Olivier Taboureau

Summary

Affiliation: Center for Biological Sequence Analysis
Country: Denmark

Publications

  1. pmc ChemProt-2.0: visual navigation in a disease chemical biology database
    Sonny Kim Kjærulff
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Nucleic Acids Res 41:D464-9. 2013
  2. pmc ChemProt: a disease chemical biology database
    Olivier Taboureau
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, DK 2800 Denmark
    Nucleic Acids Res 39:D367-72. 2011
  3. ncbi request reprint In silico predictions of hERG channel blockers in drug discovery: from ligand-based and target-based approaches to systems chemical biology
    Olivier Taboureau
    Center for Biological Sequences Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Comb Chem High Throughput Screen 14:375-87. 2011
  4. doi request reprint HExpoChem: a systems biology resource to explore human exposure to chemicals
    Olivier Taboureau
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark
    Bioinformatics 29:1231-2. 2013
  5. ncbi request reprint The effect of network biology on drug toxicology
    Laurent Gautier
    Technical University of Denmark, Center for Biological Sequence Analysis, Department of Systems Biology, Lyngby, Denmark
    Expert Opin Drug Metab Toxicol 9:1409-18. 2013
  6. pmc Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks
    Karine Audouze
    Department of Systems Biology, Technical University of Denmark, Center for Biological Sequence Analysis, Lyngby, Denmark
    PLoS Comput Biol 6:e1000788. 2010
  7. doi request reprint Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico/in vitro work flow
    Irene Kouskoumvekaki
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    J Chem Inf Model 53:923-37. 2013
  8. pmc Identification of odorant-receptor interactions by global mapping of the human odorome
    Karine Audouze
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 9:e93037. 2014
  9. doi request reprint Established and emerging trends in computational drug discovery in the structural genomics era
    Olivier Taboureau
    Center for Biological Sequences Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
    Chem Biol 19:29-41. 2012
  10. doi request reprint Identification of LasR ligands through a virtual screening approach
    Søren Skovstrup
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark
    ChemMedChem 8:157-63. 2013

Collaborators

Detail Information

Publications12

  1. pmc ChemProt-2.0: visual navigation in a disease chemical biology database
    Sonny Kim Kjærulff
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark
    Nucleic Acids Res 41:D464-9. 2013
    ..Filtering options were included in order to facilitate and to guide dynamic search of specific queries...
  2. pmc ChemProt: a disease chemical biology database
    Olivier Taboureau
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, DK 2800 Denmark
    Nucleic Acids Res 39:D367-72. 2011
    ..The server can be accessed at http://www.cbs.dtu.dk/services/ChemProt/...
  3. ncbi request reprint In silico predictions of hERG channel blockers in drug discovery: from ligand-based and target-based approaches to systems chemical biology
    Olivier Taboureau
    Center for Biological Sequences Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    Comb Chem High Throughput Screen 14:375-87. 2011
    ..Finally, integration of network-based analysis on drugs inducing potentially long-QT syndrome and arrhythmia will be discussed as a new perspective for a better understanding of the drug responses in systems chemical biology...
  4. doi request reprint HExpoChem: a systems biology resource to explore human exposure to chemicals
    Olivier Taboureau
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark
    Bioinformatics 29:1231-2. 2013
    ....
  5. ncbi request reprint The effect of network biology on drug toxicology
    Laurent Gautier
    Technical University of Denmark, Center for Biological Sequence Analysis, Department of Systems Biology, Lyngby, Denmark
    Expert Opin Drug Metab Toxicol 9:1409-18. 2013
    ..With this approach, the assessment of chemical safety can be done across multiple scales of complexity from molecular to cellular and system levels in human health. Network biology can be used at several levels of complexity...
  6. pmc Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks
    Karine Audouze
    Department of Systems Biology, Technical University of Denmark, Center for Biological Sequence Analysis, Lyngby, Denmark
    PLoS Comput Biol 6:e1000788. 2010
    ..The chemical-protein associations are supported through recent published studies, which illustrate the power of our approach that integrates toxicogenomics data with other data types...
  7. doi request reprint Discovery of a novel selective PPARγ ligand with partial agonist binding properties by integrated in silico/in vitro work flow
    Irene Kouskoumvekaki
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, DK 2800 Kgs Lyngby, Denmark
    J Chem Inf Model 53:923-37. 2013
    ..Further studies on the transcriptional regulation properties of compound 9 revealed a gene regulatory profile that was to a large extent unique, however functionally closer to that of a partial agonist...
  8. pmc Identification of odorant-receptor interactions by global mapping of the human odorome
    Karine Audouze
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 9:e93037. 2014
    ..Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome. ..
  9. doi request reprint Established and emerging trends in computational drug discovery in the structural genomics era
    Olivier Taboureau
    Center for Biological Sequences Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
    Chem Biol 19:29-41. 2012
    ..A list of generally freely available software packages and online resources is provided, and examples of successful applications are briefly commented upon...
  10. doi request reprint Identification of LasR ligands through a virtual screening approach
    Søren Skovstrup
    Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Kgs Lyngby, Denmark
    ChemMedChem 8:157-63. 2013
    ..The binding modes of these compounds to the OHN binding site in LasR were predicted and used to identify the key interactions that contribute to the induction and inhibition of LasR activity...
  11. doi request reprint Methods for building quantitative structure-activity relationship (QSAR) descriptors and predictive models for computer-aided design of antimicrobial peptides
    Olivier Taboureau
    Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    Methods Mol Biol 618:77-86. 2010
    ..Therefore, this chapter is devoted to describe the QSAR method and recent progress applied in AMP...
  12. doi request reprint hERG classification model based on a combination of support vector machine method and GRIND descriptors
    Qiyuan Li
    Center for Biological Sequence Analysis, BioCentrum DTU, Technical University of Denmark, Building 208, DK 2800 Lyngby, Denmark
    Mol Pharm 5:117-27. 2008
    ....