associated with high phthalate excretion in urine samples from 725 healthy school girls, which may suggest anti-androgenic actions of phthalates in our study group of girls...
  12. ncbi Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty
    A Mouritsen
    Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 33:346-59. 2010
    ..The effects may differ between boys and girls, as there are sex differences in age at onset of puberty, hormonal profiles and prevalence of precocius puberty...
  13. ncbi Abnormal sex chromosome constitution and longitudinal growth: serum levels of insulin-like growth factor (IGF)-I, IGF binding protein-3, luteinizing hormone, and testosterone in 109 males with 47,XXY, 47,XYY, or sex-determining region of the Y chromosome
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:169-76. 2008
    ..Growth is a highly complex process regulated by the interaction between sex steroids and the GH IGF-axis. However, other factors such as sex chromosome-related genes play independent roles...
  14. doi Low semen volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX male syndrome
    L Aksglaede
    University Department of Growth and Reproduction, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 32:376-84. 2009
    ..The small semen volume supports the notion of 47,XXY patients being androgen insufficient despite serum testosterone levels within the normal range...
  15. doi Recent decline in age at breast development: the Copenhagen Puberty Study
    Lise Aksglaede
    Rigshospitalet, Department of Growth and Reproduction GR, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Pediatrics 123:e932-9. 2009
    ..Here we present new European data systematically collected from the same region and by 1 research group at the beginning and end of the recent 15-year period...
  16. doi Adverse metabolic risk profiles in Greenlandic Inuit children compared to Danish children
    T Munch-Andersen
    Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 21:1226-31. 2013
    ..The objective was, therefore, in the comparison with Danish children, to evaluate metabolic profiles in Greenlandic Inuit children from the capital in the southern and from the northern most villages..
  17. ncbi Preserved fertility in a non-mosaic Klinefelter patient with a mutation in the fibroblast growth factor receptor 3 gene: case report
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet Section 5064, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod 22:1907-11. 2007
    ....
  18. doi Early breast development in girls after prenatal exposure to non-persistent pesticides
    C Wohlfahrt-Veje
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 35:273-82. 2012
    ..In addition, lower serum AMH levels indicated a reduced pool of antral ovarian follicles. The long-term consequences of our findings with regard to establishment of future reproductive function still remain unknown...
  19. ncbi A simple screening method for detection of Klinefelter syndrome and other X-chromosome aneuploidies based on copy number of the androgen receptor gene
    A M Ottesen
    Department of Growth and Reproduction, Juliane Marie Centre, Section GR 5064, The National University Hospital of Copenhagen, DK 2100, Copenhagen, Denmark
    Mol Hum Reprod 13:745-50. 2007
    ..Our findings demonstrated that the AR-qPCR technique is a simple and reliable screening method for diagnosis of patients with Klinefelter syndrome or other chromosomal disorders involving an aberrant number of X-chromosomes...
  20. doi Serum levels of anti-Müllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients
    Casper P Hagen
    Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 95:5003-10. 2010
    ..In adult women, anti-Müllerian hormone (AMH) is related to the ovarian follicle pool. Little is known about AMH in girls...
  21. doi Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:3736-44. 2010
    ..Early menarche is associated with increased risk of cardiovascular disease in adulthood. It is unknown whether metabolic risk factors are adversely affected in girls with central precocious puberty (CPP) already at time of diagnosis...
  22. ncbi Primary testicular failure in Klinefelter's syndrome: the use of bivariate luteinizing hormone-testosterone reference charts
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Clin Endocrinol (Oxf) 66:276-81. 2007
    ..The combined evaluation of serum LH and testosterone levels in the evaluation of testicular failure has not been widely advocated...
  23. pmc Forty years trends in timing of pubertal growth spurt in 157,000 Danish school children
    Lise Aksglaede
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 3:e2728. 2008
    ..The aim of our study was to determine if the age at onset of pubertal growth spurt (OGS) and at peak height velocity (PHV) during puberty show secular trends during four decades in a large cohort of school children...
  24. pmc Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark
    Diabetes Care 32:909-14. 2009
    ..The aim of the present study was to evaluate SHBG as a predictor of glucose metabolism and metabolic risk during puberty...
  25. ncbi Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark
    J Clin Endocrinol Metab 94:2966-9. 2009
    ..The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH...
  26. ncbi Recent changes in pubertal timing in healthy Danish boys: associations with body mass index
    Kaspar Sørensen
    Department of Growth and Reproduction, Copenhagen University Hospital, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:263-70. 2010
    ..In the 1990s, the American population-based study NHANES III renewed the focus on possible secular trends in male puberty. However, no conclusions could be made on pubertal onset due to the lack of compatible data...
  27. ncbi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010
    ..The GH/IGF-I axis influences gonadal development and function. Recently, a deletion of exon 3 in the GH receptor gene (GHRd3) has been linked to increased responsiveness to GH...
  28. ncbi Natural history of seminiferous tubule degeneration in Klinefelter syndrome
    Lise Aksglaede
    Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Hum Reprod Update 12:39-48. 2006
    ....
  29. pmc Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes
    Lise Aksglaede
    University Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Section 5064, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Eur J Endocrinol 158:803-10. 2008
    ..The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes...
  30. doi Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy
    Anne Marie Ottesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Am J Med Genet A 152:1206-12. 2010
    ..0 (-3.5 to -0.8) in 49,XXXXX (n = 3). Height increased with an increasing number of extra X or Y chromosomes, except in males with five, and in females with four or five sex chromosomes, consistent with a nonlinear effect on height...
  31. ncbi The sensitivity of the child to sex steroids: possible impact of exogenous estrogens
    Lise Aksglaede
    University Department of Growth and Reproduction, GR 5064, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Hum Reprod Update 12:341-9. 2006
    ..Because no lower threshold for estrogenic action has been established, caution should be taken to avoid unnecessary exposure of fetuses and children to exogenous sex steroids and endocrine disruptors, even at very low levels...